Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C1976
  Reference Plasmid   1111525849736575_bin.4__k141_1165
  Reference Plasmid Size   28238
  Reference Plasmid GC Content   0.57
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0021764 OPCPCBOH_00011 17821 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -3669T>C None
M0021765 OPCPCBOH_00018 18430 5 Skin 0.12 protein_coding synonymous_variant LOW 249A>G Leu83Leu
M0021766 OPCPCBOH_00004 6716 6 Skin 0.14 protein_coding missense_variant MODERATE 379A>C Met127Leu
M0021767 OPCPCBOH_00005 7645 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -92A>C None
M0021768 OPCPCBOH_00006 9130 4 Skin 0.10 protein_coding missense_variant MODERATE 655A>G Thr219Ala
M0021769 OPCPCBOH_00008 10002 3 Skin 0.07 protein_coding missense_variant MODERATE 401C>G Thr134Ser
M0021770 OPCPCBOH_00006 9277 3 Skin 0.07 protein_coding missense_variant MODERATE 802T>G Ser268Ala
M0021771 OPCPCBOH_00006 9306 3 Skin 0.07 protein_coding synonymous_variant LOW 831A>G Pro277Pro
M0021772 OPCPCBOH_00009 11534 6 Skin 0.14 protein_coding synonymous_variant LOW 21G>A Val7Val
M0021773 OPCPCBOH_00009 11545 6 Skin 0.14 protein_coding synonymous_variant LOW 10T>C Leu4Leu
M0021774 OPCPCBOH_00007 11577 5 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -1654T>C None
M0021775 OPCPCBOH_00007 11583 5 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -1660G>T None
M0021776 OPCPCBOH_00007 11589 5 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -1666C>T None
M0021777 OPCPCBOH_00010 12353 5 Skin 0.12 protein_coding synonymous_variant LOW 420G>A Glu140Glu
M0021778 OPCPCBOH_00018 18060 3 Skin 0.07 protein_coding synonymous_variant LOW 619T>C Leu207Leu
M0021779 OPCPCBOH_00018 18086 3 Skin 0.07 protein_coding missense_variant MODERATE 593A>G Asp198Gly
M0021780 OPCPCBOH_00017 17255 4 Skin 0.10 protein_coding synonymous_variant LOW 511T>C Leu171Leu
M0021781 OPCPCBOH_00010 12116 4 Skin 0.10 protein_coding synonymous_variant LOW 183T>C Ala61Ala
M0021782 OPCPCBOH_00010 12125 4 Skin 0.10 protein_coding synonymous_variant LOW 192T>G Thr64Thr
M0021783 OPCPCBOH_00006 9089 3 Skin 0.07 protein_coding missense_variant MODERATE 614C>A Ala205Glu
M0021784 OPCPCBOH_00004 6985 3 Skin 0.07 protein_coding synonymous_variant LOW 648T>G Pro216Pro
M0021785 OPCPCBOH_00004 6994 3 Skin 0.07 protein_coding synonymous_variant LOW 657T>C Phe219Phe
M0021786 OPCPCBOH_00009 10877 4 Skin 0.10 protein_coding synonymous_variant LOW 678T>C Cys226Cys
M0021787 OPCPCBOH_00009 10991 4 Skin 0.10 protein_coding synonymous_variant LOW 564C>T Ile188Ile
M0021788 OPCPCBOH_00009 11009 4 Skin 0.10 protein_coding synonymous_variant LOW 546T>G Leu182Leu
M0021789 OPCPCBOH_00010 12473 4 Skin 0.10 protein_coding synonymous_variant LOW 540A>G Val180Val
M0021790 OPCPCBOH_00016 17057 3 Skin 0.07 protein_coding synonymous_variant LOW 51T>C Ala17Ala
M0021791 OPCPCBOH_00019 18809 5 Skin 0.12 protein_coding synonymous_variant LOW 225T>C Ala75Ala
M0021792 OPCPCBOH_00019 18831 5 Skin 0.12 protein_coding missense_variant MODERATE 203C>T Pro68Leu
M0021793 OPCPCBOH_00019 18847 5 Skin 0.12 protein_coding missense_variant MODERATE 187T>G Ser63Ala
M0021794 OPCPCBOH_00019 19008 4 Skin 0.10 protein_coding missense_variant MODERATE 26C>A Thr9Asn
M0021795 OPCPCBOH_00019 19019 4 Skin 0.10 protein_coding synonymous_variant LOW 15A>G Glu5Glu
M0021796 OPCPCBOH_00004 6988 3 Skin 0.07 protein_coding synonymous_variant LOW 651G>A Val217Val
M0021797 OPCPCBOH_00010 13309 3 Skin 0.07 protein_coding missense_variant MODERATE 1376G>C Arg459Thr
M0021798 OPCPCBOH_00010 12840 3 Skin 0.07 protein_coding missense_variant MODERATE 907G>A Asp303Asn
M0021799 OPCPCBOH_00006 8360 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -116A>C None
M0021800 OPCPCBOH_00006 8367 3 Skin 0.07 protein_coding upstream_gene_variant MODIFIER -109C>T None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
OPCPCBOH_00004 PHI:2962 glyA 72.1 7e-178 1 415 0.9952 0.9976 bony fishes enteric septicemia serine hydroxymethyltransferase reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term