Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2452
  Reference Plasmid   1111525849768046_bin.37__k141_52174
  Reference Plasmid Size   6676
  Reference Plasmid GC Content   0.36
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0127231 IFLHNPLC_00004 30 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4273A>G None
M0127232 IFLHNPLC_00004 67 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -4236G>A None
M0127233 IFLHNPLC_00004 529 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3774A>G None
M0127234 IFLHNPLC_00001 684 5 Oral 0.42 protein_coding synonymous_variant LOW 1194A>T Ala398Ala
M0127235 IFLHNPLC_00001 780 5 Oral 0.42 protein_coding synonymous_variant LOW 1098C>T Gly366Gly
M0127236 IFLHNPLC_00001 1008 3 Oral 0.25 protein_coding synonymous_variant LOW 870C>T Asp290Asp
M0127237 IFLHNPLC_00001 1227 3 Oral 0.25 protein_coding synonymous_variant LOW 651A>G Lys217Lys
M0127238 IFLHNPLC_00001 1464 3 Oral 0.25 protein_coding synonymous_variant LOW 414A>G Lys138Lys
M0127239 IFLHNPLC_00002 2056 4 Oral 0.33 protein_coding synonymous_variant LOW 648A>T Ser216Ser
M0127240 IFLHNPLC_00002 2080 5 Oral 0.42 protein_coding synonymous_variant LOW 624C>T Gly208Gly
M0127241 IFLHNPLC_00002 2113 4 Oral 0.33 protein_coding synonymous_variant LOW 591T>C Cys197Cys
M0127242 IFLHNPLC_00002 2125 4 Oral 0.33 protein_coding synonymous_variant LOW 579A>G Val193Val
M0127243 IFLHNPLC_00002 2197 3 Oral 0.25 protein_coding synonymous_variant LOW 507C>T Ile169Ile
M0127244 IFLHNPLC_00002 2428 4 Oral 0.33 protein_coding synonymous_variant LOW 276G>A Thr92Thr
M0127245 IFLHNPLC_00002 2491 4 Oral 0.33 protein_coding synonymous_variant LOW 213T>C Ser71Ser
M0127246 IFLHNPLC_00002 2596 3 Oral 0.25 protein_coding synonymous_variant LOW 108T>C Asn36Asn
M0127247 IFLHNPLC_00002 2602 4 Oral 0.33 protein_coding synonymous_variant LOW 102T>C Gly34Gly
M0127248 IFLHNPLC_00002 2641 4 Oral 0.33 protein_coding synonymous_variant LOW 63G>A Lys21Lys
M0127249 IFLHNPLC_00003 2745 4 Oral 0.33 protein_coding synonymous_variant LOW 1386A>G Glu462Glu
M0127250 IFLHNPLC_00003 2751 3 Oral 0.25 protein_coding synonymous_variant LOW 1380A>T Val460Val
M0127251 IFLHNPLC_00003 2778 5 Oral 0.42 protein_coding synonymous_variant LOW 1353A>T Ser451Ser
M0127252 IFLHNPLC_00003 2979 5 Oral 0.42 protein_coding synonymous_variant LOW 1152C>T Ser384Ser
M0127253 IFLHNPLC_00003 3060 3 Oral 0.25 protein_coding synonymous_variant LOW 1071G>A Val357Val
M0127254 IFLHNPLC_00003 3078 3 Oral 0.25 protein_coding synonymous_variant LOW 1053A>T Ala351Ala
M0127255 IFLHNPLC_00003 3216 4 Oral 0.33 protein_coding synonymous_variant LOW 915C>T Gly305Gly
M0127256 IFLHNPLC_00003 3225 4 Oral 0.33 protein_coding synonymous_variant LOW 906T>C Gly302Gly
M0127257 IFLHNPLC_00003 3264 5 Oral 0.42 protein_coding missense_variant MODERATE 867C>A Asp289Glu
M0127258 IFLHNPLC_00003 3357 3 Oral 0.25 protein_coding synonymous_variant LOW 774C>T Val258Val
M0127259 IFLHNPLC_00003 3420 4 Oral 0.33 protein_coding synonymous_variant LOW 711G>C Gly237Gly
M0127260 IFLHNPLC_00002 2329 4 Oral 0.33 protein_coding synonymous_variant LOW 375C>T Asp125Asp
M0127261 IFLHNPLC_00002 2353 4 Oral 0.33 protein_coding synonymous_variant LOW 351G>A Val117Val
M0127262 IFLHNPLC_00003 3759 4 Oral 0.33 protein_coding synonymous_variant LOW 372T>C Leu124Leu
M0127263 IFLHNPLC_00001 4136 8 Oral 0.67 protein_coding upstream_gene_variant MODIFIER -2259G>A None
M0127264 IFLHNPLC_00004 4320 8 Oral 0.67 protein_coding synonymous_variant LOW 18T>C Ile6Ile
M0127265 IFLHNPLC_00004 4416 8 Oral 0.67 protein_coding synonymous_variant LOW 114T>C Asp38Asp
M0127266 IFLHNPLC_00004 4425 6 Oral 0.50 protein_coding synonymous_variant LOW 123G>A Ala41Ala
M0127267 IFLHNPLC_00004 4484 6 Oral 0.50 protein_coding missense_variant MODERATE 182A>G Lys61Arg
M0127268 IFLHNPLC_00004 4499 6 Oral 0.50 protein_coding missense_variant MODERATE 197T>C Val66Ala
M0127269 IFLHNPLC_00004 4518 6 Oral 0.50 protein_coding synonymous_variant LOW 216C>T Arg72Arg
M0127270 IFLHNPLC_00004 4551 5 Oral 0.42 protein_coding synonymous_variant LOW 249T>C Asp83Asp
M0127271 IFLHNPLC_00004 4569 5 Oral 0.42 protein_coding synonymous_variant LOW 267A>G Gly89Gly
M0127272 IFLHNPLC_00004 4752 3 Oral 0.25 protein_coding synonymous_variant LOW 450C>T Ile150Ile
M0127273 IFLHNPLC_00004 4869 8 Oral 0.67 protein_coding synonymous_variant LOW 567A>T Ala189Ala
M0127274 IFLHNPLC_00004 4929 7 Oral 0.58 protein_coding synonymous_variant LOW 627T>C Ser209Ser
M0127275 IFLHNPLC_00004 5067 6 Oral 0.50 protein_coding synonymous_variant LOW 765T>A Gly255Gly
M0127276 IFLHNPLC_00004 5125 4 Oral 0.33 protein_coding missense_variant MODERATE 823T>G Ser275Ala
M0127277 IFLHNPLC_00004 5130 6 Oral 0.50 protein_coding synonymous_variant LOW 828T>C Ser276Ser
M0127278 IFLHNPLC_00004 5163 5 Oral 0.42 protein_coding synonymous_variant LOW 861T>A Pro287Pro
M0127279 IFLHNPLC_00004 5205 3 Oral 0.25 protein_coding synonymous_variant LOW 903C>T Gly301Gly
M0127280 IFLHNPLC_00001 5362 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3485T>C None
M0127281 IFLHNPLC_00001 5434 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -3557T>C None
M0127282 IFLHNPLC_00001 5482 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -3605A>G None
M0127283 IFLHNPLC_00001 5483 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -3606C>T None
M0127284 IFLHNPLC_00001 5554 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3677A>G None
M0127285 IFLHNPLC_00001 5575 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -3698C>T None
M0127286 IFLHNPLC_00001 5589 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -3712A>G None
M0127287 IFLHNPLC_00001 5641 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3764T>C None
M0127288 IFLHNPLC_00001 5690 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -3813A>G None
M0127289 IFLHNPLC_00001 5697 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -3820T>C None
M0127290 IFLHNPLC_00001 5737 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -3860C>T None
M0127291 IFLHNPLC_00001 5870 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3993C>T None
M0127292 IFLHNPLC_00001 5872 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -3995T>C None
M0127293 IFLHNPLC_00001 5873 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -3996A>G None
M0127294 IFLHNPLC_00001 6058 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -4181G>A None
M0127295 IFLHNPLC_00001 6094 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4217T>C None
M0127296 IFLHNPLC_00001 6178 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4301C>T None
M0127297 IFLHNPLC_00001 6181 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -4304C>T None
M0127298 IFLHNPLC_00001 6205 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4328A>G None
M0127299 IFLHNPLC_00001 6262 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -4385G>A None
M0127300 IFLHNPLC_00001 6340 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -4463A>G None
M0127301 IFLHNPLC_00001 6344 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4467A>G None
M0127302 IFLHNPLC_00001 6358 7 Oral 0.58 protein_coding upstream_gene_variant MODIFIER -4481A>T None
M0127303 IFLHNPLC_00001 6397 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4520G>T None
M0127304 IFLHNPLC_00001 6451 5 Oral 0.42 protein_coding upstream_gene_variant MODIFIER -4574T>A None
M0127305 IFLHNPLC_00001 6478 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4601A>G None
M0127306 IFLHNPLC_00001 6526 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4649A>G None
M0127307 IFLHNPLC_00001 6565 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4688A>G None
M0127308 IFLHNPLC_00003 2964 4 Oral 0.33 protein_coding synonymous_variant LOW 1167G>A Val389Val
M0127309 IFLHNPLC_00003 3234 3 Oral 0.25 protein_coding synonymous_variant LOW 897T>C Asp299Asp
M0127310 IFLHNPLC_00003 3585 4 Oral 0.33 protein_coding synonymous_variant LOW 546A>C Ile182Ile
M0127311 IFLHNPLC_00003 3765 5 Oral 0.42 protein_coding synonymous_variant LOW 366G>A Ser122Ser
M0127312 IFLHNPLC_00003 3810 5 Oral 0.42 protein_coding synonymous_variant LOW 321A>T Gly107Gly
M0127313 IFLHNPLC_00003 3813 3 Oral 0.25 protein_coding synonymous_variant LOW 318T>A Pro106Pro
M0127314 IFLHNPLC_00003 3933 6 Oral 0.50 protein_coding synonymous_variant LOW 198A>G Leu66Leu
M0127315 IFLHNPLC_00003 3998 6 Oral 0.50 protein_coding missense_variant MODERATE 133G>C Ala45Pro
M0127316 IFLHNPLC_00004 4780 3 Oral 0.25 protein_coding missense_variant MODERATE 478A>G Ser160Gly
M0127317 IFLHNPLC_00004 4782 3 Oral 0.25 protein_coding missense_variant MODERATE 480T>A Ser160Arg
M0127318 IFLHNPLC_00004 4797 6 Oral 0.50 protein_coding synonymous_variant LOW 495T>C Asp165Asp
M0127319 IFLHNPLC_00004 4878 4 Oral 0.33 protein_coding synonymous_variant LOW 576C>T Leu192Leu
M0127320 IFLHNPLC_00004 4983 5 Oral 0.42 protein_coding synonymous_variant LOW 681C>T Cys227Cys
M0127321 IFLHNPLC_00004 5142 3 Oral 0.25 protein_coding synonymous_variant LOW 840C>T Asp280Asp
M0127322 IFLHNPLC_00004 5154 3 Oral 0.25 protein_coding synonymous_variant LOW 852C>T His284His
M0127323 IFLHNPLC_00001 1915 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -38A>C None
M0127324 IFLHNPLC_00001 1993 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -116A>G None
M0127325 IFLHNPLC_00001 5746 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3869G>A None
M0127326 IFLHNPLC_00001 6037 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4160T>C None
M0127327 IFLHNPLC_00001 6184 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4307T>C None
M0127328 IFLHNPLC_00001 6196 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -4319T>C None
M0127329 IFLHNPLC_00001 6271 6 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -4394A>G None
M0127330 IFLHNPLC_00001 6424 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -4547G>A None
M0127331 IFLHNPLC_00001 5692 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3815T>C None
M0127332 IFLHNPLC_00001 5719 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3842T>C None
M0127333 IFLHNPLC_00001 5722 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3845A>T None
M0127334 IFLHNPLC_00001 5760 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3883C>T None
M0127335 IFLHNPLC_00001 5770 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -3893A>G None
M0127336 IFLHNPLC_00002 2526 3 Oral 0.25 protein_coding missense_variant MODERATE 178A>G Asn60Asp
M0127337 IFLHNPLC_00002 2623 3 Oral 0.25 protein_coding synonymous_variant LOW 81A>G Leu27Leu
M0127338 IFLHNPLC_00003 3555 3 Oral 0.25 protein_coding synonymous_variant LOW 576C>A Thr192Thr
M0127339 IFLHNPLC_00003 3594 3 Oral 0.25 protein_coding synonymous_variant LOW 537A>T Pro179Pro
M0127340 IFLHNPLC_00003 3795 3 Oral 0.25 protein_coding synonymous_variant LOW 336A>G Thr112Thr
M0127341 IFLHNPLC_00003 3798 4 Oral 0.33 protein_coding synonymous_variant LOW 333C>T Ser111Ser
M0127342 IFLHNPLC_00003 3876 4 Oral 0.33 protein_coding synonymous_variant LOW 255A>G Glu85Glu
M0127343 IFLHNPLC_00003 3897 4 Oral 0.33 protein_coding synonymous_variant LOW 234C>T Arg78Arg
M0127344 IFLHNPLC_00004 4807 3 Oral 0.25 protein_coding synonymous_variant LOW 505C>A Arg169Arg
M0127345 IFLHNPLC_00004 5049 3 Oral 0.25 protein_coding synonymous_variant LOW 747T>C Asp249Asp
M0127346 IFLHNPLC_00004 5119 3 Oral 0.25 protein_coding missense_variant MODERATE 817G>A Val273Ile
M0127347 IFLHNPLC_00001 5302 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3425A>T None
M0127348 IFLHNPLC_00001 5800 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -3923C>T None
M0127349 IFLHNPLC_00001 5914 3 Oral 0.25 protein_coding upstream_gene_variant MODIFIER -4037T>G None
M0127350 IFLHNPLC_00001 6352 4 Oral 0.33 protein_coding upstream_gene_variant MODIFIER -4475A>G None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term