Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2580
  Reference Plasmid   1111525849853957_bin.30_new__k141_789025
  Reference Plasmid Size   59714
  Reference Plasmid GC Content   0.42
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0047668 MOEHJGKB_00038 28189 3 Skin 0.50 protein_coding synonymous_variant LOW 438G>T Val146Val
M0047669 MOEHJGKB_00038 28567 3 Skin 0.50 protein_coding synonymous_variant LOW 60C>T Asn20Asn
M0047670 MOEHJGKB_00038 28704 3 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -78T>C None
M0047671 MOEHJGKB_00038 28705 3 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -79A>G None
M0047672 MOEHJGKB_00040 29965 3 Skin 0.50 protein_coding missense_variant MODERATE 179T>C Ile60Thr
M0047673 MOEHJGKB_00040 29974 3 Skin 0.50 protein_coding missense_variant MODERATE 188A>G Lys63Arg
M0047674 MOEHJGKB_00040 30119 3 Skin 0.50 protein_coding synonymous_variant LOW 333C>T Ala111Ala
M0047675 MOEHJGKB_00040 30252 3 Skin 0.50 protein_coding missense_variant MODERATE 466A>G Ile156Val
M0047676 MOEHJGKB_00040 30270 3 Skin 0.50 protein_coding synonymous_variant LOW 484T>C Leu162Leu
M0047677 MOEHJGKB_00040 30455 3 Skin 0.50 protein_coding synonymous_variant LOW 669T>C Phe223Phe
M0047678 MOEHJGKB_00040 30857 3 Skin 0.50 protein_coding synonymous_variant LOW 1071T>G Ala357Ala
M0047679 MOEHJGKB_00040 30959 3 Skin 0.50 protein_coding missense_variant MODERATE 1173G>T Glu391Asp
M0047680 MOEHJGKB_00040 31146 3 Skin 0.50 protein_coding missense_variant MODERATE 1360G>C Glu454Gln
M0047681 MOEHJGKB_00040 31338 3 Skin 0.50 protein_coding missense_variant MODERATE 1552A>C Ile518Leu






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
MOEHJGKB_00033 PHI:124080 AdcA 71.8 4e-204 1 500 1.0000 1.0000 rodents streptococcal toxic shock syndrome Zn-binding lipoproteins reduced virulence
MOEHJGKB_00047 PHI:7052 epsC 72.2 1.1e-161 1 381 0.9896 0.9974 rodents infective endocarditis exopolysaccharide synthesis enzyme [UDP-N-acetylglucosamine 2-epimerase] reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
MOEHJGKB_00044 SQG31244.1|GT51 99.1 0 1 804 1 1
MOEHJGKB_00046 CCO12868.2|GH1 75.9 0 1 1193 0.9819 0.9868
MOEHJGKB_00050 SQG31238.1|GT2 100 7.77999999984745e-314 1 436 1 1
MOEHJGKB_00051 VDY72836.1|GH8 99.7 3.77e-266 1 368 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
MOEHJGKB_00031 3.A.1.15.3 89.4 1.3e-123 1 236 1.0000 0.7524 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
MOEHJGKB_00032 3.A.1.15.3 88.1 1.4e-118 1 268 1.0000 0.8617 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
MOEHJGKB_00033 3.A.1.15.3 81 1.6e-237 1 500 1.0000 1.6109 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
MOEHJGKB_00041 3.A.1.1.28 75 2.4e-161 1 375 0.9973 0.9973 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily