Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1805
  Reference Plasmid   1111525849645470_bin.12__k141_376842
  Reference Plasmid Size   48914
  Reference Plasmid GC Content   0.44
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0117977 HPHKCOGH_00001 1070 3 Oral 0.19 protein_coding downstream_gene_variant MODIFIER *305C>T None
M0117978 HPHKCOGH_00003 1170 3 Oral 0.19 protein_coding missense_variant MODERATE 289G>A Ala97Thr
M0117979 HPHKCOGH_00003 1285 4 Oral 0.25 protein_coding synonymous_variant LOW 174C>T Leu58Leu
M0117980 HPHKCOGH_00003 1358 4 Oral 0.25 protein_coding missense_variant MODERATE 101G>A Ser34Asn
M0117981 HPHKCOGH_00003 1434 4 Oral 0.25 protein_coding missense_variant MODERATE 25T>C Phe9Leu
M0117982 HPHKCOGH_00004 1718 3 Oral 0.19 protein_coding synonymous_variant LOW 1017A>G Pro339Pro
M0117983 HPHKCOGH_00004 1726 3 Oral 0.19 protein_coding missense_variant MODERATE 1009A>G Ile337Val
M0117984 HPHKCOGH_00004 1846 6 Oral 0.38 protein_coding missense_variant MODERATE 889C>T Pro297Ser
M0117985 HPHKCOGH_00004 1891 3 Oral 0.19 protein_coding missense_variant MODERATE 844A>G Lys282Glu
M0117986 HPHKCOGH_00004 1948 6 Oral 0.38 protein_coding synonymous_variant LOW 787C>T Leu263Leu
M0117987 HPHKCOGH_00004 1967 6 Oral 0.38 protein_coding synonymous_variant LOW 768T>C Phe256Phe
M0117988 HPHKCOGH_00004 1988 6 Oral 0.38 protein_coding synonymous_variant LOW 747T>C Leu249Leu
M0117989 HPHKCOGH_00004 1997 6 Oral 0.38 protein_coding synonymous_variant LOW 738A>T Ile246Ile
M0117990 HPHKCOGH_00004 2079 5 Oral 0.31 protein_coding missense_variant MODERATE 656C>G Thr219Arg
M0117991 HPHKCOGH_00004 2180 7 Oral 0.44 protein_coding synonymous_variant LOW 555A>G Leu185Leu
M0117992 HPHKCOGH_00004 2453 7 Oral 0.44 protein_coding synonymous_variant LOW 282A>G Val94Val
M0117993 HPHKCOGH_00004 2476 3 Oral 0.19 protein_coding missense_variant MODERATE 259G>A Val87Ile
M0117994 HPHKCOGH_00004 2538 6 Oral 0.38 protein_coding missense_variant MODERATE 197C>G Ala66Gly
M0117995 HPHKCOGH_00004 2567 6 Oral 0.38 protein_coding synonymous_variant LOW 168A>G Gln56Gln
M0117996 HPHKCOGH_00004 2570 6 Oral 0.38 protein_coding synonymous_variant LOW 165C>A Thr55Thr
M0117997 HPHKCOGH_00004 2571 6 Oral 0.38 protein_coding missense_variant MODERATE 164C>G Thr55Ser
M0117998 HPHKCOGH_00004 2671 6 Oral 0.38 protein_coding synonymous_variant LOW 64T>C Leu22Leu
M0117999 HPHKCOGH_00004 2720 5 Oral 0.31 protein_coding synonymous_variant LOW 15G>A Val5Val
M0118000 HPHKCOGH_00004 2722 5 Oral 0.31 protein_coding missense_variant MODERATE 13G>A Val5Met
M0118001 HPHKCOGH_00003 2751 6 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -1293C>A None
M0118002 HPHKCOGH_00003 2756 5 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -1298C>T None
M0118003 HPHKCOGH_00005 2779 6 Oral 0.38 protein_coding missense_variant MODERATE 1235A>G His412Arg
M0118004 HPHKCOGH_00005 2940 6 Oral 0.38 protein_coding synonymous_variant LOW 1074T>C Asn358Asn
M0118005 HPHKCOGH_00005 3024 6 Oral 0.38 protein_coding synonymous_variant LOW 990G>A Gln330Gln
M0118006 HPHKCOGH_00005 3079 6 Oral 0.38 protein_coding missense_variant MODERATE 935T>A Leu312Gln
M0118007 HPHKCOGH_00005 3154 6 Oral 0.38 protein_coding missense_variant MODERATE 860G>A Gly287Asp
M0118008 HPHKCOGH_00005 3162 6 Oral 0.38 protein_coding synonymous_variant LOW 852T>C Asn284Asn
M0118009 HPHKCOGH_00005 3175 3 Oral 0.19 protein_coding missense_variant MODERATE 839T>A Met280Lys
M0118010 HPHKCOGH_00005 3176 3 Oral 0.19 protein_coding missense_variant MODERATE 838A>G Met280Val
M0118011 HPHKCOGH_00005 3202 6 Oral 0.38 protein_coding missense_variant MODERATE 812G>T Arg271Leu
M0118012 HPHKCOGH_00005 3282 5 Oral 0.31 protein_coding missense_variant MODERATE 732G>C Met244Ile
M0118013 HPHKCOGH_00005 3316 5 Oral 0.31 protein_coding missense_variant MODERATE 698A>G Gln233Arg
M0118014 HPHKCOGH_00005 3606 5 Oral 0.31 protein_coding synonymous_variant LOW 408A>G Lys136Lys
M0118015 HPHKCOGH_00005 3615 5 Oral 0.31 protein_coding synonymous_variant LOW 399A>G Thr133Thr
M0118016 HPHKCOGH_00006 6310 3 Oral 0.19 protein_coding synonymous_variant LOW 1254C>T Leu418Leu
M0118017 HPHKCOGH_00006 6328 4 Oral 0.25 protein_coding synonymous_variant LOW 1236A>G Glu412Glu
M0118018 HPHKCOGH_00006 6333 7 Oral 0.44 protein_coding missense_variant MODERATE 1231G>A Val411Ile
M0118019 HPHKCOGH_00006 6337 6 Oral 0.38 protein_coding synonymous_variant LOW 1227C>A Leu409Leu
M0118020 HPHKCOGH_00006 6339 7 Oral 0.44 protein_coding missense_variant MODERATE 1225C>T Leu409Phe
M0118021 HPHKCOGH_00006 6351 4 Oral 0.25 protein_coding missense_variant MODERATE 1213A>G Ile405Val
M0118022 HPHKCOGH_00006 6403 4 Oral 0.25 protein_coding synonymous_variant LOW 1161T>C Ala387Ala
M0118023 HPHKCOGH_00006 6556 3 Oral 0.19 protein_coding synonymous_variant LOW 1008A>G Leu336Leu
M0118024 HPHKCOGH_00006 6573 3 Oral 0.19 protein_coding synonymous_variant LOW 991C>T Leu331Leu
M0118025 HPHKCOGH_00006 6574 6 Oral 0.38 protein_coding synonymous_variant LOW 990A>T Gly330Gly
M0118026 HPHKCOGH_00006 6577 3 Oral 0.19 protein_coding synonymous_variant LOW 987G>A Gly329Gly
M0118027 HPHKCOGH_00006 6673 5 Oral 0.31 protein_coding synonymous_variant LOW 891G>A Gly297Gly
M0118028 HPHKCOGH_00006 6706 3 Oral 0.19 protein_coding synonymous_variant LOW 858C>T Pro286Pro
M0118029 HPHKCOGH_00006 6919 3 Oral 0.19 protein_coding synonymous_variant LOW 645C>T Arg215Arg
M0118030 HPHKCOGH_00006 7051 4 Oral 0.25 protein_coding synonymous_variant LOW 513C>T Pro171Pro
M0118031 HPHKCOGH_00006 7063 4 Oral 0.25 protein_coding synonymous_variant LOW 501T>C Gly167Gly
M0118032 HPHKCOGH_00006 7174 6 Oral 0.38 protein_coding synonymous_variant LOW 390C>T Gly130Gly
M0118033 HPHKCOGH_00006 7189 6 Oral 0.38 protein_coding synonymous_variant LOW 375T>C Asn125Asn
M0118034 HPHKCOGH_00006 7235 3 Oral 0.19 protein_coding missense_variant MODERATE 329G>A Gly110Asp
M0118035 HPHKCOGH_00006 7281 3 Oral 0.19 protein_coding missense_variant MODERATE 283A>T Thr95Ser
M0118036 HPHKCOGH_00006 7297 5 Oral 0.31 protein_coding synonymous_variant LOW 267A>C Val89Val
M0118037 HPHKCOGH_00017 21288 6 Oral 0.38 protein_coding missense_variant MODERATE 735G>T Lys245Asn
M0118038 HPHKCOGH_00004 2010 4 Oral 0.25 protein_coding missense_variant MODERATE 725T>C Val242Ala
M0118039 HPHKCOGH_00004 2053 4 Oral 0.25 protein_coding missense_variant MODERATE 682C>G Gln228Glu
M0118040 HPHKCOGH_00004 2141 4 Oral 0.25 protein_coding synonymous_variant LOW 594T>C Ile198Ile
M0118041 HPHKCOGH_00004 2202 4 Oral 0.25 protein_coding missense_variant MODERATE 533A>C Glu178Ala
M0118042 HPHKCOGH_00004 2302 3 Oral 0.19 protein_coding missense_variant MODERATE 433T>C Ser145Pro
M0118043 HPHKCOGH_00004 2408 3 Oral 0.19 protein_coding synonymous_variant LOW 327A>C Thr109Thr
M0118044 HPHKCOGH_00005 3385 3 Oral 0.19 protein_coding missense_variant MODERATE 629T>C Val210Ala
M0118045 HPHKCOGH_00005 3411 3 Oral 0.19 protein_coding synonymous_variant LOW 603T>C Asn201Asn
M0118046 HPHKCOGH_00005 3414 3 Oral 0.19 protein_coding synonymous_variant LOW 600T>C Phe200Phe
M0118047 HPHKCOGH_00005 3518 3 Oral 0.19 protein_coding missense_variant MODERATE 496A>G Asn166Asp
M0118048 HPHKCOGH_00005 3659 5 Oral 0.31 protein_coding missense_variant MODERATE 355G>A Val119Ile
M0118049 HPHKCOGH_00005 3694 4 Oral 0.25 protein_coding missense_variant MODERATE 320C>A Ala107Glu
M0118050 HPHKCOGH_00005 3699 4 Oral 0.25 protein_coding synonymous_variant LOW 315C>G Ala105Ala
M0118051 HPHKCOGH_00005 3708 4 Oral 0.25 protein_coding missense_variant MODERATE 306T>A Asp102Glu
M0118052 HPHKCOGH_00005 3714 4 Oral 0.25 protein_coding synonymous_variant LOW 300G>A Gln100Gln
M0118053 HPHKCOGH_00005 3724 4 Oral 0.25 protein_coding missense_variant MODERATE 290A>G Asp97Gly
M0118054 HPHKCOGH_00006 4242 3 Oral 0.19 protein_coding missense_variant MODERATE 3322G>A Val1108Ile
M0118055 HPHKCOGH_00006 4297 6 Oral 0.38 protein_coding missense_variant MODERATE 3267C>A His1089Gln
M0118056 HPHKCOGH_00006 4359 4 Oral 0.25 protein_coding missense_variant MODERATE 3205A>G Ile1069Val
M0118057 HPHKCOGH_00006 4366 6 Oral 0.38 protein_coding synonymous_variant LOW 3198A>C Leu1066Leu
M0118058 HPHKCOGH_00006 4459 3 Oral 0.19 protein_coding missense_variant MODERATE 3105T>A Phe1035Leu
M0118059 HPHKCOGH_00006 4547 4 Oral 0.25 protein_coding missense_variant MODERATE 3017T>C Met1006Thr
M0118060 HPHKCOGH_00006 4558 6 Oral 0.38 protein_coding synonymous_variant LOW 3006C>T Phe1002Phe
M0118061 HPHKCOGH_00006 4575 5 Oral 0.31 protein_coding missense_variant MODERATE 2989A>G Ile997Val
M0118062 HPHKCOGH_00006 4585 4 Oral 0.25 protein_coding synonymous_variant LOW 2979C>G Leu993Leu
M0118063 HPHKCOGH_00006 4596 5 Oral 0.31 protein_coding missense_variant MODERATE 2968A>G Thr990Ala
M0118064 HPHKCOGH_00006 4609 4 Oral 0.25 protein_coding synonymous_variant LOW 2955A>G Val985Val
M0118065 HPHKCOGH_00006 4639 5 Oral 0.31 protein_coding synonymous_variant LOW 2925G>A Gln975Gln
M0118066 HPHKCOGH_00006 4717 5 Oral 0.31 protein_coding synonymous_variant LOW 2847T>C His949His
M0118067 HPHKCOGH_00006 4836 3 Oral 0.19 protein_coding missense_variant MODERATE 2728G>C Asp910His
M0118068 HPHKCOGH_00006 4986 5 Oral 0.31 protein_coding missense_variant MODERATE 2578C>G Pro860Ala
M0118069 HPHKCOGH_00006 4993 5 Oral 0.31 protein_coding synonymous_variant LOW 2571C>T Gly857Gly
M0118070 HPHKCOGH_00006 5016 4 Oral 0.25 protein_coding missense_variant MODERATE 2548C>A Arg850Ser
M0118071 HPHKCOGH_00006 5086 6 Oral 0.38 protein_coding synonymous_variant LOW 2478C>A Ala826Ala
M0118072 HPHKCOGH_00006 5251 4 Oral 0.25 protein_coding synonymous_variant LOW 2313T>C Thr771Thr
M0118073 HPHKCOGH_00006 5290 4 Oral 0.25 protein_coding synonymous_variant LOW 2274T>G Pro758Pro
M0118074 HPHKCOGH_00006 5295 4 Oral 0.25 protein_coding missense_variant MODERATE 2269G>C Val757Leu
M0118075 HPHKCOGH_00006 5298 6 Oral 0.38 protein_coding missense_variant MODERATE 2266G>A Asp756Asn
M0118076 HPHKCOGH_00006 5470 3 Oral 0.19 protein_coding synonymous_variant LOW 2094T>C Ala698Ala
M0118077 HPHKCOGH_00006 5479 5 Oral 0.31 protein_coding synonymous_variant LOW 2085A>G Val695Val
M0118078 HPHKCOGH_00006 5537 5 Oral 0.31 protein_coding missense_variant MODERATE 2027G>A Gly676Asp
M0118079 HPHKCOGH_00006 5560 5 Oral 0.31 protein_coding synonymous_variant LOW 2004T>C Asn668Asn
M0118080 HPHKCOGH_00006 5565 6 Oral 0.38 protein_coding missense_variant MODERATE 1999A>G Lys667Glu
M0118081 HPHKCOGH_00006 5752 3 Oral 0.19 protein_coding synonymous_variant LOW 1812A>G Leu604Leu
M0118082 HPHKCOGH_00006 5764 6 Oral 0.38 protein_coding synonymous_variant LOW 1800T>C Ile600Ile
M0118083 HPHKCOGH_00006 5777 5 Oral 0.31 protein_coding missense_variant MODERATE 1787G>C Gly596Ala
M0118084 HPHKCOGH_00006 5830 3 Oral 0.19 protein_coding synonymous_variant LOW 1734G>C Gly578Gly
M0118085 HPHKCOGH_00006 5859 6 Oral 0.38 protein_coding missense_variant MODERATE 1705A>G Lys569Glu
M0118086 HPHKCOGH_00006 5911 3 Oral 0.19 protein_coding synonymous_variant LOW 1653A>G Thr551Thr
M0118087 HPHKCOGH_00006 5944 3 Oral 0.19 protein_coding synonymous_variant LOW 1620A>T Arg540Arg
M0118088 HPHKCOGH_00006 5956 3 Oral 0.19 protein_coding synonymous_variant LOW 1608T>C Ile536Ile
M0118089 HPHKCOGH_00006 6044 4 Oral 0.25 protein_coding missense_variant MODERATE 1520T>C Leu507Ser
M0118090 HPHKCOGH_00006 6135 6 Oral 0.38 protein_coding missense_variant MODERATE 1429G>A Val477Ile
M0118091 HPHKCOGH_00006 6144 3 Oral 0.19 protein_coding missense_variant MODERATE 1420G>T Gly474Cys
M0118092 HPHKCOGH_00006 6156 6 Oral 0.38 protein_coding missense_variant MODERATE 1408G>A Val470Met
M0118093 HPHKCOGH_00006 6565 3 Oral 0.19 protein_coding synonymous_variant LOW 999G>A Glu333Glu
M0118094 HPHKCOGH_00006 6976 3 Oral 0.19 protein_coding synonymous_variant LOW 588T>C Ala196Ala
M0118095 HPHKCOGH_00005 3915 4 Oral 0.25 protein_coding synonymous_variant LOW 99T>C Ala33Ala
M0118096 HPHKCOGH_00005 3930 4 Oral 0.25 protein_coding synonymous_variant LOW 84G>A Lys28Lys
M0118097 HPHKCOGH_00005 3987 4 Oral 0.25 protein_coding synonymous_variant LOW 27G>A Leu9Leu
M0118098 HPHKCOGH_00006 5921 3 Oral 0.19 protein_coding missense_variant MODERATE 1643T>G Met548Arg
M0118099 HPHKCOGH_00018 22111 5 Oral 0.31 protein_coding synonymous_variant LOW 327G>C Ser109Ser
M0118100 HPHKCOGH_00013 22634 4 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -4756G>T None
M0118101 HPHKCOGH_00013 22743 3 Oral 0.19 protein_coding upstream_gene_variant MODIFIER -4865T>C None
M0118102 HPHKCOGH_00019 22850 3 Oral 0.19 protein_coding missense_variant MODERATE 418A>C Ser140Arg
M0118103 HPHKCOGH_00020 23658 3 Oral 0.19 protein_coding missense_variant MODERATE 625G>T Ala209Ser
M0118104 HPHKCOGH_00006 5524 3 Oral 0.19 protein_coding synonymous_variant LOW 2040A>G Lys680Lys
M0118105 HPHKCOGH_00006 5530 3 Oral 0.19 protein_coding synonymous_variant LOW 2034C>T Arg678Arg
M0118106 HPHKCOGH_00004 1690 3 Oral 0.19 protein_coding synonymous_variant LOW 1045C>A Arg349Arg
M0118107 HPHKCOGH_00004 2005 3 Oral 0.19 protein_coding missense_variant MODERATE 730A>C Met244Leu
M0118108 HPHKCOGH_00004 2111 3 Oral 0.19 protein_coding synonymous_variant LOW 624T>C His208His






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term