Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C3153
  Reference Plasmid   MET0265_bin.1__k81_996
  Reference Plasmid Size   2023
  Reference Plasmid GC Content   0.28
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0076527 OFPOFJPP_00001 424 3 Skin 0.60 protein_coding missense_variant MODERATE 320A>C Lys107Thr
M0076528 OFPOFJPP_00001 435 3 Skin 0.60 protein_coding missense_variant MODERATE 331C>A His111Asn
M0076529 OFPOFJPP_00001 519 3 Skin 0.60 protein_coding missense_variant MODERATE 415A>C Asn139His
M0076530 OFPOFJPP_00001 539 3 Skin 0.60 protein_coding synonymous_variant LOW 435G>A Lys145Lys
M0076531 OFPOFJPP_00001 602 3 Skin 0.60 protein_coding synonymous_variant LOW 498T>C Tyr166Tyr
M0076532 OFPOFJPP_00001 624 3 Skin 0.60 protein_coding missense_variant MODERATE 520A>G Ile174Val
M0076533 OFPOFJPP_00001 665 3 Skin 0.60 protein_coding synonymous_variant LOW 561C>A Gly187Gly
M0076534 OFPOFJPP_00001 717 3 Skin 0.60 protein_coding missense_variant MODERATE 613A>G Asn205Asp
M0076535 OFPOFJPP_00001 741 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *7G>T None
M0076536 OFPOFJPP_00001 749 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *15A>G None
M0076537 OFPOFJPP_00001 762 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *28T>A None
M0076538 OFPOFJPP_00001 765 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *31C>T None
M0076539 OFPOFJPP_00001 767 4 Skin 0.80 protein_coding downstream_gene_variant MODIFIER *33G>A None
M0076540 OFPOFJPP_00001 783 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *49T>C None
M0076541 OFPOFJPP_00001 787 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *53C>T None
M0076542 OFPOFJPP_00001 788 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *54C>A None
M0076543 OFPOFJPP_00001 790 4 Skin 0.80 protein_coding downstream_gene_variant MODIFIER *56A>T None
M0076544 OFPOFJPP_00001 812 3 Skin 0.60 protein_coding downstream_gene_variant MODIFIER *78A>G None
M0076545 OFPOFJPP_00002 838 3 Skin 0.60 protein_coding synonymous_variant LOW 573A>G Glu191Glu
M0076546 OFPOFJPP_00002 844 3 Skin 0.60 protein_coding synonymous_variant LOW 567C>T Leu189Leu
M0076547 OFPOFJPP_00002 875 3 Skin 0.60 protein_coding missense_variant MODERATE 536T>C Ile179Thr
M0076548 OFPOFJPP_00002 925 3 Skin 0.60 protein_coding synonymous_variant LOW 486T>A Ile162Ile
M0076549 OFPOFJPP_00002 960 3 Skin 0.60 protein_coding missense_variant MODERATE 451T>C Tyr151His
M0076550 OFPOFJPP_00002 963 3 Skin 0.60 protein_coding missense_variant MODERATE 448G>A Asp150Asn
M0076551 OFPOFJPP_00002 964 3 Skin 0.60 protein_coding synonymous_variant LOW 447C>T Asp149Asp
M0076552 OFPOFJPP_00002 976 3 Skin 0.60 protein_coding synonymous_variant LOW 435T>C Ile145Ile
M0076553 OFPOFJPP_00002 1005 3 Skin 0.60 protein_coding missense_variant MODERATE 406T>C Tyr136His
M0076554 OFPOFJPP_00002 1022 4 Skin 0.80 protein_coding missense_variant MODERATE 389A>G Asn130Ser
M0076555 OFPOFJPP_00002 1036 3 Skin 0.60 protein_coding synonymous_variant LOW 375A>G Ala125Ala
M0076556 OFPOFJPP_00002 1077 3 Skin 0.60 protein_coding missense_variant MODERATE 334C>T Pro112Ser
M0076557 OFPOFJPP_00002 1090 3 Skin 0.60 protein_coding synonymous_variant LOW 321T>C Arg107Arg
M0076558 OFPOFJPP_00002 1100 3 Skin 0.60 protein_coding missense_variant MODERATE 311T>A Met104Lys
M0076559 OFPOFJPP_00002 1105 3 Skin 0.60 protein_coding synonymous_variant LOW 306C>T Asn102Asn
M0076560 OFPOFJPP_00002 1171 3 Skin 0.60 protein_coding synonymous_variant LOW 240A>C Thr80Thr
M0076561 OFPOFJPP_00002 1174 3 Skin 0.60 protein_coding synonymous_variant LOW 237C>T Val79Val
M0076562 OFPOFJPP_00002 1187 3 Skin 0.60 protein_coding missense_variant MODERATE 224C>T Thr75Ile
M0076563 OFPOFJPP_00002 1222 3 Skin 0.60 protein_coding synonymous_variant LOW 189G>A Thr63Thr
M0076564 OFPOFJPP_00002 1254 3 Skin 0.60 protein_coding missense_variant MODERATE 157A>G Asn53Asp
M0076565 OFPOFJPP_00002 1255 3 Skin 0.60 protein_coding synonymous_variant LOW 156C>T Ile52Ile
M0076566 OFPOFJPP_00002 1276 3 Skin 0.60 protein_coding synonymous_variant LOW 135A>G Pro45Pro
M0076567 OFPOFJPP_00002 1278 3 Skin 0.60 protein_coding missense_variant MODERATE 133C>A Pro45Thr
M0076568 OFPOFJPP_00002 1285 3 Skin 0.60 protein_coding missense_variant MODERATE 126A>C Gln42His
M0076569 OFPOFJPP_00002 1287 3 Skin 0.60 protein_coding missense_variant MODERATE 124C>A Gln42Lys
M0076570 OFPOFJPP_00002 1294 3 Skin 0.60 protein_coding synonymous_variant LOW 117C>T Ser39Ser
M0076571 OFPOFJPP_00002 1302 3 Skin 0.60 protein_coding missense_variant MODERATE 109G>A Val37Ile
M0076572 OFPOFJPP_00002 1307 3 Skin 0.60 protein_coding missense_variant MODERATE 104A>G Lys35Arg
M0076573 OFPOFJPP_00002 1450 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -40T>A None
M0076574 OFPOFJPP_00002 1469 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -59G>T None
M0076575 OFPOFJPP_00002 1473 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -63A>G None
M0076576 OFPOFJPP_00002 1478 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -68C>A None
M0076577 OFPOFJPP_00002 1499 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -89G>T None
M0076578 OFPOFJPP_00002 1500 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -90T>C None
M0076579 OFPOFJPP_00002 1514 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -104A>G None
M0076580 OFPOFJPP_00002 1516 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -106A>T None
M0076581 OFPOFJPP_00002 1542 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -132A>G None
M0076582 OFPOFJPP_00002 1543 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -133T>A None
M0076583 OFPOFJPP_00002 1604 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -194G>A None
M0076584 OFPOFJPP_00002 1672 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -262G>A None
M0076585 OFPOFJPP_00002 1682 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -272C>T None
M0076586 OFPOFJPP_00003 1689 3 Skin 0.60 protein_coding splice_region_variant&stop_retained_variant LOW 249G>A Ter83Ter
M0076587 OFPOFJPP_00002 1967 3 Skin 0.60 protein_coding upstream_gene_variant MODIFIER -557C>T None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term