Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2368
  Reference Plasmid   1111525849768046_bin.37__k141_111361
  Reference Plasmid Size   29654
  Reference Plasmid GC Content   0.39
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0119337 EDGEJLMG_00009 8458 5 Oral 0.38 protein_coding synonymous_variant LOW 1467T>C Asn489Asn
M0119338 EDGEJLMG_00009 8515 3 Oral 0.23 protein_coding missense_variant MODERATE 1410C>A Asn470Lys
M0119339 EDGEJLMG_00009 8530 4 Oral 0.31 protein_coding synonymous_variant LOW 1395A>G Val465Val
M0119340 EDGEJLMG_00009 8544 5 Oral 0.38 protein_coding missense_variant MODERATE 1381A>G Met461Val
M0119341 EDGEJLMG_00009 8614 6 Oral 0.46 protein_coding synonymous_variant LOW 1311T>C Gly437Gly
M0119342 EDGEJLMG_00009 8647 6 Oral 0.46 protein_coding synonymous_variant LOW 1278T>C Asn426Asn
M0119343 EDGEJLMG_00009 8656 6 Oral 0.46 protein_coding synonymous_variant LOW 1269T>C Gly423Gly
M0119344 EDGEJLMG_00009 8668 6 Oral 0.46 protein_coding synonymous_variant LOW 1257T>C Tyr419Tyr
M0119345 EDGEJLMG_00009 8734 3 Oral 0.23 protein_coding synonymous_variant LOW 1191C>A Thr397Thr
M0119346 EDGEJLMG_00009 8735 3 Oral 0.23 protein_coding missense_variant MODERATE 1190C>A Thr397Asn
M0119347 EDGEJLMG_00009 8783 3 Oral 0.23 protein_coding missense_variant MODERATE 1142C>A Thr381Lys
M0119348 EDGEJLMG_00009 8784 3 Oral 0.23 protein_coding missense_variant MODERATE 1141A>G Thr381Ala
M0119349 EDGEJLMG_00009 8812 6 Oral 0.46 protein_coding synonymous_variant LOW 1113C>T Asn371Asn
M0119350 EDGEJLMG_00009 8878 6 Oral 0.46 protein_coding synonymous_variant LOW 1047A>T Ile349Ile
M0119351 EDGEJLMG_00009 8885 5 Oral 0.38 protein_coding missense_variant MODERATE 1040C>G Thr347Ser
M0119352 EDGEJLMG_00009 8900 4 Oral 0.31 protein_coding missense_variant MODERATE 1025C>T Thr342Ile
M0119353 EDGEJLMG_00009 8902 6 Oral 0.46 protein_coding synonymous_variant LOW 1023A>G Val341Val
M0119354 EDGEJLMG_00009 8928 4 Oral 0.31 protein_coding synonymous_variant LOW 997T>C Leu333Leu
M0119355 EDGEJLMG_00009 8929 4 Oral 0.31 protein_coding missense_variant MODERATE 996G>C Glu332Asp
M0119356 EDGEJLMG_00009 9040 4 Oral 0.31 protein_coding synonymous_variant LOW 885C>T Tyr295Tyr
M0119357 EDGEJLMG_00009 9044 5 Oral 0.38 protein_coding missense_variant MODERATE 881A>G Asn294Ser
M0119358 EDGEJLMG_00009 9046 6 Oral 0.46 protein_coding synonymous_variant LOW 879A>G Leu293Leu
M0119359 EDGEJLMG_00009 9172 3 Oral 0.23 protein_coding synonymous_variant LOW 753T>C Thr251Thr
M0119360 EDGEJLMG_00009 9220 4 Oral 0.31 protein_coding synonymous_variant LOW 705T>A Ala235Ala
M0119361 EDGEJLMG_00009 9283 3 Oral 0.23 protein_coding synonymous_variant LOW 642T>G Val214Val
M0119362 EDGEJLMG_00009 9301 3 Oral 0.23 protein_coding synonymous_variant LOW 624T>A Thr208Thr
M0119363 EDGEJLMG_00009 9319 5 Oral 0.38 protein_coding missense_variant MODERATE 606A>T Glu202Asp
M0119364 EDGEJLMG_00009 9385 3 Oral 0.23 protein_coding synonymous_variant LOW 540A>C Thr180Thr
M0119365 EDGEJLMG_00009 9532 3 Oral 0.23 protein_coding synonymous_variant LOW 393T>G Ala131Ala
M0119366 EDGEJLMG_00009 9694 5 Oral 0.38 protein_coding synonymous_variant LOW 231G>A Gly77Gly
M0119367 EDGEJLMG_00009 9775 5 Oral 0.38 protein_coding synonymous_variant LOW 150A>G Ala50Ala
M0119368 EDGEJLMG_00009 9799 3 Oral 0.23 protein_coding synonymous_variant LOW 126A>T Ala42Ala
M0119369 EDGEJLMG_00009 9907 4 Oral 0.31 protein_coding synonymous_variant LOW 18C>T Phe6Phe
M0119370 EDGEJLMG_00007 9966 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -4016T>A None
M0119371 EDGEJLMG_00007 9967 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -4017T>C None
M0119372 EDGEJLMG_00007 9968 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -4018A>G None
M0119373 EDGEJLMG_00010 10016 4 Oral 0.31 protein_coding missense_variant MODERATE 151G>C Ala51Pro
M0119374 EDGEJLMG_00010 10017 4 Oral 0.31 protein_coding synonymous_variant LOW 150G>A Glu50Glu
M0119375 EDGEJLMG_00010 10026 5 Oral 0.38 protein_coding synonymous_variant LOW 141C>T Ile47Ile
M0119376 EDGEJLMG_00010 10121 5 Oral 0.38 protein_coding missense_variant MODERATE 46T>G Ser16Ala
M0119377 EDGEJLMG_00020 27002 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4493T>G None
M0119378 EDGEJLMG_00009 7780 4 Oral 0.31 protein_coding missense_variant MODERATE 2145A>G Ile715Met
M0119379 EDGEJLMG_00009 7849 3 Oral 0.23 protein_coding synonymous_variant LOW 2076C>A Thr692Thr
M0119380 EDGEJLMG_00009 8039 4 Oral 0.31 protein_coding missense_variant MODERATE 1886G>A Arg629Lys
M0119381 EDGEJLMG_00009 8117 3 Oral 0.23 protein_coding missense_variant MODERATE 1808C>G Ala603Gly
M0119382 EDGEJLMG_00009 8119 3 Oral 0.23 protein_coding synonymous_variant LOW 1806C>T Asp602Asp
M0119383 EDGEJLMG_00009 8137 4 Oral 0.31 protein_coding synonymous_variant LOW 1788A>T Ala596Ala
M0119384 EDGEJLMG_00009 8416 4 Oral 0.31 protein_coding synonymous_variant LOW 1509T>C Tyr503Tyr
M0119385 EDGEJLMG_00009 8494 3 Oral 0.23 protein_coding synonymous_variant LOW 1431G>T Ala477Ala
M0119386 EDGEJLMG_00009 8497 3 Oral 0.23 protein_coding synonymous_variant LOW 1428A>G Lys476Lys
M0119387 EDGEJLMG_00009 8582 3 Oral 0.23 protein_coding missense_variant MODERATE 1343G>C Arg448Thr
M0119388 EDGEJLMG_00009 8583 3 Oral 0.23 protein_coding missense_variant MODERATE 1342A>G Arg448Gly
M0119389 EDGEJLMG_00009 8584 3 Oral 0.23 protein_coding missense_variant MODERATE 1341A>T Glu447Asp
M0119390 EDGEJLMG_00009 8585 3 Oral 0.23 protein_coding missense_variant MODERATE 1340A>C Glu447Ala
M0119391 EDGEJLMG_00009 8746 4 Oral 0.31 protein_coding synonymous_variant LOW 1179A>C Thr393Thr
M0119392 EDGEJLMG_00009 8990 3 Oral 0.23 protein_coding missense_variant MODERATE 935G>C Arg312Pro
M0119393 EDGEJLMG_00009 8997 5 Oral 0.38 protein_coding missense_variant MODERATE 928A>G Thr310Ala
M0119394 EDGEJLMG_00009 9003 3 Oral 0.23 protein_coding missense_variant MODERATE 922C>A Gln308Lys
M0119395 EDGEJLMG_00009 9004 3 Oral 0.23 protein_coding synonymous_variant LOW 921C>T Asn307Asn
M0119396 EDGEJLMG_00009 9093 4 Oral 0.31 protein_coding missense_variant MODERATE 832A>G Asn278Asp
M0119397 EDGEJLMG_00007 9959 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -4009A>G None
M0119398 EDGEJLMG_00021 23222 3 Oral 0.23 protein_coding synonymous_variant LOW 258G>T Thr86Thr
M0119399 EDGEJLMG_00021 23237 3 Oral 0.23 protein_coding synonymous_variant LOW 243G>A Lys81Lys
M0119400 EDGEJLMG_00021 23315 6 Oral 0.46 protein_coding synonymous_variant LOW 165A>T Ile55Ile
M0119401 EDGEJLMG_00021 23327 5 Oral 0.38 protein_coding synonymous_variant LOW 153T>A Ile51Ile
M0119402 EDGEJLMG_00021 23393 5 Oral 0.38 protein_coding synonymous_variant LOW 87T>C Gly29Gly
M0119403 EDGEJLMG_00018 23583 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4845T>A None
M0119404 EDGEJLMG_00018 23588 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4850G>A None
M0119405 EDGEJLMG_00019 23794 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -2758C>T None
M0119406 EDGEJLMG_00019 23797 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -2761C>T None
M0119407 EDGEJLMG_00022 23833 4 Oral 0.31 protein_coding synonymous_variant LOW 2997T>G Val999Val
M0119408 EDGEJLMG_00022 23842 4 Oral 0.31 protein_coding synonymous_variant LOW 2988C>T Asn996Asn
M0119409 EDGEJLMG_00022 23965 4 Oral 0.31 protein_coding missense_variant MODERATE 2865G>C Leu955Phe
M0119410 EDGEJLMG_00022 23967 4 Oral 0.31 protein_coding synonymous_variant LOW 2863T>C Leu955Leu
M0119411 EDGEJLMG_00022 24001 5 Oral 0.38 protein_coding synonymous_variant LOW 2829A>G Lys943Lys
M0119412 EDGEJLMG_00022 24841 3 Oral 0.23 protein_coding synonymous_variant LOW 1989C>A Thr663Thr
M0119413 EDGEJLMG_00022 24853 3 Oral 0.23 protein_coding synonymous_variant LOW 1977A>G Glu659Glu
M0119414 EDGEJLMG_00022 24859 4 Oral 0.31 protein_coding synonymous_variant LOW 1971A>C Gly657Gly
M0119415 EDGEJLMG_00022 25102 4 Oral 0.31 protein_coding synonymous_variant LOW 1728T>C Arg576Arg
M0119416 EDGEJLMG_00022 25285 3 Oral 0.23 protein_coding synonymous_variant LOW 1545T>C Ile515Ile
M0119417 EDGEJLMG_00022 25378 4 Oral 0.31 protein_coding synonymous_variant LOW 1452T>C Gly484Gly
M0119418 EDGEJLMG_00022 25630 4 Oral 0.31 protein_coding synonymous_variant LOW 1200C>T His400His
M0119419 EDGEJLMG_00022 25632 4 Oral 0.31 protein_coding missense_variant MODERATE 1198C>T His400Tyr
M0119420 EDGEJLMG_00022 25633 4 Oral 0.31 protein_coding missense_variant MODERATE 1197G>C Leu399Phe
M0119421 EDGEJLMG_00022 25635 4 Oral 0.31 protein_coding synonymous_variant LOW 1195T>C Leu399Leu
M0119422 EDGEJLMG_00022 25729 3 Oral 0.23 protein_coding synonymous_variant LOW 1101A>G Glu367Glu
M0119423 EDGEJLMG_00022 26368 3 Oral 0.23 protein_coding synonymous_variant LOW 462G>A Val154Val
M0119424 EDGEJLMG_00022 26476 3 Oral 0.23 protein_coding synonymous_variant LOW 354T>C Gly118Gly
M0119425 EDGEJLMG_00022 26820 3 Oral 0.23 protein_coding missense_variant MODERATE 10A>C Thr4Pro
M0119426 EDGEJLMG_00007 5573 5 Oral 0.38 protein_coding synonymous_variant LOW 378T>G Pro126Pro
M0119427 EDGEJLMG_00007 5576 3 Oral 0.23 protein_coding synonymous_variant LOW 375G>T Thr125Thr
M0119428 EDGEJLMG_00007 5720 3 Oral 0.23 protein_coding synonymous_variant LOW 231T>G Leu77Leu
M0119429 EDGEJLMG_00007 5739 3 Oral 0.23 protein_coding missense_variant MODERATE 212T>A Val71Glu
M0119430 EDGEJLMG_00007 5852 4 Oral 0.31 protein_coding synonymous_variant LOW 99T>C Thr33Thr
M0119431 EDGEJLMG_00007 5869 5 Oral 0.38 protein_coding missense_variant MODERATE 82G>A Ala28Thr
M0119432 EDGEJLMG_00008 6383 5 Oral 0.38 protein_coding synonymous_variant LOW 27T>C Ser9Ser
M0119433 EDGEJLMG_00018 22699 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -3961T>C None
M0119434 EDGEJLMG_00018 22721 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -3983T>G None
M0119435 EDGEJLMG_00018 22797 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -4059T>A None
M0119436 EDGEJLMG_00021 23036 5 Oral 0.38 protein_coding synonymous_variant LOW 444T>C Ala148Ala
M0119437 EDGEJLMG_00018 23707 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4969G>A None
M0119438 EDGEJLMG_00019 23765 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -2729T>C None
M0119439 EDGEJLMG_00022 24709 3 Oral 0.23 protein_coding synonymous_variant LOW 2121G>A Lys707Lys
M0119440 EDGEJLMG_00022 25846 3 Oral 0.23 protein_coding missense_variant MODERATE 984A>T Gln328His
M0119441 EDGEJLMG_00022 25848 3 Oral 0.23 protein_coding missense_variant MODERATE 982C>A Gln328Lys
M0119442 EDGEJLMG_00022 25861 3 Oral 0.23 protein_coding synonymous_variant LOW 969T>C Asp323Asp
M0119443 EDGEJLMG_00022 25864 3 Oral 0.23 protein_coding missense_variant MODERATE 966T>A Asn322Lys
M0119444 EDGEJLMG_00022 25865 3 Oral 0.23 protein_coding missense_variant MODERATE 965A>C Asn322Thr
M0119445 EDGEJLMG_00008 6140 3 Oral 0.23 protein_coding synonymous_variant LOW 270G>A Val90Val
M0119446 EDGEJLMG_00018 22824 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4086G>A None
M0119447 EDGEJLMG_00018 22825 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4087T>G None
M0119448 EDGEJLMG_00018 22827 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4089G>C None
M0119449 EDGEJLMG_00018 22831 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4093A>C None
M0119450 EDGEJLMG_00018 22832 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4094G>A None
M0119451 EDGEJLMG_00018 22839 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4101G>A None
M0119452 EDGEJLMG_00018 22840 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4102G>T None
M0119453 EDGEJLMG_00018 22841 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -4103C>G None
M0119454 EDGEJLMG_00021 23345 4 Oral 0.31 protein_coding synonymous_variant LOW 135A>G Thr45Thr
M0119455 EDGEJLMG_00009 9430 3 Oral 0.23 protein_coding synonymous_variant LOW 495C>T Arg165Arg
M0119456 EDGEJLMG_00009 9437 3 Oral 0.23 protein_coding missense_variant MODERATE 488A>G Asn163Ser
M0119457 EDGEJLMG_00008 6049 3 Oral 0.23 protein_coding synonymous_variant LOW 361T>C Leu121Leu
M0119458 EDGEJLMG_00007 6451 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -501A>T None
M0119459 EDGEJLMG_00007 6473 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -523T>C None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
EDGEJLMG_00022 EFC71165.1|GH85 90.9 0 1 1008 1 1
EDGEJLMG_00023 EFC71166.1|GH85 82.7 0 1 875 1 0.8698





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term