Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C379
  Reference Plasmid   NZ_AP024950.1
  Reference Plasmid Size   42798
  Reference Plasmid GC Content   0.61
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0086951 IBHAHPKB_00026 21231 12 Skin 0.75 protein_coding missense_variant MODERATE 812G>C Gly271Ala
M0086952 IBHAHPKB_00026 21256 12 Skin 0.75 protein_coding synonymous_variant LOW 837A>T Ala279Ala
M0086953 IBHAHPKB_00026 21263 12 Skin 0.75 protein_coding missense_variant MODERATE 844T>C Tyr282His
M0086954 IBHAHPKB_00026 21391 13 Skin 0.81 protein_coding synonymous_variant LOW 972A>C Gly324Gly
M0086955 IBHAHPKB_00026 21526 13 Skin 0.81 protein_coding synonymous_variant LOW 1107A>G Pro369Pro
M0086956 IBHAHPKB_00026 21541 13 Skin 0.81 protein_coding synonymous_variant LOW 1122C>G Thr374Thr
M0086957 IBHAHPKB_00026 21563 13 Skin 0.81 protein_coding missense_variant MODERATE 1144C>T Pro382Ser
M0086958 IBHAHPKB_00026 21565 13 Skin 0.81 protein_coding synonymous_variant LOW 1146C>G Pro382Pro
M0086959 IBHAHPKB_00026 21589 14 Skin 0.88 protein_coding missense_variant MODERATE 1170G>A Met390Ile
M0086960 IBHAHPKB_00026 21615 14 Skin 0.88 protein_coding missense_variant MODERATE 1196A>T Glu399Val
M0086961 IBHAHPKB_00026 21663 14 Skin 0.88 protein_coding missense_variant MODERATE 1244A>C Asp415Ala
M0086962 IBHAHPKB_00026 21664 14 Skin 0.88 protein_coding missense_variant MODERATE 1245C>A Asp415Glu
M0086963 IBHAHPKB_00026 21706 14 Skin 0.88 protein_coding synonymous_variant LOW 1287G>A Pro429Pro
M0086964 IBHAHPKB_00026 21715 14 Skin 0.88 protein_coding missense_variant MODERATE 1296G>C Met432Ile
M0086965 IBHAHPKB_00026 21771 15 Skin 0.94 protein_coding missense_variant MODERATE 1352G>C Arg451Thr
M0086966 IBHAHPKB_00026 22045 15 Skin 0.94 protein_coding synonymous_variant LOW 1626C>T Asn542Asn
M0086967 IBHAHPKB_00026 22193 15 Skin 0.94 protein_coding missense_variant MODERATE 1774G>A Ala592Thr
M0086968 IBHAHPKB_00026 22354 15 Skin 0.94 protein_coding synonymous_variant LOW 1935C>G Ala645Ala
M0086969 IBHAHPKB_00026 22827 15 Skin 0.94 protein_coding missense_variant MODERATE 2408C>T Ala803Val
M0086970 IBHAHPKB_00026 22912 13 Skin 0.81 protein_coding synonymous_variant LOW 2493C>T Ala831Ala
M0086971 IBHAHPKB_00026 22932 13 Skin 0.81 protein_coding missense_variant MODERATE 2513T>C Ile838Thr
M0086972 IBHAHPKB_00026 22935 13 Skin 0.81 protein_coding missense_variant MODERATE 2516G>C Gly839Ala
M0086973 IBHAHPKB_00026 22939 13 Skin 0.81 protein_coding missense_variant MODERATE 2520A>C Glu840Asp
M0086974 IBHAHPKB_00026 23009 13 Skin 0.81 protein_coding synonymous_variant LOW 2590C>T Leu864Leu
M0086975 IBHAHPKB_00026 23201 14 Skin 0.88 protein_coding synonymous_variant LOW 2782C>T Leu928Leu
M0086976 IBHAHPKB_00026 23251 14 Skin 0.88 protein_coding synonymous_variant LOW 2832G>C Val944Val
M0086977 IBHAHPKB_00026 23252 14 Skin 0.88 protein_coding synonymous_variant LOW 2833C>T Leu945Leu
M0086978 IBHAHPKB_00026 23257 14 Skin 0.88 protein_coding synonymous_variant LOW 2838A>C Ala946Ala
M0086979 IBHAHPKB_00026 23259 14 Skin 0.88 protein_coding missense_variant MODERATE 2840A>T Gln947Leu
M0086980 IBHAHPKB_00026 23296 14 Skin 0.88 protein_coding synonymous_variant LOW 2877T>C Tyr959Tyr
M0086981 IBHAHPKB_00026 23377 14 Skin 0.88 protein_coding synonymous_variant LOW 2958G>A Leu986Leu
M0086982 IBHAHPKB_00022 23388 14 Skin 0.88 protein_coding upstream_gene_variant MODIFIER -4516C>T None
M0086983 IBHAHPKB_00025 20040 6 Skin 0.38 protein_coding synonymous_variant LOW 369T>A Arg123Arg
M0086984 IBHAHPKB_00025 20043 6 Skin 0.38 protein_coding synonymous_variant LOW 372A>G Ser124Ser
M0086985 IBHAHPKB_00025 20052 6 Skin 0.38 protein_coding synonymous_variant LOW 381T>C His127His
M0086986 IBHAHPKB_00025 20055 6 Skin 0.38 protein_coding synonymous_variant LOW 384G>A Leu128Leu
M0086987 IBHAHPKB_00025 20059 6 Skin 0.38 protein_coding missense_variant MODERATE 388G>A Ala130Thr
M0086988 IBHAHPKB_00025 20062 6 Skin 0.38 protein_coding missense_variant MODERATE 391C>A Leu131Met
M0086989 IBHAHPKB_00025 20064 6 Skin 0.38 protein_coding synonymous_variant LOW 393G>C Leu131Leu
M0086990 IBHAHPKB_00025 20073 6 Skin 0.38 protein_coding synonymous_variant LOW 402A>G Ser134Ser
M0086991 IBHAHPKB_00025 20103 6 Skin 0.38 protein_coding synonymous_variant LOW 432A>G Ser144Ser
M0086992 IBHAHPKB_00025 20115 6 Skin 0.38 protein_coding synonymous_variant LOW 444C>T Asn148Asn
M0086993 IBHAHPKB_00025 20148 7 Skin 0.44 protein_coding synonymous_variant LOW 477G>A Leu159Leu
M0086994 IBHAHPKB_00025 20172 7 Skin 0.44 protein_coding synonymous_variant LOW 501T>G Ala167Ala
M0086995 IBHAHPKB_00025 20247 8 Skin 0.50 protein_coding synonymous_variant LOW 576C>T Gly192Gly
M0086996 IBHAHPKB_00025 20250 8 Skin 0.50 protein_coding synonymous_variant LOW 579C>G Gly193Gly
M0086997 IBHAHPKB_00025 20322 8 Skin 0.50 protein_coding synonymous_variant LOW 651G>A Ala217Ala
M0086998 IBHAHPKB_00026 20442 9 Skin 0.56 protein_coding missense_variant MODERATE 23C>A Thr8Lys
M0086999 IBHAHPKB_00026 20557 9 Skin 0.56 protein_coding synonymous_variant LOW 138C>T Phe46Phe
M0087000 IBHAHPKB_00026 20614 9 Skin 0.56 protein_coding synonymous_variant LOW 195T>C Leu65Leu
M0087001 IBHAHPKB_00026 20630 9 Skin 0.56 protein_coding missense_variant MODERATE 211C>A Leu71Ile
M0087002 IBHAHPKB_00026 20635 9 Skin 0.56 protein_coding synonymous_variant LOW 216C>T Asp72Asp
M0087003 IBHAHPKB_00026 20689 9 Skin 0.56 protein_coding synonymous_variant LOW 270T>C Arg90Arg
M0087004 IBHAHPKB_00026 20719 9 Skin 0.56 protein_coding synonymous_variant LOW 300G>A Val100Val






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
IBHAHPKB_00018 Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] 100 1.1e-60 1 115 1.0000 1.0000 experiment






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
IBHAHPKB_00017 ARO:3000410 100 2.94e-199 1 279 1.0000 1.0000 sulfonamide antibiotic sulfonamide resistant sul antibiotic target replacement
IBHAHPKB_00018 ARO:3005010 100 2.01e-78 1 115 1.0000 1.0000 disinfecting agents and antiseptics major facilitator superfamily (MFS) antibiotic efflux pump antibiotic efflux
IBHAHPKB_00020 ARO:3002578 99.2 1.11e-194 1 261 1.0000 1.0000 aminoglycoside antibiotic AAC(6') antibiotic inactivation
IBHAHPKB_00022 ARO:3004239 98.8 4.5e-189 1 260 1.0000 1.0000 cephalosporin NPS beta-lactamase antibiotic inactivation






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term