Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1833
  Reference Plasmid   1111525849663039_bin.22__k141_108348
  Reference Plasmid Size   19804
  Reference Plasmid GC Content   0.63
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0018076 EFEOOMFK_00002 96 6 Skin 0.11 protein_coding upstream_gene_variant MODIFIER -1473A>T None
M0018077 EFEOOMFK_00001 144 7 Skin 0.12 protein_coding synonymous_variant LOW 1222T>C Leu408Leu
M0018078 EFEOOMFK_00001 166 7 Skin 0.12 protein_coding synonymous_variant LOW 1200G>A Glu400Glu
M0018079 EFEOOMFK_00001 202 7 Skin 0.12 protein_coding synonymous_variant LOW 1164G>C Thr388Thr
M0018080 EFEOOMFK_00001 1550 9 Skin 0.16 protein_coding upstream_gene_variant MODIFIER -185A>G None
M0018081 EFEOOMFK_00004 5441 7 Skin 0.12 protein_coding synonymous_variant LOW 996T>C Asn332Asn
M0018082 EFEOOMFK_00001 6056 5 Skin 0.09 protein_coding upstream_gene_variant MODIFIER -4691G>C None
M0018083 EFEOOMFK_00001 6059 4 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -4694G>A None
M0018084 EFEOOMFK_00005 6523 11 Skin 0.19 protein_coding synonymous_variant LOW 252C>T His84His
M0018085 EFEOOMFK_00005 6739 39 Skin 0.68 protein_coding synonymous_variant LOW 468T>G Ala156Ala
M0018086 EFEOOMFK_00007 9994 3 Skin 0.05 protein_coding missense_variant MODERATE 599T>C Met200Thr
M0018087 EFEOOMFK_00008 10628 6 Skin 0.11 protein_coding synonymous_variant LOW 214T>C Leu72Leu
M0018088 EFEOOMFK_00006 7898 10 Skin 0.18 protein_coding synonymous_variant LOW 174T>C Arg58Arg
M0018089 EFEOOMFK_00009 12088 20 Skin 0.35 protein_coding missense_variant MODERATE 737C>A Pro246His
M0018090 EFEOOMFK_00012 14965 13 Skin 0.23 protein_coding synonymous_variant LOW 432C>G Ala144Ala
M0018091 EFEOOMFK_00012 15268 4 Skin 0.07 protein_coding synonymous_variant LOW 735A>G Leu245Leu
M0018092 EFEOOMFK_00013 16308 14 Skin 0.25 protein_coding synonymous_variant LOW 336C>T Ile112Ile
M0018093 EFEOOMFK_00014 16782 10 Skin 0.18 protein_coding synonymous_variant LOW 417G>A Ala139Ala
M0018094 EFEOOMFK_00014 16797 10 Skin 0.18 protein_coding synonymous_variant LOW 432T>C Asn144Asn
M0018095 EFEOOMFK_00014 16800 10 Skin 0.18 protein_coding synonymous_variant LOW 435A>G Ala145Ala
M0018096 EFEOOMFK_00014 16803 10 Skin 0.18 protein_coding synonymous_variant LOW 438C>G Pro146Pro
M0018097 EFEOOMFK_00014 16806 10 Skin 0.18 protein_coding synonymous_variant LOW 441T>G Val147Val
M0018098 EFEOOMFK_00014 16860 10 Skin 0.18 protein_coding synonymous_variant LOW 495C>T Cys165Cys
M0018099 EFEOOMFK_00014 16869 10 Skin 0.18 protein_coding synonymous_variant LOW 504G>A Ala168Ala
M0018100 EFEOOMFK_00014 16872 10 Skin 0.18 protein_coding synonymous_variant LOW 507A>G Val169Val
M0018101 EFEOOMFK_00014 17230 3 Skin 0.05 protein_coding synonymous_variant LOW 865T>C Leu289Leu
M0018102 EFEOOMFK_00014 17265 3 Skin 0.05 protein_coding synonymous_variant LOW 900C>T His300His
M0018103 EFEOOMFK_00014 17295 3 Skin 0.05 protein_coding synonymous_variant LOW 930A>G Ala310Ala
M0018104 EFEOOMFK_00014 17301 3 Skin 0.05 protein_coding synonymous_variant LOW 936G>C Gly312Gly
M0018105 EFEOOMFK_00014 17307 3 Skin 0.05 protein_coding synonymous_variant LOW 942G>A Val314Val
M0018106 EFEOOMFK_00014 17324 3 Skin 0.05 protein_coding missense_variant MODERATE 959G>C Gly320Ala
M0018107 EFEOOMFK_00014 17325 3 Skin 0.05 protein_coding synonymous_variant LOW 960T>C Gly320Gly
M0018108 EFEOOMFK_00010 17480 8 Skin 0.14 protein_coding downstream_gene_variant MODIFIER *4192T>C None
M0018109 EFEOOMFK_00015 17969 4 Skin 0.07 protein_coding synonymous_variant LOW 1173C>G Ala391Ala
M0018110 EFEOOMFK_00015 17975 4 Skin 0.07 protein_coding synonymous_variant LOW 1167T>C His389His
M0018111 EFEOOMFK_00004 5102 4 Skin 0.07 protein_coding synonymous_variant LOW 657A>C Ile219Ile
M0018112 EFEOOMFK_00001 6062 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -4697G>A None
M0018113 EFEOOMFK_00006 8017 6 Skin 0.11 protein_coding missense_variant MODERATE 293C>G Thr98Ser
M0018114 EFEOOMFK_00006 8095 5 Skin 0.09 protein_coding missense_variant MODERATE 371C>G Thr124Ser
M0018115 EFEOOMFK_00006 9116 4 Skin 0.07 protein_coding synonymous_variant LOW 1392G>A Gln464Gln
M0018116 EFEOOMFK_00006 9140 5 Skin 0.09 protein_coding synonymous_variant LOW 1416A>G Glu472Glu
M0018117 EFEOOMFK_00005 7243 3 Skin 0.05 protein_coding synonymous_variant LOW 972A>G Gln324Gln
M0018118 EFEOOMFK_00007 9714 10 Skin 0.18 protein_coding synonymous_variant LOW 319T>C Leu107Leu
M0018119 EFEOOMFK_00008 10521 5 Skin 0.09 protein_coding missense_variant MODERATE 107G>A Arg36Lys
M0018120 EFEOOMFK_00009 12167 3 Skin 0.05 protein_coding synonymous_variant LOW 816C>A Ile272Ile
M0018121 EFEOOMFK_00009 12242 4 Skin 0.07 protein_coding synonymous_variant LOW 891C>G Arg297Arg
M0018122 EFEOOMFK_00009 12245 4 Skin 0.07 protein_coding synonymous_variant LOW 894T>C His298His
M0018123 EFEOOMFK_00009 12254 4 Skin 0.07 protein_coding synonymous_variant LOW 903A>G Pro301Pro
M0018124 EFEOOMFK_00009 12257 4 Skin 0.07 protein_coding synonymous_variant LOW 906T>C Pro302Pro
M0018125 EFEOOMFK_00004 5792 3 Skin 0.05 protein_coding synonymous_variant LOW 1347C>T Ile449Ile
M0018126 EFEOOMFK_00008 10483 4 Skin 0.07 protein_coding synonymous_variant LOW 69A>G Ser23Ser
M0018127 EFEOOMFK_00009 11588 4 Skin 0.07 protein_coding synonymous_variant LOW 237T>C Gly79Gly
M0018128 EFEOOMFK_00004 5318 3 Skin 0.05 protein_coding synonymous_variant LOW 873C>A Ile291Ile






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
EFEOOMFK_00003 3.A.1.5.39 80.6 4.1e-263 1 541 1.0000 1.0114 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
EFEOOMFK_00004 3.A.1.5.39 70.6 1.1e-223 7 529 0.9868 0.9962 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily