Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2114
  Reference Plasmid   1111525849742984_bin.4__k141_1123626
  Reference Plasmid Size   2930
  Reference Plasmid GC Content   0.34
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0025345 KDHIGHLA_00002 2743 3 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -2059T>A None
M0025346 KDHIGHLA_00002 289 4 Skin 0.57 protein_coding synonymous_variant LOW 396T>C Arg132Arg
M0025347 KDHIGHLA_00002 322 4 Skin 0.57 protein_coding synonymous_variant LOW 363C>T Gly121Gly
M0025348 KDHIGHLA_00002 343 4 Skin 0.57 protein_coding synonymous_variant LOW 342C>T Ala114Ala
M0025349 KDHIGHLA_00002 373 4 Skin 0.57 protein_coding synonymous_variant LOW 312A>G Lys104Lys
M0025350 KDHIGHLA_00002 391 4 Skin 0.57 protein_coding synonymous_variant LOW 294A>T Ala98Ala
M0025351 KDHIGHLA_00002 436 4 Skin 0.57 protein_coding missense_variant MODERATE 249A>T Glu83Asp
M0025352 KDHIGHLA_00002 486 4 Skin 0.57 protein_coding missense_variant MODERATE 199A>G Thr67Ala
M0025353 KDHIGHLA_00002 517 4 Skin 0.57 protein_coding synonymous_variant LOW 168G>A Leu56Leu
M0025354 KDHIGHLA_00003 789 3 Skin 0.43 protein_coding synonymous_variant LOW 1128C>T Ala376Ala
M0025355 KDHIGHLA_00003 864 4 Skin 0.57 protein_coding synonymous_variant LOW 1053T>C Ser351Ser
M0025356 KDHIGHLA_00003 900 4 Skin 0.57 protein_coding synonymous_variant LOW 1017T>C His339His
M0025357 KDHIGHLA_00003 926 4 Skin 0.57 protein_coding synonymous_variant LOW 991T>C Leu331Leu
M0025358 KDHIGHLA_00003 933 4 Skin 0.57 protein_coding synonymous_variant LOW 984T>C Ala328Ala
M0025359 KDHIGHLA_00003 951 4 Skin 0.57 protein_coding synonymous_variant LOW 966A>G Leu322Leu
M0025360 KDHIGHLA_00003 1338 4 Skin 0.57 protein_coding synonymous_variant LOW 579A>G Gln193Gln
M0025361 KDHIGHLA_00003 1386 4 Skin 0.57 protein_coding synonymous_variant LOW 531T>C Thr177Thr
M0025362 KDHIGHLA_00003 1410 4 Skin 0.57 protein_coding synonymous_variant LOW 507A>G Ala169Ala
M0025363 KDHIGHLA_00003 1518 4 Skin 0.57 protein_coding synonymous_variant LOW 399T>C Asn133Asn
M0025364 KDHIGHLA_00003 1653 4 Skin 0.57 protein_coding synonymous_variant LOW 264A>G Thr88Thr
M0025365 KDHIGHLA_00003 1728 4 Skin 0.57 protein_coding synonymous_variant LOW 189A>T Pro63Pro
M0025366 KDHIGHLA_00003 1731 4 Skin 0.57 protein_coding synonymous_variant LOW 186A>G Gln62Gln
M0025367 KDHIGHLA_00003 1797 4 Skin 0.57 protein_coding synonymous_variant LOW 120C>T Phe40Phe
M0025368 KDHIGHLA_00003 1809 3 Skin 0.43 protein_coding synonymous_variant LOW 108C>T Leu36Leu
M0025369 KDHIGHLA_00003 1812 3 Skin 0.43 protein_coding synonymous_variant LOW 105C>T Val35Val
M0025370 KDHIGHLA_00004 1977 4 Skin 0.57 protein_coding synonymous_variant LOW 450C>T Tyr150Tyr
M0025371 KDHIGHLA_00004 2130 3 Skin 0.43 protein_coding synonymous_variant LOW 297T>C Pro99Pro
M0025372 KDHIGHLA_00004 2154 4 Skin 0.57 protein_coding synonymous_variant LOW 273A>G Ala91Ala
M0025373 KDHIGHLA_00004 2190 3 Skin 0.43 protein_coding synonymous_variant LOW 237A>G Leu79Leu
M0025374 KDHIGHLA_00004 2192 3 Skin 0.43 protein_coding synonymous_variant LOW 235T>C Leu79Leu
M0025375 KDHIGHLA_00004 2193 3 Skin 0.43 protein_coding synonymous_variant LOW 234A>G Gly78Gly
M0025376 KDHIGHLA_00004 2359 4 Skin 0.57 protein_coding missense_variant MODERATE 68G>C Arg23Pro
M0025377 KDHIGHLA_00002 634 3 Skin 0.43 protein_coding synonymous_variant LOW 51T>A Ala17Ala
M0025378 KDHIGHLA_00002 651 3 Skin 0.43 protein_coding missense_variant MODERATE 34G>A Ala12Thr
M0025379 KDHIGHLA_00002 2598 3 Skin 0.43 protein_coding upstream_gene_variant MODIFIER -1914G>T None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term