Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2017
  Reference Plasmid   1111525849737037_bin.1__k141_382855
  Reference Plasmid Size   16191
  Reference Plasmid GC Content   0.72
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0022671 LEHBOFNJ_00005 4191 5 Skin 0.42 protein_coding missense_variant MODERATE 871C>G Gln291Glu
M0022672 LEHBOFNJ_00005 4323 3 Skin 0.25 protein_coding missense_variant MODERATE 739C>G Arg247Gly
M0022673 LEHBOFNJ_00005 4414 7 Skin 0.58 protein_coding synonymous_variant LOW 648T>G Leu216Leu
M0022674 LEHBOFNJ_00005 4425 3 Skin 0.25 protein_coding missense_variant MODERATE 637A>G Thr213Ala
M0022675 LEHBOFNJ_00005 4447 6 Skin 0.50 protein_coding synonymous_variant LOW 615C>G Thr205Thr
M0022676 LEHBOFNJ_00005 4507 7 Skin 0.58 protein_coding synonymous_variant LOW 555A>G Gly185Gly
M0022677 LEHBOFNJ_00005 4926 7 Skin 0.58 protein_coding missense_variant MODERATE 136T>G Ser46Ala
M0022678 LEHBOFNJ_00005 5031 7 Skin 0.58 protein_coding missense_variant MODERATE 31T>G Ser11Ala
M0022679 LEHBOFNJ_00002 5100 7 Skin 0.58 protein_coding upstream_gene_variant MODIFIER -3849T>C None
M0022680 LEHBOFNJ_00002 5170 7 Skin 0.58 protein_coding upstream_gene_variant MODIFIER -3919A>T None
M0022681 LEHBOFNJ_00002 5317 8 Skin 0.67 protein_coding upstream_gene_variant MODIFIER -4066C>T None
M0022682 LEHBOFNJ_00002 5460 6 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -4209A>C None
M0022683 LEHBOFNJ_00002 5472 5 Skin 0.42 protein_coding upstream_gene_variant MODIFIER -4221C>T None
M0022684 LEHBOFNJ_00007 5514 5 Skin 0.42 protein_coding missense_variant MODERATE 39T>A Asp13Glu
M0022685 LEHBOFNJ_00007 5562 3 Skin 0.25 protein_coding synonymous_variant LOW 87G>T Ala29Ala
M0022686 LEHBOFNJ_00007 5570 7 Skin 0.58 protein_coding missense_variant MODERATE 95T>C Leu32Pro
M0022687 LEHBOFNJ_00007 5637 6 Skin 0.50 protein_coding synonymous_variant LOW 162T>C Ile54Ile
M0022688 LEHBOFNJ_00007 5649 5 Skin 0.42 protein_coding synonymous_variant LOW 174G>C Ala58Ala
M0022689 LEHBOFNJ_00007 5712 5 Skin 0.42 protein_coding missense_variant MODERATE 237G>T Glu79Asp
M0022690 LEHBOFNJ_00007 5745 3 Skin 0.25 protein_coding synonymous_variant LOW 270G>T Val90Val
M0022691 LEHBOFNJ_00007 5786 10 Skin 0.83 protein_coding missense_variant MODERATE 311T>C Ile104Thr
M0022692 LEHBOFNJ_00007 5814 8 Skin 0.67 protein_coding synonymous_variant LOW 339A>C Thr113Thr
M0022693 LEHBOFNJ_00007 5920 3 Skin 0.25 protein_coding missense_variant MODERATE 445A>G Asn149Asp
M0022694 LEHBOFNJ_00007 5922 3 Skin 0.25 protein_coding synonymous_variant LOW 447T>C Asn149Asn
M0022695 LEHBOFNJ_00007 6105 3 Skin 0.25 protein_coding synonymous_variant LOW 630T>C Leu210Leu
M0022696 LEHBOFNJ_00007 6180 8 Skin 0.67 protein_coding synonymous_variant LOW 705T>G Pro235Pro
M0022697 LEHBOFNJ_00007 6216 8 Skin 0.67 protein_coding synonymous_variant LOW 741A>C Gly247Gly
M0022698 LEHBOFNJ_00008 6302 8 Skin 0.67 protein_coding synonymous_variant LOW 51T>C Ala17Ala
M0022699 LEHBOFNJ_00008 6584 6 Skin 0.50 protein_coding synonymous_variant LOW 333G>C Val111Val
M0022700 LEHBOFNJ_00008 6647 7 Skin 0.58 protein_coding synonymous_variant LOW 396T>C Val132Val
M0022701 LEHBOFNJ_00008 6671 4 Skin 0.33 protein_coding synonymous_variant LOW 420C>T Arg140Arg
M0022702 LEHBOFNJ_00008 6866 3 Skin 0.25 protein_coding synonymous_variant LOW 615A>C Ala205Ala
M0022703 LEHBOFNJ_00008 6965 5 Skin 0.42 protein_coding synonymous_variant LOW 714G>A Glu238Glu
M0022704 LEHBOFNJ_00008 7008 6 Skin 0.50 protein_coding missense_variant MODERATE 757A>G Thr253Ala
M0022705 LEHBOFNJ_00010 8576 3 Skin 0.25 protein_coding missense_variant MODERATE 1112T>G Leu371Trp
M0022706 LEHBOFNJ_00011 8848 4 Skin 0.33 protein_coding missense_variant MODERATE 242T>C Ile81Thr
M0022707 LEHBOFNJ_00005 9420 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -4359G>T None
M0022708 LEHBOFNJ_00005 9474 4 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -4413T>C None
M0022709 LEHBOFNJ_00012 9926 3 Skin 0.25 protein_coding synonymous_variant LOW 441T>C Gly147Gly
M0022710 LEHBOFNJ_00013 10558 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -130C>G None
M0022711 LEHBOFNJ_00013 11101 3 Skin 0.25 protein_coding synonymous_variant LOW 414C>T Phe138Phe
M0022712 LEHBOFNJ_00013 11530 3 Skin 0.25 protein_coding synonymous_variant LOW 843A>C Ala281Ala
M0022713 LEHBOFNJ_00014 11672 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -29G>A None
M0022714 LEHBOFNJ_00014 11676 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -25A>G None
M0022715 LEHBOFNJ_00014 11689 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -12A>G None
M0022716 LEHBOFNJ_00014 11691 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -10G>A None
M0022717 LEHBOFNJ_00014 11712 3 Skin 0.25 protein_coding synonymous_variant LOW 12A>G Glu4Glu
M0022718 LEHBOFNJ_00014 11730 3 Skin 0.25 protein_coding synonymous_variant LOW 30T>C Thr10Thr
M0022719 LEHBOFNJ_00014 11769 3 Skin 0.25 protein_coding synonymous_variant LOW 69A>G Ala23Ala
M0022720 LEHBOFNJ_00014 12234 3 Skin 0.25 protein_coding synonymous_variant LOW 534A>G Leu178Leu
M0022721 LEHBOFNJ_00014 12253 3 Skin 0.25 protein_coding missense_variant MODERATE 553T>G Ser185Ala
M0022722 LEHBOFNJ_00014 12282 3 Skin 0.25 protein_coding synonymous_variant LOW 582T>C His194His
M0022723 LEHBOFNJ_00014 12291 3 Skin 0.25 protein_coding synonymous_variant LOW 591C>G Ala197Ala
M0022724 LEHBOFNJ_00014 12351 3 Skin 0.25 protein_coding synonymous_variant LOW 651G>C Arg217Arg
M0022725 LEHBOFNJ_00015 13099 3 Skin 0.25 protein_coding synonymous_variant LOW 1437T>C Asp479Asp
M0022726 LEHBOFNJ_00005 4357 4 Skin 0.33 protein_coding synonymous_variant LOW 705C>G Ser235Ser
M0022727 LEHBOFNJ_00005 4369 4 Skin 0.33 protein_coding synonymous_variant LOW 693C>G Arg231Arg
M0022728 LEHBOFNJ_00005 4678 6 Skin 0.50 protein_coding synonymous_variant LOW 384G>C Leu128Leu
M0022729 LEHBOFNJ_00005 4761 6 Skin 0.50 protein_coding missense_variant MODERATE 301A>G Ile101Val
M0022730 LEHBOFNJ_00005 4798 3 Skin 0.25 protein_coding synonymous_variant LOW 264C>T Arg88Arg
M0022731 LEHBOFNJ_00005 4799 6 Skin 0.50 protein_coding missense_variant MODERATE 263G>C Arg88Pro
M0022732 LEHBOFNJ_00007 6097 3 Skin 0.25 protein_coding missense_variant MODERATE 622G>C Asp208His
M0022733 LEHBOFNJ_00007 6249 4 Skin 0.33 protein_coding synonymous_variant LOW 774C>G Ser258Ser
M0022734 LEHBOFNJ_00008 6788 4 Skin 0.33 protein_coding synonymous_variant LOW 537G>C Ala179Ala
M0022735 LEHBOFNJ_00008 6789 4 Skin 0.33 protein_coding synonymous_variant LOW 538C>T Leu180Leu
M0022736 LEHBOFNJ_00009 7115 5 Skin 0.42 protein_coding missense_variant MODERATE 103G>C Gly35Arg
M0022737 LEHBOFNJ_00009 7210 6 Skin 0.50 protein_coding synonymous_variant LOW 198T>C Val66Val
M0022738 LEHBOFNJ_00009 7387 4 Skin 0.33 protein_coding synonymous_variant LOW 375C>G Pro125Pro
M0022739 LEHBOFNJ_00010 7518 3 Skin 0.25 protein_coding synonymous_variant LOW 54G>C Pro18Pro
M0022740 LEHBOFNJ_00010 7590 3 Skin 0.25 protein_coding synonymous_variant LOW 126G>C Pro42Pro
M0022741 LEHBOFNJ_00010 7656 3 Skin 0.25 protein_coding synonymous_variant LOW 192C>T Ala64Ala
M0022742 LEHBOFNJ_00010 7659 4 Skin 0.33 protein_coding synonymous_variant LOW 195T>C Ala65Ala
M0022743 LEHBOFNJ_00011 9332 3 Skin 0.25 protein_coding synonymous_variant LOW 726C>T Tyr242Tyr
M0022744 LEHBOFNJ_00012 9703 3 Skin 0.25 protein_coding missense_variant MODERATE 218T>C Val73Ala
M0022745 LEHBOFNJ_00012 10304 3 Skin 0.25 protein_coding synonymous_variant LOW 819A>C Thr273Thr
M0022746 LEHBOFNJ_00003 2242 3 Skin 0.25 protein_coding synonymous_variant LOW 669T>C Phe223Phe
M0022747 LEHBOFNJ_00003 2332 4 Skin 0.33 protein_coding synonymous_variant LOW 579T>G Pro193Pro
M0022748 LEHBOFNJ_00003 2428 3 Skin 0.25 protein_coding synonymous_variant LOW 483C>G Val161Val
M0022749 LEHBOFNJ_00003 2659 3 Skin 0.25 protein_coding synonymous_variant LOW 252A>C Arg84Arg
M0022750 LEHBOFNJ_00003 2800 3 Skin 0.25 protein_coding synonymous_variant LOW 111G>C Gly37Gly
M0022751 LEHBOFNJ_00003 2806 3 Skin 0.25 protein_coding synonymous_variant LOW 105A>G Gln35Gln
M0022752 LEHBOFNJ_00003 2863 4 Skin 0.33 protein_coding synonymous_variant LOW 48T>C Asn16Asn
M0022753 LEHBOFNJ_00002 2982 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1731G>T None
M0022754 LEHBOFNJ_00002 2987 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1736C>G None
M0022755 LEHBOFNJ_00002 2988 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1737G>C None
M0022756 LEHBOFNJ_00002 2989 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1738A>C None
M0022757 LEHBOFNJ_00004 3519 5 Skin 0.42 protein_coding synonymous_variant LOW 441T>C Ser147Ser
M0022758 LEHBOFNJ_00004 3798 3 Skin 0.25 protein_coding synonymous_variant LOW 162T>C Asp54Asp
M0022759 LEHBOFNJ_00002 5466 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -4215C>G None
M0022760 LEHBOFNJ_00007 5515 3 Skin 0.25 protein_coding missense_variant MODERATE 40A>G Ser14Gly
M0022761 LEHBOFNJ_00007 5556 3 Skin 0.25 protein_coding synonymous_variant LOW 81G>A Gln27Gln
M0022762 LEHBOFNJ_00008 6758 4 Skin 0.33 protein_coding synonymous_variant LOW 507G>C Leu169Leu
M0022763 LEHBOFNJ_00008 6770 3 Skin 0.25 protein_coding synonymous_variant LOW 519T>C Asp173Asp
M0022764 LEHBOFNJ_00008 6936 3 Skin 0.25 protein_coding synonymous_variant LOW 685C>T Leu229Leu
M0022765 LEHBOFNJ_00009 7113 3 Skin 0.25 protein_coding missense_variant MODERATE 101C>G Ser34Cys
M0022766 LEHBOFNJ_00009 7157 4 Skin 0.33 protein_coding missense_variant MODERATE 145G>A Gly49Ser
M0022767 LEHBOFNJ_00009 7231 3 Skin 0.25 protein_coding synonymous_variant LOW 219C>T Val73Val
M0022768 LEHBOFNJ_00009 7232 3 Skin 0.25 protein_coding missense_variant MODERATE 220C>T Arg74Trp
M0022769 LEHBOFNJ_00009 7285 4 Skin 0.33 protein_coding synonymous_variant LOW 273C>G Arg91Arg
M0022770 LEHBOFNJ_00009 7371 3 Skin 0.25 protein_coding missense_variant MODERATE 359T>C Val120Ala
M0022771 LEHBOFNJ_00009 7413 3 Skin 0.25 protein_coding missense_variant MODERATE 401T>C Ile134Thr
M0022772 LEHBOFNJ_00003 1765 3 Skin 0.25 protein_coding synonymous_variant LOW 1146A>G Glu382Glu
M0022773 LEHBOFNJ_00004 3378 5 Skin 0.42 protein_coding synonymous_variant LOW 582G>C Thr194Thr
M0022774 LEHBOFNJ_00002 3998 3 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2747G>A None
M0022775 LEHBOFNJ_00005 4036 4 Skin 0.33 protein_coding synonymous_variant LOW 1026A>C Ala342Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term