Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2437
  Reference Plasmid   1111525849768046_bin.37__k141_32453
  Reference Plasmid Size   7075
  Reference Plasmid GC Content   0.40
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0125754 BCPOICIE_00001 454 3 Oral 0.43 protein_coding synonymous_variant LOW 265C>T Leu89Leu
M0125755 BCPOICIE_00002 1473 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -274T>C None
M0125756 BCPOICIE_00002 1493 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -254G>A None
M0125757 BCPOICIE_00002 1499 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -248A>G None
M0125758 BCPOICIE_00002 1815 3 Oral 0.43 protein_coding synonymous_variant LOW 69A>G Leu23Leu
M0125759 BCPOICIE_00002 1836 3 Oral 0.43 protein_coding synonymous_variant LOW 90T>C Asn30Asn
M0125760 BCPOICIE_00003 1949 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -266G>A None
M0125761 BCPOICIE_00004 2547 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -87G>A None
M0125762 BCPOICIE_00004 2555 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -79A>G None
M0125763 BCPOICIE_00004 2560 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -74G>A None
M0125764 BCPOICIE_00004 2564 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -70G>A None
M0125765 BCPOICIE_00004 2574 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -60G>A None
M0125766 BCPOICIE_00004 2591 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -43G>T None
M0125767 BCPOICIE_00004 2609 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -25C>T None
M0125768 BCPOICIE_00004 2723 5 Oral 0.71 protein_coding synonymous_variant LOW 90T>C Ile30Ile
M0125769 BCPOICIE_00004 2798 3 Oral 0.43 protein_coding synonymous_variant LOW 165T>G Ser55Ser
M0125770 BCPOICIE_00004 2981 5 Oral 0.71 protein_coding synonymous_variant LOW 348A>G Leu116Leu
M0125771 BCPOICIE_00004 2984 5 Oral 0.71 protein_coding synonymous_variant LOW 351T>C Ile117Ile
M0125772 BCPOICIE_00004 3026 4 Oral 0.57 protein_coding synonymous_variant LOW 393T>C Phe131Phe
M0125773 BCPOICIE_00004 3104 4 Oral 0.57 protein_coding synonymous_variant LOW 471A>C Leu157Leu
M0125774 BCPOICIE_00004 3416 4 Oral 0.57 protein_coding synonymous_variant LOW 783A>G Val261Val
M0125775 BCPOICIE_00004 3522 5 Oral 0.71 protein_coding missense_variant MODERATE 889A>G Ile297Val
M0125776 BCPOICIE_00004 3530 3 Oral 0.43 protein_coding synonymous_variant LOW 897G>A Glu299Glu
M0125777 BCPOICIE_00004 3535 5 Oral 0.71 protein_coding missense_variant MODERATE 902G>A Ser301Asn
M0125778 BCPOICIE_00004 3569 3 Oral 0.43 protein_coding synonymous_variant LOW 936G>A Leu312Leu
M0125779 BCPOICIE_00004 3588 3 Oral 0.43 protein_coding synonymous_variant LOW 955T>C Leu319Leu
M0125780 BCPOICIE_00004 3842 5 Oral 0.71 protein_coding synonymous_variant LOW 1209T>C Leu403Leu
M0125781 BCPOICIE_00004 3971 5 Oral 0.71 protein_coding synonymous_variant LOW 1338A>C Val446Val
M0125782 BCPOICIE_00004 3986 5 Oral 0.71 protein_coding synonymous_variant LOW 1353T>C Ser451Ser
M0125783 BCPOICIE_00004 3992 5 Oral 0.71 protein_coding synonymous_variant LOW 1359T>C Ser453Ser
M0125784 BCPOICIE_00004 4083 5 Oral 0.71 protein_coding missense_variant MODERATE 1450G>A Val484Ile
M0125785 BCPOICIE_00006 4110 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1088T>A None
M0125786 BCPOICIE_00006 4114 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1084G>C None
M0125787 BCPOICIE_00006 4123 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1075G>A None
M0125788 BCPOICIE_00005 4258 3 Oral 0.43 protein_coding synonymous_variant LOW 828T>A Val276Val
M0125789 BCPOICIE_00005 4438 5 Oral 0.71 protein_coding synonymous_variant LOW 648C>T Asn216Asn
M0125790 BCPOICIE_00005 4561 3 Oral 0.43 protein_coding synonymous_variant LOW 525T>A Gly175Gly
M0125791 BCPOICIE_00005 4642 4 Oral 0.57 protein_coding synonymous_variant LOW 444A>G Ser148Ser
M0125792 BCPOICIE_00005 4870 3 Oral 0.43 protein_coding synonymous_variant LOW 216C>T Gly72Gly
M0125793 BCPOICIE_00005 4912 5 Oral 0.71 protein_coding synonymous_variant LOW 174C>T Asp58Asp
M0125794 BCPOICIE_00005 5147 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -62A>C None
M0125795 BCPOICIE_00005 5150 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -65T>G None
M0125796 BCPOICIE_00006 5320 5 Oral 0.71 protein_coding synonymous_variant LOW 123T>A Ile41Ile
M0125797 BCPOICIE_00006 5369 5 Oral 0.71 protein_coding synonymous_variant LOW 172T>C Leu58Leu
M0125798 BCPOICIE_00006 5425 3 Oral 0.43 protein_coding synonymous_variant LOW 228T>A Thr76Thr
M0125799 BCPOICIE_00006 5479 5 Oral 0.71 protein_coding synonymous_variant LOW 282T>A Val94Val
M0125800 BCPOICIE_00005 6302 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1217G>T None
M0125801 BCPOICIE_00005 6306 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1221G>T None
M0125802 BCPOICIE_00005 6307 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1222A>G None
M0125803 BCPOICIE_00005 6333 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1248C>T None
M0125804 BCPOICIE_00005 6340 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -1255T>C None
M0125805 BCPOICIE_00008 6348 5 Oral 0.71 protein_coding synonymous_variant LOW 6T>C Asn2Asn
M0125806 BCPOICIE_00008 6363 5 Oral 0.71 protein_coding synonymous_variant LOW 21A>G Gln7Gln
M0125807 BCPOICIE_00008 6567 4 Oral 0.57 protein_coding synonymous_variant LOW 225A>G Leu75Leu
M0125808 BCPOICIE_00008 6663 5 Oral 0.71 protein_coding synonymous_variant LOW 321A>T Val107Val
M0125809 BCPOICIE_00008 6729 3 Oral 0.43 protein_coding synonymous_variant LOW 387A>C Ile129Ile
M0125810 BCPOICIE_00008 6750 3 Oral 0.43 protein_coding synonymous_variant LOW 408G>A Glu136Glu
M0125811 BCPOICIE_00008 6753 3 Oral 0.43 protein_coding synonymous_variant LOW 411T>A Gly137Gly
M0125812 BCPOICIE_00008 6756 3 Oral 0.43 protein_coding synonymous_variant LOW 414G>A Lys138Lys
M0125813 BCPOICIE_00008 6780 5 Oral 0.71 protein_coding synonymous_variant LOW 438A>G Glu146Glu
M0125814 BCPOICIE_00008 6801 3 Oral 0.43 protein_coding synonymous_variant LOW 459C>T Thr153Thr
M0125815 BCPOICIE_00005 6914 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -1829A>T None
M0125816 BCPOICIE_00005 6946 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -1861A>G None
M0125817 BCPOICIE_00004 3056 4 Oral 0.57 protein_coding synonymous_variant LOW 423A>T Thr141Thr
M0125818 BCPOICIE_00004 3269 3 Oral 0.43 protein_coding synonymous_variant LOW 636T>C Tyr212Tyr
M0125819 BCPOICIE_00004 3275 3 Oral 0.43 protein_coding synonymous_variant LOW 642A>T Ile214Ile
M0125820 BCPOICIE_00004 3305 3 Oral 0.43 protein_coding synonymous_variant LOW 672C>A Ala224Ala
M0125821 BCPOICIE_00004 3515 3 Oral 0.43 protein_coding synonymous_variant LOW 882T>A Gly294Gly
M0125822 BCPOICIE_00006 5587 4 Oral 0.57 protein_coding synonymous_variant LOW 390G>A Gln130Gln
M0125823 BCPOICIE_00007 5846 3 Oral 0.43 protein_coding synonymous_variant LOW 183A>G Glu61Glu
M0125824 BCPOICIE_00007 5910 4 Oral 0.57 protein_coding missense_variant MODERATE 247G>A Val83Ile
M0125825 BCPOICIE_00007 6171 4 Oral 0.57 protein_coding missense_variant MODERATE 508G>A Ala170Thr
M0125826 BCPOICIE_00007 6182 4 Oral 0.57 protein_coding synonymous_variant LOW 519T>C Asp173Asp
M0125827 BCPOICIE_00007 6197 4 Oral 0.57 protein_coding synonymous_variant LOW 534A>G Thr178Thr
M0125828 BCPOICIE_00007 6203 3 Oral 0.43 protein_coding synonymous_variant LOW 540T>C Gly180Gly
M0125829 BCPOICIE_00008 6456 3 Oral 0.43 protein_coding synonymous_variant LOW 114C>T Phe38Phe
M0125830 BCPOICIE_00008 6462 4 Oral 0.57 protein_coding missense_variant MODERATE 120T>G Asn40Lys
M0125831 BCPOICIE_00008 6489 4 Oral 0.57 protein_coding synonymous_variant LOW 147T>C Pro49Pro
M0125832 BCPOICIE_00008 6490 4 Oral 0.57 protein_coding missense_variant MODERATE 148G>C Glu50Gln
M0125833 BCPOICIE_00004 3200 3 Oral 0.43 protein_coding synonymous_variant LOW 567G>A Pro189Pro
M0125834 BCPOICIE_00004 3917 3 Oral 0.43 protein_coding synonymous_variant LOW 1284C>T Ile428Ile
M0125835 BCPOICIE_00004 4021 3 Oral 0.43 protein_coding missense_variant MODERATE 1388G>T Gly463Val
M0125836 BCPOICIE_00004 4026 3 Oral 0.43 protein_coding missense_variant MODERATE 1393A>G Ser465Gly
M0125837 BCPOICIE_00004 4027 3 Oral 0.43 protein_coding missense_variant MODERATE 1394G>C Ser465Thr
M0125838 BCPOICIE_00004 4028 3 Oral 0.43 protein_coding missense_variant MODERATE 1395C>A Ser465Arg
M0125839 BCPOICIE_00005 4657 3 Oral 0.43 protein_coding synonymous_variant LOW 429T>A Ile143Ile
M0125840 BCPOICIE_00005 4660 3 Oral 0.43 protein_coding synonymous_variant LOW 426T>A Ile142Ile
M0125841 BCPOICIE_00006 5530 3 Oral 0.43 protein_coding synonymous_variant LOW 333G>A Ser111Ser
M0125842 BCPOICIE_00007 6137 3 Oral 0.43 protein_coding synonymous_variant LOW 474A>C Ala158Ala
M0125843 BCPOICIE_00008 6696 3 Oral 0.43 protein_coding synonymous_variant LOW 354G>A Ala118Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term