Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C230
  Reference Plasmid   HG796779.1
  Reference Plasmid Size   5934
  Reference Plasmid GC Content   0.41
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0149160 FKONDFMH_00003 87 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -740A>G None
M0149161 FKONDFMH_00003 90 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -737T>C None
M0149162 FKONDFMH_00001 107 15 Gut 0.79 protein_coding missense_variant MODERATE 257A>G Asp86Gly
M0149163 FKONDFMH_00001 112 5 Gut 0.26 protein_coding synonymous_variant LOW 252T>C Gly84Gly
M0149164 FKONDFMH_00001 136 5 Gut 0.26 protein_coding synonymous_variant LOW 228T>C Asp76Asp
M0149165 FKONDFMH_00001 141 4 Gut 0.21 protein_coding synonymous_variant LOW 223C>T Leu75Leu
M0149166 FKONDFMH_00001 328 3 Gut 0.16 protein_coding synonymous_variant LOW 36T>C Asn12Asn
M0149167 FKONDFMH_00002 745 15 Gut 0.79 protein_coding missense_variant MODERATE 13A>G Ile5Val
M0149168 FKONDFMH_00001 813 10 Gut 0.53 protein_coding upstream_gene_variant MODIFIER -450A>T None
M0149169 FKONDFMH_00001 1815 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -1452T>C None
M0149170 FKONDFMH_00004 1915 3 Gut 0.16 protein_coding synonymous_variant LOW 78G>A Lys26Lys
M0149171 FKONDFMH_00005 2112 4 Gut 0.21 protein_coding missense_variant MODERATE 7G>T Asp3Tyr
M0149172 FKONDFMH_00006 2233 4 Gut 0.21 protein_coding synonymous_variant LOW 82C>T Leu28Leu
M0149173 FKONDFMH_00006 2313 4 Gut 0.21 protein_coding synonymous_variant LOW 162T>A Gly54Gly
M0149174 FKONDFMH_00006 2334 8 Gut 0.42 protein_coding synonymous_variant LOW 183G>A Ala61Ala
M0149175 FKONDFMH_00006 2382 8 Gut 0.42 protein_coding synonymous_variant LOW 231A>C Val77Val
M0149176 FKONDFMH_00008 3818 3 Gut 0.16 protein_coding missense_variant MODERATE 861G>T Gln287His
M0149177 FKONDFMH_00008 3842 4 Gut 0.21 protein_coding synonymous_variant LOW 837G>A Lys279Lys
M0149178 FKONDFMH_00008 3858 7 Gut 0.37 protein_coding missense_variant MODERATE 821T>C Val274Ala
M0149179 FKONDFMH_00008 3873 4 Gut 0.21 protein_coding missense_variant MODERATE 806C>T Pro269Leu
M0149180 FKONDFMH_00008 3878 4 Gut 0.21 protein_coding synonymous_variant LOW 801A>G Gln267Gln
M0149181 FKONDFMH_00008 3914 3 Gut 0.16 protein_coding synonymous_variant LOW 765T>G Arg255Arg
M0149182 FKONDFMH_00008 3951 7 Gut 0.37 protein_coding missense_variant MODERATE 728A>T Asn243Ile
M0149183 FKONDFMH_00008 4019 7 Gut 0.37 protein_coding synonymous_variant LOW 660A>C Ile220Ile
M0149184 FKONDFMH_00008 4109 7 Gut 0.37 protein_coding synonymous_variant LOW 570C>T Thr190Thr
M0149185 FKONDFMH_00008 4111 7 Gut 0.37 protein_coding missense_variant MODERATE 568A>T Thr190Ser
M0149186 FKONDFMH_00008 4216 3 Gut 0.16 protein_coding missense_variant MODERATE 463A>G Ser155Gly
M0149187 FKONDFMH_00008 4280 8 Gut 0.42 protein_coding synonymous_variant LOW 399T>C Phe133Phe
M0149188 FKONDFMH_00008 4374 5 Gut 0.26 protein_coding missense_variant MODERATE 305A>G Lys102Arg
M0149189 FKONDFMH_00008 4538 7 Gut 0.37 protein_coding synonymous_variant LOW 141T>A Ser47Ser
M0149190 FKONDFMH_00008 4541 7 Gut 0.37 protein_coding synonymous_variant LOW 138T>C Asn46Asn
M0149191 FKONDFMH_00008 4592 9 Gut 0.47 protein_coding synonymous_variant LOW 87A>G Glu29Glu
M0149192 FKONDFMH_00008 4644 8 Gut 0.42 protein_coding missense_variant MODERATE 35T>C Ile12Thr
M0149193 FKONDFMH_00008 4667 5 Gut 0.26 protein_coding synonymous_variant LOW 12G>A Lys4Lys
M0149194 FKONDFMH_00008 4673 5 Gut 0.26 protein_coding synonymous_variant LOW 6C>T Asn2Asn
M0149195 FKONDFMH_00009 4700 3 Gut 0.16 protein_coding missense_variant MODERATE 578G>A Arg193Lys
M0149196 FKONDFMH_00009 4704 3 Gut 0.16 protein_coding missense_variant MODERATE 574G>A Glu192Lys
M0149197 FKONDFMH_00009 4759 5 Gut 0.26 protein_coding synonymous_variant LOW 519T>C Ser173Ser
M0149198 FKONDFMH_00009 4771 3 Gut 0.16 protein_coding synonymous_variant LOW 507G>A Lys169Lys
M0149199 FKONDFMH_00009 4773 3 Gut 0.16 protein_coding missense_variant MODERATE 505A>C Lys169Gln
M0149200 FKONDFMH_00009 4774 3 Gut 0.16 protein_coding stop_gained HIGH 504T>G Tyr168*
M0149201 FKONDFMH_00009 4775 3 Gut 0.16 protein_coding missense_variant MODERATE 503A>T Tyr168Phe
M0149202 FKONDFMH_00009 4776 3 Gut 0.16 protein_coding missense_variant MODERATE 502T>A Tyr168Asn
M0149203 FKONDFMH_00009 4780 3 Gut 0.16 protein_coding synonymous_variant LOW 498A>G Lys166Lys
M0149204 FKONDFMH_00009 4783 3 Gut 0.16 protein_coding synonymous_variant LOW 495T>C Ile165Ile
M0149205 FKONDFMH_00009 4785 3 Gut 0.16 protein_coding missense_variant MODERATE 493A>C Ile165Leu
M0149206 FKONDFMH_00009 4786 3 Gut 0.16 protein_coding synonymous_variant LOW 492G>A Gln164Gln
M0149207 FKONDFMH_00009 4813 6 Gut 0.32 protein_coding synonymous_variant LOW 465A>G Lys155Lys
M0149208 FKONDFMH_00009 4825 6 Gut 0.32 protein_coding missense_variant MODERATE 453G>T Glu151Asp
M0149209 FKONDFMH_00009 4875 3 Gut 0.16 protein_coding missense_variant MODERATE 403A>G Thr135Ala
M0149210 FKONDFMH_00009 4877 5 Gut 0.26 protein_coding missense_variant MODERATE 401A>G Lys134Arg
M0149211 FKONDFMH_00009 4889 3 Gut 0.16 protein_coding missense_variant MODERATE 389A>G Lys130Arg
M0149212 FKONDFMH_00009 4915 3 Gut 0.16 protein_coding synonymous_variant LOW 363T>A Ile121Ile
M0149213 FKONDFMH_00009 4919 4 Gut 0.21 protein_coding missense_variant MODERATE 359A>G Glu120Gly
M0149214 FKONDFMH_00009 4930 4 Gut 0.21 protein_coding synonymous_variant LOW 348G>A Glu116Glu
M0149215 FKONDFMH_00009 5080 6 Gut 0.32 protein_coding synonymous_variant LOW 198T>C Asp66Asp
M0149216 FKONDFMH_00009 5119 6 Gut 0.32 protein_coding synonymous_variant LOW 159T>C Ser53Ser
M0149217 FKONDFMH_00009 5254 5 Gut 0.26 protein_coding synonymous_variant LOW 24G>A Thr8Thr
M0149218 FKONDFMH_00001 5347 6 Gut 0.32 protein_coding upstream_gene_variant MODIFIER -4984T>C None
M0149219 FKONDFMH_00002 5390 9 Gut 0.47 protein_coding upstream_gene_variant MODIFIER -4633T>A None
M0149220 FKONDFMH_00002 5391 6 Gut 0.32 protein_coding upstream_gene_variant MODIFIER -4634T>A None
M0149221 FKONDFMH_00002 5401 7 Gut 0.37 protein_coding upstream_gene_variant MODIFIER -4644A>T None
M0149222 FKONDFMH_00008 4643 3 Gut 0.16 protein_coding synonymous_variant LOW 36T>C Ile12Ile
M0149223 FKONDFMH_00009 4681 4 Gut 0.21 protein_coding synonymous_variant LOW 597G>A Gly199Gly
M0149224 FKONDFMH_00009 4720 3 Gut 0.16 protein_coding synonymous_variant LOW 558C>T Asp186Asp
M0149225 FKONDFMH_00001 449 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -86G>A None
M0149226 FKONDFMH_00001 537 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -174A>G None
M0149227 FKONDFMH_00002 653 3 Gut 0.16 protein_coding synonymous_variant LOW 105C>A Leu35Leu
M0149228 FKONDFMH_00001 779 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -416A>G None
M0149229 FKONDFMH_00006 2349 4 Gut 0.21 protein_coding synonymous_variant LOW 198C>A Pro66Pro
M0149230 FKONDFMH_00006 2421 4 Gut 0.21 protein_coding synonymous_variant LOW 270G>T Ala90Ala
M0149231 FKONDFMH_00006 2442 4 Gut 0.21 protein_coding synonymous_variant LOW 291A>G Ala97Ala
M0149232 FKONDFMH_00006 2457 4 Gut 0.21 protein_coding synonymous_variant LOW 306C>A Thr102Thr
M0149233 FKONDFMH_00006 2472 4 Gut 0.21 protein_coding synonymous_variant LOW 321A>G Pro107Pro
M0149234 FKONDFMH_00006 2481 4 Gut 0.21 protein_coding synonymous_variant LOW 330A>G Glu110Glu
M0149235 FKONDFMH_00006 2572 3 Gut 0.16 protein_coding missense_variant MODERATE 421G>A Asp141Asn
M0149236 FKONDFMH_00006 2578 3 Gut 0.16 protein_coding synonymous_variant LOW 427C>T Leu143Leu
M0149237 FKONDFMH_00008 3828 3 Gut 0.16 protein_coding missense_variant MODERATE 851A>G Glu284Gly
M0149238 FKONDFMH_00008 3838 3 Gut 0.16 protein_coding missense_variant MODERATE 841C>A Gln281Lys
M0149239 FKONDFMH_00008 3906 3 Gut 0.16 protein_coding missense_variant MODERATE 773G>T Ser258Ile
M0149240 FKONDFMH_00008 3908 3 Gut 0.16 protein_coding synonymous_variant LOW 771G>A Glu257Glu
M0149241 FKONDFMH_00008 3930 3 Gut 0.16 protein_coding missense_variant MODERATE 749A>G His250Arg
M0149242 FKONDFMH_00008 4031 3 Gut 0.16 protein_coding synonymous_variant LOW 648C>T Ser216Ser
M0149243 FKONDFMH_00008 4064 3 Gut 0.16 protein_coding synonymous_variant LOW 615C>A Thr205Thr
M0149244 FKONDFMH_00008 4076 5 Gut 0.26 protein_coding synonymous_variant LOW 603C>T Ala201Ala
M0149245 FKONDFMH_00008 4100 3 Gut 0.16 protein_coding synonymous_variant LOW 579C>T Asp193Asp
M0149246 FKONDFMH_00008 4142 5 Gut 0.26 protein_coding synonymous_variant LOW 537C>T Phe179Phe
M0149247 FKONDFMH_00008 4367 3 Gut 0.16 protein_coding synonymous_variant LOW 312C>G Val104Val
M0149248 FKONDFMH_00008 4415 4 Gut 0.21 protein_coding synonymous_variant LOW 264A>G Lys88Lys
M0149249 FKONDFMH_00008 4417 4 Gut 0.21 protein_coding missense_variant MODERATE 262A>C Lys88Gln
M0149250 FKONDFMH_00008 4478 3 Gut 0.16 protein_coding synonymous_variant LOW 201A>G Leu67Leu
M0149251 FKONDFMH_00008 4502 5 Gut 0.26 protein_coding synonymous_variant LOW 177A>G Lys59Lys
M0149252 FKONDFMH_00008 4526 3 Gut 0.16 protein_coding synonymous_variant LOW 153A>C Ile51Ile
M0149253 FKONDFMH_00008 4566 4 Gut 0.21 protein_coding missense_variant MODERATE 113G>A Arg38Gln
M0149254 FKONDFMH_00008 4580 3 Gut 0.16 protein_coding synonymous_variant LOW 99C>T Arg33Arg
M0149255 FKONDFMH_00002 5532 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -4775G>T None
M0149256 FKONDFMH_00002 5534 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -4777C>T None
M0149257 FKONDFMH_00002 5570 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -4813A>G None
M0149258 FKONDFMH_00002 5592 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -4835T>C None
M0149259 FKONDFMH_00005 5802 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -3684T>C None
M0149260 FKONDFMH_00005 5817 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -3699A>C None
M0149261 FKONDFMH_00005 5850 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -3732A>G None
M0149262 FKONDFMH_00005 5856 4 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -3738T>C None
M0149263 FKONDFMH_00002 5598 3 Gut 0.16 protein_coding upstream_gene_variant MODIFIER -4841T>C None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
FKONDFMH_00007 ARO:3003097 80 8.14e-171 1 315 0.9937 0.9517 cephalosporin CfxA beta-lactamase antibiotic inactivation






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term