Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2457
  Reference Plasmid   1111525849768046_bin.37__k141_56720
  Reference Plasmid Size   6860
  Reference Plasmid GC Content   0.38
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0127550 HKBAKLLD_00002 4159 3 Oral 0.60 protein_coding missense_variant MODERATE 266A>G His89Arg
M0127551 HKBAKLLD_00002 4181 3 Oral 0.60 protein_coding missense_variant MODERATE 244C>A Pro82Thr
M0127552 HKBAKLLD_00002 4236 3 Oral 0.60 protein_coding synonymous_variant LOW 189G>A Glu63Glu
M0127553 HKBAKLLD_00002 4270 3 Oral 0.60 protein_coding missense_variant MODERATE 155A>G Asn52Ser
M0127554 HKBAKLLD_00002 4352 3 Oral 0.60 protein_coding missense_variant MODERATE 73A>G Ser25Gly
M0127555 HKBAKLLD_00002 4400 3 Oral 0.60 protein_coding missense_variant MODERATE 25A>G Thr9Ala
M0127556 HKBAKLLD_00002 4659 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -235C>T None
M0127557 HKBAKLLD_00002 4711 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -287A>T None
M0127558 HKBAKLLD_00003 4776 3 Oral 0.60 protein_coding synonymous_variant LOW 57G>A Arg19Arg
M0127559 HKBAKLLD_00003 5041 3 Oral 0.60 protein_coding missense_variant MODERATE 322A>T Asn108Tyr
M0127560 HKBAKLLD_00003 5166 3 Oral 0.60 protein_coding synonymous_variant LOW 447A>T Val149Val
M0127561 HKBAKLLD_00003 5169 3 Oral 0.60 protein_coding synonymous_variant LOW 450A>G Ala150Ala
M0127562 HKBAKLLD_00003 5271 3 Oral 0.60 protein_coding synonymous_variant LOW 552C>T Asn184Asn
M0127563 HKBAKLLD_00003 5301 3 Oral 0.60 protein_coding synonymous_variant LOW 582A>T Ser194Ser
M0127564 HKBAKLLD_00003 5313 3 Oral 0.60 protein_coding synonymous_variant LOW 594C>T Asn198Asn
M0127565 HKBAKLLD_00003 5505 3 Oral 0.60 protein_coding synonymous_variant LOW 786T>G Ser262Ser
M0127566 HKBAKLLD_00002 5761 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1337A>G None
M0127567 HKBAKLLD_00002 5791 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1367T>C None
M0127568 HKBAKLLD_00002 5842 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1418A>G None
M0127569 HKBAKLLD_00002 5845 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1421A>G None
M0127570 HKBAKLLD_00002 5965 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1541A>G None
M0127571 HKBAKLLD_00002 6207 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1783T>C None
M0127572 HKBAKLLD_00002 6212 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1788G>A None
M0127573 HKBAKLLD_00002 6298 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -1874G>A None
M0127574 HKBAKLLD_00002 6693 3 Oral 0.60 protein_coding upstream_gene_variant MODIFIER -2269C>T None
M0127575 HKBAKLLD_00001 59 4 Oral 0.80 protein_coding missense_variant MODERATE 33A>T Glu11Asp
M0127576 HKBAKLLD_00001 60 4 Oral 0.80 protein_coding missense_variant MODERATE 34A>C Asn12His
M0127577 HKBAKLLD_00001 62 4 Oral 0.80 protein_coding missense_variant MODERATE 36C>A Asn12Lys
M0127578 HKBAKLLD_00001 64 4 Oral 0.80 protein_coding missense_variant MODERATE 38A>C Gln13Pro
M0127579 HKBAKLLD_00001 65 4 Oral 0.80 protein_coding missense_variant MODERATE 39A>T Gln13His
M0127580 HKBAKLLD_00001 728 3 Oral 0.60 protein_coding synonymous_variant LOW 702T>C Thr234Thr
M0127581 HKBAKLLD_00001 914 3 Oral 0.60 protein_coding synonymous_variant LOW 888C>T Pro296Pro
M0127582 HKBAKLLD_00001 950 3 Oral 0.60 protein_coding synonymous_variant LOW 924T>A Ala308Ala
M0127583 HKBAKLLD_00001 977 4 Oral 0.80 protein_coding synonymous_variant LOW 951T>C Phe317Phe
M0127584 HKBAKLLD_00001 983 4 Oral 0.80 protein_coding missense_variant MODERATE 957C>A Asn319Lys
M0127585 HKBAKLLD_00001 1020 4 Oral 0.80 protein_coding missense_variant MODERATE 994A>T Thr332Ser
M0127586 HKBAKLLD_00001 1130 3 Oral 0.60 protein_coding synonymous_variant LOW 1104A>C Gly368Gly
M0127587 HKBAKLLD_00001 55 3 Oral 0.60 protein_coding missense_variant MODERATE 29T>A Phe10Tyr
M0127588 HKBAKLLD_00001 245 3 Oral 0.60 protein_coding synonymous_variant LOW 219C>T Phe73Phe
M0127589 HKBAKLLD_00001 259 3 Oral 0.60 protein_coding missense_variant MODERATE 233T>C Val78Ala
M0127590 HKBAKLLD_00001 533 3 Oral 0.60 protein_coding synonymous_variant LOW 507C>T Ser169Ser
M0127591 HKBAKLLD_00001 1262 3 Oral 0.60 protein_coding synonymous_variant LOW 1236C>T Leu412Leu
M0127592 HKBAKLLD_00001 1265 3 Oral 0.60 protein_coding synonymous_variant LOW 1239T>A Gly413Gly
M0127593 HKBAKLLD_00001 1352 3 Oral 0.60 protein_coding synonymous_variant LOW 1326T>C Ala442Ala
M0127594 HKBAKLLD_00001 1928 3 Oral 0.60 protein_coding synonymous_variant LOW 1902T>C Ala634Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
HKBAKLLD_00001 EFC71377.1|GH85 92.2 0 1 1102 1 0.876





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term