Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C3197
  Reference Plasmid   MET0333_bin.3__k81_18938
  Reference Plasmid Size   4213
  Reference Plasmid GC Content   0.39
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0079595 AMPLIOPG_00001 731 4 Skin 0.50 protein_coding synonymous_variant LOW 60C>T Val20Val
M0079596 AMPLIOPG_00001 763 4 Skin 0.50 protein_coding missense_variant MODERATE 92T>C Ile31Thr
M0079597 AMPLIOPG_00001 773 4 Skin 0.50 protein_coding synonymous_variant LOW 102A>G Ala34Ala
M0079598 AMPLIOPG_00001 791 4 Skin 0.50 protein_coding synonymous_variant LOW 120G>A Lys40Lys
M0079599 AMPLIOPG_00001 803 4 Skin 0.50 protein_coding missense_variant MODERATE 132T>G His44Gln
M0079600 AMPLIOPG_00001 815 4 Skin 0.50 protein_coding synonymous_variant LOW 144A>T Ala48Ala
M0079601 AMPLIOPG_00001 851 4 Skin 0.50 protein_coding synonymous_variant LOW 180G>A Glu60Glu
M0079602 AMPLIOPG_00001 860 4 Skin 0.50 protein_coding synonymous_variant LOW 189A>G Gly63Gly
M0079603 AMPLIOPG_00001 1124 5 Skin 0.63 protein_coding synonymous_variant LOW 453G>A Gln151Gln
M0079604 AMPLIOPG_00001 1139 5 Skin 0.63 protein_coding synonymous_variant LOW 468A>G Ala156Ala
M0079605 AMPLIOPG_00001 1152 5 Skin 0.63 protein_coding missense_variant MODERATE 481A>G Ile161Val
M0079606 AMPLIOPG_00002 2300 7 Skin 0.88 protein_coding upstream_gene_variant MODIFIER -37T>C None
M0079607 AMPLIOPG_00002 1363 4 Skin 0.50 protein_coding synonymous_variant LOW 901T>C Leu301Leu
M0079608 AMPLIOPG_00002 1393 3 Skin 0.38 protein_coding missense_variant MODERATE 871C>A His291Asn
M0079609 AMPLIOPG_00002 1544 4 Skin 0.50 protein_coding synonymous_variant LOW 720T>C Ser240Ser
M0079610 AMPLIOPG_00002 1582 4 Skin 0.50 protein_coding missense_variant MODERATE 682G>C Glu228Gln
M0079611 AMPLIOPG_00002 1586 4 Skin 0.50 protein_coding missense_variant MODERATE 678C>A His226Gln
M0079612 AMPLIOPG_00002 1595 3 Skin 0.38 protein_coding synonymous_variant LOW 669T>C Ser223Ser
M0079613 AMPLIOPG_00002 1615 4 Skin 0.50 protein_coding missense_variant MODERATE 649A>G Thr217Ala
M0079614 AMPLIOPG_00002 1668 3 Skin 0.38 protein_coding missense_variant MODERATE 596T>C Met199Thr
M0079615 AMPLIOPG_00002 1680 3 Skin 0.38 protein_coding missense_variant MODERATE 584C>T Ala195Val
M0079616 AMPLIOPG_00002 1747 3 Skin 0.38 protein_coding missense_variant MODERATE 517A>G Thr173Ala
M0079617 AMPLIOPG_00002 1765 4 Skin 0.50 protein_coding missense_variant MODERATE 499T>A Ser167Thr
M0079618 AMPLIOPG_00002 1772 4 Skin 0.50 protein_coding synonymous_variant LOW 492G>A Lys164Lys
M0079619 AMPLIOPG_00002 1972 4 Skin 0.50 protein_coding missense_variant MODERATE 292G>A Ala98Thr
M0079620 AMPLIOPG_00002 2096 3 Skin 0.38 protein_coding synonymous_variant LOW 168T>C Gly56Gly
M0079621 AMPLIOPG_00002 2108 5 Skin 0.63 protein_coding synonymous_variant LOW 156T>C Cys52Cys
M0079622 AMPLIOPG_00002 2138 4 Skin 0.50 protein_coding synonymous_variant LOW 126T>C Leu42Leu
M0079623 AMPLIOPG_00002 2404 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -141G>A None
M0079624 AMPLIOPG_00002 2444 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -181C>T None
M0079625 AMPLIOPG_00002 2449 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -186G>A None
M0079626 AMPLIOPG_00002 2453 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -190G>A None
M0079627 AMPLIOPG_00002 2459 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -196C>T None
M0079628 AMPLIOPG_00002 2472 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -209T>A None
M0079629 AMPLIOPG_00002 2474 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -211T>C None
M0079630 AMPLIOPG_00002 2500 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -237G>T None
M0079631 AMPLIOPG_00002 2507 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -244A>G None
M0079632 AMPLIOPG_00002 2509 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -246C>T None
M0079633 AMPLIOPG_00003 3126 4 Skin 0.50 protein_coding missense_variant MODERATE 476G>A Arg159His
M0079634 AMPLIOPG_00003 3141 4 Skin 0.50 protein_coding missense_variant MODERATE 461G>T Arg154Met
M0079635 AMPLIOPG_00003 3269 3 Skin 0.38 protein_coding synonymous_variant LOW 333G>C Val111Val
M0079636 AMPLIOPG_00003 3308 3 Skin 0.38 protein_coding synonymous_variant LOW 294C>T Phe98Phe
M0079637 AMPLIOPG_00003 3311 3 Skin 0.38 protein_coding synonymous_variant LOW 291C>G Gly97Gly
M0079638 AMPLIOPG_00003 3322 3 Skin 0.38 protein_coding synonymous_variant LOW 280T>C Leu94Leu
M0079639 AMPLIOPG_00002 3785 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -1522C>T None
M0079640 AMPLIOPG_00002 3806 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1543G>A None
M0079641 AMPLIOPG_00002 3839 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1576T>C None
M0079642 AMPLIOPG_00002 3855 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1592G>A None
M0079643 AMPLIOPG_00002 3857 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1594T>C None
M0079644 AMPLIOPG_00002 3902 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1639T>C None
M0079645 AMPLIOPG_00002 3905 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1642G>A None
M0079646 AMPLIOPG_00002 3965 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -1702A>G None
M0079647 AMPLIOPG_00002 4151 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1888C>T None
M0079648 AMPLIOPG_00002 4169 4 Skin 0.50 protein_coding upstream_gene_variant MODIFIER -1906G>A None
M0079649 AMPLIOPG_00002 2662 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -399T>A None
M0079650 AMPLIOPG_00003 2818 3 Skin 0.38 protein_coding missense_variant MODERATE 784T>G Leu262Val
M0079651 AMPLIOPG_00003 2837 3 Skin 0.38 protein_coding synonymous_variant LOW 765T>C Asn255Asn
M0079652 AMPLIOPG_00003 2921 3 Skin 0.38 protein_coding synonymous_variant LOW 681G>A Ala227Ala
M0079653 AMPLIOPG_00003 3050 3 Skin 0.38 protein_coding synonymous_variant LOW 552G>T Val184Val
M0079654 AMPLIOPG_00003 3052 3 Skin 0.38 protein_coding missense_variant MODERATE 550G>A Val184Met
M0079655 AMPLIOPG_00003 3055 3 Skin 0.38 protein_coding missense_variant MODERATE 547G>A Gly183Ser
M0079656 AMPLIOPG_00003 3113 3 Skin 0.38 protein_coding synonymous_variant LOW 489G>A Val163Val
M0079657 AMPLIOPG_00003 3146 3 Skin 0.38 protein_coding synonymous_variant LOW 456G>T Ala152Ala
M0079658 AMPLIOPG_00002 2559 3 Skin 0.38 protein_coding upstream_gene_variant MODIFIER -296C>T None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term