Annotation Categories of the Plasmid Cluster
Summary of the plasmid cluster
Basic Information about the Plasmid Cluster
Cluster Information |
Plasmid Cluster ID |
C3312 |
Reference Plasmid |
MGYG000298306__MGYG000298306_331 |
Reference Plasmid Size |
17493 |
Reference Plasmid GC Content |
0.45 |
Reference Plasmid Mobility Type |
non-mobilizable |
Mutation sites in the plasmid cluster
The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..
mutid |
gname |
pos |
count |
tissue |
frequnt |
biotype |
consequence |
impact |
nucchange |
aachange |
M0134816 |
COGNOBHK_00001 |
2034 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1722G>A |
Lys574Lys |
M0134817 |
COGNOBHK_00002 |
2484 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
399T>C |
Leu133Leu |
M0134818 |
COGNOBHK_00002 |
2565 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
480T>C |
Phe160Phe |
M0134819 |
COGNOBHK_00002 |
2736 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
651T>C |
Arg217Arg |
M0134820 |
COGNOBHK_00002 |
2817 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
732G>T |
Gly244Gly |
M0134821 |
COGNOBHK_00002 |
3099 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1014T>C |
Pro338Pro |
M0134822 |
COGNOBHK_00002 |
3393 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
1308T>C |
Asn436Asn |
M0134823 |
COGNOBHK_00002 |
4038 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1953T>C |
Leu651Leu |
M0134824 |
COGNOBHK_00002 |
4249 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
2164A>C |
Asn722His |
M0134825 |
COGNOBHK_00002 |
4344 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
2259A>G |
Leu753Leu |
M0134826 |
COGNOBHK_00002 |
4356 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
2271A>T |
Gly757Gly |
M0134827 |
COGNOBHK_00002 |
4419 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
2334T>A |
Ala778Ala |
M0134828 |
COGNOBHK_00002 |
4459 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
2374A>C |
Thr792Pro |
M0134829 |
COGNOBHK_00002 |
4460 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
2375C>A |
Thr792Lys |
M0134830 |
COGNOBHK_00002 |
4563 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
2478A>G |
Ala826Ala |
M0134831 |
COGNOBHK_00001 |
70 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-243T>C |
None |
M0134832 |
COGNOBHK_00001 |
136 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-177G>A |
None |
M0134833 |
COGNOBHK_00001 |
190 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-123G>A |
None |
M0134834 |
COGNOBHK_00001 |
336 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
24C>T |
Gly8Gly |
M0134835 |
COGNOBHK_00001 |
465 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
153T>C |
Gly51Gly |
M0134836 |
COGNOBHK_00001 |
900 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
588T>C |
Gly196Gly |
M0134837 |
COGNOBHK_00001 |
1039 |
8 |
Oral |
0.35 |
protein_coding |
missense_variant |
MODERATE |
727A>G |
Thr243Ala |
M0134838 |
COGNOBHK_00001 |
1182 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
870T>A |
Gly290Gly |
M0134839 |
COGNOBHK_00001 |
1275 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
963A>G |
Thr321Thr |
M0134840 |
COGNOBHK_00001 |
1357 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
1045A>G |
Ile349Val |
M0134841 |
COGNOBHK_00001 |
1450 |
9 |
Oral |
0.39 |
protein_coding |
missense_variant |
MODERATE |
1138A>G |
Lys380Glu |
M0134842 |
COGNOBHK_00001 |
1485 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1173T>C |
Thr391Thr |
M0134843 |
COGNOBHK_00001 |
1491 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1179C>T |
Asp393Asp |
M0134844 |
COGNOBHK_00001 |
1546 |
8 |
Oral |
0.35 |
protein_coding |
missense_variant |
MODERATE |
1234T>A |
Cys412Ser |
M0134845 |
COGNOBHK_00001 |
1548 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
1236T>C |
Cys412Cys |
M0134846 |
COGNOBHK_00001 |
1833 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1521T>C |
Asp507Asp |
M0134847 |
COGNOBHK_00001 |
1895 |
7 |
Oral |
0.30 |
protein_coding |
missense_variant |
MODERATE |
1583A>C |
Lys528Thr |
M0134848 |
COGNOBHK_00001 |
1926 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1614A>G |
Ala538Ala |
M0134849 |
COGNOBHK_00001 |
1956 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1644C>T |
Ala548Ala |
M0134850 |
COGNOBHK_00001 |
2017 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
1705A>C |
Asn569His |
M0134851 |
COGNOBHK_00001 |
2041 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
1729G>A |
Ala577Thr |
M0134852 |
COGNOBHK_00002 |
2922 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
837C>T |
Gly279Gly |
M0134853 |
COGNOBHK_00002 |
3483 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1398G>A |
Leu466Leu |
M0134854 |
COGNOBHK_00002 |
3579 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1494T>C |
Asn498Asn |
M0134855 |
COGNOBHK_00002 |
3936 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1851A>C |
Leu617Leu |
M0134856 |
COGNOBHK_00002 |
4098 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2013T>C |
Arg671Arg |
M0134857 |
COGNOBHK_00002 |
4272 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2187C>T |
Asp729Asp |
M0134858 |
COGNOBHK_00002 |
4335 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
2250T>C |
Asp750Asp |
M0134859 |
COGNOBHK_00002 |
4385 |
7 |
Oral |
0.30 |
protein_coding |
missense_variant |
MODERATE |
2300G>A |
Arg767His |
M0134860 |
COGNOBHK_00002 |
4386 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
2301T>A |
Arg767Arg |
M0134861 |
COGNOBHK_00003 |
4655 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-351C>T |
None |
M0134862 |
COGNOBHK_00003 |
4696 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-310T>C |
None |
M0134863 |
COGNOBHK_00003 |
4748 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-258C>T |
None |
M0134864 |
COGNOBHK_00003 |
4770 |
9 |
Oral |
0.39 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-236T>C |
None |
M0134865 |
COGNOBHK_00003 |
4791 |
10 |
Oral |
0.43 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-215A>G |
None |
M0134866 |
COGNOBHK_00003 |
5293 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
288C>T |
Tyr96Tyr |
M0134867 |
COGNOBHK_00003 |
5353 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
348T>C |
Asn116Asn |
M0134868 |
COGNOBHK_00003 |
5422 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
417T>C |
Ala139Ala |
M0134869 |
COGNOBHK_00003 |
5455 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
450C>T |
Asp150Asp |
M0134870 |
COGNOBHK_00003 |
5494 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
489C>G |
Val163Val |
M0134871 |
COGNOBHK_00003 |
5590 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
585G>A |
Gln195Gln |
M0134872 |
COGNOBHK_00003 |
5614 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
609C>T |
Thr203Thr |
M0134873 |
COGNOBHK_00003 |
5914 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
909C>T |
Leu303Leu |
M0134874 |
COGNOBHK_00004 |
6192 |
9 |
Oral |
0.39 |
protein_coding |
missense_variant |
MODERATE |
127G>A |
Val43Ile |
M0134875 |
COGNOBHK_00004 |
6218 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
153C>T |
Pro51Pro |
M0134876 |
COGNOBHK_00004 |
6449 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
384T>C |
Tyr128Tyr |
M0134877 |
COGNOBHK_00004 |
6458 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
393A>G |
Glu131Glu |
M0134878 |
COGNOBHK_00004 |
6666 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
601T>C |
Leu201Leu |
M0134879 |
COGNOBHK_00004 |
6752 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
687G>A |
Thr229Thr |
M0134880 |
COGNOBHK_00004 |
7025 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
960T>C |
Ser320Ser |
M0134881 |
COGNOBHK_00004 |
7064 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
999A>C |
Val333Val |
M0134882 |
COGNOBHK_00004 |
7241 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1176A>G |
Lys392Lys |
M0134883 |
COGNOBHK_00004 |
7343 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
1278G>A |
Thr426Thr |
M0134884 |
COGNOBHK_00004 |
7412 |
13 |
Oral |
0.57 |
protein_coding |
synonymous_variant |
LOW |
1347A>T |
Thr449Thr |
M0134885 |
COGNOBHK_00004 |
7469 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
1404A>G |
Lys468Lys |
M0134886 |
COGNOBHK_00004 |
7484 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
1419T>G |
Gly473Gly |
M0134887 |
COGNOBHK_00004 |
7494 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
1429T>C |
Leu477Leu |
M0134888 |
COGNOBHK_00004 |
7625 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
1560C>T |
Arg520Arg |
M0134889 |
COGNOBHK_00004 |
7820 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1755T>C |
Phe585Phe |
M0134890 |
COGNOBHK_00004 |
7952 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1887A>T |
Ile629Ile |
M0134891 |
COGNOBHK_00004 |
8432 |
12 |
Oral |
0.52 |
protein_coding |
synonymous_variant |
LOW |
2367T>G |
Leu789Leu |
M0134892 |
COGNOBHK_00004 |
8627 |
15 |
Oral |
0.65 |
protein_coding |
synonymous_variant |
LOW |
2562T>C |
Asn854Asn |
M0134893 |
COGNOBHK_00004 |
8843 |
13 |
Oral |
0.57 |
protein_coding |
synonymous_variant |
LOW |
2778T>A |
Thr926Thr |
M0134894 |
COGNOBHK_00004 |
8897 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
2832A>T |
Val944Val |
M0134895 |
COGNOBHK_00004 |
9180 |
7 |
Oral |
0.30 |
protein_coding |
missense_variant |
MODERATE |
3115G>A |
Val1039Ile |
M0134896 |
COGNOBHK_00005 |
9570 |
16 |
Oral |
0.70 |
protein_coding |
synonymous_variant |
LOW |
126T>C |
Thr42Thr |
M0134897 |
COGNOBHK_00005 |
9762 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
318G>C |
Thr106Thr |
M0134898 |
COGNOBHK_00005 |
9984 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
540T>C |
Ile180Ile |
M0134899 |
COGNOBHK_00005 |
9990 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
546A>T |
Ala182Ala |
M0134900 |
COGNOBHK_00005 |
10192 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
748T>A |
Leu250Met |
M0134901 |
COGNOBHK_00005 |
10233 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
789C>T |
Ala263Ala |
M0134902 |
COGNOBHK_00005 |
10236 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
792C>T |
Ile264Ile |
M0134903 |
COGNOBHK_00005 |
10272 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
828T>C |
Leu276Leu |
M0134904 |
COGNOBHK_00005 |
10365 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
921C>T |
Arg307Arg |
M0134905 |
COGNOBHK_00005 |
10366 |
9 |
Oral |
0.39 |
protein_coding |
missense_variant |
MODERATE |
922T>C |
Phe308Leu |
M0134906 |
COGNOBHK_00005 |
10416 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
972G>A |
Glu324Glu |
M0134907 |
COGNOBHK_00005 |
10536 |
14 |
Oral |
0.61 |
protein_coding |
synonymous_variant |
LOW |
1092C>T |
Asn364Asn |
M0134908 |
COGNOBHK_00005 |
10842 |
13 |
Oral |
0.57 |
protein_coding |
synonymous_variant |
LOW |
1398A>T |
Pro466Pro |
M0134909 |
COGNOBHK_00006 |
10964 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
33A>C |
Ala11Ala |
M0134910 |
COGNOBHK_00006 |
11042 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
111C>T |
Val37Val |
M0134911 |
COGNOBHK_00006 |
11109 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
178C>G |
Gln60Glu |
M0134912 |
COGNOBHK_00006 |
11165 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
234C>T |
Asp78Asp |
M0134913 |
COGNOBHK_00006 |
11240 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
309T>A |
Val103Val |
M0134914 |
COGNOBHK_00006 |
11336 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
405C>T |
Asp135Asp |
M0134915 |
COGNOBHK_00006 |
11339 |
14 |
Oral |
0.61 |
protein_coding |
synonymous_variant |
LOW |
408T>C |
Ser136Ser |
M0134916 |
COGNOBHK_00006 |
11348 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
417T>C |
Ala139Ala |
M0134917 |
COGNOBHK_00006 |
11543 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
612T>C |
Phe204Phe |
M0134918 |
COGNOBHK_00006 |
11555 |
16 |
Oral |
0.70 |
protein_coding |
synonymous_variant |
LOW |
624C>T |
Asn208Asn |
M0134919 |
COGNOBHK_00006 |
11970 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
1039A>G |
Ile347Val |
M0134920 |
COGNOBHK_00007 |
12241 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-138T>G |
None |
M0134921 |
COGNOBHK_00007 |
12603 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
225G>C |
Ser75Ser |
M0134922 |
COGNOBHK_00007 |
12624 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
246C>G |
Asn82Lys |
M0134923 |
COGNOBHK_00007 |
12636 |
13 |
Oral |
0.57 |
protein_coding |
synonymous_variant |
LOW |
258A>G |
Thr86Thr |
M0134924 |
COGNOBHK_00007 |
13212 |
15 |
Oral |
0.65 |
protein_coding |
synonymous_variant |
LOW |
834A>C |
Gly278Gly |
M0134925 |
COGNOBHK_00007 |
13725 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
1347A>G |
Thr449Thr |
M0134926 |
COGNOBHK_00007 |
13794 |
13 |
Oral |
0.57 |
protein_coding |
synonymous_variant |
LOW |
1416A>G |
Val472Val |
M0134927 |
COGNOBHK_00007 |
13848 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
1470C>T |
Asp490Asp |
M0134928 |
COGNOBHK_00007 |
13851 |
14 |
Oral |
0.61 |
protein_coding |
synonymous_variant |
LOW |
1473C>T |
Asp491Asp |
M0134929 |
COGNOBHK_00007 |
13959 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1581C>T |
Asp527Asp |
M0134930 |
COGNOBHK_00008 |
14152 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
76A>G |
Thr26Ala |
M0134931 |
COGNOBHK_00008 |
14307 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
231A>G |
Ser77Ser |
M0134932 |
COGNOBHK_00008 |
14418 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
342C>T |
Asp114Asp |
M0134933 |
COGNOBHK_00008 |
14427 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
351T>C |
Ser117Ser |
M0134934 |
COGNOBHK_00008 |
14535 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
459C>T |
Asn153Asn |
M0134935 |
COGNOBHK_00008 |
14970 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
894C>T |
Arg298Arg |
M0134936 |
COGNOBHK_00009 |
15240 |
6 |
Oral |
0.26 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-92G>A |
None |
M0134937 |
COGNOBHK_00009 |
15291 |
12 |
Oral |
0.52 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-41T>C |
None |
M0134938 |
COGNOBHK_00009 |
15422 |
6 |
Oral |
0.26 |
protein_coding |
missense_variant |
MODERATE |
91A>C |
Lys31Gln |
M0134939 |
COGNOBHK_00009 |
15556 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
225A>G |
Pro75Pro |
M0134940 |
COGNOBHK_00009 |
15561 |
10 |
Oral |
0.43 |
protein_coding |
missense_variant |
MODERATE |
230T>A |
Phe77Tyr |
M0134941 |
COGNOBHK_00009 |
15583 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
252A>T |
Ser84Ser |
M0134942 |
COGNOBHK_00009 |
15589 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
258C>T |
Phe86Phe |
M0134943 |
COGNOBHK_00009 |
15772 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
441G>T |
Ala147Ala |
M0134944 |
COGNOBHK_00009 |
16075 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
744C>T |
Ile248Ile |
M0134945 |
COGNOBHK_00009 |
16120 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
789C>T |
Phe263Phe |
M0134946 |
COGNOBHK_00009 |
16189 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
858A>G |
Val286Val |
M0134947 |
COGNOBHK_00009 |
16240 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
909A>G |
Leu303Leu |
M0134948 |
COGNOBHK_00009 |
16246 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
915C>T |
Tyr305Tyr |
M0134949 |
COGNOBHK_00009 |
16421 |
10 |
Oral |
0.43 |
protein_coding |
missense_variant |
MODERATE |
1090A>G |
Ser364Gly |
M0134950 |
COGNOBHK_00009 |
16648 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1317C>T |
Gly439Gly |
M0134951 |
COGNOBHK_00009 |
16767 |
6 |
Oral |
0.26 |
protein_coding |
missense_variant |
MODERATE |
1436T>C |
Val479Ala |
M0134952 |
COGNOBHK_00009 |
16768 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1437G>A |
Val479Val |
M0134953 |
COGNOBHK_00009 |
16900 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
1569T>C |
Ala523Ala |
M0134954 |
COGNOBHK_00009 |
16952 |
10 |
Oral |
0.43 |
protein_coding |
missense_variant |
MODERATE |
1621A>G |
Asn541Asp |
M0134955 |
COGNOBHK_00009 |
17045 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
1714C>G |
Gln572Glu |
M0134956 |
COGNOBHK_00009 |
17084 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
1753C>A |
Gln585Lys |
M0134957 |
COGNOBHK_00009 |
17102 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
1771A>G |
Ile591Val |
M0134958 |
COGNOBHK_00009 |
17143 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
1812T>C |
Asn604Asn |
M0134959 |
COGNOBHK_00009 |
17167 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1836G>A |
Glu612Glu |
M0134960 |
COGNOBHK_00009 |
17230 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1899C>T |
Phe633Phe |
M0134961 |
COGNOBHK_00009 |
17287 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1956T>C |
Ser652Ser |
M0134962 |
COGNOBHK_00009 |
17314 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1983A>G |
Val661Val |
M0134963 |
COGNOBHK_00009 |
17345 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
2014T>C |
Leu672Leu |
M0134964 |
COGNOBHK_00009 |
17365 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
2034A>G |
Thr678Thr |
M0134965 |
COGNOBHK_00007 |
17380 |
7 |
Oral |
0.30 |
protein_coding |
downstream_gene_variant |
MODIFIER |
*3307A>G |
None |
M0134966 |
COGNOBHK_00007 |
17385 |
7 |
Oral |
0.30 |
protein_coding |
downstream_gene_variant |
MODIFIER |
*3312C>G |
None |
M0134967 |
COGNOBHK_00007 |
17390 |
5 |
Oral |
0.22 |
protein_coding |
downstream_gene_variant |
MODIFIER |
*3317T>C |
None |
M0134968 |
COGNOBHK_00006 |
11613 |
9 |
Oral |
0.39 |
protein_coding |
missense_variant |
MODERATE |
682A>G |
Thr228Ala |
M0134969 |
COGNOBHK_00006 |
11768 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
837A>G |
Leu279Leu |
M0134970 |
COGNOBHK_00006 |
11827 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
896C>T |
Thr299Ile |
M0134971 |
COGNOBHK_00006 |
12191 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1260T>C |
Ser420Ser |
M0134972 |
COGNOBHK_00007 |
12311 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-68C>G |
None |
M0134973 |
COGNOBHK_00007 |
12669 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
291G>T |
Thr97Thr |
M0134974 |
COGNOBHK_00001 |
1320 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1008G>A |
Gly336Gly |
M0134975 |
COGNOBHK_00001 |
1365 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1053G>T |
Ala351Ala |
M0134976 |
COGNOBHK_00001 |
1431 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1119C>G |
Gly373Gly |
M0134977 |
COGNOBHK_00002 |
2547 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
462C>T |
Leu154Leu |
M0134978 |
COGNOBHK_00002 |
2953 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
868A>T |
Ser290Cys |
M0134979 |
COGNOBHK_00002 |
4251 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
2166T>C |
Asn722Asn |
M0134980 |
COGNOBHK_00002 |
4347 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2262G>A |
Leu754Leu |
M0134981 |
COGNOBHK_00002 |
4611 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2526C>T |
His842His |
M0134982 |
COGNOBHK_00003 |
4735 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-271A>G |
None |
M0134983 |
COGNOBHK_00003 |
5416 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
411C>G |
Ala137Ala |
M0134984 |
COGNOBHK_00004 |
6332 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
267A>G |
Ser89Ser |
M0134985 |
COGNOBHK_00004 |
6335 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
270A>G |
Leu90Leu |
M0134986 |
COGNOBHK_00004 |
6426 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
361G>A |
Ala121Thr |
M0134987 |
COGNOBHK_00004 |
6430 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
365C>T |
Ala122Val |
M0134988 |
COGNOBHK_00004 |
6431 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
366C>T |
Ala122Ala |
M0134989 |
COGNOBHK_00004 |
6542 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
477C>T |
Ile159Ile |
M0134990 |
COGNOBHK_00004 |
6599 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
534C>T |
Ala178Ala |
M0134991 |
COGNOBHK_00004 |
6689 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
624C>T |
Asp208Asp |
M0134992 |
COGNOBHK_00004 |
8090 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
2025T>C |
Phe675Phe |
M0134993 |
COGNOBHK_00004 |
8270 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2205T>A |
Arg735Arg |
M0134994 |
COGNOBHK_00004 |
8402 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
2337A>T |
Thr779Thr |
M0134995 |
COGNOBHK_00004 |
8756 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2691C>T |
Ile897Ile |
M0134996 |
COGNOBHK_00004 |
8867 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
2802G>A |
Leu934Leu |
M0134997 |
COGNOBHK_00004 |
9068 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
3003A>G |
Gln1001Gln |
M0134998 |
COGNOBHK_00004 |
9209 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
3144C>T |
Asp1048Asp |
M0134999 |
COGNOBHK_00004 |
9230 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
3165C>T |
Asn1055Asn |
M0135000 |
COGNOBHK_00004 |
9320 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
3255G>A |
Thr1085Thr |
M0135001 |
COGNOBHK_00005 |
10221 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
777C>T |
Asp259Asp |
M0135002 |
COGNOBHK_00005 |
10437 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
993G>A |
Glu331Glu |
M0135003 |
COGNOBHK_00006 |
10983 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
52C>T |
Leu18Phe |
M0135004 |
COGNOBHK_00006 |
11000 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
69G>A |
Ser23Ser |
M0135005 |
COGNOBHK_00006 |
11027 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
96T>A |
Ala32Ala |
M0135006 |
COGNOBHK_00006 |
11171 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
240A>G |
Pro80Pro |
M0135007 |
COGNOBHK_00006 |
11252 |
9 |
Oral |
0.39 |
protein_coding |
synonymous_variant |
LOW |
321T>G |
Pro107Pro |
M0135008 |
COGNOBHK_00006 |
11416 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
485C>G |
Thr162Ser |
M0135009 |
COGNOBHK_00006 |
11654 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
723G>A |
Lys241Lys |
M0135010 |
COGNOBHK_00007 |
12748 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
370C>T |
Leu124Leu |
M0135011 |
COGNOBHK_00007 |
12771 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
393G>A |
Thr131Thr |
M0135012 |
COGNOBHK_00007 |
13008 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
630C>T |
Phe210Phe |
M0135013 |
COGNOBHK_00007 |
13029 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
651T>C |
Ile217Ile |
M0135014 |
COGNOBHK_00007 |
13132 |
11 |
Oral |
0.48 |
protein_coding |
missense_variant |
MODERATE |
754A>G |
Thr252Ala |
M0135015 |
COGNOBHK_00007 |
13134 |
11 |
Oral |
0.48 |
protein_coding |
synonymous_variant |
LOW |
756G>T |
Thr252Thr |
M0135016 |
COGNOBHK_00007 |
13224 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
846A>G |
Thr282Thr |
M0135017 |
COGNOBHK_00007 |
13336 |
9 |
Oral |
0.39 |
protein_coding |
missense_variant |
MODERATE |
958A>G |
Ser320Gly |
M0135018 |
COGNOBHK_00007 |
13434 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1056A>G |
Ala352Ala |
M0135019 |
COGNOBHK_00007 |
13659 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1281C>T |
Gly427Gly |
M0135020 |
COGNOBHK_00007 |
13806 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1428A>G |
Ala476Ala |
M0135021 |
COGNOBHK_00007 |
13845 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1467A>G |
Ser489Ser |
M0135022 |
COGNOBHK_00007 |
13932 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1554C>T |
Ile518Ile |
M0135023 |
COGNOBHK_00008 |
14124 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
48G>A |
Thr16Thr |
M0135024 |
COGNOBHK_00008 |
14235 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
159T>C |
Val53Val |
M0135025 |
COGNOBHK_00008 |
14283 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
207C>T |
Asn69Asn |
M0135026 |
COGNOBHK_00008 |
14439 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
363A>G |
Gln121Gln |
M0135027 |
COGNOBHK_00008 |
14482 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
406A>G |
Thr136Ala |
M0135028 |
COGNOBHK_00008 |
14487 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
411T>C |
Cys137Cys |
M0135029 |
COGNOBHK_00008 |
14490 |
10 |
Oral |
0.43 |
protein_coding |
synonymous_variant |
LOW |
414C>T |
Asp138Asp |
M0135030 |
COGNOBHK_00004 |
8711 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
2646T>A |
Thr882Thr |
M0135031 |
COGNOBHK_00005 |
9870 |
6 |
Oral |
0.26 |
protein_coding |
missense_variant |
MODERATE |
426T>G |
Asp142Glu |
M0135032 |
COGNOBHK_00005 |
9891 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
447C>T |
Asn149Asn |
M0135033 |
COGNOBHK_00005 |
10368 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
924T>G |
Phe308Leu |
M0135034 |
COGNOBHK_00005 |
10447 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
1003T>A |
Ser335Thr |
M0135035 |
COGNOBHK_00005 |
10537 |
7 |
Oral |
0.30 |
protein_coding |
missense_variant |
MODERATE |
1093C>T |
Pro365Ser |
M0135036 |
COGNOBHK_00005 |
10702 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
1258A>G |
Thr420Ala |
M0135037 |
COGNOBHK_00008 |
14379 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
303T>C |
Asn101Asn |
M0135038 |
COGNOBHK_00008 |
15028 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
952C>T |
Leu318Leu |
M0135039 |
COGNOBHK_00008 |
15135 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1059T>C |
Gly353Gly |
M0135040 |
COGNOBHK_00009 |
15895 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
564T>C |
Asn188Asn |
M0135041 |
COGNOBHK_00009 |
16033 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
702G>A |
Leu234Leu |
M0135042 |
COGNOBHK_00009 |
16039 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
708T>A |
Ala236Ala |
M0135043 |
COGNOBHK_00009 |
16051 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
720C>A |
Ala240Ala |
M0135044 |
COGNOBHK_00009 |
16087 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
756A>T |
Thr252Thr |
M0135045 |
COGNOBHK_00009 |
16222 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
891A>G |
Ala297Ala |
M0135046 |
COGNOBHK_00009 |
16243 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
912C>T |
Ser304Ser |
M0135047 |
COGNOBHK_00009 |
16279 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
948T>C |
Ala316Ala |
M0135048 |
COGNOBHK_00009 |
16512 |
10 |
Oral |
0.43 |
protein_coding |
missense_variant |
MODERATE |
1181A>G |
Glu394Gly |
M0135049 |
COGNOBHK_00009 |
17047 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
1716G>A |
Gln572Gln |
M0135050 |
COGNOBHK_00007 |
17419 |
6 |
Oral |
0.26 |
protein_coding |
downstream_gene_variant |
MODIFIER |
*3346A>G |
None |
M0135051 |
COGNOBHK_00004 |
9167 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
3102C>T |
Tyr1034Tyr |
M0135052 |
COGNOBHK_00005 |
9957 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
513C>T |
Arg171Arg |
M0135053 |
COGNOBHK_00005 |
10330 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
886C>T |
Leu296Leu |
M0135054 |
COGNOBHK_00005 |
10644 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1200T>C |
Asn400Asn |
M0135055 |
COGNOBHK_00005 |
10650 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1206C>T |
Arg402Arg |
M0135056 |
COGNOBHK_00003 |
5659 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
654C>T |
Asp218Asp |
M0135057 |
COGNOBHK_00004 |
7184 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1119C>G |
Gly373Gly |
M0135058 |
COGNOBHK_00004 |
7568 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
1503C>A |
Gly501Gly |
M0135059 |
COGNOBHK_00004 |
7631 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1566G>A |
Thr522Thr |
M0135060 |
COGNOBHK_00004 |
8912 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
2847T>C |
Asp949Asp |
M0135061 |
COGNOBHK_00004 |
8927 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
2862C>T |
Phe954Phe |
M0135062 |
COGNOBHK_00005 |
9846 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
402G>A |
Leu134Leu |
M0135063 |
COGNOBHK_00005 |
9983 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
539T>C |
Ile180Thr |
M0135064 |
COGNOBHK_00005 |
10254 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
810G>T |
Val270Val |
M0135065 |
COGNOBHK_00005 |
10495 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
1051T>A |
Ser351Thr |
M0135066 |
COGNOBHK_00005 |
10497 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1053G>A |
Ser351Ser |
M0135067 |
COGNOBHK_00006 |
11159 |
8 |
Oral |
0.35 |
protein_coding |
synonymous_variant |
LOW |
228A>T |
Ala76Ala |
M0135068 |
COGNOBHK_00006 |
11160 |
7 |
Oral |
0.30 |
protein_coding |
missense_variant |
MODERATE |
229T>G |
Ser77Ala |
M0135069 |
COGNOBHK_00006 |
11246 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
315C>T |
Phe105Phe |
M0135070 |
COGNOBHK_00006 |
11816 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
885A>G |
Glu295Glu |
M0135071 |
COGNOBHK_00007 |
12284 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-95G>A |
None |
M0135072 |
COGNOBHK_00007 |
12300 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-79C>T |
None |
M0135073 |
COGNOBHK_00007 |
12768 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
390G>A |
Ser130Ser |
M0135074 |
COGNOBHK_00007 |
12888 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
510C>T |
Gly170Gly |
M0135075 |
COGNOBHK_00007 |
12993 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
615T>A |
Ser205Ser |
M0135076 |
COGNOBHK_00007 |
13566 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1188G>A |
Thr396Thr |
M0135077 |
COGNOBHK_00007 |
13690 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
1312G>A |
Ala438Thr |
M0135078 |
COGNOBHK_00007 |
13857 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1479C>T |
Phe493Phe |
M0135079 |
COGNOBHK_00004 |
7532 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1467C>T |
Ser489Ser |
M0135080 |
COGNOBHK_00001 |
1158 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
846A>C |
Pro282Pro |
M0135081 |
COGNOBHK_00002 |
3363 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1278T>C |
Tyr426Tyr |
M0135082 |
COGNOBHK_00003 |
4806 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-200T>A |
None |
M0135083 |
COGNOBHK_00003 |
5360 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
355C>T |
Leu119Leu |
M0135084 |
COGNOBHK_00003 |
5845 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
840C>T |
Asp280Asp |
M0135085 |
COGNOBHK_00004 |
7739 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1674A>G |
Ser558Ser |
M0135086 |
COGNOBHK_00004 |
8615 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2550G>A |
Ser850Ser |
M0135087 |
COGNOBHK_00004 |
8957 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
2892G>T |
Val964Val |
M0135088 |
COGNOBHK_00005 |
10117 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
673G>A |
Ala225Thr |
M0135089 |
COGNOBHK_00005 |
10119 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
675A>G |
Ala225Ala |
M0135090 |
COGNOBHK_00005 |
10713 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1269C>T |
Asn423Asn |
M0135091 |
COGNOBHK_00006 |
11234 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
303C>T |
Pro101Pro |
M0135092 |
COGNOBHK_00007 |
12909 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
531C>T |
Ser177Ser |
M0135093 |
COGNOBHK_00007 |
13350 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
972G>A |
Leu324Leu |
M0135094 |
COGNOBHK_00007 |
13411 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1033T>C |
Leu345Leu |
M0135095 |
COGNOBHK_00008 |
14574 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
498G>A |
Ala166Ala |
M0135096 |
COGNOBHK_00008 |
14952 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
876C>T |
Val292Val |
M0135097 |
COGNOBHK_00008 |
14982 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
906G>A |
Leu302Leu |
M0135098 |
COGNOBHK_00008 |
14985 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
909T>C |
Ala303Ala |
M0135099 |
COGNOBHK_00008 |
15115 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1039T>C |
Leu347Leu |
M0135100 |
COGNOBHK_00008 |
15153 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1077C>T |
Phe359Phe |
M0135101 |
COGNOBHK_00009 |
15196 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-136A>G |
None |
M0135102 |
COGNOBHK_00009 |
15199 |
9 |
Oral |
0.39 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-133G>A |
None |
M0135103 |
COGNOBHK_00009 |
15204 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-128C>T |
None |
M0135104 |
COGNOBHK_00009 |
15214 |
7 |
Oral |
0.30 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-118A>G |
None |
M0135105 |
COGNOBHK_00009 |
15216 |
7 |
Oral |
0.30 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-116C>T |
None |
M0135106 |
COGNOBHK_00009 |
15220 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-112T>C |
None |
M0135107 |
COGNOBHK_00009 |
15236 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-96C>T |
None |
M0135108 |
COGNOBHK_00009 |
15297 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-35G>A |
None |
M0135109 |
COGNOBHK_00001 |
901 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
589T>C |
Leu197Leu |
M0135110 |
COGNOBHK_00002 |
2223 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
138C>T |
Asp46Asp |
M0135111 |
COGNOBHK_00002 |
2592 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
507G>A |
Gln169Gln |
M0135112 |
COGNOBHK_00002 |
4158 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
2073C>T |
Ile691Ile |
M0135113 |
COGNOBHK_00003 |
4719 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-287T>C |
None |
M0135114 |
COGNOBHK_00004 |
6143 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
78C>T |
Leu26Leu |
M0135115 |
COGNOBHK_00004 |
6293 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
228G>A |
Gly76Gly |
M0135116 |
COGNOBHK_00005 |
9807 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
363T>C |
Leu121Leu |
M0135117 |
COGNOBHK_00006 |
11594 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
663A>G |
Ala221Ala |
M0135118 |
COGNOBHK_00006 |
11852 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
921C>T |
Asp307Asp |
M0135119 |
COGNOBHK_00007 |
13365 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
987G>A |
Glu329Glu |
M0135120 |
COGNOBHK_00007 |
13473 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1095T>C |
Pro365Pro |
M0135121 |
COGNOBHK_00009 |
15208 |
5 |
Oral |
0.22 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-124A>T |
None |
M0135122 |
COGNOBHK_00009 |
15210 |
4 |
Oral |
0.17 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-122T>C |
None |
M0135123 |
COGNOBHK_00009 |
15844 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
513T>C |
Asn171Asn |
M0135124 |
COGNOBHK_00009 |
15847 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
516C>T |
Ser172Ser |
M0135125 |
COGNOBHK_00009 |
15848 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
517C>T |
Leu173Phe |
M0135126 |
COGNOBHK_00009 |
15850 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
519C>G |
Leu173Leu |
M0135127 |
COGNOBHK_00009 |
15949 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
618A>T |
Pro206Pro |
M0135128 |
COGNOBHK_00009 |
17220 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
1889T>C |
Val630Ala |
M0135129 |
COGNOBHK_00003 |
4910 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-96G>A |
None |
M0135130 |
COGNOBHK_00003 |
4971 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-35G>A |
None |
M0135131 |
COGNOBHK_00003 |
5525 |
4 |
Oral |
0.17 |
protein_coding |
missense_variant |
MODERATE |
520G>A |
Ala174Thr |
M0135132 |
COGNOBHK_00003 |
5942 |
5 |
Oral |
0.22 |
protein_coding |
missense_variant |
MODERATE |
937A>C |
Ile313Leu |
M0135133 |
COGNOBHK_00004 |
7376 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1311T>A |
Ile437Ile |
M0135134 |
COGNOBHK_00005 |
10089 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
645G>A |
Lys215Lys |
M0135135 |
COGNOBHK_00009 |
15277 |
3 |
Oral |
0.13 |
protein_coding |
upstream_gene_variant |
MODIFIER |
-55G>A |
None |
M0135136 |
COGNOBHK_00009 |
15649 |
7 |
Oral |
0.30 |
protein_coding |
synonymous_variant |
LOW |
318T>C |
Asp106Asp |
M0135137 |
COGNOBHK_00009 |
16015 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
684T>A |
Ala228Ala |
M0135138 |
COGNOBHK_00009 |
16564 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1233A>G |
Ala411Ala |
M0135139 |
COGNOBHK_00009 |
16650 |
3 |
Oral |
0.13 |
protein_coding |
missense_variant |
MODERATE |
1319C>G |
Ala440Gly |
M0135140 |
COGNOBHK_00009 |
16717 |
5 |
Oral |
0.22 |
protein_coding |
synonymous_variant |
LOW |
1386C>T |
Asp462Asp |
M0135141 |
COGNOBHK_00009 |
16885 |
6 |
Oral |
0.26 |
protein_coding |
synonymous_variant |
LOW |
1554C>T |
Asp518Asp |
M0135142 |
COGNOBHK_00007 |
13488 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1110C>T |
Gly370Gly |
M0135143 |
COGNOBHK_00007 |
13914 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1536G>A |
Glu512Glu |
M0135144 |
COGNOBHK_00009 |
16796 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1465T>C |
Leu489Leu |
M0135145 |
COGNOBHK_00009 |
17056 |
4 |
Oral |
0.17 |
protein_coding |
synonymous_variant |
LOW |
1725G>A |
Gln575Gln |
M0135146 |
COGNOBHK_00009 |
16444 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1113G>A |
Gln371Gln |
M0135147 |
COGNOBHK_00004 |
7145 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1080C>T |
Val360Val |
M0135148 |
COGNOBHK_00009 |
16651 |
3 |
Oral |
0.13 |
protein_coding |
synonymous_variant |
LOW |
1320C>A |
Ala440Ala |
Analysis of virulence factors contributing to bacterial pathogenicity
This table presents virulence factors identified within the plasmid cluster.
Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.
Gene Name |
vf_gene_id |
vf_name |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
vf_category |
gene_description |
condition |
Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact
This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.
Gene Name |
compound |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
group |
Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents
This table presents antimicrobial resistance genes identified within the plasmid cluster.
Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.
Gene Name |
aro_accession |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
drug_class |
amr_gene_family |
resistance_mechanism |
Analysis of pathogenicity genes to explore pathogen-host interactions
This table presents host pathogen-host interactions within the plasmid cluster.
Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.
Gene Name |
phi_molconn_id |
host gene_name |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
host_descripton |
disease_name |
function |
phenotype_of_mutant |
Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation
This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.
Gene Name |
cazy_id |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
COGNOBHK_00001 |
VEH15050.1|GT3 |
81.7 |
0 |
32 |
578 |
0.9383 |
0.9945 |
COGNOBHK_00002 |
VEH15051.1|GT35 |
92.4 |
0 |
1 |
853 |
1 |
1 |
Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification
This table presents transport proteins within the plasmid cluster.
Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.
Gene Name |
tcid |
identity |
evalue |
qstart |
qend |
query_coverage |
subject_coverage |
class_field |
class_term |
subclass |
subclass_term |
family |
family_term |