Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2451
  Reference Plasmid   1111525849768046_bin.37__k141_49976
  Reference Plasmid Size   2577
  Reference Plasmid GC Content   0.37
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0127208 EDMBDIBM_00001 137 3 Oral 1.00 protein_coding missense_variant MODERATE 115A>C Ile39Leu
M0127209 EDMBDIBM_00001 193 3 Oral 1.00 protein_coding synonymous_variant LOW 171A>C Ile57Ile
M0127210 EDMBDIBM_00001 238 3 Oral 1.00 protein_coding synonymous_variant LOW 216A>G Lys72Lys
M0127211 EDMBDIBM_00001 307 3 Oral 1.00 protein_coding synonymous_variant LOW 285T>C Ile95Ile
M0127212 EDMBDIBM_00001 469 3 Oral 1.00 protein_coding synonymous_variant LOW 447T>C Asn149Asn
M0127213 EDMBDIBM_00001 472 3 Oral 1.00 protein_coding synonymous_variant LOW 450G>A Lys150Lys
M0127214 EDMBDIBM_00001 509 3 Oral 1.00 protein_coding synonymous_variant LOW 487T>C Leu163Leu
M0127215 EDMBDIBM_00001 538 3 Oral 1.00 protein_coding synonymous_variant LOW 516G>A Glu172Glu
M0127216 EDMBDIBM_00001 725 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *142A>G None
M0127217 EDMBDIBM_00001 764 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *181G>A None
M0127218 EDMBDIBM_00001 776 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *193G>A None
M0127219 EDMBDIBM_00001 842 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *259T>C None
M0127220 EDMBDIBM_00001 1241 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *658G>A None
M0127221 EDMBDIBM_00001 1334 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *751C>T None
M0127222 EDMBDIBM_00001 1415 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *832C>T None
M0127223 EDMBDIBM_00001 1705 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1122T>C None
M0127224 EDMBDIBM_00001 1823 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1240T>C None
M0127225 EDMBDIBM_00001 1850 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1267C>T None
M0127226 EDMBDIBM_00001 2348 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1765C>T None
M0127227 EDMBDIBM_00001 2357 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1774C>T None
M0127228 EDMBDIBM_00001 2438 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1855T>C None
M0127229 EDMBDIBM_00001 2453 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1870C>T None
M0127230 EDMBDIBM_00001 2477 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *1894G>A None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term