Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C28
  Reference Plasmid   MET0466_bin.10__k81_15780
  Reference Plasmid Size   28057
  Reference Plasmid GC Content   0.38
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0080394 FGEBMIGK_00028 21276 3 Skin 0.27 protein_coding missense_variant MODERATE 386G>A Gly129Asp
M0080395 FGEBMIGK_00033 27316 4 Skin 0.36 protein_coding synonymous_variant LOW 627G>A Leu209Leu
M0141378 FGEBMIGK_00001 345 5 Vaginal 0.50 protein_coding missense_variant MODERATE 11C>T Pro4Leu
M0141379 FGEBMIGK_00002 528 4 Vaginal 0.40 protein_coding missense_variant MODERATE 172A>C Lys58Gln
M0141380 FGEBMIGK_00001 755 5 Vaginal 0.50 protein_coding upstream_gene_variant MODIFIER -400A>C None
M0141381 FGEBMIGK_00015 13573 4 Vaginal 0.40 protein_coding missense_variant MODERATE 860G>A Gly287Glu
M0141382 FGEBMIGK_00025 19447 4 Vaginal 0.40 protein_coding synonymous_variant LOW 534T>C Cys178Cys
M0141383 FGEBMIGK_00031 24702 3 Vaginal 0.30 protein_coding missense_variant MODERATE 1126T>C Ser376Pro
M0141384 FGEBMIGK_00031 24890 3 Vaginal 0.30 protein_coding missense_variant MODERATE 938A>C Gln313Pro
M0141385 FGEBMIGK_00032 25870 3 Vaginal 0.30 protein_coding missense_variant MODERATE 1298C>T Ala433Val
M0141386 FGEBMIGK_00032 26378 3 Vaginal 0.30 protein_coding missense_variant MODERATE 790G>A Ala264Thr
M0141387 FGEBMIGK_00032 26394 3 Vaginal 0.30 protein_coding synonymous_variant LOW 774C>T Ile258Ile
M0141388 FGEBMIGK_00032 26484 3 Vaginal 0.30 protein_coding synonymous_variant LOW 684T>C Asp228Asp
M0141389 FGEBMIGK_00032 26495 3 Vaginal 0.30 protein_coding missense_variant MODERATE 673A>G Ser225Gly
M0141390 FGEBMIGK_00032 26643 3 Vaginal 0.30 protein_coding synonymous_variant LOW 525A>T Gly175Gly
M0141391 FGEBMIGK_00032 26688 3 Vaginal 0.30 protein_coding synonymous_variant LOW 480G>A Gln160Gln
M0141392 FGEBMIGK_00032 26799 3 Vaginal 0.30 protein_coding synonymous_variant LOW 369C>T Gly123Gly
M0141393 FGEBMIGK_00032 26961 3 Vaginal 0.30 protein_coding synonymous_variant LOW 207C>T Ser69Ser
M0141394 FGEBMIGK_00033 27316 6 Vaginal 0.60 protein_coding synonymous_variant LOW 627G>A Leu209Leu
M0141395 FGEBMIGK_00033 27403 3 Vaginal 0.30 protein_coding missense_variant MODERATE 540A>T Glu180Asp
M0141396 FGEBMIGK_00033 27454 3 Vaginal 0.30 protein_coding synonymous_variant LOW 489G>A Ala163Ala
M0141397 FGEBMIGK_00033 27544 3 Vaginal 0.30 protein_coding synonymous_variant LOW 399C>T Phe133Phe
M0141398 FGEBMIGK_00033 27590 3 Vaginal 0.30 protein_coding missense_variant MODERATE 353A>G His118Arg
M0141399 FGEBMIGK_00033 27612 3 Vaginal 0.30 protein_coding missense_variant MODERATE 331G>A Asp111Asn
M0141400 FGEBMIGK_00033 27825 3 Vaginal 0.30 protein_coding missense_variant MODERATE 118C>A Gln40Lys






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term