Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1551
  Reference Plasmid   1111525849479998_bin.19__k141_1196943
  Reference Plasmid Size   3384
  Reference Plasmid GC Content   0.32
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0007416 EAKAPFCP_00001 330 3 Skin 0.60 protein_coding synonymous_variant LOW 309A>G Val103Val
M0007417 EAKAPFCP_00001 526 3 Skin 0.60 protein_coding missense_variant MODERATE 505A>G Lys169Glu
M0007418 EAKAPFCP_00001 768 3 Skin 0.60 protein_coding synonymous_variant LOW 747A>G Glu249Glu
M0007419 EAKAPFCP_00001 779 3 Skin 0.60 protein_coding missense_variant MODERATE 758G>A Ser253Asn
M0007420 EAKAPFCP_00001 798 3 Skin 0.60 protein_coding synonymous_variant LOW 777T>C Ile259Ile
M0007421 EAKAPFCP_00001 953 3 Skin 0.60 protein_coding missense_variant MODERATE 932T>C Ile311Thr
M0007422 EAKAPFCP_00002 1105 3 Skin 0.60 protein_coding synonymous_variant LOW 48A>T Ile16Ile
M0007423 EAKAPFCP_00002 1258 3 Skin 0.60 protein_coding synonymous_variant LOW 201C>T Asn67Asn
M0007424 EAKAPFCP_00002 1480 3 Skin 0.60 protein_coding synonymous_variant LOW 423T>C Asp141Asp
M0007425 EAKAPFCP_00002 1504 3 Skin 0.60 protein_coding synonymous_variant LOW 447T>C Ser149Ser
M0007426 EAKAPFCP_00002 1574 3 Skin 0.60 protein_coding missense_variant MODERATE 517G>T Ala173Ser
M0007427 EAKAPFCP_00001 1827 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *786A>T None
M0007428 EAKAPFCP_00001 1850 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *809T>C None
M0007429 EAKAPFCP_00003 1894 3 Skin 0.60 protein_coding splice_region_variant&stop_retained_variant LOW 1475G>A Ter492Ter
M0007430 EAKAPFCP_00003 2394 5 Skin 1.00 protein_coding synonymous_variant LOW 975G>A Arg325Arg
M0007431 EAKAPFCP_00003 2548 5 Skin 1.00 protein_coding missense_variant MODERATE 821T>C Phe274Ser
M0007432 EAKAPFCP_00003 2765 3 Skin 0.60 protein_coding missense_variant MODERATE 604G>A Val202Ile
M0007433 EAKAPFCP_00003 2781 3 Skin 0.60 protein_coding synonymous_variant LOW 588A>G Leu196Leu
M0007434 EAKAPFCP_00003 2830 3 Skin 0.60 protein_coding missense_variant MODERATE 539A>G Tyr180Cys
M0007435 EAKAPFCP_00003 2866 3 Skin 0.60 protein_coding missense_variant MODERATE 503G>A Arg168Lys
M0007436 EAKAPFCP_00003 2892 3 Skin 0.60 protein_coding synonymous_variant LOW 477A>G Gln159Gln
M0007437 EAKAPFCP_00003 3083 3 Skin 0.60 protein_coding missense_variant MODERATE 286A>G Lys96Glu
M0007438 EAKAPFCP_00003 3155 3 Skin 0.60 protein_coding missense_variant MODERATE 214T>C Tyr72His
M0007439 EAKAPFCP_00003 3248 3 Skin 0.60 protein_coding missense_variant MODERATE 121T>C Ser41Pro
M0007440 EAKAPFCP_00003 3335 3 Skin 0.60 protein_coding missense_variant MODERATE 34T>C Cys12Arg






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
EAKAPFCP_00002 PHI:8330 agrA 88.2 2.8e-123 1 238 1.0000 1.0000 primates skin infection; food poisoning; respiratory disease virulence gene transcription factor increased virulence (hypervirulence)






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
EAKAPFCP_00003 QRJ68954.1|GH32 99.8 0 1 491 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
EAKAPFCP_00001 9.B.14.1.13 89.8 2e-159 7 339 0.9823 0.7762 9 Incompletely Characterized Transport Systems 9.B Putative transport proteins 9.B.14 The Putative Heme Handling Protein (HHP) Family