Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2651
  Reference Plasmid   1111525849858868_bin.34__k141_49664
  Reference Plasmid Size   10063
  Reference Plasmid GC Content   0.68
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0051125 LMHKMECL_00001 229 3 Skin 0.50 protein_coding synonymous_variant LOW 189G>C Pro63Pro
M0051126 LMHKMECL_00001 274 3 Skin 0.50 protein_coding synonymous_variant LOW 234G>T Ala78Ala
M0051127 LMHKMECL_00001 277 3 Skin 0.50 protein_coding synonymous_variant LOW 237C>A Pro79Pro
M0051128 LMHKMECL_00001 283 5 Skin 0.83 protein_coding synonymous_variant LOW 243A>T Pro81Pro
M0051129 LMHKMECL_00001 286 5 Skin 0.83 protein_coding synonymous_variant LOW 246T>A Ala82Ala
M0051130 LMHKMECL_00001 289 5 Skin 0.83 protein_coding synonymous_variant LOW 249T>C Pro83Pro
M0051131 LMHKMECL_00001 400 3 Skin 0.50 protein_coding synonymous_variant LOW 360C>T Arg120Arg
M0051132 LMHKMECL_00001 464 3 Skin 0.50 protein_coding missense_variant MODERATE 424C>T Pro142Ser
M0051133 LMHKMECL_00001 775 5 Skin 0.83 protein_coding synonymous_variant LOW 735T>C Ile245Ile
M0051134 LMHKMECL_00002 1463 5 Skin 0.83 protein_coding synonymous_variant LOW 825T>C Gly275Gly
M0051135 LMHKMECL_00002 1546 4 Skin 0.67 protein_coding synonymous_variant LOW 742C>T Leu248Leu
M0051136 LMHKMECL_00002 1547 4 Skin 0.67 protein_coding synonymous_variant LOW 741C>G Arg247Arg
M0051137 LMHKMECL_00002 1553 4 Skin 0.67 protein_coding synonymous_variant LOW 735G>C Gly245Gly
M0051138 LMHKMECL_00002 1769 5 Skin 0.83 protein_coding synonymous_variant LOW 519G>C Pro173Pro
M0051139 LMHKMECL_00002 2111 3 Skin 0.50 protein_coding synonymous_variant LOW 177T>C Gly59Gly
M0051140 LMHKMECL_00002 2213 6 Skin 1.00 protein_coding synonymous_variant LOW 75T>G Ala25Ala
M0051141 LMHKMECL_00003 2558 5 Skin 0.83 protein_coding missense_variant MODERATE 1295C>T Ala432Val
M0051142 LMHKMECL_00003 2764 6 Skin 1.00 protein_coding synonymous_variant LOW 1089A>G Ala363Ala
M0051143 LMHKMECL_00003 3286 4 Skin 0.67 protein_coding synonymous_variant LOW 567T>C Ser189Ser
M0051144 LMHKMECL_00003 3682 6 Skin 1.00 protein_coding synonymous_variant LOW 171C>T Val57Val
M0051145 LMHKMECL_00004 4087 5 Skin 0.83 protein_coding synonymous_variant LOW 66T>C Pro22Pro
M0051146 LMHKMECL_00004 4135 4 Skin 0.67 protein_coding synonymous_variant LOW 114G>A Val38Val
M0051147 LMHKMECL_00005 5468 4 Skin 0.67 protein_coding missense_variant MODERATE 680T>C Val227Ala
M0051148 LMHKMECL_00005 5547 4 Skin 0.67 protein_coding synonymous_variant LOW 759T>C Tyr253Tyr
M0051149 LMHKMECL_00005 5998 4 Skin 0.67 protein_coding missense_variant MODERATE 1210C>A Leu404Ile
M0051150 LMHKMECL_00005 6321 5 Skin 0.83 protein_coding synonymous_variant LOW 1533T>C Ala511Ala
M0051151 LMHKMECL_00005 6399 5 Skin 0.83 protein_coding synonymous_variant LOW 1611T>C Thr537Thr
M0051152 LMHKMECL_00005 7221 5 Skin 0.83 protein_coding synonymous_variant LOW 2433T>G Val811Val
M0051153 LMHKMECL_00005 7224 4 Skin 0.67 protein_coding synonymous_variant LOW 2436T>C Val812Val
M0051154 LMHKMECL_00005 7530 5 Skin 0.83 protein_coding synonymous_variant LOW 2742T>G Thr914Thr
M0051155 LMHKMECL_00005 8100 5 Skin 0.83 protein_coding synonymous_variant LOW 3312T>C Ala1104Ala
M0051156 LMHKMECL_00005 8103 3 Skin 0.50 protein_coding synonymous_variant LOW 3315A>G Gln1105Gln
M0051157 LMHKMECL_00005 8115 4 Skin 0.67 protein_coding synonymous_variant LOW 3327T>C Asp1109Asp
M0051158 LMHKMECL_00001 799 3 Skin 0.50 protein_coding synonymous_variant LOW 759C>T Thr253Thr
M0051159 LMHKMECL_00004 1268 3 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -2754C>A None
M0051160 LMHKMECL_00002 1295 4 Skin 0.67 protein_coding synonymous_variant LOW 993A>G Leu331Leu
M0051161 LMHKMECL_00002 1612 4 Skin 0.67 protein_coding missense_variant MODERATE 676A>G Asn226Asp
M0051162 LMHKMECL_00002 1676 4 Skin 0.67 protein_coding synonymous_variant LOW 612A>G Ala204Ala
M0051163 LMHKMECL_00002 2286 3 Skin 0.50 protein_coding start_lost HIGH 2T>C Met1?
M0051164 LMHKMECL_00003 3044 3 Skin 0.50 protein_coding missense_variant MODERATE 809C>T Ala270Val
M0051165 LMHKMECL_00002 3901 4 Skin 0.67 protein_coding upstream_gene_variant MODIFIER -1614A>G None
M0051166 LMHKMECL_00005 5590 3 Skin 0.50 protein_coding missense_variant MODERATE 802A>C Thr268Pro
M0051167 LMHKMECL_00005 5918 3 Skin 0.50 protein_coding missense_variant MODERATE 1130A>T Gln377Leu
M0051168 LMHKMECL_00006 8642 3 Skin 0.50 protein_coding synonymous_variant LOW 474T>C Ala158Ala
M0051169 LMHKMECL_00006 8777 3 Skin 0.50 protein_coding synonymous_variant LOW 609G>A Leu203Leu
M0051170 LMHKMECL_00006 8834 3 Skin 0.50 protein_coding synonymous_variant LOW 666G>C Ala222Ala
M0051171 LMHKMECL_00006 9324 4 Skin 0.67 protein_coding missense_variant MODERATE 1156C>A Pro386Thr
M0051172 LMHKMECL_00004 9531 3 Skin 0.50 protein_coding downstream_gene_variant MODIFIER *4739G>C None
M0051173 LMHKMECL_00004 9610 4 Skin 0.67 protein_coding downstream_gene_variant MODIFIER *4818A>G None
M0051174 LMHKMECL_00005 9951 3 Skin 0.50 protein_coding downstream_gene_variant MODIFIER *1782A>G None
M0051175 LMHKMECL_00002 2090 3 Skin 0.50 protein_coding synonymous_variant LOW 198A>G Glu66Glu
M0051176 LMHKMECL_00003 3127 3 Skin 0.50 protein_coding synonymous_variant LOW 726C>T Gly242Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term