Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2598
  Reference Plasmid   1111525849854152_bin.51__k141_98772
  Reference Plasmid Size   21443
  Reference Plasmid GC Content   0.64
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0048597 MEAONMFD_00015 18034 3 Skin 0.20 protein_coding missense_variant MODERATE 1016G>C Ser339Thr
M0048598 MEAONMFD_00015 18074 3 Skin 0.20 protein_coding synonymous_variant LOW 1056C>G Ala352Ala
M0048599 MEAONMFD_00012 18376 3 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -4312A>G None
M0048600 MEAONMFD_00012 18382 3 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -4318C>T None
M0048601 MEAONMFD_00012 18418 3 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -4354T>C None
M0048602 MEAONMFD_00003 1933 3 Skin 0.20 protein_coding synonymous_variant LOW 1014T>C Gly338Gly
M0048603 MEAONMFD_00003 2023 3 Skin 0.20 protein_coding synonymous_variant LOW 924A>G Lys308Lys
M0048604 MEAONMFD_00003 2628 3 Skin 0.20 protein_coding missense_variant MODERATE 319T>G Ser107Ala
M0048605 MEAONMFD_00003 2652 3 Skin 0.20 protein_coding missense_variant MODERATE 295A>C Met99Leu
M0048606 MEAONMFD_00003 2695 4 Skin 0.27 protein_coding missense_variant MODERATE 252A>C Glu84Asp
M0048607 MEAONMFD_00003 2696 5 Skin 0.33 protein_coding missense_variant MODERATE 251A>G Glu84Gly
M0048608 MEAONMFD_00005 3354 5 Skin 0.33 protein_coding synonymous_variant LOW 1623T>C Tyr541Tyr
M0048609 MEAONMFD_00005 3602 6 Skin 0.40 protein_coding synonymous_variant LOW 1375T>C Leu459Leu
M0048610 MEAONMFD_00005 3943 6 Skin 0.40 protein_coding missense_variant MODERATE 1034A>C Glu345Ala
M0048611 MEAONMFD_00005 4113 3 Skin 0.20 protein_coding synonymous_variant LOW 864G>A Leu288Leu
M0048612 MEAONMFD_00005 4134 4 Skin 0.27 protein_coding synonymous_variant LOW 843A>G Ala281Ala
M0048613 MEAONMFD_00005 4168 4 Skin 0.27 protein_coding missense_variant MODERATE 809G>A Arg270Gln
M0048614 MEAONMFD_00005 4178 5 Skin 0.33 protein_coding missense_variant MODERATE 799A>C Met267Leu
M0048615 MEAONMFD_00005 4311 6 Skin 0.40 protein_coding synonymous_variant LOW 666T>C Leu222Leu
M0048616 MEAONMFD_00005 4572 6 Skin 0.40 protein_coding synonymous_variant LOW 405G>A Leu135Leu
M0048617 MEAONMFD_00005 4684 6 Skin 0.40 protein_coding missense_variant MODERATE 293T>C Ile98Thr
M0048618 MEAONMFD_00005 4736 5 Skin 0.33 protein_coding synonymous_variant LOW 241T>C Leu81Leu
M0048619 MEAONMFD_00005 4860 5 Skin 0.33 protein_coding synonymous_variant LOW 117A>G Ala39Ala
M0048620 MEAONMFD_00005 4894 3 Skin 0.20 protein_coding missense_variant MODERATE 83C>T Ala28Val
M0048621 MEAONMFD_00002 5040 4 Skin 0.27 protein_coding upstream_gene_variant MODIFIER -3580T>C None
M0048622 MEAONMFD_00006 5172 5 Skin 0.33 protein_coding missense_variant MODERATE 1558A>G Thr520Ala
M0048623 MEAONMFD_00006 5289 6 Skin 0.40 protein_coding missense_variant MODERATE 1441A>G Ser481Gly
M0048624 MEAONMFD_00006 5656 3 Skin 0.20 protein_coding synonymous_variant LOW 1074A>G Glu358Glu
M0048625 MEAONMFD_00006 5661 4 Skin 0.27 protein_coding missense_variant MODERATE 1069A>G Asn357Asp
M0048626 MEAONMFD_00006 5697 4 Skin 0.27 protein_coding missense_variant MODERATE 1033A>G Lys345Glu
M0048627 MEAONMFD_00006 6352 5 Skin 0.33 protein_coding synonymous_variant LOW 378T>C Thr126Thr
M0048628 MEAONMFD_00006 6696 4 Skin 0.27 protein_coding missense_variant MODERATE 34A>G Ile12Val
M0048629 MEAONMFD_00007 6923 4 Skin 0.27 protein_coding synonymous_variant LOW 189T>C Val63Val
M0048630 MEAONMFD_00007 7094 4 Skin 0.27 protein_coding synonymous_variant LOW 360T>C Arg120Arg
M0048631 MEAONMFD_00007 7104 4 Skin 0.27 protein_coding missense_variant MODERATE 370A>C Met124Leu
M0048632 MEAONMFD_00007 7151 4 Skin 0.27 protein_coding synonymous_variant LOW 417G>C Arg139Arg
M0048633 MEAONMFD_00007 7178 5 Skin 0.33 protein_coding synonymous_variant LOW 444T>C Ser148Ser
M0048634 MEAONMFD_00007 7388 4 Skin 0.27 protein_coding synonymous_variant LOW 654A>G Val218Val
M0048635 MEAONMFD_00007 7562 4 Skin 0.27 protein_coding synonymous_variant LOW 828C>G Ala276Ala
M0048636 MEAONMFD_00007 7733 5 Skin 0.33 protein_coding synonymous_variant LOW 999G>C Arg333Arg
M0048637 MEAONMFD_00007 7742 5 Skin 0.33 protein_coding synonymous_variant LOW 1008T>G Gly336Gly
M0048638 MEAONMFD_00007 7847 5 Skin 0.33 protein_coding synonymous_variant LOW 1113G>C Ala371Ala
M0048639 MEAONMFD_00003 7883 4 Skin 0.27 protein_coding upstream_gene_variant MODIFIER -4937A>C None
M0048640 MEAONMFD_00008 7913 4 Skin 0.27 protein_coding missense_variant MODERATE 1234A>G Thr412Ala
M0048641 MEAONMFD_00008 7929 4 Skin 0.27 protein_coding synonymous_variant LOW 1218T>C Ala406Ala
M0048642 MEAONMFD_00008 8091 4 Skin 0.27 protein_coding synonymous_variant LOW 1056T>C Asp352Asp
M0048643 MEAONMFD_00008 8100 4 Skin 0.27 protein_coding synonymous_variant LOW 1047C>G Leu349Leu
M0048644 MEAONMFD_00008 8105 4 Skin 0.27 protein_coding missense_variant MODERATE 1042A>C Lys348Gln
M0048645 MEAONMFD_00008 8106 4 Skin 0.27 protein_coding synonymous_variant LOW 1041G>T Val347Val
M0048646 MEAONMFD_00008 8112 4 Skin 0.27 protein_coding synonymous_variant LOW 1035C>A Ala345Ala
M0048647 MEAONMFD_00008 8118 4 Skin 0.27 protein_coding synonymous_variant LOW 1029G>C Ala343Ala
M0048648 MEAONMFD_00008 8121 4 Skin 0.27 protein_coding synonymous_variant LOW 1026C>G Leu342Leu
M0048649 MEAONMFD_00008 8127 3 Skin 0.20 protein_coding synonymous_variant LOW 1020G>A Glu340Glu
M0048650 MEAONMFD_00008 8193 4 Skin 0.27 protein_coding synonymous_variant LOW 954C>A Ala318Ala
M0048651 MEAONMFD_00008 8202 3 Skin 0.20 protein_coding missense_variant MODERATE 945T>G Ile315Met
M0048652 MEAONMFD_00008 8211 3 Skin 0.20 protein_coding synonymous_variant LOW 936A>C Pro312Pro
M0048653 MEAONMFD_00008 8214 3 Skin 0.20 protein_coding synonymous_variant LOW 933A>C Val311Val
M0048654 MEAONMFD_00008 8271 4 Skin 0.27 protein_coding synonymous_variant LOW 876C>G Leu292Leu
M0048655 MEAONMFD_00008 8277 5 Skin 0.33 protein_coding synonymous_variant LOW 870T>C His290His
M0048656 MEAONMFD_00008 8289 5 Skin 0.33 protein_coding synonymous_variant LOW 858C>G Leu286Leu
M0048657 MEAONMFD_00008 8292 5 Skin 0.33 protein_coding synonymous_variant LOW 855C>G Pro285Pro
M0048658 MEAONMFD_00008 8323 3 Skin 0.20 protein_coding missense_variant MODERATE 824A>G Lys275Arg
M0048659 MEAONMFD_00008 8405 4 Skin 0.27 protein_coding missense_variant MODERATE 742A>G Ile248Val
M0048660 MEAONMFD_00013 14332 7 Skin 0.47 protein_coding synonymous_variant LOW 228A>T Arg76Arg
M0048661 MEAONMFD_00013 14552 6 Skin 0.40 protein_coding missense_variant MODERATE 448G>T Ala150Ser
M0048662 MEAONMFD_00013 15208 6 Skin 0.40 protein_coding synonymous_variant LOW 1104G>A Gln368Gln
M0048663 MEAONMFD_00013 15229 6 Skin 0.40 protein_coding synonymous_variant LOW 1125A>T Gly375Gly
M0048664 MEAONMFD_00013 15231 6 Skin 0.40 protein_coding missense_variant MODERATE 1127A>G Gln376Arg
M0048665 MEAONMFD_00013 15232 6 Skin 0.40 protein_coding missense_variant MODERATE 1128A>C Gln376His
M0048666 MEAONMFD_00013 15235 6 Skin 0.40 protein_coding synonymous_variant LOW 1131G>C Leu377Leu
M0048667 MEAONMFD_00013 15241 6 Skin 0.40 protein_coding synonymous_variant LOW 1137G>A Pro379Pro
M0048668 MEAONMFD_00013 15244 6 Skin 0.40 protein_coding missense_variant MODERATE 1140C>G Asp380Glu
M0048669 MEAONMFD_00010 15455 6 Skin 0.40 protein_coding upstream_gene_variant MODIFIER -3754A>G None
M0048670 MEAONMFD_00010 15500 5 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -3799C>T None
M0048671 MEAONMFD_00014 15531 4 Skin 0.27 protein_coding synonymous_variant LOW 27G>A Gln9Gln
M0048672 MEAONMFD_00014 15862 7 Skin 0.47 protein_coding synonymous_variant LOW 358T>C Leu120Leu
M0048673 MEAONMFD_00014 16007 8 Skin 0.53 protein_coding missense_variant MODERATE 503A>G Gln168Arg
M0048674 MEAONMFD_00005 3556 4 Skin 0.27 protein_coding missense_variant MODERATE 1421T>C Val474Ala
M0048675 MEAONMFD_00007 6839 3 Skin 0.20 protein_coding synonymous_variant LOW 105T>C Thr35Thr
M0048676 MEAONMFD_00008 8223 3 Skin 0.20 protein_coding synonymous_variant LOW 924G>C Ala308Ala
M0048677 MEAONMFD_00008 8226 3 Skin 0.20 protein_coding synonymous_variant LOW 921C>G Ala307Ala
M0048678 MEAONMFD_00008 8229 3 Skin 0.20 protein_coding synonymous_variant LOW 918C>G Ala306Ala
M0048679 MEAONMFD_00012 13099 4 Skin 0.27 protein_coding synonymous_variant LOW 966C>T Phe322Phe
M0048680 MEAONMFD_00012 13170 3 Skin 0.20 protein_coding synonymous_variant LOW 895T>C Leu299Leu
M0048681 MEAONMFD_00012 13192 4 Skin 0.27 protein_coding synonymous_variant LOW 873A>G Ala291Ala
M0048682 MEAONMFD_00012 13198 4 Skin 0.27 protein_coding synonymous_variant LOW 867T>C Gly289Gly
M0048683 MEAONMFD_00012 13258 3 Skin 0.20 protein_coding synonymous_variant LOW 807T>G Leu269Leu
M0048684 MEAONMFD_00012 13262 3 Skin 0.20 protein_coding missense_variant MODERATE 803G>A Arg268Lys
M0048685 MEAONMFD_00012 13286 4 Skin 0.27 protein_coding missense_variant MODERATE 779A>G His260Arg
M0048686 MEAONMFD_00012 13289 3 Skin 0.20 protein_coding missense_variant MODERATE 776T>C Val259Ala
M0048687 MEAONMFD_00012 13333 4 Skin 0.27 protein_coding synonymous_variant LOW 732G>A Val244Val
M0048688 MEAONMFD_00012 13528 3 Skin 0.20 protein_coding synonymous_variant LOW 537C>T Ala179Ala
M0048689 MEAONMFD_00012 13558 3 Skin 0.20 protein_coding synonymous_variant LOW 507G>T Leu169Leu
M0048690 MEAONMFD_00012 13571 3 Skin 0.20 protein_coding missense_variant MODERATE 494T>C Val165Ala
M0048691 MEAONMFD_00012 13572 3 Skin 0.20 protein_coding missense_variant MODERATE 493G>A Val165Ile
M0048692 MEAONMFD_00012 13575 5 Skin 0.33 protein_coding missense_variant MODERATE 490G>C Val164Leu
M0048693 MEAONMFD_00012 13577 3 Skin 0.20 protein_coding missense_variant MODERATE 488C>G Ala163Gly
M0048694 MEAONMFD_00012 13579 3 Skin 0.20 protein_coding synonymous_variant LOW 486C>G Ala162Ala
M0048695 MEAONMFD_00012 13582 3 Skin 0.20 protein_coding synonymous_variant LOW 483C>A Ala161Ala
M0048696 MEAONMFD_00012 13585 3 Skin 0.20 protein_coding synonymous_variant LOW 480G>C Ala160Ala
M0048697 MEAONMFD_00012 13588 3 Skin 0.20 protein_coding synonymous_variant LOW 477C>T Val159Val
M0048698 MEAONMFD_00012 13591 3 Skin 0.20 protein_coding synonymous_variant LOW 474T>C Gly158Gly
M0048699 MEAONMFD_00012 13594 3 Skin 0.20 protein_coding synonymous_variant LOW 471A>G Ala157Ala
M0048700 MEAONMFD_00012 13597 3 Skin 0.20 protein_coding synonymous_variant LOW 468C>G Ala156Ala
M0048701 MEAONMFD_00012 13750 4 Skin 0.27 protein_coding synonymous_variant LOW 315A>G Lys105Lys
M0048702 MEAONMFD_00012 13756 4 Skin 0.27 protein_coding synonymous_variant LOW 309G>C Thr103Thr
M0048703 MEAONMFD_00012 13762 4 Skin 0.27 protein_coding synonymous_variant LOW 303T>G Leu101Leu
M0048704 MEAONMFD_00012 13825 4 Skin 0.27 protein_coding synonymous_variant LOW 240A>G Gly80Gly
M0048705 MEAONMFD_00012 13903 4 Skin 0.27 protein_coding synonymous_variant LOW 162G>C Gly54Gly
M0048706 MEAONMFD_00012 14008 5 Skin 0.33 protein_coding synonymous_variant LOW 57T>G Val19Val
M0048707 MEAONMFD_00013 14229 3 Skin 0.20 protein_coding missense_variant MODERATE 125G>C Arg42Pro
M0048708 MEAONMFD_00013 14234 3 Skin 0.20 protein_coding missense_variant MODERATE 130G>T Ala44Ser
M0048709 MEAONMFD_00013 14520 4 Skin 0.27 protein_coding missense_variant MODERATE 416C>T Ala139Val
M0048710 MEAONMFD_00013 14537 4 Skin 0.27 protein_coding missense_variant MODERATE 433G>T Ala145Ser
M0048711 MEAONMFD_00013 14923 4 Skin 0.27 protein_coding synonymous_variant LOW 819T>C Ala273Ala
M0048712 MEAONMFD_00013 15238 4 Skin 0.27 protein_coding synonymous_variant LOW 1134G>C Ser378Ser
M0048713 MEAONMFD_00013 15240 3 Skin 0.20 protein_coding missense_variant MODERATE 1136C>T Pro379Leu
M0048714 MEAONMFD_00013 15327 3 Skin 0.20 protein_coding missense_variant MODERATE 1223A>G Gln408Arg
M0048715 MEAONMFD_00013 15328 3 Skin 0.20 protein_coding synonymous_variant LOW 1224G>A Gln408Gln
M0048716 MEAONMFD_00013 15430 3 Skin 0.20 protein_coding synonymous_variant LOW 1326G>A Gln442Gln
M0048717 MEAONMFD_00014 15771 3 Skin 0.20 protein_coding synonymous_variant LOW 267G>A Gln89Gln
M0048718 MEAONMFD_00014 15831 3 Skin 0.20 protein_coding synonymous_variant LOW 327C>T Asn109Asn
M0048719 MEAONMFD_00014 15923 3 Skin 0.20 protein_coding missense_variant MODERATE 419G>T Arg140Met
M0048720 MEAONMFD_00014 15927 3 Skin 0.20 protein_coding synonymous_variant LOW 423A>T Arg141Arg
M0048721 MEAONMFD_00014 16020 4 Skin 0.27 protein_coding missense_variant MODERATE 516C>A Asp172Glu
M0048722 MEAONMFD_00015 17460 3 Skin 0.20 protein_coding missense_variant MODERATE 442T>G Ser148Ala
M0048723 MEAONMFD_00015 17477 3 Skin 0.20 protein_coding synonymous_variant LOW 459G>C Leu153Leu
M0048724 MEAONMFD_00015 17756 3 Skin 0.20 protein_coding synonymous_variant LOW 738C>T Pro246Pro
M0048725 MEAONMFD_00005 3699 3 Skin 0.20 protein_coding synonymous_variant LOW 1278T>C Asp426Asp
M0048726 MEAONMFD_00009 9148 3 Skin 0.20 protein_coding missense_variant MODERATE 1195T>G Ser399Ala
M0048727 MEAONMFD_00009 9159 4 Skin 0.27 protein_coding missense_variant MODERATE 1184A>G Gln395Arg
M0048728 MEAONMFD_00009 10019 5 Skin 0.33 protein_coding synonymous_variant LOW 324T>C Gly108Gly
M0048729 MEAONMFD_00009 10144 4 Skin 0.27 protein_coding synonymous_variant LOW 199T>C Leu67Leu
M0048730 MEAONMFD_00009 10205 3 Skin 0.20 protein_coding synonymous_variant LOW 138A>G Ser46Ser
M0048731 MEAONMFD_00009 10280 5 Skin 0.33 protein_coding synonymous_variant LOW 63C>T Asp21Asp
M0048732 MEAONMFD_00008 8988 3 Skin 0.20 protein_coding synonymous_variant LOW 159C>G Ala53Ala
M0048733 MEAONMFD_00009 9950 3 Skin 0.20 protein_coding synonymous_variant LOW 393C>T Phe131Phe
M0048734 MEAONMFD_00010 10817 4 Skin 0.27 protein_coding synonymous_variant LOW 885T>C Ala295Ala
M0048735 MEAONMFD_00010 11108 3 Skin 0.20 protein_coding synonymous_variant LOW 594T>C Arg198Arg
M0048736 MEAONMFD_00010 11144 3 Skin 0.20 protein_coding synonymous_variant LOW 558T>C Ser186Ser
M0048737 MEAONMFD_00010 11255 3 Skin 0.20 protein_coding synonymous_variant LOW 447T>G Gly149Gly
M0048738 MEAONMFD_00010 11324 3 Skin 0.20 protein_coding synonymous_variant LOW 378A>G Gln126Gln
M0048739 MEAONMFD_00010 11329 3 Skin 0.20 protein_coding missense_variant MODERATE 373T>G Leu125Val
M0048740 MEAONMFD_00010 11422 3 Skin 0.20 protein_coding synonymous_variant LOW 280C>T Leu94Leu
M0048741 MEAONMFD_00010 11432 3 Skin 0.20 protein_coding synonymous_variant LOW 270C>T Ser90Ser
M0048742 MEAONMFD_00010 11433 3 Skin 0.20 protein_coding missense_variant MODERATE 269G>T Ser90Ile
M0048743 MEAONMFD_00010 11521 3 Skin 0.20 protein_coding missense_variant MODERATE 181C>G Leu61Val
M0048744 MEAONMFD_00010 11522 3 Skin 0.20 protein_coding synonymous_variant LOW 180T>C Asp60Asp
M0048745 MEAONMFD_00010 11655 3 Skin 0.20 protein_coding missense_variant MODERATE 47T>C Leu16Pro
M0048746 MEAONMFD_00009 10313 3 Skin 0.20 protein_coding synonymous_variant LOW 30A>G Arg10Arg
M0048747 MEAONMFD_00010 10881 3 Skin 0.20 protein_coding missense_variant MODERATE 821G>C Gly274Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
MEAONMFD_00008 ADY27693.1|GT4 77.7 4.41e-206 3 374 0.89 0.992
MEAONMFD_00009 ADY27692.1|GT4 73.3 1.07e-192 1 389 0.9749 0.9747





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term