Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2280
  Reference Plasmid   1111525849758951_bin.8__k141_165966
  Reference Plasmid Size   11601
  Reference Plasmid GC Content   0.56
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0033149 ELLNDEND_00004 4120 6 Skin 0.30 protein_coding missense_variant MODERATE 793T>G Ser265Ala
M0033150 ELLNDEND_00004 4152 6 Skin 0.30 protein_coding synonymous_variant LOW 825T>C Asp275Asp
M0033151 ELLNDEND_00004 4179 5 Skin 0.25 protein_coding synonymous_variant LOW 852G>A Lys284Lys
M0033152 ELLNDEND_00002 4215 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2219T>C None
M0033153 ELLNDEND_00002 4266 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2270T>C None
M0033154 ELLNDEND_00002 4283 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2287T>C None
M0033155 ELLNDEND_00005 4825 5 Skin 0.25 protein_coding synonymous_variant LOW 501A>G Arg167Arg
M0033156 ELLNDEND_00005 4888 4 Skin 0.20 protein_coding synonymous_variant LOW 564C>T Gly188Gly
M0033157 ELLNDEND_00005 4890 4 Skin 0.20 protein_coding missense_variant MODERATE 566A>G His189Arg
M0033158 ELLNDEND_00006 5407 16 Skin 0.80 protein_coding synonymous_variant LOW 324T>C Ser108Ser
M0033159 ELLNDEND_00006 5509 9 Skin 0.45 protein_coding synonymous_variant LOW 222G>A Ala74Ala
M0033160 ELLNDEND_00008 6149 7 Skin 0.35 protein_coding synonymous_variant LOW 262C>T Leu88Leu
M0033161 ELLNDEND_00008 6154 7 Skin 0.35 protein_coding synonymous_variant LOW 267G>A Ala89Ala
M0033162 ELLNDEND_00008 6947 9 Skin 0.45 protein_coding missense_variant MODERATE 1060A>G Thr354Ala
M0033163 ELLNDEND_00008 7396 5 Skin 0.25 protein_coding synonymous_variant LOW 1509A>G Glu503Glu
M0033164 ELLNDEND_00001 234 4 Skin 0.20 protein_coding synonymous_variant LOW 132T>G Pro44Pro
M0033165 ELLNDEND_00001 250 4 Skin 0.20 protein_coding synonymous_variant LOW 148T>C Leu50Leu
M0033166 ELLNDEND_00002 977 4 Skin 0.20 protein_coding synonymous_variant LOW 1020C>A Ala340Ala
M0033167 ELLNDEND_00002 1685 5 Skin 0.25 protein_coding synonymous_variant LOW 312T>C Cys104Cys
M0033168 ELLNDEND_00002 1904 4 Skin 0.20 protein_coding missense_variant MODERATE 93G>C Arg31Ser
M0033169 ELLNDEND_00002 2105 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -109A>C None
M0033170 ELLNDEND_00003 2407 3 Skin 0.15 protein_coding synonymous_variant LOW 813T>C Thr271Thr
M0033171 ELLNDEND_00002 4988 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2992T>G None
M0033172 ELLNDEND_00006 5699 10 Skin 0.50 protein_coding missense_variant MODERATE 32G>A Cys11Tyr
M0033173 ELLNDEND_00003 7667 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -4448G>A None
M0033174 ELLNDEND_00009 7808 4 Skin 0.20 protein_coding missense_variant MODERATE 329A>C Asp110Ala
M0033175 ELLNDEND_00011 9234 4 Skin 0.20 protein_coding synonymous_variant LOW 576A>G Leu192Leu
M0033176 ELLNDEND_00011 9273 3 Skin 0.15 protein_coding synonymous_variant LOW 537G>A Ala179Ala
M0033177 ELLNDEND_00004 3984 3 Skin 0.15 protein_coding synonymous_variant LOW 657G>A Lys219Lys
M0033178 ELLNDEND_00008 7597 5 Skin 0.25 protein_coding synonymous_variant LOW 1710T>C Asn570Asn
M0033179 ELLNDEND_00009 7960 5 Skin 0.25 protein_coding synonymous_variant LOW 177T>C Asp59Asp
M0033180 ELLNDEND_00009 8062 3 Skin 0.15 protein_coding synonymous_variant LOW 75A>G Gly25Gly
M0033181 ELLNDEND_00010 8482 4 Skin 0.20 protein_coding synonymous_variant LOW 559T>C Leu187Leu
M0033182 ELLNDEND_00005 4678 5 Skin 0.25 protein_coding synonymous_variant LOW 354A>G Glu118Glu
M0033183 ELLNDEND_00008 6115 3 Skin 0.15 protein_coding synonymous_variant LOW 228G>A Pro76Pro
M0033184 ELLNDEND_00008 6355 6 Skin 0.30 protein_coding synonymous_variant LOW 468G>C Leu156Leu
M0033185 ELLNDEND_00008 6388 6 Skin 0.30 protein_coding synonymous_variant LOW 501G>A Val167Val
M0033186 ELLNDEND_00010 8459 3 Skin 0.15 protein_coding synonymous_variant LOW 582C>T Ala194Ala
M0033187 ELLNDEND_00001 453 3 Skin 0.15 protein_coding synonymous_variant LOW 351A>G Gly117Gly
M0033188 ELLNDEND_00002 1367 3 Skin 0.15 protein_coding synonymous_variant LOW 630C>T Ala210Ala
M0033189 ELLNDEND_00002 1478 3 Skin 0.15 protein_coding synonymous_variant LOW 519G>T Ala173Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term