Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C378
  Reference Plasmid   NZ_AP024743.1
  Reference Plasmid Size   23724
  Reference Plasmid GC Content   0.31
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0086931 FHKKBNBK_00008 4732 3 Skin 0.50 protein_coding missense_variant MODERATE 1216A>C Ile406Leu
M0086932 FHKKBNBK_00008 4737 3 Skin 0.50 protein_coding missense_variant MODERATE 1211T>C Ile404Thr
M0086933 FHKKBNBK_00008 4821 3 Skin 0.50 protein_coding missense_variant MODERATE 1127A>G His376Arg
M0086934 FHKKBNBK_00008 4865 3 Skin 0.50 protein_coding synonymous_variant LOW 1083T>C Leu361Leu
M0086935 FHKKBNBK_00008 4970 3 Skin 0.50 protein_coding synonymous_variant LOW 978T>A Ile326Ile
M0086936 FHKKBNBK_00008 4973 3 Skin 0.50 protein_coding synonymous_variant LOW 975T>C Arg325Arg
M0086937 FHKKBNBK_00008 4982 3 Skin 0.50 protein_coding synonymous_variant LOW 966T>C Thr322Thr
M0086938 FHKKBNBK_00008 4985 3 Skin 0.50 protein_coding synonymous_variant LOW 963G>A Gly321Gly
M0086939 FHKKBNBK_00008 4997 3 Skin 0.50 protein_coding synonymous_variant LOW 951T>A Thr317Thr
M0086940 FHKKBNBK_00008 5006 3 Skin 0.50 protein_coding synonymous_variant LOW 942C>A Thr314Thr
M0086941 FHKKBNBK_00008 5048 3 Skin 0.50 protein_coding synonymous_variant LOW 900T>C Ile300Ile
M0086942 FHKKBNBK_00008 5111 3 Skin 0.50 protein_coding synonymous_variant LOW 837G>A Lys279Lys
M0086943 FHKKBNBK_00008 5258 3 Skin 0.50 protein_coding synonymous_variant LOW 690T>A Pro230Pro
M0086944 FHKKBNBK_00008 5270 3 Skin 0.50 protein_coding synonymous_variant LOW 678C>A Ile226Ile
M0086945 FHKKBNBK_00008 5273 3 Skin 0.50 protein_coding synonymous_variant LOW 675C>T Tyr225Tyr
M0086946 FHKKBNBK_00008 5282 3 Skin 0.50 protein_coding synonymous_variant LOW 666A>T Ser222Ser
M0086947 FHKKBNBK_00008 5294 3 Skin 0.50 protein_coding synonymous_variant LOW 654C>T Phe218Phe
M0086948 FHKKBNBK_00008 5303 3 Skin 0.50 protein_coding synonymous_variant LOW 645G>T Gly215Gly
M0086949 FHKKBNBK_00008 5321 3 Skin 0.50 protein_coding synonymous_variant LOW 627A>C Gly209Gly
M0086950 FHKKBNBK_00008 5345 3 Skin 0.50 protein_coding synonymous_variant LOW 603T>A Ile201Ile






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
FHKKBNBK_00025 ARO:3000617 99.7 0 1 668 1.0000 1.0000 penicillin beta-lactam methicillin resistant PBP2 antibiotic target replacement
NNKMDPGF_00025 ARO:3000617 99.7 0 1 668 1.0000 1.0000 penicillin beta-lactam methicillin resistant PBP2 antibiotic target replacement
CEMNCHJA_00025 ARO:3000617 99.7 0 1 668 1.0000 1.0000 penicillin beta-lactam methicillin resistant PBP2 antibiotic target replacement






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
FHKKBNBK_00025 PHI:6884 MecA 99.9 0 1 668 1.0000 1.0000 rodents pneumonia penicillin-binding protein unaffected pathogenicity
NNKMDPGF_00025 PHI:6884 MecA 99.9 0 1 668 1.0000 1.0000 rodents pneumonia penicillin-binding protein unaffected pathogenicity
CEMNCHJA_00025 PHI:6884 MecA 99.9 0 1 668 1.0000 1.0000 rodents pneumonia penicillin-binding protein unaffected pathogenicity






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term