Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1510
  Reference Plasmid   1111525849478649_bin.13__k141_134241
  Reference Plasmid Size   84727
  Reference Plasmid GC Content   0.64
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0002173 IHKANBDG_00042 56516 20 Skin 0.11 protein_coding synonymous_variant LOW 273C>T Thr91Thr
M0002174 IHKANBDG_00042 56870 24 Skin 0.13 protein_coding synonymous_variant LOW 627G>A Lys209Lys
M0002175 IHKANBDG_00042 56894 24 Skin 0.13 protein_coding synonymous_variant LOW 651T>C Tyr217Tyr
M0002176 IHKANBDG_00050 64819 25 Skin 0.14 protein_coding synonymous_variant LOW 352C>T Leu118Leu
M0002177 IHKANBDG_00050 64845 25 Skin 0.14 protein_coding missense_variant MODERATE 378C>A Asp126Glu
M0002178 IHKANBDG_00007 9915 3 Skin 0.02 protein_coding synonymous_variant LOW 39C>T His13His
M0002179 IHKANBDG_00029 37635 27 Skin 0.15 protein_coding missense_variant MODERATE 3232G>A Ala1078Thr
M0002180 IHKANBDG_00029 37685 27 Skin 0.15 protein_coding missense_variant MODERATE 3182G>T Ser1061Ile
M0002181 IHKANBDG_00029 38261 21 Skin 0.12 protein_coding missense_variant MODERATE 2606A>G Gln869Arg
M0002182 IHKANBDG_00029 40337 18 Skin 0.10 protein_coding missense_variant MODERATE 530G>C Gly177Ala
M0002183 IHKANBDG_00029 40360 18 Skin 0.10 protein_coding synonymous_variant LOW 507A>G Pro169Pro
M0002184 IHKANBDG_00029 40374 18 Skin 0.10 protein_coding missense_variant MODERATE 493G>C Asp165His
M0002185 IHKANBDG_00029 40379 18 Skin 0.10 protein_coding missense_variant MODERATE 488C>A Thr163Lys
M0002186 IHKANBDG_00053 68877 3 Skin 0.02 protein_coding synonymous_variant LOW 543T>A Val181Val
M0002187 IHKANBDG_00057 74331 4 Skin 0.02 protein_coding synonymous_variant LOW 699A>G Ala233Ala
M0002188 IHKANBDG_00057 74337 4 Skin 0.02 protein_coding synonymous_variant LOW 705T>C Thr235Thr
M0002189 IHKANBDG_00057 74408 4 Skin 0.02 protein_coding missense_variant MODERATE 776G>A Gly259Asp
M0002190 IHKANBDG_00057 74430 4 Skin 0.02 protein_coding synonymous_variant LOW 798G>A Val266Val
M0002191 IHKANBDG_00058 75516 5 Skin 0.03 protein_coding missense_variant MODERATE 801C>A Asp267Glu
M0002192 IHKANBDG_00058 75552 5 Skin 0.03 protein_coding synonymous_variant LOW 837G>T Leu279Leu
M0002193 IHKANBDG_00058 75630 8 Skin 0.04 protein_coding synonymous_variant LOW 915T>C Pro305Pro
M0002194 IHKANBDG_00001 2062 13 Skin 0.07 protein_coding synonymous_variant LOW 1506C>T Gly502Gly
M0002195 IHKANBDG_00002 3089 3 Skin 0.02 protein_coding synonymous_variant LOW 618G>A Glu206Glu
M0002196 IHKANBDG_00002 3350 15 Skin 0.08 protein_coding synonymous_variant LOW 879T>C Ile293Ile
M0002197 IHKANBDG_00002 3740 17 Skin 0.09 protein_coding synonymous_variant LOW 1269T>C Ala423Ala
M0002198 IHKANBDG_00002 3755 17 Skin 0.09 protein_coding synonymous_variant LOW 1284C>T Arg428Arg
M0002199 IHKANBDG_00002 3761 17 Skin 0.09 protein_coding synonymous_variant LOW 1290T>C Ala430Ala
M0002200 IHKANBDG_00002 3803 16 Skin 0.09 protein_coding synonymous_variant LOW 1332C>G Ala444Ala
M0002201 IHKANBDG_00002 4116 16 Skin 0.09 protein_coding missense_variant MODERATE 1645G>T Ala549Ser
M0002202 IHKANBDG_00004 5459 17 Skin 0.09 protein_coding missense_variant MODERATE 601G>C Glu201Gln
M0002203 IHKANBDG_00004 5485 17 Skin 0.09 protein_coding synonymous_variant LOW 627A>G Leu209Leu
M0002204 IHKANBDG_00005 6491 18 Skin 0.10 protein_coding synonymous_variant LOW 1275T>C Asn425Asn
M0002205 IHKANBDG_00005 6511 18 Skin 0.10 protein_coding missense_variant MODERATE 1255A>G Ile419Val
M0002206 IHKANBDG_00005 6527 18 Skin 0.10 protein_coding synonymous_variant LOW 1239T>C Asp413Asp
M0002207 IHKANBDG_00005 6563 18 Skin 0.10 protein_coding synonymous_variant LOW 1203G>A Glu401Glu
M0002208 IHKANBDG_00005 6566 18 Skin 0.10 protein_coding synonymous_variant LOW 1200A>G Glu400Glu
M0002209 IHKANBDG_00009 11962 30 Skin 0.16 protein_coding missense_variant MODERATE 299A>G Lys100Arg
M0002210 IHKANBDG_00011 14376 16 Skin 0.09 protein_coding synonymous_variant LOW 2229A>G Val743Val
M0002211 IHKANBDG_00011 15183 13 Skin 0.07 protein_coding synonymous_variant LOW 1422C>G Ala474Ala
M0002212 IHKANBDG_00044 58616 7 Skin 0.04 protein_coding synonymous_variant LOW 855G>A Thr285Thr
M0002213 IHKANBDG_00054 74536 4 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -3616A>G None
M0002214 IHKANBDG_00059 79121 3 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -984G>A None
M0002215 IHKANBDG_00059 79122 3 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -985C>T None
M0002216 IHKANBDG_00023 30880 7 Skin 0.04 protein_coding synonymous_variant LOW 138C>G Val46Val
M0002217 IHKANBDG_00024 31245 46 Skin 0.25 protein_coding synonymous_variant LOW 72T>G Thr24Thr
M0002218 IHKANBDG_00024 31557 5 Skin 0.03 protein_coding stop_gained HIGH 384C>A Tyr128*
M0002219 IHKANBDG_00019 31981 6 Skin 0.03 protein_coding upstream_gene_variant MODIFIER -4920G>A None
M0002220 IHKANBDG_00019 32031 4 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -4970G>C None
M0002221 IHKANBDG_00029 37878 3 Skin 0.02 protein_coding missense_variant MODERATE 2989G>T Asp997Tyr
M0002222 IHKANBDG_00020 27493 6 Skin 0.03 protein_coding synonymous_variant LOW 720G>A Val240Val
M0002223 IHKANBDG_00022 30424 5 Skin 0.03 protein_coding synonymous_variant LOW 1323G>A Val441Val
M0002224 IHKANBDG_00047 61043 3 Skin 0.02 protein_coding missense_variant MODERATE 128A>C Lys43Thr
M0002225 IHKANBDG_00019 26615 3 Skin 0.02 protein_coding synonymous_variant LOW 447C>T Ile149Ile
M0002226 IHKANBDG_00029 38077 3 Skin 0.02 protein_coding synonymous_variant LOW 2790C>T Arg930Arg
M0002227 IHKANBDG_00024 31785 5 Skin 0.03 protein_coding synonymous_variant LOW 612C>T Asp204Asp
M0002228 IHKANBDG_00044 58349 5 Skin 0.03 protein_coding synonymous_variant LOW 588T>C Thr196Thr
M0002229 IHKANBDG_00004 6106 3 Skin 0.02 protein_coding missense_variant MODERATE 1248T>G His416Gln
M0002230 IHKANBDG_00010 12973 4 Skin 0.02 protein_coding missense_variant MODERATE 449G>A Arg150Gln
M0002231 IHKANBDG_00001 667 13 Skin 0.07 protein_coding missense_variant MODERATE 111A>T Glu37Asp
M0002232 IHKANBDG_00050 64530 3 Skin 0.02 protein_coding synonymous_variant LOW 63T>C Val21Val
M0002233 IHKANBDG_00059 76908 3 Skin 0.02 protein_coding synonymous_variant LOW 1230G>A Ala410Ala
M0002234 IHKANBDG_00061 79571 4 Skin 0.02 protein_coding missense_variant MODERATE 400C>T Arg134Trp
M0002235 IHKANBDG_00053 69312 5 Skin 0.03 protein_coding synonymous_variant LOW 108C>T Asp36Asp
M0002236 IHKANBDG_00047 61977 3 Skin 0.02 protein_coding synonymous_variant LOW 1062A>G Arg354Arg
M0002237 IHKANBDG_00058 75708 6 Skin 0.03 protein_coding synonymous_variant LOW 993T>C Ala331Ala
M0002238 IHKANBDG_00063 81495 8 Skin 0.04 protein_coding missense_variant MODERATE 905G>C Ser302Thr
M0002239 IHKANBDG_00062 80271 6 Skin 0.03 protein_coding missense_variant MODERATE 412C>T Pro138Ser
M0002240 IHKANBDG_00047 61813 3 Skin 0.02 protein_coding synonymous_variant LOW 898C>T Leu300Leu
M0002241 IHKANBDG_00049 64430 3 Skin 0.02 protein_coding missense_variant MODERATE 1381G>A Val461Ile
M0002242 IHKANBDG_00063 81224 3 Skin 0.02 protein_coding synonymous_variant LOW 1176G>T Leu392Leu
M0002243 IHKANBDG_00053 69336 4 Skin 0.02 protein_coding synonymous_variant LOW 84G>A Lys28Lys
M0002244 IHKANBDG_00051 69503 4 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -2396C>G None
M0002245 IHKANBDG_00051 69574 5 Skin 0.03 protein_coding upstream_gene_variant MODIFIER -2467G>A None
M0002246 IHKANBDG_00051 69589 5 Skin 0.03 protein_coding upstream_gene_variant MODIFIER -2482G>C None
M0002247 IHKANBDG_00051 69601 6 Skin 0.03 protein_coding upstream_gene_variant MODIFIER -2494G>C None
M0002248 IHKANBDG_00051 69608 6 Skin 0.03 protein_coding upstream_gene_variant MODIFIER -2501G>A None
M0002249 IHKANBDG_00060 78358 4 Skin 0.02 protein_coding synonymous_variant LOW 120A>G Gln40Gln
M0002250 IHKANBDG_00063 80981 8 Skin 0.04 protein_coding synonymous_variant LOW 1419A>G Val473Val
M0002251 IHKANBDG_00022 29869 4 Skin 0.02 protein_coding synonymous_variant LOW 768C>T His256His
M0002252 IHKANBDG_00022 29900 4 Skin 0.02 protein_coding missense_variant MODERATE 799C>G His267Asp
M0002253 IHKANBDG_00033 44640 6 Skin 0.03 protein_coding synonymous_variant LOW 385C>T Leu129Leu
M0002254 IHKANBDG_00023 30985 3 Skin 0.02 protein_coding synonymous_variant LOW 243C>G Ala81Ala
M0002255 IHKANBDG_00017 22587 14 Skin 0.08 protein_coding missense_variant MODERATE 2359A>G Ser787Gly
M0002256 IHKANBDG_00007 10128 6 Skin 0.03 protein_coding synonymous_variant LOW 252T>C Gly84Gly
M0002257 IHKANBDG_00007 10140 6 Skin 0.03 protein_coding synonymous_variant LOW 264T>C Thr88Thr
M0002258 IHKANBDG_00058 75954 3 Skin 0.02 protein_coding synonymous_variant LOW 1239G>C Ser413Ser
M0002259 IHKANBDG_00020 28072 3 Skin 0.02 protein_coding synonymous_variant LOW 141G>A Gln47Gln
M0002260 IHKANBDG_00024 31872 3 Skin 0.02 protein_coding synonymous_variant LOW 699A>T Ile233Ile
M0002261 IHKANBDG_00024 31881 3 Skin 0.02 protein_coding synonymous_variant LOW 708T>G Ala236Ala
M0002262 IHKANBDG_00024 31884 4 Skin 0.02 protein_coding synonymous_variant LOW 711G>A Ala237Ala
M0002263 IHKANBDG_00054 70435 5 Skin 0.03 protein_coding missense_variant MODERATE 486T>G Asp162Glu
M0002264 IHKANBDG_00058 75000 5 Skin 0.03 protein_coding synonymous_variant LOW 285C>T Leu95Leu
M0002265 IHKANBDG_00063 81062 4 Skin 0.02 protein_coding synonymous_variant LOW 1338T>C Arg446Arg
M0002266 IHKANBDG_00022 29473 5 Skin 0.03 protein_coding synonymous_variant LOW 372G>A Glu124Glu
M0002267 IHKANBDG_00008 11512 5 Skin 0.03 protein_coding synonymous_variant LOW 204C>T Pro68Pro
M0002268 IHKANBDG_00059 77823 4 Skin 0.02 protein_coding synonymous_variant LOW 315C>T Gly105Gly
M0002269 IHKANBDG_00044 58187 3 Skin 0.02 protein_coding synonymous_variant LOW 426A>G Val142Val
M0002270 IHKANBDG_00059 77905 3 Skin 0.02 protein_coding missense_variant MODERATE 233G>A Arg78His
M0002271 IHKANBDG_00025 32465 5 Skin 0.03 protein_coding synonymous_variant LOW 789G>A Ala263Ala
M0002272 IHKANBDG_00029 38830 3 Skin 0.02 protein_coding synonymous_variant LOW 2037A>G Gln679Gln
M0002273 IHKANBDG_00022 30029 4 Skin 0.02 protein_coding missense_variant MODERATE 928C>G Arg310Gly
M0002274 IHKANBDG_00028 36256 3 Skin 0.02 protein_coding synonymous_variant LOW 582T>C Arg194Arg
M0002275 IHKANBDG_00007 9885 3 Skin 0.02 protein_coding synonymous_variant LOW 9G>A Ala3Ala
M0002276 IHKANBDG_00011 13866 6 Skin 0.03 protein_coding synonymous_variant LOW 2739G>C Arg913Arg
M0002277 IHKANBDG_00016 21254 3 Skin 0.02 protein_coding synonymous_variant LOW 690G>A Val230Val
M0002278 IHKANBDG_00031 43142 3 Skin 0.02 protein_coding synonymous_variant LOW 703T>C Leu235Leu
M0002279 IHKANBDG_00036 47857 5 Skin 0.03 protein_coding synonymous_variant LOW 315A>G Ala105Ala
M0002280 IHKANBDG_00052 68081 3 Skin 0.02 protein_coding synonymous_variant LOW 828T>C Asn276Asn
M0002281 IHKANBDG_00063 82316 4 Skin 0.02 protein_coding synonymous_variant LOW 84C>G Val28Val
M0002282 IHKANBDG_00007 10165 5 Skin 0.03 protein_coding missense_variant MODERATE 289C>G Gln97Glu
M0002283 IHKANBDG_00057 74496 3 Skin 0.02 protein_coding synonymous_variant LOW 864G>A Glu288Glu
M0002284 IHKANBDG_00054 74548 3 Skin 0.02 protein_coding upstream_gene_variant MODIFIER -3628T>A None
M0002285 IHKANBDG_00027 34997 3 Skin 0.02 protein_coding synonymous_variant LOW 519T>A Arg173Arg
M0002286 IHKANBDG_00030 42147 3 Skin 0.02 protein_coding missense_variant MODERATE 940A>G Ile314Val
M0002287 IHKANBDG_00027 35270 3 Skin 0.02 protein_coding synonymous_variant LOW 246G>A Val82Val
M0002288 IHKANBDG_00044 58323 3 Skin 0.02 protein_coding missense_variant MODERATE 562A>G Ile188Val
M0002289 IHKANBDG_00043 57427 4 Skin 0.02 protein_coding synonymous_variant LOW 219T>C Asn73Asn






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
IHKANBDG_00020 UTH30043.1|GT0 74.7 1.17e-201 1 379 0.987 0.9869
IHKANBDG_00038 UTL93545.1|GH148 96.7 0 1 866 1 1
IHKANBDG_00042 AXQ48069.1|GT2 100 2.15e-233 1 318 1 1
IHKANBDG_00044 UTL93551.1|GT2 97.8 6.24e-241 1 325 1 1
IHKANBDG_00046 AXQ48071.1|GT4 100 5.43e-294 1 401 1 1
IHKANBDG_00047 UTL93554.1|GT2 94.2 4.09e-254 1 394 0.9975 0.9975
IHKANBDG_00048 AXQ48072.1|GT26 99.6 5.49e-183 1 253 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term