Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2735
  Reference Plasmid   1111525849861727_bin.16__k141_91402
  Reference Plasmid Size   3751
  Reference Plasmid GC Content   0.38
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0132563 LABHCDLP_00001 272 5 Oral 0.63 protein_coding synonymous_variant LOW 147T>A Ala49Ala
M0132564 LABHCDLP_00001 451 6 Oral 0.75 protein_coding missense_variant MODERATE 326T>C Ile109Thr
M0132565 LABHCDLP_00002 716 5 Oral 0.63 protein_coding synonymous_variant LOW 24T>C Tyr8Tyr
M0132566 LABHCDLP_00002 1029 7 Oral 0.88 protein_coding missense_variant MODERATE 337G>A Ala113Thr
M0132567 LABHCDLP_00002 1076 6 Oral 0.75 protein_coding synonymous_variant LOW 384A>G Ala128Ala
M0132568 LABHCDLP_00002 1238 5 Oral 0.63 protein_coding synonymous_variant LOW 546T>C Ile182Ile
M0132569 LABHCDLP_00003 1502 7 Oral 0.88 protein_coding synonymous_variant LOW 66T>C Gly22Gly
M0132570 LABHCDLP_00003 1511 7 Oral 0.88 protein_coding synonymous_variant LOW 75T>C Gly25Gly
M0132571 LABHCDLP_00003 1514 7 Oral 0.88 protein_coding synonymous_variant LOW 78A>T Ala26Ala
M0132572 LABHCDLP_00003 1580 3 Oral 0.38 protein_coding synonymous_variant LOW 144T>A Thr48Thr
M0132573 LABHCDLP_00003 1584 5 Oral 0.63 protein_coding missense_variant MODERATE 148G>A Asp50Asn
M0132574 LABHCDLP_00003 1709 7 Oral 0.88 protein_coding synonymous_variant LOW 273G>C Ala91Ala
M0132575 LABHCDLP_00003 1754 6 Oral 0.75 protein_coding synonymous_variant LOW 318A>G Leu106Leu
M0132576 LABHCDLP_00003 1757 5 Oral 0.63 protein_coding missense_variant MODERATE 321A>C Gln107His
M0132577 LABHCDLP_00003 1760 5 Oral 0.63 protein_coding synonymous_variant LOW 324G>A Gln108Gln
M0132578 LABHCDLP_00003 1784 6 Oral 0.75 protein_coding synonymous_variant LOW 348G>A Glu116Glu
M0132579 LABHCDLP_00003 1811 3 Oral 0.38 protein_coding synonymous_variant LOW 375G>A Val125Val
M0132580 LABHCDLP_00003 1885 7 Oral 0.88 protein_coding missense_variant MODERATE 449A>T Asp150Val
M0132581 LABHCDLP_00003 1953 7 Oral 0.88 protein_coding synonymous_variant LOW 517T>C Leu173Leu
M0132582 LABHCDLP_00003 2030 3 Oral 0.38 protein_coding synonymous_variant LOW 594C>T Arg198Arg
M0132583 LABHCDLP_00003 2075 3 Oral 0.38 protein_coding synonymous_variant LOW 639C>T Gly213Gly
M0132584 LABHCDLP_00003 2222 6 Oral 0.75 protein_coding synonymous_variant LOW 786A>G Glu262Glu
M0132585 LABHCDLP_00003 2246 3 Oral 0.38 protein_coding synonymous_variant LOW 810C>T Asn270Asn
M0132586 LABHCDLP_00003 2280 7 Oral 0.88 protein_coding synonymous_variant LOW 844C>T Leu282Leu
M0132587 LABHCDLP_00003 2288 6 Oral 0.75 protein_coding synonymous_variant LOW 852T>C Asn284Asn
M0132588 LABHCDLP_00003 2387 7 Oral 0.88 protein_coding synonymous_variant LOW 951T>C His317His
M0132589 LABHCDLP_00003 2404 7 Oral 0.88 protein_coding missense_variant MODERATE 968A>G Lys323Arg
M0132590 LABHCDLP_00003 2459 7 Oral 0.88 protein_coding synonymous_variant LOW 1023T>C Tyr341Tyr
M0132591 LABHCDLP_00003 2591 4 Oral 0.50 protein_coding synonymous_variant LOW 1155C>A Ile385Ile
M0132592 LABHCDLP_00003 2655 3 Oral 0.38 protein_coding missense_variant MODERATE 1219A>C Lys407Gln
M0132593 LABHCDLP_00001 2801 6 Oral 0.75 protein_coding downstream_gene_variant MODIFIER *2301A>T None
M0132594 LABHCDLP_00001 2891 4 Oral 0.50 protein_coding downstream_gene_variant MODIFIER *2391T>C None
M0132595 LABHCDLP_00001 3257 7 Oral 0.88 protein_coding downstream_gene_variant MODIFIER *2757T>C None
M0132596 LABHCDLP_00001 3269 7 Oral 0.88 protein_coding downstream_gene_variant MODIFIER *2769T>C None
M0132597 LABHCDLP_00001 3317 6 Oral 0.75 protein_coding downstream_gene_variant MODIFIER *2817A>T None
M0132598 LABHCDLP_00001 3533 7 Oral 0.88 protein_coding downstream_gene_variant MODIFIER *3033A>G None
M0132599 LABHCDLP_00001 3539 3 Oral 0.38 protein_coding downstream_gene_variant MODIFIER *3039A>G None
M0132600 LABHCDLP_00001 3542 7 Oral 0.88 protein_coding downstream_gene_variant MODIFIER *3042T>C None
M0132601 LABHCDLP_00003 1381 5 Oral 0.63 protein_coding upstream_gene_variant MODIFIER -56T>C None
M0132602 LABHCDLP_00003 1413 5 Oral 0.63 protein_coding upstream_gene_variant MODIFIER -24T>C None
M0132603 LABHCDLP_00003 1416 4 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -21T>C None
M0132604 LABHCDLP_00003 1417 4 Oral 0.50 protein_coding upstream_gene_variant MODIFIER -20T>C None
M0132605 LABHCDLP_00003 1964 6 Oral 0.75 protein_coding synonymous_variant LOW 528A>T Ala176Ala
M0132606 LABHCDLP_00001 3302 4 Oral 0.50 protein_coding downstream_gene_variant MODIFIER *2802C>T None
M0132607 LABHCDLP_00001 3422 5 Oral 0.63 protein_coding downstream_gene_variant MODIFIER *2922T>C None
M0132608 LABHCDLP_00001 3479 5 Oral 0.63 protein_coding downstream_gene_variant MODIFIER *2979A>G None
M0132609 LABHCDLP_00002 965 3 Oral 0.38 protein_coding synonymous_variant LOW 273T>C Tyr91Tyr
M0132610 LABHCDLP_00002 1098 3 Oral 0.38 protein_coding missense_variant MODERATE 406G>A Ala136Thr
M0132611 LABHCDLP_00003 1943 4 Oral 0.50 protein_coding synonymous_variant LOW 507C>T Leu169Leu
M0132612 LABHCDLP_00003 2432 4 Oral 0.50 protein_coding synonymous_variant LOW 996A>G Glu332Glu
M0132613 LABHCDLP_00001 3587 4 Oral 0.50 protein_coding downstream_gene_variant MODIFIER *3087T>A None
M0132614 LABHCDLP_00001 3686 3 Oral 0.38 protein_coding downstream_gene_variant MODIFIER *3186G>A None
M0132615 LABHCDLP_00001 3704 3 Oral 0.38 protein_coding downstream_gene_variant MODIFIER *3204G>A None
M0132616 LABHCDLP_00003 2561 4 Oral 0.50 protein_coding synonymous_variant LOW 1125T>A Gly375Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term