Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C3181
  Reference Plasmid   MET0302_bin.6__k81_8841
  Reference Plasmid Size   11909
  Reference Plasmid GC Content   0.33
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0078216 JOBCOHHH_00001 158 4 Skin 0.44 protein_coding upstream_gene_variant MODIFIER -712T>C None
M0078217 JOBCOHHH_00001 330 4 Skin 0.44 protein_coding upstream_gene_variant MODIFIER -540T>C None
M0078218 JOBCOHHH_00001 379 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -491A>T None
M0078219 JOBCOHHH_00001 1074 3 Skin 0.33 protein_coding synonymous_variant LOW 205C>T Leu69Leu
M0078220 JOBCOHHH_00001 108 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -762A>C None
M0078221 JOBCOHHH_00001 507 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -363C>T None
M0078222 JOBCOHHH_00001 1481 4 Skin 0.44 protein_coding synonymous_variant LOW 612T>C Val204Val
M0078223 JOBCOHHH_00001 1552 5 Skin 0.56 protein_coding missense_variant MODERATE 683C>T Ala228Val
M0078224 JOBCOHHH_00001 1579 4 Skin 0.44 protein_coding missense_variant MODERATE 710T>C Val237Ala
M0078225 JOBCOHHH_00001 1611 4 Skin 0.44 protein_coding missense_variant MODERATE 742T>C Phe248Leu
M0078226 JOBCOHHH_00002 1701 5 Skin 0.56 protein_coding synonymous_variant LOW 27T>C Tyr9Tyr
M0078227 JOBCOHHH_00002 1788 3 Skin 0.33 protein_coding synonymous_variant LOW 114C>T Tyr38Tyr
M0078228 JOBCOHHH_00002 1812 3 Skin 0.33 protein_coding synonymous_variant LOW 138A>G Pro46Pro
M0078229 JOBCOHHH_00002 1838 3 Skin 0.33 protein_coding missense_variant MODERATE 164C>G Ala55Gly
M0078230 JOBCOHHH_00002 1851 6 Skin 0.67 protein_coding synonymous_variant LOW 177G>C Gly59Gly
M0078231 JOBCOHHH_00002 1860 3 Skin 0.33 protein_coding synonymous_variant LOW 186T>A Gly62Gly
M0078232 JOBCOHHH_00002 1881 4 Skin 0.44 protein_coding synonymous_variant LOW 207A>G Lys69Lys
M0078233 JOBCOHHH_00002 1905 4 Skin 0.44 protein_coding synonymous_variant LOW 231C>T Tyr77Tyr
M0078234 JOBCOHHH_00002 1945 4 Skin 0.44 protein_coding missense_variant MODERATE 271T>G Leu91Val
M0078235 JOBCOHHH_00002 2001 4 Skin 0.44 protein_coding synonymous_variant LOW 327T>C Phe109Phe
M0078236 JOBCOHHH_00002 2067 4 Skin 0.44 protein_coding synonymous_variant LOW 393G>C Gly131Gly
M0078237 JOBCOHHH_00002 2082 4 Skin 0.44 protein_coding synonymous_variant LOW 408G>A Leu136Leu
M0078238 JOBCOHHH_00002 2226 4 Skin 0.44 protein_coding synonymous_variant LOW 552T>C Phe184Phe
M0078239 JOBCOHHH_00002 2247 5 Skin 0.56 protein_coding synonymous_variant LOW 573A>G Glu191Glu
M0078240 JOBCOHHH_00002 2415 4 Skin 0.44 protein_coding synonymous_variant LOW 741A>G Thr247Thr
M0078241 JOBCOHHH_00002 2463 4 Skin 0.44 protein_coding missense_variant MODERATE 789G>T Met263Ile
M0078242 JOBCOHHH_00003 2526 4 Skin 0.44 protein_coding upstream_gene_variant MODIFIER -88A>T None
M0078243 JOBCOHHH_00003 2982 6 Skin 0.67 protein_coding missense_variant MODERATE 369A>T Lys123Asn
M0078244 JOBCOHHH_00003 3018 3 Skin 0.33 protein_coding synonymous_variant LOW 405T>C Gly135Gly
M0078245 JOBCOHHH_00001 636 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -234A>C None
M0078246 JOBCOHHH_00001 678 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -192A>T None
M0078247 JOBCOHHH_00004 3320 3 Skin 0.33 protein_coding missense_variant MODERATE 52G>A Val18Ile
M0078248 JOBCOHHH_00004 3598 4 Skin 0.44 protein_coding synonymous_variant LOW 330C>T Gly110Gly
M0078249 JOBCOHHH_00006 6384 3 Skin 0.33 protein_coding missense_variant MODERATE 382A>C Asn128His
M0078250 JOBCOHHH_00002 2424 3 Skin 0.33 protein_coding synonymous_variant LOW 750T>A Leu250Leu
M0078251 JOBCOHHH_00003 2497 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -117G>A None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
JOBCOHHH_00005 2.A.1.2.101 75.1 5.1e-154 1 390 0.9974 0.9873 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.1 The Major Facilitator Superfamily (MFS)