Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2730
  Reference Plasmid   1111525849861727_bin.16__k141_74571
  Reference Plasmid Size   5658
  Reference Plasmid GC Content   0.37
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0132203 MFMPNAGL_00001 1366 4 Oral 0.57 protein_coding synonymous_variant LOW 432G>A Lys144Lys
M0132204 MFMPNAGL_00001 1539 3 Oral 0.43 protein_coding missense_variant MODERATE 259C>A Leu87Ile
M0132205 MFMPNAGL_00001 1606 3 Oral 0.43 protein_coding synonymous_variant LOW 192A>G Gly64Gly
M0132206 MFMPNAGL_00001 1639 3 Oral 0.43 protein_coding synonymous_variant LOW 159A>G Glu53Glu
M0132207 MFMPNAGL_00001 1660 5 Oral 0.71 protein_coding synonymous_variant LOW 138C>A Ser46Ser
M0132208 MFMPNAGL_00001 1663 4 Oral 0.57 protein_coding synonymous_variant LOW 135T>C Thr45Thr
M0132209 MFMPNAGL_00001 1705 4 Oral 0.57 protein_coding synonymous_variant LOW 93A>G Val31Val
M0132210 MFMPNAGL_00001 1723 5 Oral 0.71 protein_coding synonymous_variant LOW 75T>C Thr25Thr
M0132211 MFMPNAGL_00001 1879 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -82G>A None
M0132212 MFMPNAGL_00001 1882 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -85A>T None
M0132213 MFMPNAGL_00001 1940 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -143A>G None
M0132214 MFMPNAGL_00001 1995 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -198T>C None
M0132215 MFMPNAGL_00001 2018 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -221A>G None
M0132216 MFMPNAGL_00002 2065 5 Oral 0.71 protein_coding synonymous_variant LOW 2481T>C Ala827Ala
M0132217 MFMPNAGL_00002 2273 5 Oral 0.71 protein_coding missense_variant MODERATE 2273A>G Asp758Gly
M0132218 MFMPNAGL_00002 2545 5 Oral 0.71 protein_coding synonymous_variant LOW 2001T>C Pro667Pro
M0132219 MFMPNAGL_00002 2704 4 Oral 0.57 protein_coding synonymous_variant LOW 1842T>C Ser614Ser
M0132220 MFMPNAGL_00002 2761 4 Oral 0.57 protein_coding synonymous_variant LOW 1785A>T Pro595Pro
M0132221 MFMPNAGL_00002 2770 3 Oral 0.43 protein_coding synonymous_variant LOW 1776C>T Asp592Asp
M0132222 MFMPNAGL_00002 2854 3 Oral 0.43 protein_coding synonymous_variant LOW 1692T>C Arg564Arg
M0132223 MFMPNAGL_00002 2956 5 Oral 0.71 protein_coding synonymous_variant LOW 1590T>C Gly530Gly
M0132224 MFMPNAGL_00002 2998 3 Oral 0.43 protein_coding synonymous_variant LOW 1548C>T Thr516Thr
M0132225 MFMPNAGL_00002 3031 5 Oral 0.71 protein_coding synonymous_variant LOW 1515G>T Val505Val
M0132226 MFMPNAGL_00002 3040 5 Oral 0.71 protein_coding synonymous_variant LOW 1506G>A Lys502Lys
M0132227 MFMPNAGL_00002 3333 4 Oral 0.57 protein_coding missense_variant MODERATE 1213T>A Phe405Ile
M0132228 MFMPNAGL_00002 3376 3 Oral 0.43 protein_coding synonymous_variant LOW 1170G>A Lys390Lys
M0132229 MFMPNAGL_00002 3382 3 Oral 0.43 protein_coding synonymous_variant LOW 1164T>A Leu388Leu
M0132230 MFMPNAGL_00002 3391 3 Oral 0.43 protein_coding synonymous_variant LOW 1155T>C Val385Val
M0132231 MFMPNAGL_00002 3403 3 Oral 0.43 protein_coding synonymous_variant LOW 1143C>T Tyr381Tyr
M0132232 MFMPNAGL_00002 3475 3 Oral 0.43 protein_coding synonymous_variant LOW 1071T>A Ile357Ile
M0132233 MFMPNAGL_00002 3481 4 Oral 0.57 protein_coding synonymous_variant LOW 1065T>A Pro355Pro
M0132234 MFMPNAGL_00002 3513 4 Oral 0.57 protein_coding synonymous_variant LOW 1033C>T Leu345Leu
M0132235 MFMPNAGL_00002 3541 4 Oral 0.57 protein_coding synonymous_variant LOW 1005T>C Asp335Asp
M0132236 MFMPNAGL_00002 3586 3 Oral 0.43 protein_coding synonymous_variant LOW 960A>T Ile320Ile
M0132237 MFMPNAGL_00002 3817 4 Oral 0.57 protein_coding synonymous_variant LOW 729C>T Gly243Gly
M0132238 MFMPNAGL_00002 3853 3 Oral 0.43 protein_coding synonymous_variant LOW 693T>C Val231Val
M0132239 MFMPNAGL_00002 3934 3 Oral 0.43 protein_coding synonymous_variant LOW 612A>G Lys204Lys
M0132240 MFMPNAGL_00002 4042 4 Oral 0.57 protein_coding synonymous_variant LOW 504T>C Asn168Asn
M0132241 MFMPNAGL_00002 4114 4 Oral 0.57 protein_coding synonymous_variant LOW 432C>T Ile144Ile
M0132242 MFMPNAGL_00002 4239 3 Oral 0.43 protein_coding missense_variant MODERATE 307G>T Ala103Ser
M0132243 MFMPNAGL_00002 4408 3 Oral 0.43 protein_coding synonymous_variant LOW 138T>C Ile46Ile
M0132244 MFMPNAGL_00002 4414 3 Oral 0.43 protein_coding synonymous_variant LOW 132G>A Ala44Ala
M0132245 MFMPNAGL_00001 4613 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -2816A>T None
M0132246 MFMPNAGL_00001 4622 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -2825T>G None
M0132247 MFMPNAGL_00001 4698 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -2901A>G None
M0132248 MFMPNAGL_00003 44 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -4856T>A None
M0132249 MFMPNAGL_00003 118 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4782A>T None
M0132250 MFMPNAGL_00003 127 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4773T>A None
M0132251 MFMPNAGL_00003 133 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4767T>C None
M0132252 MFMPNAGL_00003 187 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4713G>A None
M0132253 MFMPNAGL_00003 196 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4704G>A None
M0132254 MFMPNAGL_00003 236 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -4664T>C None
M0132255 MFMPNAGL_00003 374 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -4526C>T None
M0132256 MFMPNAGL_00003 579 4 Oral 0.57 protein_coding upstream_gene_variant MODIFIER -4321A>G None
M0132257 MFMPNAGL_00003 610 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4290A>G None
M0132258 MFMPNAGL_00003 620 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4280G>T None
M0132259 MFMPNAGL_00003 647 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4253A>G None
M0132260 MFMPNAGL_00003 659 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4241A>G None
M0132261 MFMPNAGL_00003 667 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4233A>G None
M0132262 MFMPNAGL_00003 671 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4229G>C None
M0132263 MFMPNAGL_00003 698 5 Oral 0.71 protein_coding upstream_gene_variant MODIFIER -4202G>A None
M0132264 MFMPNAGL_00001 736 4 Oral 0.57 protein_coding missense_variant MODERATE 1062G>T Glu354Asp
M0132265 MFMPNAGL_00001 742 4 Oral 0.57 protein_coding synonymous_variant LOW 1056A>C Thr352Thr
M0132266 MFMPNAGL_00001 868 3 Oral 0.43 protein_coding synonymous_variant LOW 930G>A Val310Val
M0132267 MFMPNAGL_00001 907 5 Oral 0.71 protein_coding synonymous_variant LOW 891A>G Glu297Glu
M0132268 MFMPNAGL_00001 946 4 Oral 0.57 protein_coding synonymous_variant LOW 852A>G Leu284Leu
M0132269 MFMPNAGL_00001 979 5 Oral 0.71 protein_coding missense_variant MODERATE 819T>G Asp273Glu
M0132270 MFMPNAGL_00001 1102 4 Oral 0.57 protein_coding synonymous_variant LOW 696A>G Lys232Lys
M0132271 MFMPNAGL_00001 1357 4 Oral 0.57 protein_coding synonymous_variant LOW 441A>T Ala147Ala
M0132272 MFMPNAGL_00002 2218 4 Oral 0.57 protein_coding synonymous_variant LOW 2328C>A Thr776Thr
M0132273 MFMPNAGL_00002 3880 3 Oral 0.43 protein_coding synonymous_variant LOW 666C>A Gly222Gly
M0132274 MFMPNAGL_00002 4093 3 Oral 0.43 protein_coding synonymous_variant LOW 453C>T Leu151Leu
M0132275 MFMPNAGL_00003 128 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -4772A>G None
M0132276 MFMPNAGL_00001 1339 3 Oral 0.43 protein_coding synonymous_variant LOW 459G>A Gln153Gln
M0132277 MFMPNAGL_00001 1961 3 Oral 0.43 protein_coding upstream_gene_variant MODIFIER -164A>G None
M0132278 MFMPNAGL_00002 2482 3 Oral 0.43 protein_coding synonymous_variant LOW 2064C>T Asp688Asp






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term