Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1895
  Reference Plasmid   1111525849668081_bin.10__k141_319281
  Reference Plasmid Size   5827
  Reference Plasmid GC Content   0.63
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0019457 INHCHMLI_00001 216 13 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -2T>C None
M0019458 INHCHMLI_00001 230 13 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -16G>T None
M0019459 INHCHMLI_00001 235 13 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -21T>C None
M0019460 INHCHMLI_00002 283 6 Skin 0.20 protein_coding missense_variant MODERATE 413C>T Ala138Val
M0019461 INHCHMLI_00002 295 5 Skin 0.17 protein_coding missense_variant MODERATE 401T>C Val134Ala
M0019462 INHCHMLI_00002 301 5 Skin 0.17 protein_coding missense_variant MODERATE 395C>A Pro132Gln
M0019463 INHCHMLI_00002 315 5 Skin 0.17 protein_coding synonymous_variant LOW 381C>T Leu127Leu
M0019464 INHCHMLI_00002 339 6 Skin 0.20 protein_coding synonymous_variant LOW 357G>A Lys119Lys
M0019465 INHCHMLI_00003 877 15 Skin 0.50 protein_coding synonymous_variant LOW 153A>G Arg51Arg
M0019466 INHCHMLI_00003 886 15 Skin 0.50 protein_coding synonymous_variant LOW 144T>C Ala48Ala
M0019467 INHCHMLI_00003 973 9 Skin 0.30 protein_coding synonymous_variant LOW 57A>G Glu19Glu
M0019468 INHCHMLI_00004 1030 22 Skin 0.73 protein_coding stop_lost&splice_region_variant HIGH 480A>G Ter160Trpext*?
M0019469 INHCHMLI_00004 1057 6 Skin 0.20 protein_coding synonymous_variant LOW 453G>A Gly151Gly
M0019470 INHCHMLI_00005 1838 21 Skin 0.70 protein_coding synonymous_variant LOW 183C>T Phe61Phe
M0019471 INHCHMLI_00005 2188 12 Skin 0.40 protein_coding missense_variant MODERATE 533G>A Ser178Asn
M0019472 INHCHMLI_00007 3348 22 Skin 0.73 protein_coding synonymous_variant LOW 186T>C Ser62Ser
M0019473 INHCHMLI_00007 3351 22 Skin 0.73 protein_coding synonymous_variant LOW 183A>G Pro61Pro
M0019474 INHCHMLI_00008 3640 9 Skin 0.30 protein_coding synonymous_variant LOW 60T>C Ile20Ile
M0019475 INHCHMLI_00008 3809 10 Skin 0.33 protein_coding missense_variant MODERATE 229G>A Val77Ile
M0019476 INHCHMLI_00001 165 7 Skin 0.23 protein_coding missense_variant MODERATE 50G>A Cys17Tyr
M0019477 INHCHMLI_00001 182 6 Skin 0.20 protein_coding synonymous_variant LOW 33A>C Gly11Gly
M0019478 INHCHMLI_00005 1913 8 Skin 0.27 protein_coding synonymous_variant LOW 258C>G Val86Val
M0019479 INHCHMLI_00005 1943 8 Skin 0.27 protein_coding synonymous_variant LOW 288T>C Asp96Asp
M0019480 INHCHMLI_00005 1988 9 Skin 0.30 protein_coding synonymous_variant LOW 333C>T Ile111Ile
M0019481 INHCHMLI_00001 2793 8 Skin 0.27 protein_coding upstream_gene_variant MODIFIER -2579T>C None
M0019482 INHCHMLI_00006 3027 10 Skin 0.33 protein_coding synonymous_variant LOW 198C>G Ser66Ser
M0019483 INHCHMLI_00009 4243 7 Skin 0.23 protein_coding synonymous_variant LOW 243A>G Glu81Glu
M0019484 INHCHMLI_00009 4285 7 Skin 0.23 protein_coding synonymous_variant LOW 285A>G Pro95Pro
M0019485 INHCHMLI_00009 4301 7 Skin 0.23 protein_coding missense_variant MODERATE 301G>C Glu101Gln
M0019486 INHCHMLI_00009 4330 7 Skin 0.23 protein_coding synonymous_variant LOW 330C>T Gly110Gly
M0019487 INHCHMLI_00009 4353 10 Skin 0.33 protein_coding missense_variant MODERATE 353T>C Val118Ala
M0019488 INHCHMLI_00009 5216 10 Skin 0.33 protein_coding missense_variant MODERATE 1216C>G Gln406Glu
M0019489 INHCHMLI_00001 2727 6 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2513T>G None
M0019490 INHCHMLI_00009 4855 4 Skin 0.13 protein_coding synonymous_variant LOW 855G>A Ala285Ala
M0019491 INHCHMLI_00009 4900 3 Skin 0.10 protein_coding synonymous_variant LOW 900T>G Leu300Leu
M0019492 INHCHMLI_00009 4954 4 Skin 0.13 protein_coding synonymous_variant LOW 954A>C Ala318Ala
M0019493 INHCHMLI_00009 4975 4 Skin 0.13 protein_coding synonymous_variant LOW 975G>A Arg325Arg
M0019494 INHCHMLI_00009 5020 3 Skin 0.10 protein_coding synonymous_variant LOW 1020C>T Arg340Arg
M0019495 INHCHMLI_00004 1318 3 Skin 0.10 protein_coding synonymous_variant LOW 192G>A Val64Val
M0019496 INHCHMLI_00007 3303 20 Skin 0.67 protein_coding synonymous_variant LOW 231T>G Pro77Pro
M0019497 INHCHMLI_00007 3306 20 Skin 0.67 protein_coding synonymous_variant LOW 228A>G Arg76Arg
M0019498 INHCHMLI_00005 55 4 Skin 0.13 protein_coding upstream_gene_variant MODIFIER -1601C>G None
M0019499 INHCHMLI_00002 660 6 Skin 0.20 protein_coding synonymous_variant LOW 36G>A Thr12Thr
M0019500 INHCHMLI_00001 700 6 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -486T>C None
M0019501 INHCHMLI_00001 1588 5 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -1374T>C None
M0019502 INHCHMLI_00001 1589 5 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -1375A>G None
M0019503 INHCHMLI_00001 1609 5 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -1395T>C None
M0019504 INHCHMLI_00001 1612 5 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -1398C>T None
M0019505 INHCHMLI_00001 1633 5 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -1419G>A None
M0019506 INHCHMLI_00005 1672 5 Skin 0.17 protein_coding missense_variant MODERATE 17C>A Pro6Gln
M0019507 INHCHMLI_00005 1697 6 Skin 0.20 protein_coding synonymous_variant LOW 42C>T Thr14Thr
M0019508 INHCHMLI_00005 1739 6 Skin 0.20 protein_coding synonymous_variant LOW 84C>T Asn28Asn
M0019509 INHCHMLI_00002 378 4 Skin 0.13 protein_coding synonymous_variant LOW 318A>G Glu106Glu
M0019510 INHCHMLI_00003 763 5 Skin 0.17 protein_coding synonymous_variant LOW 267C>T Arg89Arg
M0019511 INHCHMLI_00004 1399 6 Skin 0.20 protein_coding synonymous_variant LOW 111A>C Ala37Ala
M0019512 INHCHMLI_00001 3893 7 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -3679G>T None
M0019513 INHCHMLI_00001 3931 6 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -3717T>G None
M0019514 INHCHMLI_00009 4420 7 Skin 0.23 protein_coding synonymous_variant LOW 420G>A Gln140Gln
M0019515 INHCHMLI_00009 4441 7 Skin 0.23 protein_coding synonymous_variant LOW 441G>A Pro147Pro
M0019516 INHCHMLI_00009 4480 6 Skin 0.20 protein_coding synonymous_variant LOW 480A>G Glu160Glu
M0019517 INHCHMLI_00009 4528 7 Skin 0.23 protein_coding synonymous_variant LOW 528T>C Arg176Arg
M0019518 INHCHMLI_00009 4584 8 Skin 0.27 protein_coding missense_variant MODERATE 584C>T Pro195Leu
M0019519 INHCHMLI_00009 4588 8 Skin 0.27 protein_coding synonymous_variant LOW 588A>G Glu196Glu
M0019520 INHCHMLI_00005 1880 5 Skin 0.17 protein_coding synonymous_variant LOW 225T>C Arg75Arg
M0019521 INHCHMLI_00009 5323 3 Skin 0.10 protein_coding synonymous_variant LOW 1323A>G Glu441Glu
M0019522 INHCHMLI_00009 5344 3 Skin 0.10 protein_coding synonymous_variant LOW 1344G>A Arg448Arg
M0019523 INHCHMLI_00009 5381 3 Skin 0.10 protein_coding missense_variant MODERATE 1381G>A Ala461Thr
M0019524 INHCHMLI_00002 414 3 Skin 0.10 protein_coding synonymous_variant LOW 282T>C Arg94Arg
M0019525 INHCHMLI_00004 1483 3 Skin 0.10 protein_coding synonymous_variant LOW 27T>C Asp9Asp
M0019526 INHCHMLI_00004 1495 3 Skin 0.10 protein_coding synonymous_variant LOW 15C>T Asn5Asn
M0019527 INHCHMLI_00009 4005 4 Skin 0.13 protein_coding missense_variant MODERATE 5T>A Met2Lys






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
INHCHMLI_00002 Mercury (Hg) 85.2 3.8e-56 1 128 0.8828 0.9624 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term