Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2041
  Reference Plasmid   1111525849737189_bin.19__k141_239681
  Reference Plasmid Size   17643
  Reference Plasmid GC Content   0.64
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0023256 NLNEOHBK_00009 13189 33 Skin 0.56 protein_coding synonymous_variant LOW 1269T>C His423His
M0023257 NLNEOHBK_00010 16003 19 Skin 0.32 protein_coding missense_variant MODERATE 1057A>G Met353Val
M0023258 NLNEOHBK_00010 16324 18 Skin 0.31 protein_coding missense_variant MODERATE 1378T>A Phe460Ile
M0023259 NLNEOHBK_00011 16335 18 Skin 0.31 protein_coding missense_variant MODERATE 950G>A Arg317Gln
M0023260 NLNEOHBK_00008 11415 7 Skin 0.12 protein_coding missense_variant MODERATE 3991G>C Glu1331Gln
M0023261 NLNEOHBK_00009 13711 4 Skin 0.07 protein_coding synonymous_variant LOW 1791T>A Val597Val
M0023262 NLNEOHBK_00009 14584 3 Skin 0.05 protein_coding synonymous_variant LOW 2664G>C Arg888Arg
M0023263 NLNEOHBK_00004 3827 10 Skin 0.17 protein_coding synonymous_variant LOW 321A>G Leu107Leu
M0023264 NLNEOHBK_00004 3856 10 Skin 0.17 protein_coding missense_variant MODERATE 292T>A Phe98Ile
M0023265 NLNEOHBK_00004 3860 9 Skin 0.15 protein_coding synonymous_variant LOW 288G>C Leu96Leu
M0023266 NLNEOHBK_00004 3894 10 Skin 0.17 protein_coding missense_variant MODERATE 254C>A Ala85Asp
M0023267 NLNEOHBK_00004 3896 10 Skin 0.17 protein_coding synonymous_variant LOW 252G>T Val84Val
M0023268 NLNEOHBK_00004 3897 10 Skin 0.17 protein_coding missense_variant MODERATE 251T>A Val84Glu
M0023269 NLNEOHBK_00004 3900 10 Skin 0.17 protein_coding missense_variant MODERATE 248C>A Ala83Asp
M0023270 NLNEOHBK_00004 3904 10 Skin 0.17 protein_coding missense_variant MODERATE 244G>A Ala82Thr
M0023271 NLNEOHBK_00004 3910 9 Skin 0.15 protein_coding missense_variant MODERATE 238A>C Thr80Pro
M0023272 NLNEOHBK_00004 3952 10 Skin 0.17 protein_coding missense_variant MODERATE 196T>G Leu66Val
M0023273 NLNEOHBK_00005 4473 13 Skin 0.22 protein_coding synonymous_variant LOW 816T>C Asn272Asn
M0023274 NLNEOHBK_00005 5274 3 Skin 0.05 protein_coding synonymous_variant LOW 15A>G Pro5Pro
M0023275 NLNEOHBK_00006 5944 4 Skin 0.07 protein_coding missense_variant MODERATE 544A>G Thr182Ala
M0023276 NLNEOHBK_00008 11222 6 Skin 0.10 protein_coding synonymous_variant LOW 3798C>T Arg1266Arg
M0023277 NLNEOHBK_00008 11517 5 Skin 0.08 protein_coding missense_variant MODERATE 4093A>G Ile1365Val
M0023278 NLNEOHBK_00008 11788 4 Skin 0.07 protein_coding missense_variant MODERATE 4364G>C Gly1455Ala
M0023279 NLNEOHBK_00008 11819 5 Skin 0.08 protein_coding synonymous_variant LOW 4395G>A Gln1465Gln
M0023280 NLNEOHBK_00007 7191 3 Skin 0.05 protein_coding synonymous_variant LOW 864C>A Ala288Ala
M0023281 NLNEOHBK_00011 16844 3 Skin 0.05 protein_coding missense_variant MODERATE 441C>G His147Gln
M0023282 NLNEOHBK_00006 5574 3 Skin 0.05 protein_coding synonymous_variant LOW 174C>A Thr58Thr






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
NLNEOHBK_00003 Chromium (Cr), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], 2,6-dichloroindophenol [class: Phenolic Compounds] 91.9 4.2e-99 1 186 1.0000 1.0000 experiment
NLNEOHBK_00003 Chromium (Cr), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], 2,6-dichloroindophenol [class: Phenolic Compounds] 100 5.3e-103 1 186 1.0000 1.0000 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term