Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2877
  Reference Plasmid   DP1808006645_bin.6__NODE_1157_length_3367_cov_2.309058
  Reference Plasmid Size   3367
  Reference Plasmid GC Content   0.42
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0065018 FHKNELMN_00001 245 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -1064G>A None
M0065019 FHKNELMN_00001 266 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -1043C>T None
M0065020 FHKNELMN_00001 281 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -1028G>A None
M0065021 FHKNELMN_00001 479 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -830C>T None
M0065022 FHKNELMN_00001 517 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -792C>T None
M0065023 FHKNELMN_00001 530 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -779C>T None
M0065024 FHKNELMN_00001 533 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -776A>G None
M0065025 FHKNELMN_00001 536 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -773A>G None
M0065026 FHKNELMN_00001 537 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -772T>C None
M0065027 FHKNELMN_00001 538 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -771T>C None
M0065028 FHKNELMN_00001 542 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -767G>T None
M0065029 FHKNELMN_00001 545 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -764G>A None
M0065030 FHKNELMN_00001 548 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -761T>C None
M0065031 FHKNELMN_00001 554 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -755A>G None
M0065032 FHKNELMN_00001 575 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -734A>G None
M0065033 FHKNELMN_00001 578 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -731C>A None
M0065034 FHKNELMN_00001 605 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -704T>A None
M0065035 FHKNELMN_00001 611 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -698A>G None
M0065036 FHKNELMN_00001 626 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -683C>T None
M0065037 FHKNELMN_00001 638 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -671G>T None
M0065038 FHKNELMN_00001 708 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -601C>A None
M0065039 FHKNELMN_00001 719 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -590A>G None
M0065040 FHKNELMN_00001 725 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -584A>G None
M0065041 FHKNELMN_00001 731 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -578A>T None
M0065042 FHKNELMN_00001 733 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -576G>A None
M0065043 FHKNELMN_00001 735 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -574G>T None
M0065044 FHKNELMN_00001 740 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -569G>A None
M0065045 FHKNELMN_00001 752 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -557T>A None
M0065046 FHKNELMN_00001 761 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -548T>C None
M0065047 FHKNELMN_00001 767 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -542G>A None
M0065048 FHKNELMN_00001 770 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -539T>C None
M0065049 FHKNELMN_00001 890 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -419A>G None
M0065050 FHKNELMN_00001 908 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -401G>A None
M0065051 FHKNELMN_00001 919 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -390A>G None
M0065052 FHKNELMN_00001 920 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -389A>G None
M0065053 FHKNELMN_00001 932 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -377A>G None
M0065054 FHKNELMN_00001 965 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -344A>G None
M0065055 FHKNELMN_00001 968 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -341C>G None
M0065056 FHKNELMN_00001 973 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -336C>T None
M0065057 FHKNELMN_00001 974 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -335G>C None
M0065058 FHKNELMN_00001 982 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -327A>G None
M0065059 FHKNELMN_00001 989 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -320G>A None
M0065060 FHKNELMN_00001 1151 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -158T>G None
M0065061 FHKNELMN_00001 1394 3 Skin 0.60 protein_coding missense_variant MODERATE 86G>A Arg29His
M0065062 FHKNELMN_00001 1395 3 Skin 0.60 protein_coding synonymous_variant LOW 87C>G Arg29Arg
M0065063 FHKNELMN_00001 1545 3 Skin 0.60 protein_coding synonymous_variant LOW 237C>T Tyr79Tyr
M0065064 FHKNELMN_00001 1603 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *31C>A None
M0065065 FHKNELMN_00002 1698 3 Skin 0.60 protein_coding synonymous_variant LOW 1626A>G Lys542Lys
M0065066 FHKNELMN_00002 1713 3 Skin 0.60 protein_coding synonymous_variant LOW 1611C>T Leu537Leu
M0065067 FHKNELMN_00002 1779 3 Skin 0.60 protein_coding synonymous_variant LOW 1545A>C Gly515Gly
M0065068 FHKNELMN_00002 1818 3 Skin 0.60 protein_coding synonymous_variant LOW 1506T>C Val502Val
M0065069 FHKNELMN_00002 1853 3 Skin 0.60 protein_coding synonymous_variant LOW 1471A>C Arg491Arg
M0065070 FHKNELMN_00002 1854 3 Skin 0.60 protein_coding synonymous_variant LOW 1470C>T Arg490Arg
M0065071 FHKNELMN_00002 1901 3 Skin 0.60 protein_coding missense_variant MODERATE 1423A>G Asn475Asp
M0065072 FHKNELMN_00002 1957 3 Skin 0.60 protein_coding missense_variant MODERATE 1367A>C Asn456Thr
M0065073 FHKNELMN_00002 1959 3 Skin 0.60 protein_coding synonymous_variant LOW 1365T>C Asp455Asp
M0065074 FHKNELMN_00002 1989 3 Skin 0.60 protein_coding synonymous_variant LOW 1335T>C Ala445Ala
M0065075 FHKNELMN_00002 2003 3 Skin 0.60 protein_coding missense_variant MODERATE 1321G>A Asp441Asn
M0065076 FHKNELMN_00002 2004 3 Skin 0.60 protein_coding synonymous_variant LOW 1320T>C Pro440Pro






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term