Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1651
  Reference Plasmid   1111525849483863_bin.5__k141_510256
  Reference Plasmid Size   16346
  Reference Plasmid GC Content   0.65
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0009941 MACDHGFN_00009 11527 4 Skin 0.31 protein_coding synonymous_variant LOW 156A>G Ala52Ala
M0009942 MACDHGFN_00009 11539 4 Skin 0.31 protein_coding synonymous_variant LOW 144G>T Leu48Leu
M0009943 MACDHGFN_00008 11730 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -2014G>A None
M0009944 MACDHGFN_00008 11742 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -2026T>G None
M0009945 MACDHGFN_00008 11787 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2071A>G None
M0009946 MACDHGFN_00008 11798 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2082G>A None
M0009947 MACDHGFN_00010 12242 4 Skin 0.31 protein_coding synonymous_variant LOW 12C>T Tyr4Tyr
M0009948 MACDHGFN_00010 12338 4 Skin 0.31 protein_coding synonymous_variant LOW 108C>G Gly36Gly
M0009949 MACDHGFN_00010 12741 7 Skin 0.54 protein_coding missense_variant MODERATE 511G>A Ala171Thr
M0009950 MACDHGFN_00006 6525 3 Skin 0.23 protein_coding missense_variant MODERATE 365A>T Asn122Ile
M0009951 MACDHGFN_00006 6526 3 Skin 0.23 protein_coding missense_variant MODERATE 366C>G Asn122Lys
M0009952 MACDHGFN_00006 6866 3 Skin 0.23 protein_coding missense_variant MODERATE 706A>C Asn236His
M0009953 MACDHGFN_00007 6951 3 Skin 0.23 protein_coding synonymous_variant LOW 39T>C Ala13Ala
M0009954 MACDHGFN_00007 7689 4 Skin 0.31 protein_coding synonymous_variant LOW 777T>C Ser259Ser
M0009955 MACDHGFN_00007 7854 5 Skin 0.38 protein_coding synonymous_variant LOW 942A>G Leu314Leu
M0009956 MACDHGFN_00007 7972 5 Skin 0.38 protein_coding missense_variant MODERATE 1060A>G Thr354Ala
M0009957 MACDHGFN_00007 8109 3 Skin 0.23 protein_coding synonymous_variant LOW 1197A>G Ala399Ala
M0009958 MACDHGFN_00008 8379 3 Skin 0.23 protein_coding synonymous_variant LOW 1338C>T Asn446Asn
M0009959 MACDHGFN_00008 8748 5 Skin 0.38 protein_coding synonymous_variant LOW 969A>G Ala323Ala
M0009960 MACDHGFN_00008 8798 6 Skin 0.46 protein_coding missense_variant MODERATE 919T>C Cys307Arg
M0009961 MACDHGFN_00008 8990 4 Skin 0.31 protein_coding missense_variant MODERATE 727G>C Glu243Gln
M0009962 MACDHGFN_00008 9246 3 Skin 0.23 protein_coding synonymous_variant LOW 471C>T Phe157Phe
M0009963 MACDHGFN_00008 9249 3 Skin 0.23 protein_coding synonymous_variant LOW 468C>T Asn156Asn
M0009964 MACDHGFN_00008 9681 4 Skin 0.31 protein_coding synonymous_variant LOW 36C>T Asn12Asn
M0009965 MACDHGFN_00008 9942 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -226G>A None
M0009966 MACDHGFN_00008 10015 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -299T>C None
M0009967 MACDHGFN_00009 10119 3 Skin 0.23 protein_coding missense_variant MODERATE 1564C>G Leu522Val
M0009968 MACDHGFN_00008 11950 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2234C>T None
M0009969 MACDHGFN_00008 12211 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2495G>C None
M0009970 MACDHGFN_00010 12254 3 Skin 0.23 protein_coding synonymous_variant LOW 24C>T Arg8Arg
M0009971 MACDHGFN_00010 12502 6 Skin 0.46 protein_coding missense_variant MODERATE 272G>A Arg91Lys
M0009972 MACDHGFN_00010 12563 5 Skin 0.38 protein_coding synonymous_variant LOW 333G>T Val111Val
M0009973 MACDHGFN_00010 12587 3 Skin 0.23 protein_coding synonymous_variant LOW 357G>C Ala119Ala
M0009974 MACDHGFN_00010 13751 5 Skin 0.38 protein_coding synonymous_variant LOW 1521T>C Asp507Asp
M0009975 MACDHGFN_00010 13754 5 Skin 0.38 protein_coding synonymous_variant LOW 1524C>G Pro508Pro
M0009976 MACDHGFN_00011 14023 3 Skin 0.23 protein_coding synonymous_variant LOW 210C>G Ala70Ala
M0009977 MACDHGFN_00011 14095 3 Skin 0.23 protein_coding synonymous_variant LOW 282G>C Thr94Thr
M0009978 MACDHGFN_00011 14152 5 Skin 0.38 protein_coding synonymous_variant LOW 339T>C Ala113Ala
M0009979 MACDHGFN_00011 14154 5 Skin 0.38 protein_coding missense_variant MODERATE 341G>C Gly114Ala
M0009980 MACDHGFN_00011 14156 5 Skin 0.38 protein_coding synonymous_variant LOW 343T>C Leu115Leu
M0009981 MACDHGFN_00011 14227 3 Skin 0.23 protein_coding synonymous_variant LOW 414G>C Pro138Pro
M0009982 MACDHGFN_00011 14266 3 Skin 0.23 protein_coding synonymous_variant LOW 453T>C Ser151Ser
M0009983 MACDHGFN_00011 14284 5 Skin 0.38 protein_coding synonymous_variant LOW 471G>C Gly157Gly
M0009984 MACDHGFN_00011 14287 5 Skin 0.38 protein_coding synonymous_variant LOW 474C>G Gly158Gly
M0009985 MACDHGFN_00011 14296 5 Skin 0.38 protein_coding synonymous_variant LOW 483T>C Ile161Ile
M0009986 MACDHGFN_00011 14302 5 Skin 0.38 protein_coding synonymous_variant LOW 489G>T Val163Val
M0009987 MACDHGFN_00011 14305 5 Skin 0.38 protein_coding synonymous_variant LOW 492T>C Pro164Pro
M0009988 MACDHGFN_00011 14308 5 Skin 0.38 protein_coding synonymous_variant LOW 495C>G Val165Val
M0009989 MACDHGFN_00010 12501 5 Skin 0.38 protein_coding synonymous_variant LOW 271A>C Arg91Arg
M0009990 MACDHGFN_00010 12602 4 Skin 0.31 protein_coding synonymous_variant LOW 372T>C Leu124Leu
M0009991 MACDHGFN_00010 13298 4 Skin 0.31 protein_coding synonymous_variant LOW 1068G>C Gly356Gly
M0009992 MACDHGFN_00011 13918 5 Skin 0.38 protein_coding synonymous_variant LOW 105A>G Ala35Ala
M0009993 MACDHGFN_00011 13924 3 Skin 0.23 protein_coding synonymous_variant LOW 111A>G Glu37Glu
M0009994 MACDHGFN_00011 13927 3 Skin 0.23 protein_coding synonymous_variant LOW 114T>C Phe38Phe
M0009995 MACDHGFN_00011 13933 5 Skin 0.38 protein_coding missense_variant MODERATE 120A>G Ile40Met
M0009996 MACDHGFN_00007 8115 4 Skin 0.31 protein_coding synonymous_variant LOW 1203G>C Arg401Arg
M0009997 MACDHGFN_00010 8225 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -4006A>C None
M0009998 MACDHGFN_00008 8856 3 Skin 0.23 protein_coding synonymous_variant LOW 861G>A Gln287Gln
M0009999 MACDHGFN_00008 8896 4 Skin 0.31 protein_coding missense_variant MODERATE 821T>C Val274Ala
M0010000 MACDHGFN_00008 9417 3 Skin 0.23 protein_coding synonymous_variant LOW 300C>G Pro100Pro
M0010001 MACDHGFN_00008 9790 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -74G>A None
M0010002 MACDHGFN_00008 9793 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -77T>C None
M0010003 MACDHGFN_00008 9794 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -78T>C None
M0010004 MACDHGFN_00008 9804 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -88C>G None
M0010005 MACDHGFN_00008 9838 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -122G>T None
M0010006 MACDHGFN_00008 9863 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -147T>C None
M0010007 MACDHGFN_00009 11273 4 Skin 0.31 protein_coding missense_variant MODERATE 410A>G Lys137Arg
M0010008 MACDHGFN_00009 11293 4 Skin 0.31 protein_coding synonymous_variant LOW 390C>G Pro130Pro
M0010009 MACDHGFN_00008 10048 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -332C>T None
M0010010 MACDHGFN_00011 14257 3 Skin 0.23 protein_coding synonymous_variant LOW 444C>A Gly148Gly
M0010011 MACDHGFN_00013 15326 3 Skin 0.23 protein_coding missense_variant MODERATE 451C>T Pro151Ser
M0010012 MACDHGFN_00013 15412 3 Skin 0.23 protein_coding synonymous_variant LOW 537G>C Val179Val
M0010013 MACDHGFN_00013 15674 3 Skin 0.23 protein_coding missense_variant MODERATE 799A>G Ser267Gly
M0010014 MACDHGFN_00013 15700 3 Skin 0.23 protein_coding synonymous_variant LOW 825T>C Tyr275Tyr
M0010015 MACDHGFN_00009 15817 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -4135T>C None
M0010016 MACDHGFN_00014 15903 3 Skin 0.23 protein_coding synonymous_variant LOW 423T>C Ser141Ser
M0010017 MACDHGFN_00007 7902 3 Skin 0.23 protein_coding synonymous_variant LOW 990C>G Val330Val
M0010018 MACDHGFN_00008 8529 3 Skin 0.23 protein_coding synonymous_variant LOW 1188C>T Asp396Asp
M0010019 MACDHGFN_00008 9081 3 Skin 0.23 protein_coding synonymous_variant LOW 636C>T Asp212Asp
M0010020 MACDHGFN_00008 9084 3 Skin 0.23 protein_coding synonymous_variant LOW 633T>C Ser211Ser
M0010021 MACDHGFN_00008 9085 3 Skin 0.23 protein_coding missense_variant MODERATE 632G>A Ser211Asn
M0010022 MACDHGFN_00008 9570 3 Skin 0.23 protein_coding synonymous_variant LOW 147G>C Ala49Ala
M0010023 MACDHGFN_00008 9588 3 Skin 0.23 protein_coding synonymous_variant LOW 129C>T Asp43Asp






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term