Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2162
  Reference Plasmid   1111525849743604_bin.1__k141_163045
  Reference Plasmid Size   3845
  Reference Plasmid GC Content   0.30
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0028688 DDEEAHCM_00001 66 4 Skin 0.31 protein_coding synonymous_variant LOW 66A>C Ala22Ala
M0028689 DDEEAHCM_00004 158 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2481A>G None
M0028690 DDEEAHCM_00004 207 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -2432G>A None
M0028691 DDEEAHCM_00004 221 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2418A>G None
M0028692 DDEEAHCM_00004 243 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -2396T>C None
M0028693 DDEEAHCM_00004 246 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2393G>A None
M0028694 DDEEAHCM_00004 253 7 Skin 0.54 protein_coding upstream_gene_variant MODIFIER -2386C>T None
M0028695 DDEEAHCM_00004 255 7 Skin 0.54 protein_coding upstream_gene_variant MODIFIER -2384T>G None
M0028696 DDEEAHCM_00004 260 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -2379G>T None
M0028697 DDEEAHCM_00004 274 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2365T>C None
M0028698 DDEEAHCM_00004 277 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2362A>G None
M0028699 DDEEAHCM_00004 295 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2344A>G None
M0028700 DDEEAHCM_00004 336 9 Skin 0.69 protein_coding upstream_gene_variant MODIFIER -2303T>G None
M0028701 DDEEAHCM_00004 379 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2260G>T None
M0028702 DDEEAHCM_00002 641 6 Skin 0.46 protein_coding synonymous_variant LOW 432C>T His144His
M0028703 DDEEAHCM_00002 763 7 Skin 0.54 protein_coding synonymous_variant LOW 310T>C Leu104Leu
M0028704 DDEEAHCM_00002 764 6 Skin 0.46 protein_coding synonymous_variant LOW 309T>C Asn103Asn
M0028705 DDEEAHCM_00002 851 6 Skin 0.46 protein_coding synonymous_variant LOW 222A>G Glu74Glu
M0028706 DDEEAHCM_00002 938 3 Skin 0.23 protein_coding missense_variant MODERATE 135A>T Arg45Ser
M0028707 DDEEAHCM_00002 953 3 Skin 0.23 protein_coding missense_variant MODERATE 120T>G Asp40Glu
M0028708 DDEEAHCM_00002 1106 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -34G>A None
M0028709 DDEEAHCM_00002 1107 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -35T>C None
M0028710 DDEEAHCM_00002 1126 12 Skin 0.92 protein_coding upstream_gene_variant MODIFIER -54A>T None
M0028711 DDEEAHCM_00002 1139 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -67A>G None
M0028712 DDEEAHCM_00002 1151 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -79T>A None
M0028713 DDEEAHCM_00002 1182 8 Skin 0.62 protein_coding upstream_gene_variant MODIFIER -110C>T None
M0028714 DDEEAHCM_00002 1200 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -128A>G None
M0028715 DDEEAHCM_00002 1280 8 Skin 0.62 protein_coding upstream_gene_variant MODIFIER -208T>A None
M0028716 DDEEAHCM_00002 1286 11 Skin 0.85 protein_coding upstream_gene_variant MODIFIER -214T>C None
M0028717 DDEEAHCM_00003 1305 8 Skin 0.62 protein_coding synonymous_variant LOW 1197G>A Glu399Glu
M0028718 DDEEAHCM_00003 1310 8 Skin 0.62 protein_coding stop_gained HIGH 1192A>T Arg398*
M0028719 DDEEAHCM_00003 1313 8 Skin 0.62 protein_coding stop_gained HIGH 1189A>T Lys397*
M0028720 DDEEAHCM_00003 1319 4 Skin 0.31 protein_coding missense_variant MODERATE 1183T>C Phe395Leu
M0028721 DDEEAHCM_00003 1455 9 Skin 0.69 protein_coding synonymous_variant LOW 1047G>A Ala349Ala
M0028722 DDEEAHCM_00003 1467 9 Skin 0.69 protein_coding synonymous_variant LOW 1035G>A Ala345Ala
M0028723 DDEEAHCM_00003 1479 8 Skin 0.62 protein_coding synonymous_variant LOW 1023T>C Phe341Phe
M0028724 DDEEAHCM_00003 1485 8 Skin 0.62 protein_coding synonymous_variant LOW 1017A>G Ser339Ser
M0028725 DDEEAHCM_00003 1584 11 Skin 0.85 protein_coding synonymous_variant LOW 918T>A Ala306Ala
M0028726 DDEEAHCM_00003 1593 8 Skin 0.62 protein_coding synonymous_variant LOW 909G>A Leu303Leu
M0028727 DDEEAHCM_00003 1599 4 Skin 0.31 protein_coding missense_variant MODERATE 903G>C Met301Ile
M0028728 DDEEAHCM_00003 1632 8 Skin 0.62 protein_coding synonymous_variant LOW 870G>T Gly290Gly
M0028729 DDEEAHCM_00003 1674 4 Skin 0.31 protein_coding synonymous_variant LOW 828A>G Glu276Glu
M0028730 DDEEAHCM_00003 1773 4 Skin 0.31 protein_coding synonymous_variant LOW 729T>C Ile243Ile
M0028731 DDEEAHCM_00003 1806 4 Skin 0.31 protein_coding synonymous_variant LOW 696T>C Val232Val
M0028732 DDEEAHCM_00003 1833 4 Skin 0.31 protein_coding synonymous_variant LOW 669C>T Ile223Ile
M0028733 DDEEAHCM_00003 1839 4 Skin 0.31 protein_coding synonymous_variant LOW 663A>G Val221Val
M0028734 DDEEAHCM_00003 1869 4 Skin 0.31 protein_coding synonymous_variant LOW 633G>A Leu211Leu
M0028735 DDEEAHCM_00003 1881 4 Skin 0.31 protein_coding missense_variant MODERATE 621G>A Met207Ile
M0028736 DDEEAHCM_00003 1910 4 Skin 0.31 protein_coding missense_variant MODERATE 592C>A Leu198Ile
M0028737 DDEEAHCM_00003 1915 4 Skin 0.31 protein_coding missense_variant MODERATE 587A>T His196Leu
M0028738 DDEEAHCM_00003 1926 4 Skin 0.31 protein_coding synonymous_variant LOW 576T>C Pro192Pro
M0028739 DDEEAHCM_00003 1933 4 Skin 0.31 protein_coding missense_variant MODERATE 569G>A Arg190Lys
M0028740 DDEEAHCM_00003 1985 4 Skin 0.31 protein_coding missense_variant MODERATE 517A>G Ile173Val
M0028741 DDEEAHCM_00003 1987 4 Skin 0.31 protein_coding missense_variant MODERATE 515C>T Ala172Val
M0028742 DDEEAHCM_00003 2022 4 Skin 0.31 protein_coding synonymous_variant LOW 480A>T Val160Val
M0028743 DDEEAHCM_00003 2148 4 Skin 0.31 protein_coding synonymous_variant LOW 354T>C Phe118Phe
M0028744 DDEEAHCM_00003 2163 4 Skin 0.31 protein_coding synonymous_variant LOW 339C>T Gly113Gly
M0028745 DDEEAHCM_00003 2242 7 Skin 0.54 protein_coding missense_variant MODERATE 260C>T Thr87Ile
M0028746 DDEEAHCM_00003 2262 6 Skin 0.46 protein_coding synonymous_variant LOW 240A>G Lys80Lys
M0028747 DDEEAHCM_00003 2292 4 Skin 0.31 protein_coding synonymous_variant LOW 210C>T Gly70Gly
M0028748 DDEEAHCM_00003 2322 5 Skin 0.38 protein_coding synonymous_variant LOW 180C>T Ile60Ile
M0028749 DDEEAHCM_00003 2340 3 Skin 0.23 protein_coding synonymous_variant LOW 162T>A Ala54Ala
M0028750 DDEEAHCM_00003 2374 3 Skin 0.23 protein_coding missense_variant MODERATE 128A>G Lys43Arg
M0028751 DDEEAHCM_00003 2397 3 Skin 0.23 protein_coding synonymous_variant LOW 105A>G Thr35Thr
M0028752 DDEEAHCM_00003 2452 3 Skin 0.23 protein_coding missense_variant MODERATE 50T>C Phe17Ser
M0028753 DDEEAHCM_00002 2595 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -1523C>T None
M0028754 DDEEAHCM_00002 2626 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -1554T>C None
M0028755 DDEEAHCM_00004 2746 6 Skin 0.46 protein_coding synonymous_variant LOW 108T>C Leu36Leu
M0028756 DDEEAHCM_00004 2785 4 Skin 0.31 protein_coding synonymous_variant LOW 147G>A Ser49Ser
M0028757 DDEEAHCM_00004 2848 4 Skin 0.31 protein_coding synonymous_variant LOW 210G>A Glu70Glu
M0028758 DDEEAHCM_00004 2854 4 Skin 0.31 protein_coding synonymous_variant LOW 216A>G Leu72Leu
M0028759 DDEEAHCM_00004 2875 4 Skin 0.31 protein_coding synonymous_variant LOW 237G>A Leu79Leu
M0028760 DDEEAHCM_00004 2895 4 Skin 0.31 protein_coding missense_variant MODERATE 257A>G Lys86Arg
M0028761 DDEEAHCM_00004 2971 4 Skin 0.31 protein_coding synonymous_variant LOW 333T>A Ser111Ser
M0028762 DDEEAHCM_00004 2982 4 Skin 0.31 protein_coding missense_variant MODERATE 344C>A Ala115Asp
M0028763 DDEEAHCM_00004 3043 4 Skin 0.31 protein_coding synonymous_variant LOW 405G>A Leu135Leu
M0028764 DDEEAHCM_00004 3049 4 Skin 0.31 protein_coding missense_variant MODERATE 411T>A Asn137Lys
M0028765 DDEEAHCM_00004 3087 4 Skin 0.31 protein_coding missense_variant MODERATE 449A>G Glu150Gly
M0028766 DDEEAHCM_00004 3130 4 Skin 0.31 protein_coding synonymous_variant LOW 492C>T Asn164Asn
M0028767 DDEEAHCM_00004 3135 4 Skin 0.31 protein_coding missense_variant MODERATE 497C>G Thr166Ser
M0028768 DDEEAHCM_00004 3289 4 Skin 0.31 protein_coding synonymous_variant LOW 651T>G Leu217Leu
M0028769 DDEEAHCM_00004 3391 4 Skin 0.31 protein_coding synonymous_variant LOW 753A>G Pro251Pro
M0028770 DDEEAHCM_00004 3403 4 Skin 0.31 protein_coding synonymous_variant LOW 765C>T Asn255Asn
M0028771 DDEEAHCM_00004 3430 4 Skin 0.31 protein_coding synonymous_variant LOW 792T>A Gly264Gly
M0028772 DDEEAHCM_00004 3463 4 Skin 0.31 protein_coding synonymous_variant LOW 825G>A Ala275Ala
M0028773 DDEEAHCM_00004 3533 4 Skin 0.31 protein_coding stop_lost&splice_region_variant HIGH 895T>G Ter299Gluext*?
M0028774 DDEEAHCM_00002 3569 6 Skin 0.46 protein_coding upstream_gene_variant MODIFIER -2497A>G None
M0028775 DDEEAHCM_00002 3740 5 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -2668T>C None
M0028776 DDEEAHCM_00004 175 3 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -2464C>T None
M0028777 DDEEAHCM_00002 1140 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -68A>G None
M0028778 DDEEAHCM_00002 1235 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -163G>A None
M0028779 DDEEAHCM_00002 1239 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -167G>A None
M0028780 DDEEAHCM_00002 1293 4 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -221T>A None
M0028781 DDEEAHCM_00003 1314 4 Skin 0.31 protein_coding synonymous_variant LOW 1188C>T Asn396Asn
M0028782 DDEEAHCM_00003 1519 4 Skin 0.31 protein_coding missense_variant MODERATE 983A>G Gln328Arg
M0028783 DDEEAHCM_00002 728 3 Skin 0.23 protein_coding synonymous_variant LOW 345G>A Ser115Ser
M0028784 DDEEAHCM_00003 1401 3 Skin 0.23 protein_coding missense_variant MODERATE 1101T>A His367Gln






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term