Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C507
  Reference Plasmid   NZ_CP024254.1
  Reference Plasmid Size   107732
  Reference Plasmid GC Content   0.52
  Reference Plasmid Mobility Type   conjugative





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0167571 CAIEIOMG_00046 34178 4 Gut 0.19 protein_coding missense_variant MODERATE 1058G>A Arg353His
M0167572 CAIEIOMG_00063 51609 5 Gut 0.24 protein_coding synonymous_variant LOW 2232G>T Val744Val
M0167573 CAIEIOMG_00063 52177 4 Gut 0.19 protein_coding missense_variant MODERATE 2800C>A Leu934Ile
M0167574 CAIEIOMG_00063 52401 5 Gut 0.24 protein_coding missense_variant MODERATE 3024C>A His1008Gln
M0167575 CAIEIOMG_00063 52472 5 Gut 0.24 protein_coding missense_variant MODERATE 3095T>A Val1032Glu
M0167576 CAIEIOMG_00063 52581 4 Gut 0.19 protein_coding synonymous_variant LOW 3204G>A Glu1068Glu
M0167577 CAIEIOMG_00034 25905 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4958G>C None
M0167578 CAIEIOMG_00034 25907 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4960T>C None
M0167579 CAIEIOMG_00034 25908 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4961A>C None
M0167580 CAIEIOMG_00034 25918 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4971C>G None
M0167581 CAIEIOMG_00034 25938 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4991G>C None
M0167582 CAIEIOMG_00034 25940 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4993C>T None
M0167583 CAIEIOMG_00034 25941 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4994T>A None
M0167584 CAIEIOMG_00034 25942 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4995C>A None
M0167585 CAIEIOMG_00034 25943 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4996A>G None
M0167586 CAIEIOMG_00034 25944 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -4997T>A None
M0167587 CAIEIOMG_00065 53726 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -90A>G None
M0167588 CAIEIOMG_00037 27451 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2574C>T None
M0167589 CAIEIOMG_00037 27462 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2585G>A None
M0167590 CAIEIOMG_00037 27467 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2590A>C None
M0167591 CAIEIOMG_00037 27468 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2591T>C None
M0167592 CAIEIOMG_00037 27525 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2648C>A None
M0167593 CAIEIOMG_00037 27564 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2687T>G None
M0167594 CAIEIOMG_00037 27594 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2717C>T None
M0167595 CAIEIOMG_00037 27665 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2788T>G None
M0167596 CAIEIOMG_00037 27708 3 Gut 0.14 protein_coding upstream_gene_variant MODIFIER -2831C>G None






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism
CAIEIOMG_00032 ARO:3000166 99.3 3.06e-283 1 401 1.0000 1.0000 tetracycline antibiotic major facilitator superfamily (MFS) antibiotic efflux pump antibiotic efflux
CAIEIOMG_00033 ARO:3003479 100 1.46e-152 1 207 1.0000 0.9952 tetracycline antibiotic major facilitator superfamily (MFS) antibiotic efflux pump antibiotic target alteration






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
CAIEIOMG_00054 SPE00673.1|GH23 100 1.33e-115 1 161 1 1





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
CAIEIOMG_00032 2.A.1.2.68 99.8 6.4e-221 1 401 1.0000 1.0000 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.1 The Major Facilitator Superfamily (MFS)
CAIEIOMG_00036 2.A.27.1.4 100 5.3e-215 1 401 1.0000 1.0000 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.27 The Glutamate:Na+ Symporter (ESS) Family
CAIEIOMG_00060 3.A.7.10.1 77.9 6.6e-124 1 271 0.9748 2.8021 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
CAIEIOMG_00061 3.A.7.10.1 71.8 5e-91 1 216 0.6729 2.2500 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
CAIEIOMG_00066 3.A.7.10.1 74.9 1.5e-138 1 324 1.0000 3.4063 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
CAIEIOMG_00092 3.A.7.10.1 76.1 1.1e-189 1 401 0.9218 4.1771 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
CAIEIOMG_00094 3.A.7.10.1 79.6 0 1 724 0.9439 7.5417 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family