Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2612
  Reference Plasmid   1111525849857514_bin.37__k141_355847
  Reference Plasmid Size   30252
  Reference Plasmid GC Content   0.56
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0048898 MLDMBDLB_00004 4370 3 Skin 0.14 protein_coding synonymous_variant LOW 909A>G Pro303Pro
M0048899 MLDMBDLB_00006 6264 4 Skin 0.19 protein_coding synonymous_variant LOW 573A>G Lys191Lys
M0048900 MLDMBDLB_00006 6276 4 Skin 0.19 protein_coding synonymous_variant LOW 585A>G Val195Val
M0048901 MLDMBDLB_00006 6303 3 Skin 0.14 protein_coding synonymous_variant LOW 612A>G Gln204Gln
M0048902 MLDMBDLB_00008 7239 4 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -55C>A None
M0048903 MLDMBDLB_00008 8242 4 Skin 0.19 protein_coding synonymous_variant LOW 949T>C Leu317Leu
M0048904 MLDMBDLB_00008 8343 3 Skin 0.14 protein_coding synonymous_variant LOW 1050T>C Ala350Ala
M0048905 MLDMBDLB_00009 9614 3 Skin 0.14 protein_coding synonymous_variant LOW 1026A>G Leu342Leu
M0048906 MLDMBDLB_00009 9629 3 Skin 0.14 protein_coding synonymous_variant LOW 1041C>A Ala347Ala
M0048907 MLDMBDLB_00009 9653 3 Skin 0.14 protein_coding synonymous_variant LOW 1065C>T Phe355Phe
M0048908 MLDMBDLB_00001 2248 7 Skin 0.33 protein_coding synonymous_variant LOW 1431A>G Arg477Arg
M0048909 MLDMBDLB_00001 2269 7 Skin 0.33 protein_coding synonymous_variant LOW 1452A>G Leu484Leu
M0048910 MLDMBDLB_00002 2474 9 Skin 0.43 protein_coding synonymous_variant LOW 111A>G Leu37Leu
M0048911 MLDMBDLB_00003 2630 3 Skin 0.14 protein_coding synonymous_variant LOW 30T>C Val10Val
M0048912 MLDMBDLB_00003 2720 6 Skin 0.29 protein_coding synonymous_variant LOW 120G>C Leu40Leu
M0048913 MLDMBDLB_00003 2837 5 Skin 0.24 protein_coding synonymous_variant LOW 237T>C His79His
M0048914 MLDMBDLB_00003 3086 5 Skin 0.24 protein_coding synonymous_variant LOW 486A>G Leu162Leu
M0048915 MLDMBDLB_00004 3746 6 Skin 0.29 protein_coding synonymous_variant LOW 285C>T Gly95Gly
M0048916 MLDMBDLB_00001 177 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -641G>A None
M0048917 MLDMBDLB_00001 638 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -180T>C None
M0048918 MLDMBDLB_00004 4187 4 Skin 0.19 protein_coding synonymous_variant LOW 726C>T Gly242Gly
M0048919 MLDMBDLB_00001 114 5 Skin 0.24 protein_coding upstream_gene_variant MODIFIER -704C>T None
M0048920 MLDMBDLB_00001 1186 5 Skin 0.24 protein_coding synonymous_variant LOW 369A>T Arg123Arg
M0048921 MLDMBDLB_00001 1810 3 Skin 0.14 protein_coding synonymous_variant LOW 993G>T Ala331Ala
M0048922 MLDMBDLB_00001 2179 4 Skin 0.19 protein_coding synonymous_variant LOW 1362G>A Ala454Ala
M0048923 MLDMBDLB_00003 3038 5 Skin 0.24 protein_coding synonymous_variant LOW 438T>C Ile146Ile
M0048924 MLDMBDLB_00026 28531 5 Skin 0.24 protein_coding synonymous_variant LOW 1698A>C Val566Val
M0048925 MLDMBDLB_00026 28636 6 Skin 0.29 protein_coding synonymous_variant LOW 1593T>C Cys531Cys
M0048926 MLDMBDLB_00026 28666 6 Skin 0.29 protein_coding synonymous_variant LOW 1563G>A Val521Val
M0048927 MLDMBDLB_00018 22717 4 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -3348C>T None
M0048928 MLDMBDLB_00022 22824 3 Skin 0.14 protein_coding synonymous_variant LOW 927G>C Leu309Leu
M0048929 MLDMBDLB_00022 22845 3 Skin 0.14 protein_coding synonymous_variant LOW 906T>C Thr302Thr
M0048930 MLDMBDLB_00021 21887 3 Skin 0.14 protein_coding missense_variant MODERATE 769A>C Ser257Arg






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
MLDMBDLB_00013 2.A.1.6.1 90.7 3.6e-209 12 431 0.9745 0.9459 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.1 The Major Facilitator Superfamily (MFS)