Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2221
  Reference Plasmid   1111525849753914_bin.29__k141_153788
  Reference Plasmid Size   26713
  Reference Plasmid GC Content   0.67
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0030430 NNHEOION_00011 11790 3 Skin 0.33 protein_coding missense_variant MODERATE 1328T>C Val443Ala
M0030431 NNHEOION_00011 11930 3 Skin 0.33 protein_coding synonymous_variant LOW 1188A>G Val396Val
M0030432 NNHEOION_00011 11975 3 Skin 0.33 protein_coding synonymous_variant LOW 1143T>G Ser381Ser
M0030433 NNHEOION_00011 12719 3 Skin 0.33 protein_coding synonymous_variant LOW 399G>C Pro133Pro
M0030434 NNHEOION_00011 13034 3 Skin 0.33 protein_coding synonymous_variant LOW 84C>G Leu28Leu
M0030435 NNHEOION_00012 13245 3 Skin 0.33 protein_coding missense_variant MODERATE 848C>T Ala283Val
M0030436 NNHEOION_00012 13478 3 Skin 0.33 protein_coding synonymous_variant LOW 615T>C Gly205Gly
M0030437 NNHEOION_00013 14147 3 Skin 0.33 protein_coding missense_variant MODERATE 1076C>T Ala359Val
M0030438 NNHEOION_00013 14674 3 Skin 0.33 protein_coding synonymous_variant LOW 549C>T Phe183Phe
M0030439 NNHEOION_00013 14781 3 Skin 0.33 protein_coding synonymous_variant LOW 442T>C Leu148Leu
M0030440 NNHEOION_00013 15022 3 Skin 0.33 protein_coding synonymous_variant LOW 201A>G Val67Val
M0030441 NNHEOION_00009 15322 4 Skin 0.44 protein_coding upstream_gene_variant MODIFIER -4963A>C None
M0030442 NNHEOION_00015 16663 3 Skin 0.33 protein_coding synonymous_variant LOW 468T>C Thr156Thr
M0030443 NNHEOION_00015 16699 3 Skin 0.33 protein_coding synonymous_variant LOW 432G>A Glu144Glu
M0030444 NNHEOION_00016 17608 3 Skin 0.33 protein_coding synonymous_variant LOW 121A>C Arg41Arg
M0030445 NNHEOION_00017 17968 3 Skin 0.33 protein_coding synonymous_variant LOW 195T>C Pro65Pro
M0030446 NNHEOION_00018 19170 3 Skin 0.33 protein_coding synonymous_variant LOW 1572G>C Pro524Pro
M0030447 NNHEOION_00018 19614 3 Skin 0.33 protein_coding synonymous_variant LOW 1128A>G Leu376Leu
M0030448 NNHEOION_00018 19628 3 Skin 0.33 protein_coding missense_variant MODERATE 1114T>A Ser372Thr
M0030449 NNHEOION_00018 19635 3 Skin 0.33 protein_coding synonymous_variant LOW 1107T>C Asp369Asp






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
NNHEOION_00001 AYF00795.1|GT2 100 4.79e-191 1 268 1 0.7813





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term