Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C2947
  Reference Plasmid   DS1912041100-1_bin.11__k141_11217
  Reference Plasmid Size   41642
  Reference Plasmid GC Content   0.67
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0067808 NLCMOIPG_00007 12601 3 Skin 0.12 protein_coding synonymous_variant LOW 750C>G Arg250Arg
M0067809 NLCMOIPG_00009 13945 5 Skin 0.19 protein_coding synonymous_variant LOW 807A>G Thr269Thr
M0067810 NLCMOIPG_00010 15108 4 Skin 0.15 protein_coding synonymous_variant LOW 234A>G Lys78Lys
M0067811 NLCMOIPG_00005 15185 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4604T>C None
M0067812 NLCMOIPG_00005 15245 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4664A>G None
M0067813 NLCMOIPG_00005 15261 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4680A>C None
M0067814 NLCMOIPG_00011 15548 5 Skin 0.19 protein_coding missense_variant MODERATE 593A>G Gln198Arg
M0067815 NLCMOIPG_00011 16014 5 Skin 0.19 protein_coding synonymous_variant LOW 127C>T Leu43Leu
M0067816 NLCMOIPG_00027 29482 6 Skin 0.23 protein_coding synonymous_variant LOW 339C>T Ala113Ala
M0067817 NLCMOIPG_00027 29821 4 Skin 0.15 protein_coding synonymous_variant LOW 678G>T Ala226Ala
M0067818 NLCMOIPG_00027 30403 5 Skin 0.19 protein_coding synonymous_variant LOW 1260T>C Leu420Leu
M0067819 NLCMOIPG_00029 32266 5 Skin 0.19 protein_coding missense_variant MODERATE 107T>G Val36Gly
M0067820 NLCMOIPG_00030 32527 3 Skin 0.12 protein_coding synonymous_variant LOW 690T>C Ile230Ile
M0067821 NLCMOIPG_00030 32580 7 Skin 0.27 protein_coding missense_variant MODERATE 637C>T Leu213Phe
M0067822 NLCMOIPG_00030 32661 6 Skin 0.23 protein_coding missense_variant MODERATE 556C>T Leu186Phe
M0067823 NLCMOIPG_00030 32719 6 Skin 0.23 protein_coding synonymous_variant LOW 498C>T Pro166Pro
M0067824 NLCMOIPG_00030 33000 9 Skin 0.35 protein_coding missense_variant MODERATE 217C>A Pro73Thr
M0067825 NLCMOIPG_00031 33706 5 Skin 0.19 protein_coding missense_variant MODERATE 170C>G Ala57Gly
M0067826 NLCMOIPG_00031 33708 5 Skin 0.19 protein_coding synonymous_variant LOW 168C>G Thr56Thr
M0067827 NLCMOIPG_00031 33763 3 Skin 0.12 protein_coding missense_variant MODERATE 113T>C Val38Ala
M0067828 NLCMOIPG_00032 34608 5 Skin 0.19 protein_coding synonymous_variant LOW 174A>C Ile58Ile
M0067829 NLCMOIPG_00033 35180 4 Skin 0.15 protein_coding synonymous_variant LOW 1011G>T Val337Val
M0067830 NLCMOIPG_00033 35426 6 Skin 0.23 protein_coding synonymous_variant LOW 765A>G Gln255Gln
M0067831 NLCMOIPG_00033 35430 6 Skin 0.23 protein_coding missense_variant MODERATE 761A>G Gln254Arg
M0067832 NLCMOIPG_00033 35438 8 Skin 0.31 protein_coding synonymous_variant LOW 753G>C Gly251Gly
M0067833 NLCMOIPG_00033 35441 6 Skin 0.23 protein_coding synonymous_variant LOW 750C>G Gly250Gly
M0067834 NLCMOIPG_00033 35442 8 Skin 0.31 protein_coding missense_variant MODERATE 749G>A Gly250Asp
M0067835 NLCMOIPG_00033 35443 6 Skin 0.23 protein_coding missense_variant MODERATE 748G>C Gly250Arg
M0067836 NLCMOIPG_00033 35564 8 Skin 0.31 protein_coding synonymous_variant LOW 627T>C Gly209Gly
M0067837 NLCMOIPG_00033 35576 8 Skin 0.31 protein_coding synonymous_variant LOW 615T>G Pro205Pro
M0067838 NLCMOIPG_00033 35852 3 Skin 0.12 protein_coding synonymous_variant LOW 339C>G Arg113Arg
M0067839 NLCMOIPG_00033 35973 8 Skin 0.31 protein_coding missense_variant MODERATE 218A>T Gln73Leu
M0067840 NLCMOIPG_00033 35990 5 Skin 0.19 protein_coding synonymous_variant LOW 201T>C Gly67Gly
M0067841 NLCMOIPG_00033 35996 5 Skin 0.19 protein_coding synonymous_variant LOW 195T>C Asp65Asp
M0067842 NLCMOIPG_00033 36055 6 Skin 0.23 protein_coding synonymous_variant LOW 136T>C Leu46Leu
M0067843 NLCMOIPG_00033 36060 8 Skin 0.31 protein_coding missense_variant MODERATE 131G>C Gly44Ala
M0067844 NLCMOIPG_00033 36067 8 Skin 0.31 protein_coding missense_variant MODERATE 124G>T Ala42Ser
M0067845 NLCMOIPG_00034 36227 6 Skin 0.23 protein_coding synonymous_variant LOW 24G>C Val8Val
M0067846 NLCMOIPG_00034 36437 4 Skin 0.15 protein_coding synonymous_variant LOW 234T>C His78His
M0067847 NLCMOIPG_00034 36442 5 Skin 0.19 protein_coding missense_variant MODERATE 239G>C Gly80Ala
M0067848 NLCMOIPG_00034 36464 3 Skin 0.12 protein_coding synonymous_variant LOW 261C>G Ala87Ala
M0067849 NLCMOIPG_00034 36488 4 Skin 0.15 protein_coding synonymous_variant LOW 285C>G Ala95Ala
M0067850 NLCMOIPG_00034 36497 3 Skin 0.12 protein_coding synonymous_variant LOW 294C>T Cys98Cys
M0067851 NLCMOIPG_00034 36527 3 Skin 0.12 protein_coding synonymous_variant LOW 324A>G Ala108Ala
M0067852 NLCMOIPG_00034 36541 5 Skin 0.19 protein_coding missense_variant MODERATE 338T>C Val113Ala
M0067853 NLCMOIPG_00034 36623 6 Skin 0.23 protein_coding synonymous_variant LOW 420C>T Gly140Gly
M0067854 NLCMOIPG_00009 14494 4 Skin 0.15 protein_coding synonymous_variant LOW 258G>A Ala86Ala
M0067855 NLCMOIPG_00010 14934 4 Skin 0.15 protein_coding synonymous_variant LOW 60C>T Leu20Leu
M0067856 NLCMOIPG_00011 15691 5 Skin 0.19 protein_coding synonymous_variant LOW 450A>C Pro150Pro
M0067857 NLCMOIPG_00012 16325 5 Skin 0.19 protein_coding synonymous_variant LOW 63T>C Leu21Leu
M0067858 NLCMOIPG_00012 16757 5 Skin 0.19 protein_coding synonymous_variant LOW 495G>A Gln165Gln
M0067859 NLCMOIPG_00012 16821 4 Skin 0.15 protein_coding missense_variant MODERATE 559T>A Leu187Met
M0067860 NLCMOIPG_00012 16822 4 Skin 0.15 protein_coding missense_variant MODERATE 560T>C Leu187Ser
M0067861 NLCMOIPG_00012 16931 4 Skin 0.15 protein_coding synonymous_variant LOW 669C>T Gly223Gly
M0067862 NLCMOIPG_00012 17027 6 Skin 0.23 protein_coding synonymous_variant LOW 765G>C Pro255Pro
M0067863 NLCMOIPG_00024 25788 4 Skin 0.15 protein_coding synonymous_variant LOW 1632C>T Leu544Leu
M0067864 NLCMOIPG_00024 26468 4 Skin 0.15 protein_coding missense_variant MODERATE 952G>A Asp318Asn
M0067865 NLCMOIPG_00024 26536 5 Skin 0.19 protein_coding missense_variant MODERATE 884A>G His295Arg
M0067866 NLCMOIPG_00024 26580 4 Skin 0.15 protein_coding synonymous_variant LOW 840C>T Asp280Asp
M0067867 NLCMOIPG_00024 26766 4 Skin 0.15 protein_coding synonymous_variant LOW 654C>T Asn218Asn
M0067868 NLCMOIPG_00024 26919 4 Skin 0.15 protein_coding synonymous_variant LOW 501G>A Val167Val
M0067869 NLCMOIPG_00025 27522 5 Skin 0.19 protein_coding synonymous_variant LOW 360C>G Leu120Leu
M0067870 NLCMOIPG_00025 27540 5 Skin 0.19 protein_coding synonymous_variant LOW 342T>G Leu114Leu
M0067871 NLCMOIPG_00026 28804 7 Skin 0.27 protein_coding missense_variant MODERATE 207G>T Glu69Asp
M0067872 NLCMOIPG_00027 29198 6 Skin 0.23 protein_coding missense_variant MODERATE 55G>A Gly19Ser
M0067873 NLCMOIPG_00027 29258 5 Skin 0.19 protein_coding synonymous_variant LOW 115C>T Leu39Leu
M0067874 NLCMOIPG_00027 29419 5 Skin 0.19 protein_coding synonymous_variant LOW 276C>T Arg92Arg
M0067875 NLCMOIPG_00027 29423 6 Skin 0.23 protein_coding synonymous_variant LOW 280A>C Arg94Arg
M0067876 NLCMOIPG_00027 29654 7 Skin 0.27 protein_coding missense_variant MODERATE 511C>A Leu171Ile
M0067877 NLCMOIPG_00031 33681 3 Skin 0.12 protein_coding synonymous_variant LOW 195C>T Ile65Ile
M0067878 NLCMOIPG_00014 18046 6 Skin 0.23 protein_coding missense_variant MODERATE 458T>C Val153Ala
M0067879 NLCMOIPG_00009 19586 6 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -4835A>C None
M0067880 NLCMOIPG_00009 19588 6 Skin 0.23 protein_coding upstream_gene_variant MODIFIER -4837C>G None
M0067881 NLCMOIPG_00016 19705 4 Skin 0.15 protein_coding synonymous_variant LOW 747T>C His249His
M0067882 NLCMOIPG_00018 21675 7 Skin 0.27 protein_coding synonymous_variant LOW 486G>C Val162Val
M0067883 NLCMOIPG_00019 22891 4 Skin 0.15 protein_coding missense_variant MODERATE 637C>T Pro213Ser
M0067884 NLCMOIPG_00019 23129 5 Skin 0.19 protein_coding synonymous_variant LOW 399G>C Gly133Gly
M0067885 NLCMOIPG_00015 18617 5 Skin 0.19 protein_coding synonymous_variant LOW 903T>C Thr301Thr
M0067886 NLCMOIPG_00016 19747 4 Skin 0.15 protein_coding synonymous_variant LOW 705A>G Gln235Gln
M0067887 NLCMOIPG_00011 15949 4 Skin 0.15 protein_coding synonymous_variant LOW 192G>A Ala64Ala
M0067888 NLCMOIPG_00011 15952 4 Skin 0.15 protein_coding synonymous_variant LOW 189A>C Ala63Ala
M0067889 NLCMOIPG_00011 15961 4 Skin 0.15 protein_coding synonymous_variant LOW 180T>C Ala60Ala
M0067890 NLCMOIPG_00011 15967 4 Skin 0.15 protein_coding synonymous_variant LOW 174G>C Thr58Thr
M0067891 NLCMOIPG_00011 15970 4 Skin 0.15 protein_coding synonymous_variant LOW 171C>G Leu57Leu
M0067892 NLCMOIPG_00013 17431 3 Skin 0.12 protein_coding missense_variant MODERATE 550T>A Cys184Ser
M0067893 NLCMOIPG_00013 17442 3 Skin 0.12 protein_coding missense_variant MODERATE 539G>A Gly180Asp
M0067894 NLCMOIPG_00013 17940 4 Skin 0.15 protein_coding missense_variant MODERATE 41G>A Arg14Gln
M0067895 NLCMOIPG_00016 19816 3 Skin 0.12 protein_coding synonymous_variant LOW 636C>A Ile212Ile
M0067896 NLCMOIPG_00013 21500 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -3520C>T None
M0067897 NLCMOIPG_00019 22432 5 Skin 0.19 protein_coding synonymous_variant LOW 1096T>C Leu366Leu
M0067898 NLCMOIPG_00019 23494 3 Skin 0.12 protein_coding missense_variant MODERATE 34T>C Ser12Pro
M0067899 NLCMOIPG_00020 24246 4 Skin 0.15 protein_coding synonymous_variant LOW 630C>G Arg210Arg
M0067900 NLCMOIPG_00020 24492 4 Skin 0.15 protein_coding synonymous_variant LOW 876C>G Leu292Leu
M0067901 NLCMOIPG_00020 24519 5 Skin 0.19 protein_coding synonymous_variant LOW 903T>C Arg301Arg
M0067902 NLCMOIPG_00022 24989 3 Skin 0.12 protein_coding missense_variant MODERATE 104G>A Gly35Asp
M0067903 NLCMOIPG_00022 25034 4 Skin 0.15 protein_coding missense_variant MODERATE 149C>A Pro50Gln
M0067904 NLCMOIPG_00024 25860 3 Skin 0.12 protein_coding synonymous_variant LOW 1560C>A Val520Val
M0067905 NLCMOIPG_00024 26000 5 Skin 0.19 protein_coding missense_variant MODERATE 1420C>G Leu474Val
M0067906 NLCMOIPG_00024 26684 5 Skin 0.19 protein_coding synonymous_variant LOW 736C>T Leu246Leu
M0067907 NLCMOIPG_00024 26712 5 Skin 0.19 protein_coding synonymous_variant LOW 708A>G Gly236Gly
M0067908 NLCMOIPG_00026 28644 4 Skin 0.15 protein_coding missense_variant MODERATE 367G>A Gly123Ser
M0067909 NLCMOIPG_00024 32079 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4660A>G None
M0067910 NLCMOIPG_00032 33990 3 Skin 0.12 protein_coding synonymous_variant LOW 792C>T Asn264Asn
M0067911 NLCMOIPG_00033 34967 3 Skin 0.12 protein_coding synonymous_variant LOW 1224G>A Arg408Arg
M0067912 NLCMOIPG_00034 36295 4 Skin 0.15 protein_coding missense_variant MODERATE 92T>C Val31Ala
M0067913 NLCMOIPG_00035 37078 4 Skin 0.15 protein_coding missense_variant MODERATE 140G>A Arg47Lys
M0067914 NLCMOIPG_00028 31518 4 Skin 0.15 protein_coding synonymous_variant LOW 468G>C Leu156Leu
M0067915 NLCMOIPG_00028 31524 4 Skin 0.15 protein_coding synonymous_variant LOW 462A>G Gly154Gly
M0067916 NLCMOIPG_00028 31911 4 Skin 0.15 protein_coding synonymous_variant LOW 75A>G Ala25Ala
M0067917 NLCMOIPG_00032 34470 6 Skin 0.23 protein_coding synonymous_variant LOW 312G>C Ala104Ala
M0067918 NLCMOIPG_00034 36788 5 Skin 0.19 protein_coding synonymous_variant LOW 585A>T Ala195Ala
M0067919 NLCMOIPG_00034 36820 5 Skin 0.19 protein_coding missense_variant MODERATE 617G>A Ser206Asn
M0067920 NLCMOIPG_00034 36859 5 Skin 0.19 protein_coding missense_variant MODERATE 656A>G Asn219Ser
M0067921 NLCMOIPG_00028 36879 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4894T>A None
M0067922 NLCMOIPG_00028 36884 5 Skin 0.19 protein_coding upstream_gene_variant MODIFIER -4899G>T None
M0067923 NLCMOIPG_00035 37365 4 Skin 0.15 protein_coding missense_variant MODERATE 427T>A Ser143Thr
M0067924 NLCMOIPG_00035 37746 3 Skin 0.12 protein_coding missense_variant MODERATE 808G>A Gly270Ser
M0067925 NLCMOIPG_00035 37757 3 Skin 0.12 protein_coding synonymous_variant LOW 819T>C Ile273Ile
M0067926 NLCMOIPG_00035 37770 3 Skin 0.12 protein_coding missense_variant MODERATE 832C>G Leu278Val
M0067927 NLCMOIPG_00035 37779 3 Skin 0.12 protein_coding synonymous_variant LOW 841C>A Arg281Arg
M0067928 NLCMOIPG_00035 37780 3 Skin 0.12 protein_coding missense_variant MODERATE 842G>A Arg281Gln
M0067929 NLCMOIPG_00035 37785 3 Skin 0.12 protein_coding missense_variant MODERATE 847A>G Asn283Asp
M0067930 NLCMOIPG_00035 37811 3 Skin 0.12 protein_coding synonymous_variant LOW 873T>C Thr291Thr
M0067931 NLCMOIPG_00035 37823 3 Skin 0.12 protein_coding synonymous_variant LOW 885A>G Glu295Glu
M0067932 NLCMOIPG_00035 37832 3 Skin 0.12 protein_coding synonymous_variant LOW 894A>C Ala298Ala
M0067933 NLCMOIPG_00035 37893 3 Skin 0.12 protein_coding missense_variant MODERATE 955T>G Ser319Ala
M0067934 NLCMOIPG_00030 37950 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -4734A>G None
M0067935 NLCMOIPG_00031 38689 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -4814A>G None
M0067936 NLCMOIPG_00020 23895 3 Skin 0.12 protein_coding synonymous_variant LOW 279C>G Arg93Arg
M0067937 NLCMOIPG_00026 28491 3 Skin 0.12 protein_coding missense_variant MODERATE 520T>C Cys174Arg
M0067938 NLCMOIPG_00009 13456 3 Skin 0.12 protein_coding synonymous_variant LOW 1296A>C Gly432Gly
M0067939 NLCMOIPG_00009 13471 3 Skin 0.12 protein_coding missense_variant MODERATE 1281A>C Glu427Asp
M0067940 NLCMOIPG_00005 14808 4 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -4227T>C None
M0067941 NLCMOIPG_00011 20542 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -4402T>G None
M0067942 NLCMOIPG_00018 21812 4 Skin 0.15 protein_coding synonymous_variant LOW 349T>C Leu117Leu
M0067943 NLCMOIPG_00019 22642 3 Skin 0.12 protein_coding missense_variant MODERATE 886T>C Cys296Arg
M0067944 NLCMOIPG_00019 22650 3 Skin 0.12 protein_coding missense_variant MODERATE 878T>G Phe293Cys
M0067945 NLCMOIPG_00032 34155 3 Skin 0.12 protein_coding synonymous_variant LOW 627C>T Ser209Ser
M0067946 NLCMOIPG_00005 12802 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -2221C>G None
M0067947 NLCMOIPG_00005 12809 3 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -2228C>G None
M0067948 NLCMOIPG_00008 12846 3 Skin 0.12 protein_coding synonymous_variant LOW 294G>C Pro98Pro
M0067949 NLCMOIPG_00008 12873 3 Skin 0.12 protein_coding synonymous_variant LOW 267G>C Leu89Leu
M0067950 NLCMOIPG_00008 12909 3 Skin 0.12 protein_coding synonymous_variant LOW 231C>G Ala77Ala
M0067951 NLCMOIPG_00008 12918 3 Skin 0.12 protein_coding synonymous_variant LOW 222G>A Glu74Glu
M0067952 NLCMOIPG_00008 12972 3 Skin 0.12 protein_coding synonymous_variant LOW 168C>T Phe56Phe






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
NLCMOIPG_00005 PHI:11745 ppk2B (PA14_33240) 73.6 1.5e-129 8 306 0.9771 0.9967 nematodes opportunistic infection polyphosphate kinase reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term