Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2693
  Reference Plasmid   1111525849860804_bin.6__k141_42738
  Reference Plasmid Size   36040
  Reference Plasmid GC Content   0.46
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0053019 EBDKEAED_00012 12594 3 Skin 0.08 protein_coding missense_variant MODERATE 875C>T Ala292Val
M0053020 EBDKEAED_00015 14326 10 Skin 0.26 protein_coding missense_variant MODERATE 145A>G Asn49Asp
M0053021 EBDKEAED_00016 16853 11 Skin 0.29 protein_coding synonymous_variant LOW 1758G>A Glu586Glu
M0053022 EBDKEAED_00016 17162 11 Skin 0.29 protein_coding synonymous_variant LOW 2067G>A Leu689Leu
M0053023 EBDKEAED_00006 6177 9 Skin 0.24 protein_coding missense_variant MODERATE 1778T>C Ile593Thr
M0053024 EBDKEAED_00010 10382 13 Skin 0.34 protein_coding missense_variant MODERATE 332T>C Val111Ala
M0053025 EBDKEAED_00012 11737 3 Skin 0.08 protein_coding synonymous_variant LOW 18G>A Gln6Gln
M0053026 EBDKEAED_00014 13813 6 Skin 0.16 protein_coding missense_variant MODERATE 390C>A Asp130Glu
M0053027 EBDKEAED_00016 15235 4 Skin 0.11 protein_coding missense_variant MODERATE 140C>T Ala47Val
M0053028 EBDKEAED_00001 648 3 Skin 0.08 protein_coding synonymous_variant LOW 477A>G Pro159Pro
M0053029 EBDKEAED_00006 5682 3 Skin 0.08 protein_coding missense_variant MODERATE 1283G>A Gly428Asp
M0053030 EBDKEAED_00006 5769 3 Skin 0.08 protein_coding missense_variant MODERATE 1370T>C Ile457Thr
M0053031 EBDKEAED_00007 6856 5 Skin 0.13 protein_coding synonymous_variant LOW 609G>A Lys203Lys
M0053032 EBDKEAED_00010 10155 5 Skin 0.13 protein_coding synonymous_variant LOW 105A>G Gly35Gly
M0053033 EBDKEAED_00012 12313 5 Skin 0.13 protein_coding synonymous_variant LOW 594C>T Phe198Phe
M0053034 EBDKEAED_00009 8783 3 Skin 0.08 protein_coding missense_variant MODERATE 430G>A Asp144Asn
M0053035 EBDKEAED_00012 11813 3 Skin 0.08 protein_coding missense_variant MODERATE 94C>T Arg32Cys
M0053036 EBDKEAED_00014 13765 3 Skin 0.08 protein_coding synonymous_variant LOW 342A>G Gln114Gln
M0053037 EBDKEAED_00018 18838 4 Skin 0.11 protein_coding synonymous_variant LOW 1104T>C Gly368Gly
M0053038 EBDKEAED_00024 24182 3 Skin 0.08 protein_coding upstream_gene_variant MODIFIER -130G>A None
M0053039 EBDKEAED_00013 13038 3 Skin 0.08 protein_coding missense_variant MODERATE 413A>G His138Arg






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
EBDKEAED_00032 ARO:3000245 73.6 1.57e-55 1 110 0.9402 0.9649 rifamycin antibiotic RbpA bacterial RNA polymerase-binding protein antibiotic target protection






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
EBDKEAED_00033 VHN99424.1|GT2 87.9 3.06e-163 1 255 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
EBDKEAED_00021 9.B.321.1.1 71.5 2.9e-49 12 148 0.9133 0.8457 9 Incompletely Characterized Transport Systems 9.B Putative transport proteins 9.B.321 The Actinobacterial Nutrient-sensing Signal Transduction Pathway Controlling Glutamate Metabolism (SigT) Family