Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2875
  Reference Plasmid   DP1807004577_bin.4__NODE_148_length_9013_cov_3.816468
  Reference Plasmid Size   9013
  Reference Plasmid GC Content   0.64
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0064983 EEDMMGEO_00003 3450 15 Skin 0.29 protein_coding missense_variant MODERATE 1156A>G Thr386Ala
M0064984 EEDMMGEO_00004 4301 10 Skin 0.19 protein_coding missense_variant MODERATE 217T>G Phe73Val
M0064985 EEDMMGEO_00006 5002 17 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -724C>A None
M0064986 EEDMMGEO_00006 5003 17 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -723T>A None
M0064987 EEDMMGEO_00006 5006 16 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -720T>A None
M0064988 EEDMMGEO_00006 5007 16 Skin 0.31 protein_coding upstream_gene_variant MODIFIER -719T>G None
M0064989 EEDMMGEO_00007 6258 29 Skin 0.56 protein_coding missense_variant MODERATE 43T>C Phe15Leu
M0064990 EEDMMGEO_00008 6724 11 Skin 0.21 protein_coding missense_variant MODERATE 283A>G Ser95Gly
M0064991 EEDMMGEO_00008 6798 10 Skin 0.19 protein_coding synonymous_variant LOW 357C>T Pro119Pro
M0064992 EEDMMGEO_00008 6810 10 Skin 0.19 protein_coding synonymous_variant LOW 369T>C Asp123Asp
M0064993 EEDMMGEO_00008 6813 10 Skin 0.19 protein_coding synonymous_variant LOW 372T>G Ala124Ala
M0064994 EEDMMGEO_00003 3696 7 Skin 0.13 protein_coding missense_variant MODERATE 1402G>T Ala468Ser
M0064995 EEDMMGEO_00004 4478 13 Skin 0.25 protein_coding missense_variant MODERATE 394G>A Glu132Lys
M0064996 EEDMMGEO_00006 5769 3 Skin 0.06 protein_coding missense_variant MODERATE 44A>G Gln15Arg
M0064997 EEDMMGEO_00003 4024 5 Skin 0.10 protein_coding missense_variant MODERATE 1730T>C Val577Ala
M0064998 EEDMMGEO_00005 5249 7 Skin 0.13 protein_coding missense_variant MODERATE 269C>T Ala90Val
M0064999 EEDMMGEO_00002 1672 7 Skin 0.13 protein_coding missense_variant MODERATE 1195C>G Arg399Gly
M0065000 EEDMMGEO_00002 1394 4 Skin 0.08 protein_coding missense_variant MODERATE 917T>C Leu306Pro
M0065001 EEDMMGEO_00005 5592 4 Skin 0.08 protein_coding upstream_gene_variant MODIFIER -75A>G None
M0065002 EEDMMGEO_00008 6834 6 Skin 0.12 protein_coding synonymous_variant LOW 393C>G Ala131Ala
M0065003 EEDMMGEO_00008 6835 6 Skin 0.12 protein_coding missense_variant MODERATE 394T>A Cys132Ser
M0065004 EEDMMGEO_00008 6846 6 Skin 0.12 protein_coding synonymous_variant LOW 405C>T Asp135Asp
M0065005 EEDMMGEO_00008 6861 6 Skin 0.12 protein_coding synonymous_variant LOW 420T>G Gly140Gly
M0065006 EEDMMGEO_00008 6873 6 Skin 0.12 protein_coding synonymous_variant LOW 432G>A Thr144Thr
M0065007 EEDMMGEO_00008 6876 6 Skin 0.12 protein_coding synonymous_variant LOW 435C>T Ala145Ala






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term