Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1748
  Reference Plasmid   1111525849644360_bin.3__k141_178364
  Reference Plasmid Size   6326
  Reference Plasmid GC Content   0.68
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0014365 IKDIOIIC_00002 1615 15 Skin 0.71 protein_coding synonymous_variant LOW 501T>C Phe167Phe
M0014366 IKDIOIIC_00002 1681 7 Skin 0.33 protein_coding synonymous_variant LOW 567C>T Thr189Thr
M0014367 IKDIOIIC_00004 3109 8 Skin 0.38 protein_coding synonymous_variant LOW 273A>G Pro91Pro
M0014368 IKDIOIIC_00004 3415 12 Skin 0.57 protein_coding synonymous_variant LOW 579G>A Gln193Gln
M0014369 IKDIOIIC_00004 3417 12 Skin 0.57 protein_coding missense_variant MODERATE 581G>A Arg194His
M0014370 IKDIOIIC_00004 3418 12 Skin 0.57 protein_coding synonymous_variant LOW 582C>G Arg194Arg
M0014371 IKDIOIIC_00005 3492 13 Skin 0.62 protein_coding upstream_gene_variant MODIFIER -84A>C None
M0014372 IKDIOIIC_00005 4106 5 Skin 0.24 protein_coding synonymous_variant LOW 531G>C Val177Val
M0014373 IKDIOIIC_00005 4107 5 Skin 0.24 protein_coding synonymous_variant LOW 532C>T Leu178Leu
M0014374 IKDIOIIC_00005 4133 6 Skin 0.29 protein_coding synonymous_variant LOW 558T>G Ala186Ala
M0014375 IKDIOIIC_00005 4175 6 Skin 0.29 protein_coding synonymous_variant LOW 600A>T Ala200Ala
M0014376 IKDIOIIC_00005 4191 7 Skin 0.33 protein_coding missense_variant MODERATE 616C>G Leu206Val
M0014377 IKDIOIIC_00005 4193 7 Skin 0.33 protein_coding synonymous_variant LOW 618T>G Leu206Leu
M0014378 IKDIOIIC_00005 4196 7 Skin 0.33 protein_coding synonymous_variant LOW 621G>A Arg207Arg
M0014379 IKDIOIIC_00005 4212 7 Skin 0.33 protein_coding missense_variant MODERATE 637C>A Arg213Ser
M0014380 IKDIOIIC_00005 4213 7 Skin 0.33 protein_coding missense_variant MODERATE 638G>C Arg213Pro
M0014381 IKDIOIIC_00005 4214 7 Skin 0.33 protein_coding synonymous_variant LOW 639C>G Arg213Arg
M0014382 IKDIOIIC_00005 4217 7 Skin 0.33 protein_coding synonymous_variant LOW 642C>T Asp214Asp
M0014383 IKDIOIIC_00005 4298 8 Skin 0.38 protein_coding synonymous_variant LOW 723A>G Lys241Lys
M0014384 IKDIOIIC_00005 4331 7 Skin 0.33 protein_coding synonymous_variant LOW 756T>C Tyr252Tyr
M0014385 IKDIOIIC_00001 813 8 Skin 0.38 protein_coding missense_variant MODERATE 784T>G Phe262Val
M0014386 IKDIOIIC_00001 842 8 Skin 0.38 protein_coding synonymous_variant LOW 813C>G Gly271Gly
M0014387 IKDIOIIC_00001 892 4 Skin 0.19 protein_coding missense_variant MODERATE 863A>C Asn288Thr
M0014388 IKDIOIIC_00002 1170 6 Skin 0.29 protein_coding missense_variant MODERATE 56G>A Ser19Asn
M0014389 IKDIOIIC_00002 1525 8 Skin 0.38 protein_coding synonymous_variant LOW 411C>T Ala137Ala
M0014390 IKDIOIIC_00002 1564 8 Skin 0.38 protein_coding synonymous_variant LOW 450T>C Val150Val
M0014391 IKDIOIIC_00003 2552 3 Skin 0.14 protein_coding synonymous_variant LOW 651C>G Arg217Arg
M0014392 IKDIOIIC_00003 2567 3 Skin 0.14 protein_coding synonymous_variant LOW 666C>T Ala222Ala
M0014393 IKDIOIIC_00003 2582 3 Skin 0.14 protein_coding synonymous_variant LOW 681T>C Asp227Asp
M0014394 IKDIOIIC_00003 2801 16 Skin 0.76 protein_coding synonymous_variant LOW 900C>T Phe300Phe
M0014395 IKDIOIIC_00003 2802 16 Skin 0.76 protein_coding synonymous_variant LOW 901C>T Leu301Leu
M0014396 IKDIOIIC_00004 3235 6 Skin 0.29 protein_coding synonymous_variant LOW 399A>G Glu133Glu
M0014397 IKDIOIIC_00005 3609 7 Skin 0.33 protein_coding missense_variant MODERATE 34G>C Val12Leu
M0014398 IKDIOIIC_00005 3893 10 Skin 0.48 protein_coding synonymous_variant LOW 318G>T Thr106Thr
M0014399 IKDIOIIC_00001 62 3 Skin 0.14 protein_coding synonymous_variant LOW 33A>C Leu11Leu
M0014400 IKDIOIIC_00001 77 4 Skin 0.19 protein_coding synonymous_variant LOW 48A>G Ala16Ala
M0014401 IKDIOIIC_00001 122 3 Skin 0.14 protein_coding synonymous_variant LOW 93T>C Arg31Arg
M0014402 IKDIOIIC_00001 135 3 Skin 0.14 protein_coding synonymous_variant LOW 106T>C Leu36Leu
M0014403 IKDIOIIC_00001 142 3 Skin 0.14 protein_coding missense_variant MODERATE 113A>G Glu38Gly
M0014404 IKDIOIIC_00001 143 3 Skin 0.14 protein_coding synonymous_variant LOW 114A>G Glu38Glu
M0014405 IKDIOIIC_00001 146 3 Skin 0.14 protein_coding synonymous_variant LOW 117G>C Leu39Leu
M0014406 IKDIOIIC_00001 149 3 Skin 0.14 protein_coding synonymous_variant LOW 120C>T Gly40Gly
M0014407 IKDIOIIC_00001 158 4 Skin 0.19 protein_coding synonymous_variant LOW 129C>T Asp43Asp
M0014408 IKDIOIIC_00001 188 3 Skin 0.14 protein_coding synonymous_variant LOW 159G>A Leu53Leu
M0014409 IKDIOIIC_00001 189 3 Skin 0.14 protein_coding synonymous_variant LOW 160T>C Leu54Leu
M0014410 IKDIOIIC_00001 195 3 Skin 0.14 protein_coding missense_variant MODERATE 166G>C Ala56Pro
M0014411 IKDIOIIC_00001 203 3 Skin 0.14 protein_coding synonymous_variant LOW 174A>G Arg58Arg
M0014412 IKDIOIIC_00001 227 3 Skin 0.14 protein_coding synonymous_variant LOW 198G>C Ala66Ala
M0014413 IKDIOIIC_00001 234 3 Skin 0.14 protein_coding synonymous_variant LOW 205C>T Leu69Leu
M0014414 IKDIOIIC_00001 236 3 Skin 0.14 protein_coding synonymous_variant LOW 207A>G Leu69Leu
M0014415 IKDIOIIC_00001 239 3 Skin 0.14 protein_coding synonymous_variant LOW 210G>A Pro70Pro
M0014416 IKDIOIIC_00001 242 3 Skin 0.14 protein_coding synonymous_variant LOW 213C>T Ala71Ala
M0014417 IKDIOIIC_00001 626 6 Skin 0.29 protein_coding synonymous_variant LOW 597G>A Glu199Glu
M0014418 IKDIOIIC_00001 703 4 Skin 0.19 protein_coding missense_variant MODERATE 674G>A Arg225Lys
M0014419 IKDIOIIC_00001 704 4 Skin 0.19 protein_coding synonymous_variant LOW 675A>G Arg225Arg
M0014420 IKDIOIIC_00001 737 4 Skin 0.19 protein_coding synonymous_variant LOW 708A>C Leu236Leu
M0014421 IKDIOIIC_00002 1225 5 Skin 0.24 protein_coding synonymous_variant LOW 111C>T Gly37Gly
M0014422 IKDIOIIC_00002 1273 5 Skin 0.24 protein_coding synonymous_variant LOW 159C>T Ile53Ile
M0014423 IKDIOIIC_00002 1288 5 Skin 0.24 protein_coding synonymous_variant LOW 174G>A Arg58Arg
M0014424 IKDIOIIC_00002 1324 5 Skin 0.24 protein_coding synonymous_variant LOW 210C>T Asn70Asn
M0014425 IKDIOIIC_00002 1333 5 Skin 0.24 protein_coding synonymous_variant LOW 219G>A Glu73Glu
M0014426 IKDIOIIC_00002 1393 5 Skin 0.24 protein_coding synonymous_variant LOW 279C>T Gly93Gly
M0014427 IKDIOIIC_00002 1397 5 Skin 0.24 protein_coding synonymous_variant LOW 283C>T Leu95Leu
M0014428 IKDIOIIC_00002 1432 5 Skin 0.24 protein_coding synonymous_variant LOW 318A>G Ala106Ala
M0014429 IKDIOIIC_00002 1753 7 Skin 0.33 protein_coding synonymous_variant LOW 639C>T Asp213Asp
M0014430 IKDIOIIC_00003 2450 8 Skin 0.38 protein_coding synonymous_variant LOW 549C>G Ala183Ala
M0014431 IKDIOIIC_00003 2460 8 Skin 0.38 protein_coding synonymous_variant LOW 559C>T Leu187Leu
M0014432 IKDIOIIC_00003 2474 8 Skin 0.38 protein_coding synonymous_variant LOW 573T>C Arg191Arg
M0014433 IKDIOIIC_00003 2639 10 Skin 0.48 protein_coding synonymous_variant LOW 738C>T Arg246Arg
M0014434 IKDIOIIC_00001 983 7 Skin 0.33 protein_coding synonymous_variant LOW 954T>C Cys318Cys
M0014435 IKDIOIIC_00001 1001 7 Skin 0.33 protein_coding synonymous_variant LOW 972T>C Val324Val
M0014436 IKDIOIIC_00001 1037 7 Skin 0.33 protein_coding synonymous_variant LOW 1008C>A Thr336Thr
M0014437 IKDIOIIC_00004 2917 7 Skin 0.33 protein_coding missense_variant MODERATE 81G>T Glu27Asp
M0014438 IKDIOIIC_00006 5254 6 Skin 0.29 protein_coding missense_variant MODERATE 34A>G Ser12Gly
M0014439 IKDIOIIC_00006 5300 9 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -13C>T None
M0014440 IKDIOIIC_00007 5444 5 Skin 0.24 protein_coding missense_variant MODERATE 744G>C Trp248Cys
M0014441 IKDIOIIC_00007 5446 5 Skin 0.24 protein_coding missense_variant MODERATE 742T>C Trp248Arg
M0014442 IKDIOIIC_00007 5473 5 Skin 0.24 protein_coding missense_variant MODERATE 715G>A Val239Met
M0014443 IKDIOIIC_00007 5677 10 Skin 0.48 protein_coding missense_variant MODERATE 511A>G Thr171Ala
M0014444 IKDIOIIC_00007 6043 5 Skin 0.24 protein_coding missense_variant MODERATE 145T>C Phe49Leu
M0014445 IKDIOIIC_00007 6128 6 Skin 0.29 protein_coding synonymous_variant LOW 60C>T Pro20Pro
M0014446 IKDIOIIC_00006 6188 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -901T>C None
M0014447 IKDIOIIC_00006 6229 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -942A>C None
M0014448 IKDIOIIC_00006 6238 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -951T>C None
M0014449 IKDIOIIC_00006 6239 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -952T>C None
M0014450 IKDIOIIC_00006 6275 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -988C>G None
M0014451 IKDIOIIC_00002 1474 4 Skin 0.19 protein_coding synonymous_variant LOW 360C>A Ala120Ala
M0014452 IKDIOIIC_00003 2067 8 Skin 0.38 protein_coding missense_variant MODERATE 166G>T Ala56Ser
M0014453 IKDIOIIC_00005 4442 4 Skin 0.19 protein_coding synonymous_variant LOW 867T>C Tyr289Tyr
M0014454 IKDIOIIC_00005 4604 12 Skin 0.57 protein_coding synonymous_variant LOW 1029T>C Asp343Asp
M0014455 IKDIOIIC_00006 4729 4 Skin 0.19 protein_coding missense_variant MODERATE 559G>A Glu187Lys
M0014456 IKDIOIIC_00006 4736 4 Skin 0.19 protein_coding synonymous_variant LOW 552C>T Ala184Ala
M0014457 IKDIOIIC_00006 4780 4 Skin 0.19 protein_coding missense_variant MODERATE 508C>A Pro170Thr
M0014458 IKDIOIIC_00006 5050 4 Skin 0.19 protein_coding missense_variant MODERATE 238C>T Arg80Cys
M0014459 IKDIOIIC_00006 5209 5 Skin 0.24 protein_coding missense_variant MODERATE 79T>C Phe27Leu
M0014460 IKDIOIIC_00006 5212 5 Skin 0.24 protein_coding missense_variant MODERATE 76A>G Thr26Ala
M0014461 IKDIOIIC_00006 5239 5 Skin 0.24 protein_coding missense_variant MODERATE 49G>A Ala17Thr
M0014462 IKDIOIIC_00007 5536 5 Skin 0.24 protein_coding missense_variant MODERATE 652G>C Ala218Pro
M0014463 IKDIOIIC_00007 5539 5 Skin 0.24 protein_coding missense_variant MODERATE 649G>A Ala217Thr
M0014464 IKDIOIIC_00007 5560 5 Skin 0.24 protein_coding missense_variant MODERATE 628G>A Ala210Thr
M0014465 IKDIOIIC_00007 5746 5 Skin 0.24 protein_coding missense_variant MODERATE 442A>G Ile148Val
M0014466 IKDIOIIC_00007 5767 5 Skin 0.24 protein_coding missense_variant MODERATE 421A>G Met141Val
M0014467 IKDIOIIC_00007 5771 5 Skin 0.24 protein_coding synonymous_variant LOW 417A>G Arg139Arg
M0014468 IKDIOIIC_00007 5809 5 Skin 0.24 protein_coding missense_variant MODERATE 379G>A Glu127Lys
M0014469 IKDIOIIC_00007 5833 5 Skin 0.24 protein_coding missense_variant MODERATE 355A>G Ile119Val
M0014470 IKDIOIIC_00007 5848 5 Skin 0.24 protein_coding missense_variant MODERATE 340G>C Gly114Arg
M0014471 IKDIOIIC_00007 5863 5 Skin 0.24 protein_coding stop_gained HIGH 325C>T Gln109*
M0014472 IKDIOIIC_00007 5878 5 Skin 0.24 protein_coding missense_variant MODERATE 310A>G Thr104Ala
M0014473 IKDIOIIC_00007 5821 3 Skin 0.14 protein_coding missense_variant MODERATE 367G>A Val123Ile






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term