Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2421
  Reference Plasmid   1111525849768046_bin.37__k141_211274
  Reference Plasmid Size   8341
  Reference Plasmid GC Content   0.37
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0124295 NMJAIMEG_00007 4312 5 Oral 0.38 protein_coding missense_variant MODERATE 1228G>A Ala410Thr
M0124296 NMJAIMEG_00007 4568 4 Oral 0.31 protein_coding synonymous_variant LOW 972A>G Lys324Lys
M0124297 NMJAIMEG_00007 4619 5 Oral 0.38 protein_coding synonymous_variant LOW 921T>C Gly307Gly
M0124298 NMJAIMEG_00007 4637 6 Oral 0.46 protein_coding synonymous_variant LOW 903T>A Thr301Thr
M0124299 NMJAIMEG_00007 4718 4 Oral 0.31 protein_coding synonymous_variant LOW 822T>A Ala274Ala
M0124300 NMJAIMEG_00007 4853 6 Oral 0.46 protein_coding synonymous_variant LOW 687T>C Thr229Thr
M0124301 NMJAIMEG_00007 5016 5 Oral 0.38 protein_coding missense_variant MODERATE 524G>A Ser175Asn
M0124302 NMJAIMEG_00007 5110 6 Oral 0.46 protein_coding synonymous_variant LOW 430T>C Leu144Leu
M0124303 NMJAIMEG_00007 5119 3 Oral 0.23 protein_coding synonymous_variant LOW 421T>C Leu141Leu
M0124304 NMJAIMEG_00007 5174 4 Oral 0.31 protein_coding synonymous_variant LOW 366C>T Tyr122Tyr
M0124305 NMJAIMEG_00007 5420 6 Oral 0.46 protein_coding synonymous_variant LOW 120T>A Val40Val
M0124306 NMJAIMEG_00007 5462 5 Oral 0.38 protein_coding synonymous_variant LOW 78T>A Ser26Ser
M0124307 NMJAIMEG_00005 5576 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -2777G>A None
M0124308 NMJAIMEG_00008 5654 6 Oral 0.46 protein_coding synonymous_variant LOW 948T>C Asn316Asn
M0124309 NMJAIMEG_00008 5657 3 Oral 0.23 protein_coding synonymous_variant LOW 945C>A Val315Val
M0124310 NMJAIMEG_00008 5660 3 Oral 0.23 protein_coding synonymous_variant LOW 942C>T Asn314Asn
M0124311 NMJAIMEG_00008 5774 4 Oral 0.31 protein_coding synonymous_variant LOW 828T>C Asp276Asp
M0124312 NMJAIMEG_00008 5871 4 Oral 0.31 protein_coding missense_variant MODERATE 731C>A Ala244Asp
M0124313 NMJAIMEG_00008 5990 4 Oral 0.31 protein_coding synonymous_variant LOW 612C>T Phe204Phe
M0124314 NMJAIMEG_00008 5993 5 Oral 0.38 protein_coding synonymous_variant LOW 609T>C Asp203Asp
M0124315 NMJAIMEG_00005 4073 6 Oral 0.46 protein_coding upstream_gene_variant MODIFIER -1274C>A None
M0124316 NMJAIMEG_00005 4076 6 Oral 0.46 protein_coding upstream_gene_variant MODIFIER -1277C>T None
M0124317 NMJAIMEG_00005 4110 6 Oral 0.46 protein_coding upstream_gene_variant MODIFIER -1311A>G None
M0124318 NMJAIMEG_00007 4493 3 Oral 0.23 protein_coding synonymous_variant LOW 1047G>A Glu349Glu
M0124319 NMJAIMEG_00007 4592 3 Oral 0.23 protein_coding synonymous_variant LOW 948T>C Tyr316Tyr
M0124320 NMJAIMEG_00007 4661 3 Oral 0.23 protein_coding synonymous_variant LOW 879T>A Ala293Ala
M0124321 NMJAIMEG_00007 4706 4 Oral 0.31 protein_coding synonymous_variant LOW 834C>T Phe278Phe
M0124322 NMJAIMEG_00007 4721 4 Oral 0.31 protein_coding synonymous_variant LOW 819T>C Asn273Asn
M0124323 NMJAIMEG_00007 4886 4 Oral 0.31 protein_coding synonymous_variant LOW 654T>A Ala218Ala
M0124324 NMJAIMEG_00008 6149 5 Oral 0.38 protein_coding synonymous_variant LOW 453T>C Ser151Ser
M0124325 NMJAIMEG_00008 6181 5 Oral 0.38 protein_coding synonymous_variant LOW 421A>C Arg141Arg
M0124326 NMJAIMEG_00008 6236 5 Oral 0.38 protein_coding synonymous_variant LOW 366G>A Ala122Ala
M0124327 NMJAIMEG_00008 6239 5 Oral 0.38 protein_coding synonymous_variant LOW 363A>G Leu121Leu
M0124328 NMJAIMEG_00008 6242 4 Oral 0.31 protein_coding synonymous_variant LOW 360T>C Gly120Gly
M0124329 NMJAIMEG_00008 6308 4 Oral 0.31 protein_coding synonymous_variant LOW 294G>A Glu98Glu
M0124330 NMJAIMEG_00008 6317 3 Oral 0.23 protein_coding synonymous_variant LOW 285T>C Asp95Asp
M0124331 NMJAIMEG_00001 73 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -46G>A None
M0124332 NMJAIMEG_00001 133 7 Oral 0.54 protein_coding synonymous_variant LOW 15G>A Arg5Arg
M0124333 NMJAIMEG_00001 142 4 Oral 0.31 protein_coding synonymous_variant LOW 24G>A Ser8Ser
M0124334 NMJAIMEG_00002 429 5 Oral 0.38 protein_coding synonymous_variant LOW 96C>T Arg32Arg
M0124335 NMJAIMEG_00002 672 6 Oral 0.46 protein_coding synonymous_variant LOW 339C>T Val113Val
M0124336 NMJAIMEG_00002 691 3 Oral 0.23 protein_coding synonymous_variant LOW 358T>C Leu120Leu
M0124337 NMJAIMEG_00002 726 4 Oral 0.31 protein_coding synonymous_variant LOW 393A>G Pro131Pro
M0124338 NMJAIMEG_00002 757 7 Oral 0.54 protein_coding missense_variant MODERATE 424A>G Ile142Val
M0124339 NMJAIMEG_00002 759 6 Oral 0.46 protein_coding missense_variant MODERATE 426A>G Ile142Met
M0124340 NMJAIMEG_00002 792 5 Oral 0.38 protein_coding synonymous_variant LOW 459C>T Gly153Gly
M0124341 NMJAIMEG_00002 825 6 Oral 0.46 protein_coding synonymous_variant LOW 492A>G Glu164Glu
M0124342 NMJAIMEG_00002 856 4 Oral 0.31 protein_coding synonymous_variant LOW 523C>T Leu175Leu
M0124343 NMJAIMEG_00003 937 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -84A>G None
M0124344 NMJAIMEG_00003 940 7 Oral 0.54 protein_coding upstream_gene_variant MODIFIER -81G>A None
M0124345 NMJAIMEG_00003 950 7 Oral 0.54 protein_coding upstream_gene_variant MODIFIER -71G>C None
M0124346 NMJAIMEG_00003 952 7 Oral 0.54 protein_coding upstream_gene_variant MODIFIER -69T>C None
M0124347 NMJAIMEG_00003 955 7 Oral 0.54 protein_coding upstream_gene_variant MODIFIER -66G>A None
M0124348 NMJAIMEG_00003 1018 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -3A>G None
M0124349 NMJAIMEG_00003 1089 5 Oral 0.38 protein_coding synonymous_variant LOW 69T>C Leu23Leu
M0124350 NMJAIMEG_00003 1126 4 Oral 0.31 protein_coding synonymous_variant LOW 106T>C Leu36Leu
M0124351 NMJAIMEG_00003 1137 3 Oral 0.23 protein_coding synonymous_variant LOW 117C>T Phe39Phe
M0124352 NMJAIMEG_00003 1138 3 Oral 0.23 protein_coding missense_variant MODERATE 118A>G Ile40Val
M0124353 NMJAIMEG_00003 1248 4 Oral 0.31 protein_coding synonymous_variant LOW 228A>G Leu76Leu
M0124354 NMJAIMEG_00003 1284 4 Oral 0.31 protein_coding synonymous_variant LOW 264A>C Pro88Pro
M0124355 NMJAIMEG_00003 1317 3 Oral 0.23 protein_coding synonymous_variant LOW 297T>C Thr99Thr
M0124356 NMJAIMEG_00003 1326 7 Oral 0.54 protein_coding synonymous_variant LOW 306G>T Ser102Ser
M0124357 NMJAIMEG_00003 1350 6 Oral 0.46 protein_coding synonymous_variant LOW 330T>C Thr110Thr
M0124358 NMJAIMEG_00003 1353 5 Oral 0.38 protein_coding synonymous_variant LOW 333G>A Val111Val
M0124359 NMJAIMEG_00003 1747 6 Oral 0.46 protein_coding synonymous_variant LOW 727C>T Leu243Leu
M0124360 NMJAIMEG_00003 1779 3 Oral 0.23 protein_coding synonymous_variant LOW 759G>T Val253Val
M0124361 NMJAIMEG_00003 1853 6 Oral 0.46 protein_coding missense_variant MODERATE 833G>A Ser278Asn
M0124362 NMJAIMEG_00003 1965 3 Oral 0.23 protein_coding synonymous_variant LOW 945C>T Val315Val
M0124363 NMJAIMEG_00003 1981 5 Oral 0.38 protein_coding synonymous_variant LOW 961T>C Leu321Leu
M0124364 NMJAIMEG_00005 2794 3 Oral 0.23 protein_coding synonymous_variant LOW 6T>A Ala2Ala
M0124365 NMJAIMEG_00005 2834 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -35G>A None
M0124366 NMJAIMEG_00005 2867 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -68T>C None
M0124367 NMJAIMEG_00005 2913 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -114C>G None
M0124368 NMJAIMEG_00005 2966 4 Oral 0.31 protein_coding upstream_gene_variant MODIFIER -167T>G None
M0124369 NMJAIMEG_00005 2983 5 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -184A>G None
M0124370 NMJAIMEG_00006 3086 5 Oral 0.38 protein_coding synonymous_variant LOW 9A>G Arg3Arg
M0124371 NMJAIMEG_00006 3116 5 Oral 0.38 protein_coding missense_variant MODERATE 39G>T Met13Ile
M0124372 NMJAIMEG_00006 3245 3 Oral 0.23 protein_coding synonymous_variant LOW 168T>C Pro56Pro
M0124373 NMJAIMEG_00006 3281 4 Oral 0.31 protein_coding synonymous_variant LOW 204T>C Asn68Asn
M0124374 NMJAIMEG_00006 3332 3 Oral 0.23 protein_coding synonymous_variant LOW 255T>G Gly85Gly
M0124375 NMJAIMEG_00006 3380 4 Oral 0.31 protein_coding synonymous_variant LOW 303T>G Ala101Ala
M0124376 NMJAIMEG_00006 3383 3 Oral 0.23 protein_coding synonymous_variant LOW 306T>C Pro102Pro
M0124377 NMJAIMEG_00006 3392 4 Oral 0.31 protein_coding synonymous_variant LOW 315T>C Tyr105Tyr
M0124378 NMJAIMEG_00006 3446 4 Oral 0.31 protein_coding synonymous_variant LOW 369T>C Gly123Gly
M0124379 NMJAIMEG_00006 3449 3 Oral 0.23 protein_coding synonymous_variant LOW 372G>A Lys124Lys
M0124380 NMJAIMEG_00006 3464 3 Oral 0.23 protein_coding synonymous_variant LOW 387C>A Arg129Arg
M0124381 NMJAIMEG_00006 3536 4 Oral 0.31 protein_coding synonymous_variant LOW 459T>C His153His
M0124382 NMJAIMEG_00006 3647 5 Oral 0.38 protein_coding synonymous_variant LOW 570C>T Cys190Cys
M0124383 NMJAIMEG_00006 3692 3 Oral 0.23 protein_coding synonymous_variant LOW 615T>C Phe205Phe
M0124384 NMJAIMEG_00006 3770 4 Oral 0.31 protein_coding synonymous_variant LOW 693T>C His231His
M0124385 NMJAIMEG_00007 4301 3 Oral 0.23 protein_coding synonymous_variant LOW 1239C>T Asp413Asp
M0124386 NMJAIMEG_00007 5183 3 Oral 0.23 protein_coding synonymous_variant LOW 357A>C Pro119Pro
M0124387 NMJAIMEG_00007 5186 3 Oral 0.23 protein_coding synonymous_variant LOW 354T>C Asn118Asn
M0124388 NMJAIMEG_00008 5852 3 Oral 0.23 protein_coding synonymous_variant LOW 750T>C Asn250Asn
M0124389 NMJAIMEG_00008 5855 3 Oral 0.23 protein_coding synonymous_variant LOW 747A>G Glu249Glu
M0124390 NMJAIMEG_00008 6095 3 Oral 0.23 protein_coding synonymous_variant LOW 507T>C Asn169Asn
M0124391 NMJAIMEG_00008 6395 3 Oral 0.23 protein_coding synonymous_variant LOW 207A>G Thr69Thr
M0124392 NMJAIMEG_00008 6404 3 Oral 0.23 protein_coding synonymous_variant LOW 198C>T Ala66Ala
M0124393 NMJAIMEG_00008 6410 3 Oral 0.23 protein_coding synonymous_variant LOW 192C>A Pro64Pro
M0124394 NMJAIMEG_00008 6452 3 Oral 0.23 protein_coding synonymous_variant LOW 150C>T Pro50Pro
M0124395 NMJAIMEG_00008 6473 3 Oral 0.23 protein_coding synonymous_variant LOW 129T>A Val43Val
M0124396 NMJAIMEG_00005 2998 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -199T>A None
M0124397 NMJAIMEG_00005 3001 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -202A>T None
M0124398 NMJAIMEG_00006 3287 3 Oral 0.23 protein_coding synonymous_variant LOW 210C>T Asn70Asn
M0124399 NMJAIMEG_00003 1335 4 Oral 0.31 protein_coding synonymous_variant LOW 315G>C Ala105Ala
M0124400 NMJAIMEG_00003 1336 4 Oral 0.31 protein_coding missense_variant MODERATE 316G>A Asp106Asn
M0124401 NMJAIMEG_00003 1337 4 Oral 0.31 protein_coding missense_variant MODERATE 317A>C Asp106Ala
M0124402 NMJAIMEG_00003 1341 4 Oral 0.31 protein_coding synonymous_variant LOW 321A>G Gln107Gln
M0124403 NMJAIMEG_00003 1344 4 Oral 0.31 protein_coding synonymous_variant LOW 324A>G Lys108Lys
M0124404 NMJAIMEG_00003 1379 4 Oral 0.31 protein_coding missense_variant MODERATE 359A>T Glu120Val
M0124405 NMJAIMEG_00003 1390 4 Oral 0.31 protein_coding missense_variant MODERATE 370A>G Lys124Glu
M0124406 NMJAIMEG_00003 1440 3 Oral 0.23 protein_coding synonymous_variant LOW 420C>T Asp140Asp
M0124407 NMJAIMEG_00003 1824 4 Oral 0.31 protein_coding synonymous_variant LOW 804G>C Ala268Ala
M0124408 NMJAIMEG_00002 831 3 Oral 0.23 protein_coding synonymous_variant LOW 498G>A Glu166Glu
M0124409 NMJAIMEG_00003 999 3 Oral 0.23 protein_coding upstream_gene_variant MODIFIER -22T>A None
M0124410 NMJAIMEG_00003 1104 3 Oral 0.23 protein_coding synonymous_variant LOW 84A>T Ile28Ile
M0124411 NMJAIMEG_00003 1254 5 Oral 0.38 protein_coding synonymous_variant LOW 234A>G Val78Val
M0124412 NMJAIMEG_00003 1554 3 Oral 0.23 protein_coding synonymous_variant LOW 534A>T Leu178Leu
M0124413 NMJAIMEG_00003 1812 3 Oral 0.23 protein_coding synonymous_variant LOW 792T>A Thr264Thr
M0124414 NMJAIMEG_00003 1821 3 Oral 0.23 protein_coding synonymous_variant LOW 801G>A Leu267Leu
M0124415 NMJAIMEG_00003 1479 3 Oral 0.23 protein_coding synonymous_variant LOW 459A>G Leu153Leu






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term