Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2786
  Reference Plasmid   1111525849862995_bin.15__k141_405577
  Reference Plasmid Size   24858
  Reference Plasmid GC Content   0.70
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0056917 IOKMIAPP_00005 6074 6 Skin 0.55 protein_coding missense_variant MODERATE 856A>G Thr286Ala
M0056918 IOKMIAPP_00007 8240 5 Skin 0.45 protein_coding missense_variant MODERATE 849G>C Leu283Phe
M0056919 IOKMIAPP_00002 9219 4 Skin 0.36 protein_coding upstream_gene_variant MODIFIER -4739T>C None
M0056920 IOKMIAPP_00002 9309 4 Skin 0.36 protein_coding upstream_gene_variant MODIFIER -4829C>T None
M0056921 IOKMIAPP_00002 9311 4 Skin 0.36 protein_coding upstream_gene_variant MODIFIER -4831A>G None
M0056922 IOKMIAPP_00008 9572 3 Skin 0.27 protein_coding synonymous_variant LOW 99C>T Val33Val
M0056923 IOKMIAPP_00008 9587 3 Skin 0.27 protein_coding synonymous_variant LOW 114A>G Ala38Ala
M0056924 IOKMIAPP_00008 9597 3 Skin 0.27 protein_coding missense_variant MODERATE 124G>A Ala42Thr
M0056925 IOKMIAPP_00008 9602 3 Skin 0.27 protein_coding synonymous_variant LOW 129G>A Glu43Glu
M0056926 IOKMIAPP_00008 9605 3 Skin 0.27 protein_coding synonymous_variant LOW 132G>C Leu44Leu
M0056927 IOKMIAPP_00010 11226 3 Skin 0.27 protein_coding stop_lost&splice_region_variant HIGH 574T>A Ter192Lysext*?
M0056928 IOKMIAPP_00010 11493 3 Skin 0.27 protein_coding missense_variant MODERATE 307A>G Thr103Ala
M0056929 IOKMIAPP_00005 6123 4 Skin 0.36 protein_coding synonymous_variant LOW 807G>C Pro269Pro
M0056930 IOKMIAPP_00005 6321 4 Skin 0.36 protein_coding synonymous_variant LOW 609C>T Gly203Gly
M0056931 IOKMIAPP_00005 6343 4 Skin 0.36 protein_coding missense_variant MODERATE 587T>C Val196Ala
M0056932 IOKMIAPP_00005 6354 4 Skin 0.36 protein_coding synonymous_variant LOW 576C>T Ile192Ile
M0056933 IOKMIAPP_00005 6356 4 Skin 0.36 protein_coding missense_variant MODERATE 574A>G Ile192Val
M0056934 IOKMIAPP_00005 6471 4 Skin 0.36 protein_coding synonymous_variant LOW 459C>T Gly153Gly
M0056935 IOKMIAPP_00005 6480 4 Skin 0.36 protein_coding missense_variant MODERATE 450C>A Asp150Glu
M0056936 IOKMIAPP_00005 6800 4 Skin 0.36 protein_coding missense_variant MODERATE 130T>A Ser44Thr
M0056937 IOKMIAPP_00005 6843 3 Skin 0.27 protein_coding synonymous_variant LOW 87T>C Gly29Gly
M0056938 IOKMIAPP_00006 6971 4 Skin 0.36 protein_coding synonymous_variant LOW 834T>C Phe278Phe
M0056939 IOKMIAPP_00006 7112 4 Skin 0.36 protein_coding synonymous_variant LOW 693C>T Tyr231Tyr
M0056940 IOKMIAPP_00007 8084 4 Skin 0.36 protein_coding synonymous_variant LOW 1005A>C Thr335Thr
M0056941 IOKMIAPP_00007 8687 3 Skin 0.27 protein_coding synonymous_variant LOW 402C>G Ser134Ser
M0056942 IOKMIAPP_00002 9294 3 Skin 0.27 protein_coding upstream_gene_variant MODIFIER -4814T>C None
M0056943 IOKMIAPP_00002 9295 3 Skin 0.27 protein_coding upstream_gene_variant MODIFIER -4815C>T None
M0056944 IOKMIAPP_00020 21174 3 Skin 0.27 protein_coding missense_variant MODERATE 1141A>G Met381Val
M0056945 IOKMIAPP_00020 21239 3 Skin 0.27 protein_coding missense_variant MODERATE 1076C>T Ala359Val
M0056946 IOKMIAPP_00002 2519 3 Skin 0.27 protein_coding synonymous_variant LOW 1962G>T Pro654Pro
M0056947 IOKMIAPP_00002 3482 3 Skin 0.27 protein_coding synonymous_variant LOW 999T>C Gly333Gly
M0056948 IOKMIAPP_00002 3555 3 Skin 0.27 protein_coding missense_variant MODERATE 926A>T Gln309Leu
M0056949 IOKMIAPP_00002 3593 3 Skin 0.27 protein_coding synonymous_variant LOW 888A>C Ser296Ser
M0056950 IOKMIAPP_00002 3612 3 Skin 0.27 protein_coding missense_variant MODERATE 869G>C Gly290Ala
M0056951 IOKMIAPP_00002 3621 3 Skin 0.27 protein_coding missense_variant MODERATE 860G>T Arg287Leu
M0056952 IOKMIAPP_00002 3625 3 Skin 0.27 protein_coding missense_variant MODERATE 856G>A Asp286Asn
M0056953 IOKMIAPP_00002 3642 3 Skin 0.27 protein_coding missense_variant MODERATE 839G>A Gly280Glu
M0056954 IOKMIAPP_00002 3647 3 Skin 0.27 protein_coding synonymous_variant LOW 834C>T Ala278Ala
M0056955 IOKMIAPP_00002 3783 3 Skin 0.27 protein_coding missense_variant MODERATE 698C>T Ala233Val
M0056956 IOKMIAPP_00002 3794 3 Skin 0.27 protein_coding synonymous_variant LOW 687A>G Gln229Gln
M0056957 IOKMIAPP_00002 3800 3 Skin 0.27 protein_coding synonymous_variant LOW 681C>G Arg227Arg
M0056958 IOKMIAPP_00002 4475 3 Skin 0.27 protein_coding synonymous_variant LOW 6C>T Ser2Ser
M0056959 IOKMIAPP_00003 4945 3 Skin 0.27 protein_coding synonymous_variant LOW 252A>G Arg84Arg
M0056960 IOKMIAPP_00003 5153 3 Skin 0.27 protein_coding missense_variant MODERATE 44A>T Lys15Met
M0056961 IOKMIAPP_00004 5529 4 Skin 0.36 protein_coding missense_variant MODERATE 383C>T Thr128Ile
M0056962 IOKMIAPP_00004 5530 4 Skin 0.36 protein_coding missense_variant MODERATE 382A>C Thr128Pro
M0056963 IOKMIAPP_00004 5531 4 Skin 0.36 protein_coding synonymous_variant LOW 381C>G Leu127Leu
M0056964 IOKMIAPP_00004 5534 4 Skin 0.36 protein_coding missense_variant MODERATE 378C>G Ser126Arg
M0056965 IOKMIAPP_00004 5536 4 Skin 0.36 protein_coding missense_variant MODERATE 376A>G Ser126Gly
M0056966 IOKMIAPP_00004 5615 3 Skin 0.27 protein_coding synonymous_variant LOW 297C>T Asn99Asn
M0056967 IOKMIAPP_00004 5637 4 Skin 0.36 protein_coding missense_variant MODERATE 275T>A Val92Asp
M0056968 IOKMIAPP_00004 5795 4 Skin 0.36 protein_coding missense_variant MODERATE 117A>C Lys39Asn
M0056969 IOKMIAPP_00001 1344 3 Skin 0.27 protein_coding synonymous_variant LOW 1068T>C Arg356Arg
M0056970 IOKMIAPP_00001 1425 3 Skin 0.27 protein_coding synonymous_variant LOW 987A>G Ala329Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term