Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2445
  Reference Plasmid   1111525849768046_bin.37__k141_39012
  Reference Plasmid Size   3482
  Reference Plasmid GC Content   0.34
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0126464 MKMEALFP_00001 121 6 Oral 0.75 protein_coding upstream_gene_variant MODIFIER -223A>G None
M0126465 MKMEALFP_00001 184 7 Oral 0.88 protein_coding upstream_gene_variant MODIFIER -160G>A None
M0126466 MKMEALFP_00001 514 6 Oral 0.75 protein_coding synonymous_variant LOW 171G>A Ala57Ala
M0126467 MKMEALFP_00001 718 6 Oral 0.75 protein_coding synonymous_variant LOW 375T>C Asn125Asn
M0126468 MKMEALFP_00001 760 4 Oral 0.50 protein_coding synonymous_variant LOW 417T>C Pro139Pro
M0126469 MKMEALFP_00001 832 5 Oral 0.63 protein_coding synonymous_variant LOW 489A>T Pro163Pro
M0126470 MKMEALFP_00001 841 5 Oral 0.63 protein_coding synonymous_variant LOW 498T>C Asn166Asn
M0126471 MKMEALFP_00001 904 6 Oral 0.75 protein_coding synonymous_variant LOW 561G>A Leu187Leu
M0126472 MKMEALFP_00001 1048 5 Oral 0.63 protein_coding synonymous_variant LOW 705G>A Leu235Leu
M0126473 MKMEALFP_00001 1192 5 Oral 0.63 protein_coding synonymous_variant LOW 849T>C Tyr283Tyr
M0126474 MKMEALFP_00004 2171 3 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -108A>T None
M0126475 MKMEALFP_00004 2199 3 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -80T>A None
M0126476 MKMEALFP_00004 2216 4 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -63A>G None
M0126477 MKMEALFP_00004 2359 5 Oral 0.63 protein_coding synonymous_variant LOW 81T>C Arg27Arg
M0126478 MKMEALFP_00004 2398 4 Oral 0.50 protein_coding synonymous_variant LOW 120A>G Gln40Gln
M0126479 MKMEALFP_00004 2407 4 Oral 0.50 protein_coding synonymous_variant LOW 129T>C Ser43Ser
M0126480 MKMEALFP_00004 2587 5 Oral 0.63 protein_coding synonymous_variant LOW 309A>G Gln103Gln
M0126481 MKMEALFP_00004 2614 3 Oral 0.38 protein_coding synonymous_variant LOW 336C>T Leu112Leu
M0126482 MKMEALFP_00004 2647 3 Oral 0.38 protein_coding synonymous_variant LOW 369A>G Gly123Gly
M0126483 MKMEALFP_00004 2656 3 Oral 0.38 protein_coding synonymous_variant LOW 378C>T Asp126Asp
M0126484 MKMEALFP_00004 2659 5 Oral 0.63 protein_coding synonymous_variant LOW 381A>T Ile127Ile
M0126485 MKMEALFP_00004 2668 3 Oral 0.38 protein_coding synonymous_variant LOW 390C>T Asp130Asp
M0126486 MKMEALFP_00004 2690 5 Oral 0.63 protein_coding missense_variant MODERATE 412A>C Lys138Gln
M0126487 MKMEALFP_00004 2833 3 Oral 0.38 protein_coding synonymous_variant LOW 555G>A Leu185Leu
M0126488 MKMEALFP_00004 2842 3 Oral 0.38 protein_coding synonymous_variant LOW 564T>C Thr188Thr
M0126489 MKMEALFP_00004 2869 3 Oral 0.38 protein_coding synonymous_variant LOW 591A>T Ile197Ile
M0126490 MKMEALFP_00005 3254 4 Oral 0.50 protein_coding missense_variant MODERATE 347T>C Val116Ala
M0126491 MKMEALFP_00001 568 5 Oral 0.63 protein_coding synonymous_variant LOW 225T>C Asp75Asp
M0126492 MKMEALFP_00001 625 4 Oral 0.50 protein_coding synonymous_variant LOW 282A>T Gly94Gly
M0126493 MKMEALFP_00001 853 5 Oral 0.63 protein_coding synonymous_variant LOW 510G>A Glu170Glu
M0126494 MKMEALFP_00003 1709 3 Oral 0.38 protein_coding synonymous_variant LOW 117G>A Leu39Leu
M0126495 MKMEALFP_00004 2528 3 Oral 0.38 protein_coding missense_variant MODERATE 250G>T Ala84Ser
M0126496 MKMEALFP_00001 40 3 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -304C>T None
M0126497 MKMEALFP_00001 160 3 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -184C>T None
M0126498 MKMEALFP_00001 269 3 Oral 0.38 protein_coding upstream_gene_variant MODIFIER -75C>T None
M0126499 MKMEALFP_00001 577 3 Oral 0.38 protein_coding synonymous_variant LOW 234A>G Val78Val
M0126500 MKMEALFP_00001 580 4 Oral 0.50 protein_coding synonymous_variant LOW 237A>G Gln79Gln
M0126501 MKMEALFP_00001 598 4 Oral 0.50 protein_coding synonymous_variant LOW 255C>T Asn85Asn






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term