Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1728
  Reference Plasmid   1111525849640249_bin.109__k141_1879810
  Reference Plasmid Size   33396
  Reference Plasmid GC Content   0.64
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0012967 IJECPPCL_00028 25984 4 Skin 0.33 protein_coding synonymous_variant LOW 72G>C Ala24Ala
M0012968 IJECPPCL_00028 26047 3 Skin 0.25 protein_coding missense_variant MODERATE 9G>T Leu3Phe
M0012969 IJECPPCL_00024 26080 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -4893C>T None
M0012970 IJECPPCL_00029 26423 4 Skin 0.33 protein_coding synonymous_variant LOW 222G>A Leu74Leu
M0012971 IJECPPCL_00029 27125 4 Skin 0.33 protein_coding synonymous_variant LOW 924G>A Lys308Lys
M0012972 IJECPPCL_00030 27825 3 Skin 0.25 protein_coding synonymous_variant LOW 516C>T Thr172Thr
M0012973 IJECPPCL_00030 27831 3 Skin 0.25 protein_coding synonymous_variant LOW 522C>A Gly174Gly
M0012974 IJECPPCL_00030 27832 3 Skin 0.25 protein_coding synonymous_variant LOW 523C>T Leu175Leu
M0012975 IJECPPCL_00030 27861 3 Skin 0.25 protein_coding synonymous_variant LOW 552C>A Val184Val
M0012976 IJECPPCL_00030 27903 3 Skin 0.25 protein_coding synonymous_variant LOW 594C>T Leu198Leu
M0012977 IJECPPCL_00030 28215 3 Skin 0.25 protein_coding synonymous_variant LOW 906G>A Glu302Glu
M0012978 IJECPPCL_00031 28550 3 Skin 0.25 protein_coding synonymous_variant LOW 333T>C Ile111Ile
M0012979 IJECPPCL_00031 28838 3 Skin 0.25 protein_coding synonymous_variant LOW 621C>T Asn207Asn
M0012980 IJECPPCL_00032 29551 3 Skin 0.25 protein_coding synonymous_variant LOW 510G>A Gln170Gln
M0012981 IJECPPCL_00032 29883 4 Skin 0.33 protein_coding missense_variant MODERATE 842G>C Gly281Ala
M0012982 IJECPPCL_00033 30374 4 Skin 0.33 protein_coding missense_variant MODERATE 244G>A Ala82Thr
M0012983 IJECPPCL_00034 31316 4 Skin 0.33 protein_coding missense_variant MODERATE 815C>T Thr272Met
M0012984 IJECPPCL_00027 24732 3 Skin 0.25 protein_coding synonymous_variant LOW 486A>G Leu162Leu
M0012985 IJECPPCL_00024 25144 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -3957A>G None
M0012986 IJECPPCL_00028 25156 3 Skin 0.25 protein_coding synonymous_variant LOW 900C>T Ala300Ala
M0012987 IJECPPCL_00028 25162 3 Skin 0.25 protein_coding synonymous_variant LOW 894T>C Val298Val
M0012988 IJECPPCL_00028 25195 3 Skin 0.25 protein_coding synonymous_variant LOW 861T>G Leu287Leu
M0012989 IJECPPCL_00028 25216 3 Skin 0.25 protein_coding synonymous_variant LOW 840G>C Ser280Ser
M0012990 IJECPPCL_00028 25255 3 Skin 0.25 protein_coding synonymous_variant LOW 801G>A Lys267Lys
M0012991 IJECPPCL_00028 25267 3 Skin 0.25 protein_coding synonymous_variant LOW 789T>C Asp263Asp
M0012992 IJECPPCL_00028 25294 3 Skin 0.25 protein_coding synonymous_variant LOW 762G>T Leu254Leu
M0012993 IJECPPCL_00028 25300 3 Skin 0.25 protein_coding synonymous_variant LOW 756G>A Pro252Pro
M0012994 IJECPPCL_00028 25315 3 Skin 0.25 protein_coding synonymous_variant LOW 741C>T Cys247Cys
M0012995 IJECPPCL_00028 25336 3 Skin 0.25 protein_coding synonymous_variant LOW 720G>C Gly240Gly
M0012996 IJECPPCL_00028 25345 3 Skin 0.25 protein_coding synonymous_variant LOW 711G>A Ala237Ala
M0012997 IJECPPCL_00028 25378 3 Skin 0.25 protein_coding synonymous_variant LOW 678G>A Ser226Ser
M0012998 IJECPPCL_00028 25408 3 Skin 0.25 protein_coding synonymous_variant LOW 648G>T Gly216Gly
M0012999 IJECPPCL_00028 25411 3 Skin 0.25 protein_coding synonymous_variant LOW 645A>G Arg215Arg
M0013000 IJECPPCL_00028 25426 3 Skin 0.25 protein_coding synonymous_variant LOW 630G>T Ala210Ala
M0013001 IJECPPCL_00028 25447 3 Skin 0.25 protein_coding synonymous_variant LOW 609C>G Ala203Ala
M0013002 IJECPPCL_00028 25471 3 Skin 0.25 protein_coding synonymous_variant LOW 585G>T Leu195Leu
M0013003 IJECPPCL_00028 25515 3 Skin 0.25 protein_coding missense_variant MODERATE 541C>T Pro181Ser
M0013004 IJECPPCL_00028 25570 3 Skin 0.25 protein_coding synonymous_variant LOW 486C>T Phe162Phe
M0013005 IJECPPCL_00028 25585 3 Skin 0.25 protein_coding synonymous_variant LOW 471C>T Thr157Thr
M0013006 IJECPPCL_00028 25600 3 Skin 0.25 protein_coding synonymous_variant LOW 456C>T Phe152Phe
M0013007 IJECPPCL_00028 25603 3 Skin 0.25 protein_coding synonymous_variant LOW 453T>A Pro151Pro
M0013008 IJECPPCL_00028 25660 3 Skin 0.25 protein_coding synonymous_variant LOW 396C>T Thr132Thr
M0013009 IJECPPCL_00028 25690 3 Skin 0.25 protein_coding synonymous_variant LOW 366C>T Ile122Ile
M0013010 IJECPPCL_00028 25693 3 Skin 0.25 protein_coding synonymous_variant LOW 363C>T Asp121Asp
M0013011 IJECPPCL_00028 25729 3 Skin 0.25 protein_coding synonymous_variant LOW 327A>C Pro109Pro
M0013012 IJECPPCL_00028 25738 3 Skin 0.25 protein_coding synonymous_variant LOW 318C>T Gly106Gly
M0013013 IJECPPCL_00028 25789 3 Skin 0.25 protein_coding synonymous_variant LOW 267T>C Arg89Arg
M0013014 IJECPPCL_00028 25801 3 Skin 0.25 protein_coding synonymous_variant LOW 255C>T Arg85Arg
M0013015 IJECPPCL_00028 25807 3 Skin 0.25 protein_coding synonymous_variant LOW 249G>T Arg83Arg
M0013016 IJECPPCL_00028 25809 3 Skin 0.25 protein_coding synonymous_variant LOW 247C>A Arg83Arg
M0013017 IJECPPCL_00028 25819 3 Skin 0.25 protein_coding synonymous_variant LOW 237G>C Arg79Arg
M0013018 IJECPPCL_00028 25833 3 Skin 0.25 protein_coding missense_variant MODERATE 223G>A Gly75Ser
M0013019 IJECPPCL_00028 25840 3 Skin 0.25 protein_coding synonymous_variant LOW 216T>C Thr72Thr
M0013020 IJECPPCL_00028 25843 3 Skin 0.25 protein_coding synonymous_variant LOW 213T>G Ala71Ala
M0013021 IJECPPCL_00028 25846 3 Skin 0.25 protein_coding synonymous_variant LOW 210C>T Ile70Ile
M0013022 IJECPPCL_00028 25867 3 Skin 0.25 protein_coding synonymous_variant LOW 189C>G Gly63Gly
M0013023 IJECPPCL_00028 25897 3 Skin 0.25 protein_coding synonymous_variant LOW 159C>T Thr53Thr
M0013024 IJECPPCL_00028 25906 3 Skin 0.25 protein_coding synonymous_variant LOW 150G>A Leu50Leu
M0013025 IJECPPCL_00028 25921 3 Skin 0.25 protein_coding synonymous_variant LOW 135G>A Val45Val
M0013026 IJECPPCL_00028 25927 3 Skin 0.25 protein_coding synonymous_variant LOW 129C>A Ala43Ala
M0013027 IJECPPCL_00030 28047 3 Skin 0.25 protein_coding synonymous_variant LOW 738T>C Ile246Ile
M0013028 IJECPPCL_00032 29429 3 Skin 0.25 protein_coding synonymous_variant LOW 388T>C Leu130Leu
M0013029 IJECPPCL_00032 29994 3 Skin 0.25 protein_coding missense_variant MODERATE 953T>C Leu318Pro
M0013030 IJECPPCL_00032 30016 3 Skin 0.25 protein_coding synonymous_variant LOW 975A>C Thr325Thr
M0013031 IJECPPCL_00032 30022 3 Skin 0.25 protein_coding synonymous_variant LOW 981C>T Pro327Pro
M0013032 IJECPPCL_00033 30808 3 Skin 0.25 protein_coding synonymous_variant LOW 678G>A Ala226Ala
M0013033 IJECPPCL_00033 30877 3 Skin 0.25 protein_coding synonymous_variant LOW 747A>G Glu249Glu
M0013034 IJECPPCL_00033 30886 3 Skin 0.25 protein_coding synonymous_variant LOW 756T>C Val252Val
M0013035 IJECPPCL_00034 31240 3 Skin 0.25 protein_coding synonymous_variant LOW 891G>A Gly297Gly
M0013036 IJECPPCL_00006 6266 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2364C>T None
M0013037 IJECPPCL_00006 6286 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2384A>C None
M0013038 IJECPPCL_00011 6341 4 Skin 0.33 protein_coding missense_variant MODERATE 396T>G His132Gln
M0013039 IJECPPCL_00011 6342 4 Skin 0.33 protein_coding missense_variant MODERATE 395A>G His132Arg
M0013040 IJECPPCL_00011 6421 4 Skin 0.33 protein_coding missense_variant MODERATE 316A>C Thr106Pro
M0013041 IJECPPCL_00011 6429 4 Skin 0.33 protein_coding missense_variant MODERATE 308T>C Leu103Pro
M0013042 IJECPPCL_00011 6501 3 Skin 0.25 protein_coding missense_variant MODERATE 236G>A Cys79Tyr
M0013043 IJECPPCL_00011 6524 4 Skin 0.33 protein_coding synonymous_variant LOW 213T>C Leu71Leu
M0013044 IJECPPCL_00011 6527 4 Skin 0.33 protein_coding synonymous_variant LOW 210G>A Glu70Glu
M0013045 IJECPPCL_00011 6543 3 Skin 0.25 protein_coding missense_variant MODERATE 194G>A Gly65Asp
M0013046 IJECPPCL_00011 6557 4 Skin 0.33 protein_coding synonymous_variant LOW 180T>G Arg60Arg
M0013047 IJECPPCL_00011 6591 3 Skin 0.25 protein_coding missense_variant MODERATE 146G>A Gly49Asp
M0013048 IJECPPCL_00011 6602 3 Skin 0.25 protein_coding synonymous_variant LOW 135T>C Gly45Gly
M0013049 IJECPPCL_00011 6627 3 Skin 0.25 protein_coding missense_variant MODERATE 110C>T Thr37Met
M0013050 IJECPPCL_00011 6632 3 Skin 0.25 protein_coding synonymous_variant LOW 105A>G Ala35Ala
M0013051 IJECPPCL_00011 6634 3 Skin 0.25 protein_coding missense_variant MODERATE 103G>A Ala35Thr
M0013052 IJECPPCL_00011 6637 3 Skin 0.25 protein_coding missense_variant MODERATE 100A>G Ile34Val
M0013053 IJECPPCL_00011 6640 3 Skin 0.25 protein_coding missense_variant MODERATE 97C>G Leu33Val
M0013054 IJECPPCL_00011 6660 3 Skin 0.25 protein_coding missense_variant MODERATE 77G>A Gly26Asp
M0013055 IJECPPCL_00011 6676 3 Skin 0.25 protein_coding missense_variant MODERATE 61G>C Gly21Arg
M0013056 IJECPPCL_00006 6757 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2855T>A None
M0013057 IJECPPCL_00006 6772 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2870G>C None
M0013058 IJECPPCL_00006 6828 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2926C>T None
M0013059 IJECPPCL_00006 6835 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2933C>G None
M0013060 IJECPPCL_00006 6846 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2944C>T None
M0013061 IJECPPCL_00006 6875 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -2973G>C None
M0013062 IJECPPCL_00006 6902 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3000T>C None
M0013063 IJECPPCL_00006 6921 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3019C>T None
M0013064 IJECPPCL_00006 6925 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3023G>A None
M0013065 IJECPPCL_00006 7039 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3137C>G None
M0013066 IJECPPCL_00006 7060 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3158G>A None
M0013067 IJECPPCL_00006 7069 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3167G>A None
M0013068 IJECPPCL_00006 7214 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3312T>G None
M0013069 IJECPPCL_00006 5537 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1635T>C None
M0013070 IJECPPCL_00006 5554 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1652A>C None
M0013071 IJECPPCL_00009 5664 3 Skin 0.25 protein_coding synonymous_variant LOW 333C>T Ala111Ala
M0013072 IJECPPCL_00009 5855 3 Skin 0.25 protein_coding missense_variant MODERATE 142A>G Thr48Ala
M0013073 IJECPPCL_00009 5925 3 Skin 0.25 protein_coding synonymous_variant LOW 72C>A Ala24Ala
M0013074 IJECPPCL_00009 5928 3 Skin 0.25 protein_coding synonymous_variant LOW 69C>T Ala23Ala
M0013075 IJECPPCL_00009 5964 3 Skin 0.25 protein_coding synonymous_variant LOW 33T>C Ala11Ala
M0013076 IJECPPCL_00013 8552 3 Skin 0.25 protein_coding missense_variant MODERATE 574G>A Asp192Asn
M0013077 IJECPPCL_00014 9451 3 Skin 0.25 protein_coding missense_variant MODERATE 28A>G Thr10Ala
M0013078 IJECPPCL_00015 9502 3 Skin 0.25 protein_coding missense_variant MODERATE 337A>G Thr113Ala
M0013079 IJECPPCL_00015 9669 3 Skin 0.25 protein_coding missense_variant MODERATE 170G>T Ser57Ile
M0013080 IJECPPCL_00034 31481 3 Skin 0.25 protein_coding missense_variant MODERATE 650T>C Met217Thr
M0013081 IJECPPCL_00034 31543 3 Skin 0.25 protein_coding synonymous_variant LOW 588T>C Asn196Asn
M0013082 IJECPPCL_00034 31582 3 Skin 0.25 protein_coding synonymous_variant LOW 549T>G Leu183Leu






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term