Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2780
  Reference Plasmid   1111525849862995_bin.15__k141_204009
  Reference Plasmid Size   24555
  Reference Plasmid GC Content   0.70
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0056768 NMHLMDPL_00021 21915 3 Skin 0.38 protein_coding synonymous_variant LOW 366C>T Arg122Arg
M0056769 NMHLMDPL_00022 22294 3 Skin 0.38 protein_coding missense_variant MODERATE 114A>C Lys38Asn
M0056770 NMHLMDPL_00022 22297 3 Skin 0.38 protein_coding synonymous_variant LOW 111A>C Gly37Gly
M0056771 NMHLMDPL_00022 22324 3 Skin 0.38 protein_coding synonymous_variant LOW 84T>C Ala28Ala
M0056772 NMHLMDPL_00017 22408 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -4063A>G None
M0056773 NMHLMDPL_00017 22487 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -4142C>A None
M0056774 NMHLMDPL_00023 22802 3 Skin 0.38 protein_coding missense_variant MODERATE 1013C>T Ala338Val
M0056775 NMHLMDPL_00023 22834 3 Skin 0.38 protein_coding synonymous_variant LOW 981T>C Leu327Leu
M0056776 NMHLMDPL_00023 23083 4 Skin 0.50 protein_coding synonymous_variant LOW 732C>T Asp244Asp
M0056777 NMHLMDPL_00023 23122 4 Skin 0.50 protein_coding synonymous_variant LOW 693T>C Leu231Leu
M0056778 NMHLMDPL_00023 23134 4 Skin 0.50 protein_coding synonymous_variant LOW 681A>G Glu227Glu
M0056779 NMHLMDPL_00023 23138 4 Skin 0.50 protein_coding missense_variant MODERATE 677A>G Asp226Gly
M0056780 NMHLMDPL_00023 23144 4 Skin 0.50 protein_coding missense_variant MODERATE 671C>T Ala224Val
M0056781 NMHLMDPL_00023 23149 3 Skin 0.38 protein_coding synonymous_variant LOW 666C>G Val222Val
M0056782 NMHLMDPL_00023 23631 3 Skin 0.38 protein_coding missense_variant MODERATE 184A>G Asn62Asp
M0056783 NMHLMDPL_00024 24047 4 Skin 0.50 protein_coding missense_variant MODERATE 488G>A Ser163Asn
M0056784 NMHLMDPL_00024 24313 3 Skin 0.38 protein_coding synonymous_variant LOW 222T>C Arg74Arg
M0056785 NMHLMDPL_00010 10164 3 Skin 0.38 protein_coding synonymous_variant LOW 72G>A Ala24Ala
M0056786 NMHLMDPL_00011 10477 3 Skin 0.38 protein_coding synonymous_variant LOW 105C>T Ala35Ala
M0056787 NMHLMDPL_00008 10840 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -3929C>T None
M0056788 NMHLMDPL_00008 10855 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -3944G>T None
M0056789 NMHLMDPL_00008 10864 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -3953C>T None
M0056790 NMHLMDPL_00012 11244 3 Skin 0.38 protein_coding missense_variant MODERATE 709C>T Pro237Ser
M0056791 NMHLMDPL_00010 12032 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -1797A>G None
M0056792 NMHLMDPL_00013 12749 3 Skin 0.38 protein_coding synonymous_variant LOW 642T>C Tyr214Tyr
M0056793 NMHLMDPL_00013 12773 3 Skin 0.38 protein_coding synonymous_variant LOW 666T>C Gly222Gly
M0056794 NMHLMDPL_00013 12774 3 Skin 0.38 protein_coding synonymous_variant LOW 667T>C Leu223Leu
M0056795 NMHLMDPL_00013 12788 3 Skin 0.38 protein_coding synonymous_variant LOW 681G>C Thr227Thr
M0056796 NMHLMDPL_00013 12824 3 Skin 0.38 protein_coding synonymous_variant LOW 717A>G Glu239Glu
M0056797 NMHLMDPL_00013 12833 3 Skin 0.38 protein_coding synonymous_variant LOW 726T>C Gly242Gly
M0056798 NMHLMDPL_00013 12854 3 Skin 0.38 protein_coding synonymous_variant LOW 747C>G Leu249Leu
M0056799 NMHLMDPL_00014 13369 3 Skin 0.38 protein_coding synonymous_variant LOW 1308A>G Ser436Ser
M0056800 NMHLMDPL_00014 13460 3 Skin 0.38 protein_coding missense_variant MODERATE 1217C>T Thr406Ile
M0056801 NMHLMDPL_00014 14197 3 Skin 0.38 protein_coding missense_variant MODERATE 480A>G Ile160Met
M0056802 NMHLMDPL_00014 14216 3 Skin 0.38 protein_coding missense_variant MODERATE 461G>A Gly154Glu
M0056803 NMHLMDPL_00015 15568 3 Skin 0.38 protein_coding synonymous_variant LOW 696A>G Gly232Gly
M0056804 NMHLMDPL_00015 16267 3 Skin 0.38 protein_coding synonymous_variant LOW 1395G>A Glu465Glu
M0056805 NMHLMDPL_00019 20010 3 Skin 0.38 protein_coding synonymous_variant LOW 756A>G Ala252Ala
M0056806 NMHLMDPL_00011 10641 3 Skin 0.38 protein_coding missense_variant MODERATE 269C>A Ala90Asp






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term