Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C3095
  Reference Plasmid   MET0129_bin.1__k81_1185
  Reference Plasmid Size   4352
  Reference Plasmid GC Content   0.32
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0074561 ELIBDBMI_00002 63 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -1829A>G None
M0074562 ELIBDBMI_00002 339 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1553C>T None
M0074563 ELIBDBMI_00001 1738 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -137A>T None
M0074564 ELIBDBMI_00002 1927 4 Skin 0.20 protein_coding synonymous_variant LOW 36C>T Val12Val
M0074565 ELIBDBMI_00002 1999 5 Skin 0.25 protein_coding synonymous_variant LOW 108A>T Ile36Ile
M0074566 ELIBDBMI_00002 2002 5 Skin 0.25 protein_coding synonymous_variant LOW 111A>G Val37Val
M0074567 ELIBDBMI_00002 2290 6 Skin 0.30 protein_coding synonymous_variant LOW 399G>A Ser133Ser
M0074568 ELIBDBMI_00002 2329 6 Skin 0.30 protein_coding synonymous_variant LOW 438A>G Leu146Leu
M0074569 ELIBDBMI_00002 2338 6 Skin 0.30 protein_coding synonymous_variant LOW 447A>C Gly149Gly
M0074570 ELIBDBMI_00002 2360 6 Skin 0.30 protein_coding missense_variant MODERATE 469G>A Glu157Lys
M0074571 ELIBDBMI_00002 2986 6 Skin 0.30 protein_coding synonymous_variant LOW 1095C>T Pro365Pro
M0074572 ELIBDBMI_00002 2989 5 Skin 0.25 protein_coding synonymous_variant LOW 1098A>G Thr366Thr
M0074573 ELIBDBMI_00002 2992 7 Skin 0.35 protein_coding synonymous_variant LOW 1101G>A Glu367Glu
M0074574 ELIBDBMI_00002 3001 6 Skin 0.30 protein_coding synonymous_variant LOW 1110A>T Pro370Pro
M0074575 ELIBDBMI_00002 3004 6 Skin 0.30 protein_coding synonymous_variant LOW 1113T>A Ser371Ser
M0074576 ELIBDBMI_00002 3049 10 Skin 0.50 protein_coding synonymous_variant LOW 1158C>A Ile386Ile
M0074577 ELIBDBMI_00002 3601 4 Skin 0.20 protein_coding synonymous_variant LOW 1710G>A Gln570Gln
M0074578 ELIBDBMI_00002 3628 8 Skin 0.40 protein_coding synonymous_variant LOW 1737A>G Val579Val
M0074579 ELIBDBMI_00002 3685 3 Skin 0.15 protein_coding synonymous_variant LOW 1794C>T Thr598Thr
M0074580 ELIBDBMI_00002 3691 5 Skin 0.25 protein_coding synonymous_variant LOW 1800C>T Cys600Cys
M0074581 ELIBDBMI_00001 4160 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2559G>A None
M0074582 ELIBDBMI_00001 4214 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2613A>G None
M0074583 ELIBDBMI_00002 578 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1314C>T None
M0074584 ELIBDBMI_00002 633 7 Skin 0.35 protein_coding upstream_gene_variant MODIFIER -1259A>G None
M0074585 ELIBDBMI_00002 672 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1220A>G None
M0074586 ELIBDBMI_00002 2224 8 Skin 0.40 protein_coding synonymous_variant LOW 333A>T Leu111Leu
M0074587 ELIBDBMI_00002 2479 6 Skin 0.30 protein_coding synonymous_variant LOW 588A>G Gln196Gln
M0074588 ELIBDBMI_00002 2480 6 Skin 0.30 protein_coding missense_variant MODERATE 589A>T Ile197Leu
M0074589 ELIBDBMI_00002 2575 10 Skin 0.50 protein_coding missense_variant MODERATE 684G>C Lys228Asn
M0074590 ELIBDBMI_00002 2624 9 Skin 0.45 protein_coding missense_variant MODERATE 733A>G Lys245Glu
M0074591 ELIBDBMI_00002 2647 9 Skin 0.45 protein_coding synonymous_variant LOW 756G>A Lys252Lys
M0074592 ELIBDBMI_00002 3377 6 Skin 0.30 protein_coding missense_variant MODERATE 1486T>A Ser496Thr
M0074593 ELIBDBMI_00002 3760 4 Skin 0.20 protein_coding synonymous_variant LOW 1869C>A Pro623Pro
M0074594 ELIBDBMI_00002 3790 4 Skin 0.20 protein_coding synonymous_variant LOW 1899C>A Arg633Arg
M0074595 ELIBDBMI_00002 3832 6 Skin 0.30 protein_coding synonymous_variant LOW 1941T>C Thr647Thr
M0074596 ELIBDBMI_00002 3997 4 Skin 0.20 protein_coding synonymous_variant LOW 2106C>T Phe702Phe
M0074597 ELIBDBMI_00001 4055 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2454G>T None
M0074598 ELIBDBMI_00001 4056 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -2455T>C None
M0074599 ELIBDBMI_00001 4301 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2700A>G None
M0074600 ELIBDBMI_00001 4307 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2706A>T None
M0074601 ELIBDBMI_00001 4310 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -2709G>T None
M0074602 ELIBDBMI_00001 870 8 Skin 0.40 protein_coding synonymous_variant LOW 732G>C Leu244Leu
M0074603 ELIBDBMI_00002 264 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1628A>G None
M0074604 ELIBDBMI_00002 297 5 Skin 0.25 protein_coding upstream_gene_variant MODIFIER -1595C>T None
M0074605 ELIBDBMI_00002 384 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1508G>A None
M0074606 ELIBDBMI_00002 639 4 Skin 0.20 protein_coding upstream_gene_variant MODIFIER -1253C>A None
M0074607 ELIBDBMI_00001 971 4 Skin 0.20 protein_coding synonymous_variant LOW 631C>T Leu211Leu
M0074608 ELIBDBMI_00001 1013 4 Skin 0.20 protein_coding missense_variant MODERATE 589A>G Ile197Val
M0074609 ELIBDBMI_00001 1065 3 Skin 0.15 protein_coding synonymous_variant LOW 537T>C Ser179Ser
M0074610 ELIBDBMI_00001 1092 3 Skin 0.15 protein_coding synonymous_variant LOW 510C>T Val170Val
M0074611 ELIBDBMI_00001 1152 3 Skin 0.15 protein_coding synonymous_variant LOW 450A>G Pro150Pro
M0074612 ELIBDBMI_00001 1238 3 Skin 0.15 protein_coding missense_variant MODERATE 364A>C Met122Leu
M0074613 ELIBDBMI_00001 1425 5 Skin 0.25 protein_coding synonymous_variant LOW 177T>A Leu59Leu
M0074614 ELIBDBMI_00001 1482 4 Skin 0.20 protein_coding synonymous_variant LOW 120T>G Gly40Gly
M0074615 ELIBDBMI_00001 1653 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -52T>C None
M0074616 ELIBDBMI_00001 1704 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -103A>G None
M0074617 ELIBDBMI_00001 1721 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -120A>T None
M0074618 ELIBDBMI_00001 1730 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -129C>T None
M0074619 ELIBDBMI_00001 1733 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -132A>T None
M0074620 ELIBDBMI_00001 1746 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -145A>T None
M0074621 ELIBDBMI_00001 1756 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -155G>A None
M0074622 ELIBDBMI_00001 1757 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -156A>T None
M0074623 ELIBDBMI_00001 1865 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -264A>G None
M0074624 ELIBDBMI_00002 2083 5 Skin 0.25 protein_coding synonymous_variant LOW 192C>T Asp64Asp
M0074625 ELIBDBMI_00002 2147 4 Skin 0.20 protein_coding missense_variant MODERATE 256A>G Ile86Val
M0074626 ELIBDBMI_00002 2440 4 Skin 0.20 protein_coding synonymous_variant LOW 549A>G Ala183Ala
M0074627 ELIBDBMI_00002 2458 4 Skin 0.20 protein_coding synonymous_variant LOW 567T>C Arg189Arg
M0074628 ELIBDBMI_00002 2521 5 Skin 0.25 protein_coding synonymous_variant LOW 630A>T Pro210Pro
M0074629 ELIBDBMI_00002 2569 5 Skin 0.25 protein_coding synonymous_variant LOW 678C>T Asn226Asn
M0074630 ELIBDBMI_00002 2834 5 Skin 0.25 protein_coding missense_variant MODERATE 943G>C Asp315His
M0074631 ELIBDBMI_00002 2876 4 Skin 0.20 protein_coding synonymous_variant LOW 985T>C Leu329Leu
M0074632 ELIBDBMI_00002 2914 4 Skin 0.20 protein_coding missense_variant MODERATE 1023T>G Ile341Met
M0074633 ELIBDBMI_00002 2921 4 Skin 0.20 protein_coding missense_variant MODERATE 1030T>A Ser344Thr
M0074634 ELIBDBMI_00002 3123 5 Skin 0.25 protein_coding missense_variant MODERATE 1232A>G Asp411Gly
M0074635 ELIBDBMI_00002 3128 5 Skin 0.25 protein_coding missense_variant MODERATE 1237A>C Asn413His
M0074636 ELIBDBMI_00002 3147 6 Skin 0.30 protein_coding missense_variant MODERATE 1256T>A Ile419Lys
M0074637 ELIBDBMI_00002 3188 6 Skin 0.30 protein_coding missense_variant MODERATE 1297A>C Thr433Pro
M0074638 ELIBDBMI_00002 3193 3 Skin 0.15 protein_coding synonymous_variant LOW 1302T>C Ser434Ser
M0074639 ELIBDBMI_00002 3197 5 Skin 0.25 protein_coding missense_variant MODERATE 1306C>A His436Asn
M0074640 ELIBDBMI_00002 3238 5 Skin 0.25 protein_coding missense_variant MODERATE 1347A>T Lys449Asn
M0074641 ELIBDBMI_00002 3292 4 Skin 0.20 protein_coding synonymous_variant LOW 1401C>T Asn467Asn
M0074642 ELIBDBMI_00002 3334 4 Skin 0.20 protein_coding synonymous_variant LOW 1443T>C His481His
M0074643 ELIBDBMI_00002 3370 4 Skin 0.20 protein_coding synonymous_variant LOW 1479C>T Leu493Leu
M0074644 ELIBDBMI_00002 3796 3 Skin 0.15 protein_coding synonymous_variant LOW 1905T>C Thr635Thr
M0074645 ELIBDBMI_00002 3847 3 Skin 0.15 protein_coding synonymous_variant LOW 1956G>A Gly652Gly
M0074646 ELIBDBMI_00002 3880 3 Skin 0.15 protein_coding synonymous_variant LOW 1989C>T His663His
M0074647 ELIBDBMI_00002 3937 3 Skin 0.15 protein_coding synonymous_variant LOW 2046T>G Val682Val
M0074648 ELIBDBMI_00002 3946 3 Skin 0.15 protein_coding synonymous_variant LOW 2055A>G Lys685Lys
M0074649 ELIBDBMI_00002 3976 3 Skin 0.15 protein_coding synonymous_variant LOW 2085A>G Glu695Glu
M0074650 ELIBDBMI_00001 4054 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -2453A>G None
M0074651 ELIBDBMI_00002 677 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1215T>C None
M0074652 ELIBDBMI_00002 710 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1182C>T None
M0074653 ELIBDBMI_00001 1371 3 Skin 0.15 protein_coding synonymous_variant LOW 231T>A Gly77Gly
M0074654 ELIBDBMI_00001 1428 3 Skin 0.15 protein_coding synonymous_variant LOW 174C>T Asn58Asn
M0074655 ELIBDBMI_00001 1455 3 Skin 0.15 protein_coding synonymous_variant LOW 147T>A Leu49Leu
M0074656 ELIBDBMI_00002 477 3 Skin 0.15 protein_coding upstream_gene_variant MODIFIER -1415A>G None
M0074657 ELIBDBMI_00002 2519 3 Skin 0.15 protein_coding missense_variant MODERATE 628C>T Pro210Ser






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
ELIBDBMI_00001 PHI:6311 glcU 83.6 7.3e-134 1 287 1.0000 1.0000 rodents skin infection; food poisoning; respiratory disease glucose uptake protein reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
ELIBDBMI_00001 2.A.7.5.1 76.1 1.4e-116 4 287 0.9895 0.9861 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.7 The Drug/Metabolite Transporter (DMT) Superfamily