Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2412
  Reference Plasmid   1111525849768046_bin.37__k141_19449
  Reference Plasmid Size   4222
  Reference Plasmid GC Content   0.36
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0123574 NECGMKDB_00002 706 5 Oral 0.83 protein_coding missense_variant MODERATE 172A>G Met58Val
M0123575 NECGMKDB_00002 783 4 Oral 0.67 protein_coding synonymous_variant LOW 249C>T Ala83Ala
M0123576 NECGMKDB_00002 792 5 Oral 0.83 protein_coding synonymous_variant LOW 258A>T Gly86Gly
M0123577 NECGMKDB_00002 804 3 Oral 0.50 protein_coding synonymous_variant LOW 270A>T Val90Val
M0123578 NECGMKDB_00002 819 3 Oral 0.50 protein_coding synonymous_variant LOW 285T>C Ser95Ser
M0123579 NECGMKDB_00002 824 4 Oral 0.67 protein_coding missense_variant MODERATE 290G>A Ser97Asn
M0123580 NECGMKDB_00002 825 3 Oral 0.50 protein_coding synonymous_variant LOW 291C>T Ser97Ser
M0123581 NECGMKDB_00002 828 3 Oral 0.50 protein_coding synonymous_variant LOW 294T>C Asp98Asp
M0123582 NECGMKDB_00002 1011 5 Oral 0.83 protein_coding missense_variant MODERATE 477G>C Glu159Asp
M0123583 NECGMKDB_00002 1041 5 Oral 0.83 protein_coding synonymous_variant LOW 507C>A Thr169Thr
M0123584 NECGMKDB_00002 1042 5 Oral 0.83 protein_coding missense_variant MODERATE 508A>G Asn170Asp
M0123585 NECGMKDB_00002 1059 3 Oral 0.50 protein_coding synonymous_variant LOW 525T>A Ile175Ile
M0123586 NECGMKDB_00002 1095 5 Oral 0.83 protein_coding synonymous_variant LOW 561T>A Leu187Leu
M0123587 NECGMKDB_00002 1125 5 Oral 0.83 protein_coding synonymous_variant LOW 591C>T Phe197Phe
M0123588 NECGMKDB_00002 1131 5 Oral 0.83 protein_coding synonymous_variant LOW 597A>G Leu199Leu
M0123589 NECGMKDB_00002 1149 5 Oral 0.83 protein_coding synonymous_variant LOW 615A>T Leu205Leu
M0123590 NECGMKDB_00002 1210 4 Oral 0.67 protein_coding synonymous_variant LOW 676C>A Arg226Arg
M0123591 NECGMKDB_00002 1257 3 Oral 0.50 protein_coding synonymous_variant LOW 723A>C Gly241Gly
M0123592 NECGMKDB_00002 1338 4 Oral 0.67 protein_coding synonymous_variant LOW 804G>A Pro268Pro
M0123593 NECGMKDB_00002 1398 4 Oral 0.67 protein_coding synonymous_variant LOW 864A>C Pro288Pro
M0123594 NECGMKDB_00002 1407 4 Oral 0.67 protein_coding synonymous_variant LOW 873A>G Leu291Leu
M0123595 NECGMKDB_00002 1425 4 Oral 0.67 protein_coding synonymous_variant LOW 891C>A Ser297Ser
M0123596 NECGMKDB_00002 1429 4 Oral 0.67 protein_coding synonymous_variant LOW 895C>T Leu299Leu
M0123597 NECGMKDB_00002 1488 4 Oral 0.67 protein_coding synonymous_variant LOW 954C>T Ser318Ser
M0123598 NECGMKDB_00002 1554 4 Oral 0.67 protein_coding synonymous_variant LOW 1020T>C Val340Val
M0123599 NECGMKDB_00002 1572 4 Oral 0.67 protein_coding synonymous_variant LOW 1038A>C Pro346Pro
M0123600 NECGMKDB_00002 1587 4 Oral 0.67 protein_coding synonymous_variant LOW 1053T>C Ile351Ile
M0123601 NECGMKDB_00002 1593 4 Oral 0.67 protein_coding synonymous_variant LOW 1059A>G Gly353Gly
M0123602 NECGMKDB_00002 1602 3 Oral 0.50 protein_coding synonymous_variant LOW 1068A>G Lys356Lys
M0123603 NECGMKDB_00002 1635 4 Oral 0.67 protein_coding synonymous_variant LOW 1101T>C Ile367Ile
M0123604 NECGMKDB_00002 1641 4 Oral 0.67 protein_coding synonymous_variant LOW 1107C>A Pro369Pro
M0123605 NECGMKDB_00002 1647 4 Oral 0.67 protein_coding synonymous_variant LOW 1113T>C Leu371Leu
M0123606 NECGMKDB_00002 1656 3 Oral 0.50 protein_coding synonymous_variant LOW 1122G>A Leu374Leu
M0123607 NECGMKDB_00002 1719 4 Oral 0.67 protein_coding synonymous_variant LOW 1185A>G Lys395Lys
M0123608 NECGMKDB_00001 95 4 Oral 0.67 protein_coding synonymous_variant LOW 21A>G Leu7Leu
M0123609 NECGMKDB_00001 335 3 Oral 0.50 protein_coding synonymous_variant LOW 261C>T Asp87Asp
M0123610 NECGMKDB_00001 341 3 Oral 0.50 protein_coding synonymous_variant LOW 267T>A Pro89Pro
M0123611 NECGMKDB_00001 365 4 Oral 0.67 protein_coding synonymous_variant LOW 291T>C Phe97Phe
M0123612 NECGMKDB_00001 404 3 Oral 0.50 protein_coding synonymous_variant LOW 330A>T Val110Val
M0123613 NECGMKDB_00002 873 4 Oral 0.67 protein_coding synonymous_variant LOW 339A>G Leu113Leu
M0123614 NECGMKDB_00002 1086 3 Oral 0.50 protein_coding synonymous_variant LOW 552G>T Ser184Ser
M0123615 NECGMKDB_00002 1201 4 Oral 0.67 protein_coding missense_variant MODERATE 667T>C Tyr223His
M0123616 NECGMKDB_00002 1371 3 Oral 0.50 protein_coding synonymous_variant LOW 837C>T Ser279Ser
M0123617 NECGMKDB_00002 1374 3 Oral 0.50 protein_coding synonymous_variant LOW 840T>A Ser280Ser
M0123618 NECGMKDB_00001 113 3 Oral 0.50 protein_coding synonymous_variant LOW 39C>T Ile13Ile
M0123619 NECGMKDB_00002 681 3 Oral 0.50 protein_coding synonymous_variant LOW 147T>C Tyr49Tyr






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term