Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C23
  Reference Plasmid   MET0207_bin.49__k81_2155338
  Reference Plasmid Size   4091
  Reference Plasmid GC Content   0.44
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0075704 LKLLIHPL_00001 149 3 Skin 0.75 protein_coding downstream_gene_variant MODIFIER *43A>G None
M0075705 LKLLIHPL_00001 246 4 Skin 1.00 protein_coding synonymous_variant LOW 402A>G Lys134Lys
M0075706 LKLLIHPL_00001 308 3 Skin 0.75 protein_coding synonymous_variant LOW 340C>T Leu114Leu
M0075707 LKLLIHPL_00001 324 3 Skin 0.75 protein_coding synonymous_variant LOW 324T>C Val108Val
M0075708 LKLLIHPL_00001 447 4 Skin 1.00 protein_coding synonymous_variant LOW 201T>C Asp67Asp
M0075709 LKLLIHPL_00001 468 3 Skin 0.75 protein_coding synonymous_variant LOW 180A>T Thr60Thr
M0075710 LKLLIHPL_00001 472 3 Skin 0.75 protein_coding missense_variant MODERATE 176G>A Arg59Lys
M0075711 LKLLIHPL_00001 476 3 Skin 0.75 protein_coding synonymous_variant LOW 172T>C Leu58Leu
M0075712 LKLLIHPL_00001 486 3 Skin 0.75 protein_coding synonymous_variant LOW 162A>G Lys54Lys
M0075713 LKLLIHPL_00002 724 3 Skin 0.75 protein_coding synonymous_variant LOW 792A>G Ala264Ala
M0075714 LKLLIHPL_00002 790 3 Skin 0.75 protein_coding missense_variant MODERATE 726C>A Asp242Glu
M0075715 LKLLIHPL_00002 835 3 Skin 0.75 protein_coding missense_variant MODERATE 681A>C Arg227Ser
M0075716 LKLLIHPL_00002 1378 3 Skin 0.75 protein_coding synonymous_variant LOW 138T>C Ser46Ser
M0133280 LKLLIHPL_00001 134 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *58G>A None
M0133281 LKLLIHPL_00001 135 3 Oral 1.00 protein_coding downstream_gene_variant MODIFIER *57G>C None
M0133282 LKLLIHPL_00001 300 3 Oral 1.00 protein_coding synonymous_variant LOW 348T>A Ser116Ser
M0133283 LKLLIHPL_00001 308 3 Oral 1.00 protein_coding synonymous_variant LOW 340C>T Leu114Leu
M0133284 LKLLIHPL_00001 324 3 Oral 1.00 protein_coding synonymous_variant LOW 324T>C Val108Val
M0133285 LKLLIHPL_00001 447 3 Oral 1.00 protein_coding synonymous_variant LOW 201T>C Asp67Asp
M0133286 LKLLIHPL_00001 468 3 Oral 1.00 protein_coding synonymous_variant LOW 180A>T Thr60Thr
M0133287 LKLLIHPL_00002 790 3 Oral 1.00 protein_coding missense_variant MODERATE 726C>A Asp242Glu
M0133288 LKLLIHPL_00002 835 3 Oral 1.00 protein_coding missense_variant MODERATE 681A>C Arg227Ser
M0133289 LKLLIHPL_00002 839 3 Oral 1.00 protein_coding missense_variant MODERATE 677G>A Ser226Asn
M0133290 LKLLIHPL_00002 844 3 Oral 1.00 protein_coding synonymous_variant LOW 672T>C Thr224Thr
M0133291 LKLLIHPL_00002 846 3 Oral 1.00 protein_coding missense_variant MODERATE 670A>G Thr224Ala
M0133292 LKLLIHPL_00002 1210 3 Oral 1.00 protein_coding synonymous_variant LOW 306T>C Ser102Ser
M0133293 LKLLIHPL_00002 1285 3 Oral 1.00 protein_coding synonymous_variant LOW 231T>G Arg77Arg
M0133294 LKLLIHPL_00002 1303 3 Oral 1.00 protein_coding synonymous_variant LOW 213C>T Ser71Ser
M0133295 LKLLIHPL_00002 1378 3 Oral 1.00 protein_coding synonymous_variant LOW 138T>C Ser46Ser
M0133296 LKLLIHPL_00003 1669 3 Oral 1.00 protein_coding missense_variant MODERATE 715T>G Phe239Val
M0133297 LKLLIHPL_00003 1736 3 Oral 1.00 protein_coding synonymous_variant LOW 648G>A Leu216Leu
M0133298 LKLLIHPL_00003 1892 3 Oral 1.00 protein_coding synonymous_variant LOW 492A>G Lys164Lys
M0133299 LKLLIHPL_00003 1898 3 Oral 1.00 protein_coding synonymous_variant LOW 486A>G Leu162Leu
M0133300 LKLLIHPL_00003 1907 3 Oral 1.00 protein_coding synonymous_variant LOW 477C>T Ile159Ile
M0133301 LKLLIHPL_00003 1940 3 Oral 1.00 protein_coding synonymous_variant LOW 444T>C Thr148Thr
M0133302 LKLLIHPL_00003 1988 3 Oral 1.00 protein_coding synonymous_variant LOW 396T>G Ala132Ala
M0133303 LKLLIHPL_00003 2021 3 Oral 1.00 protein_coding synonymous_variant LOW 363T>G Leu121Leu
M0133304 LKLLIHPL_00003 2069 3 Oral 1.00 protein_coding synonymous_variant LOW 315C>G Val105Val
M0133305 LKLLIHPL_00003 2092 3 Oral 1.00 protein_coding missense_variant MODERATE 292A>G Thr98Ala
M0133306 LKLLIHPL_00003 2261 3 Oral 1.00 protein_coding synonymous_variant LOW 123G>A Lys41Lys
M0133307 LKLLIHPL_00003 2264 3 Oral 1.00 protein_coding synonymous_variant LOW 120C>A Gly40Gly
M0133308 LKLLIHPL_00001 2397 3 Oral 1.00 protein_coding upstream_gene_variant MODIFIER -1750A>C None
M0133309 LKLLIHPL_00001 2448 3 Oral 1.00 protein_coding upstream_gene_variant MODIFIER -1801T>A None
M0133310 LKLLIHPL_00001 2452 3 Oral 1.00 protein_coding upstream_gene_variant MODIFIER -1805G>A None
M0133311 LKLLIHPL_00001 2453 3 Oral 1.00 protein_coding upstream_gene_variant MODIFIER -1806A>C None
M0133312 LKLLIHPL_00004 2684 3 Oral 1.00 protein_coding synonymous_variant LOW 1383C>T His461His
M0133313 LKLLIHPL_00004 2846 3 Oral 1.00 protein_coding synonymous_variant LOW 1221C>T Tyr407Tyr
M0133314 LKLLIHPL_00004 2870 3 Oral 1.00 protein_coding synonymous_variant LOW 1197G>A Leu399Leu
M0133315 LKLLIHPL_00004 2947 3 Oral 1.00 protein_coding missense_variant MODERATE 1120G>A Gly374Ser
M0133316 LKLLIHPL_00004 3221 3 Oral 1.00 protein_coding synonymous_variant LOW 846C>T Gly282Gly
M0133317 LKLLIHPL_00004 3275 3 Oral 1.00 protein_coding synonymous_variant LOW 792A>T Leu264Leu
M0133318 LKLLIHPL_00004 3332 3 Oral 1.00 protein_coding synonymous_variant LOW 735C>T Arg245Arg
M0133319 LKLLIHPL_00004 3344 3 Oral 1.00 protein_coding synonymous_variant LOW 723A>G Thr241Thr
M0133320 LKLLIHPL_00004 3365 3 Oral 1.00 protein_coding synonymous_variant LOW 702A>T Thr234Thr
M0133321 LKLLIHPL_00004 3427 3 Oral 1.00 protein_coding missense_variant MODERATE 640A>G Thr214Ala
M0133322 LKLLIHPL_00004 3518 3 Oral 1.00 protein_coding synonymous_variant LOW 549A>G Leu183Leu
M0133323 LKLLIHPL_00004 3608 3 Oral 1.00 protein_coding synonymous_variant LOW 459G>A Gly153Gly
M0133324 LKLLIHPL_00004 3646 3 Oral 1.00 protein_coding synonymous_variant LOW 421T>C Leu141Leu
M0133325 LKLLIHPL_00004 3860 3 Oral 1.00 protein_coding synonymous_variant LOW 207C>T Ala69Ala
M0133326 LKLLIHPL_00004 3899 3 Oral 1.00 protein_coding synonymous_variant LOW 168A>G Val56Val
M0133327 LKLLIHPL_00004 3904 3 Oral 1.00 protein_coding missense_variant MODERATE 163A>G Ser55Gly
M0133328 LKLLIHPL_00004 3920 3 Oral 1.00 protein_coding synonymous_variant LOW 147A>G Leu49Leu
M0133329 LKLLIHPL_00004 4007 3 Oral 1.00 protein_coding synonymous_variant LOW 60A>C Arg20Arg
M0133330 LKLLIHPL_00004 4010 3 Oral 1.00 protein_coding synonymous_variant LOW 57C>G Thr19Thr






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term