Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C611
  Reference Plasmid   NZ_CP035883.1
  Reference Plasmid Size   186206
  Reference Plasmid GC Content   0.49
  Reference Plasmid Mobility Type   conjugative





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0169496 ICFMFLEK_00135 110057 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3794C>G None
M0169497 ICFMFLEK_00135 110117 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3854C>T None
M0169498 ICFMFLEK_00135 110174 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3911A>G None
M0169499 ICFMFLEK_00135 110209 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3946G>A None
M0169500 ICFMFLEK_00135 110217 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3954A>C None
M0169501 ICFMFLEK_00135 110241 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3978A>C None
M0169502 ICFMFLEK_00135 110297 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4034G>A None
M0169503 ICFMFLEK_00135 110302 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4039T>A None
M0169504 ICFMFLEK_00135 110307 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4044T>C None
M0169505 ICFMFLEK_00135 110344 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4081A>G None
M0169506 ICFMFLEK_00135 110346 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4083T>G None
M0169507 ICFMFLEK_00135 110372 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4109G>A None
M0169508 ICFMFLEK_00135 110392 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4129C>T None
M0169509 ICFMFLEK_00140 110462 3 Gut 0.13 protein_coding missense_variant MODERATE 10G>A Val4Ile
M0169510 ICFMFLEK_00140 110723 3 Gut 0.13 protein_coding missense_variant MODERATE 271G>T Gly91Cys
M0169511 ICFMFLEK_00140 111171 3 Gut 0.13 protein_coding missense_variant MODERATE 719C>T Thr240Ile
M0169512 ICFMFLEK_00140 111346 3 Gut 0.13 protein_coding synonymous_variant LOW 894A>G Pro298Pro
M0169513 ICFMFLEK_00141 111575 3 Gut 0.13 protein_coding missense_variant MODERATE 164T>C Phe55Ser
M0169514 ICFMFLEK_00141 111597 3 Gut 0.13 protein_coding synonymous_variant LOW 186G>A Thr62Thr
M0169515 ICFMFLEK_00139 111839 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -1802A>C None
M0169516 ICFMFLEK_00139 111861 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -1824C>T None
M0169517 ICFMFLEK_00139 111867 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -1830G>A None
M0169518 ICFMFLEK_00142 112148 3 Gut 0.13 protein_coding missense_variant MODERATE 754A>G Arg252Gly
M0169519 ICFMFLEK_00142 112321 3 Gut 0.13 protein_coding missense_variant MODERATE 581A>C Asp194Ala
M0169520 ICFMFLEK_00142 112530 3 Gut 0.13 protein_coding synonymous_variant LOW 372T>C Asp124Asp
M0169521 ICFMFLEK_00018 16888 4 Gut 0.17 protein_coding upstream_gene_variant MODIFIER -3563T>C None
M0169522 ICFMFLEK_00071 60601 3 Gut 0.13 protein_coding synonymous_variant LOW 1638T>G Gly546Gly
M0169523 ICFMFLEK_00071 60613 3 Gut 0.13 protein_coding synonymous_variant LOW 1626T>C Ser542Ser
M0169524 ICFMFLEK_00071 60623 3 Gut 0.13 protein_coding missense_variant MODERATE 1616G>T Arg539Ile
M0169525 ICFMFLEK_00071 60655 3 Gut 0.13 protein_coding synonymous_variant LOW 1584G>A Ala528Ala
M0169526 ICFMFLEK_00071 60688 3 Gut 0.13 protein_coding synonymous_variant LOW 1551C>T Val517Val
M0169527 ICFMFLEK_00071 60697 3 Gut 0.13 protein_coding synonymous_variant LOW 1542T>G Arg514Arg
M0169528 ICFMFLEK_00071 61801 4 Gut 0.17 protein_coding synonymous_variant LOW 438T>C Phe146Phe
M0169529 ICFMFLEK_00071 61825 4 Gut 0.17 protein_coding synonymous_variant LOW 414C>T Asn138Asn
M0169530 ICFMFLEK_00071 61862 4 Gut 0.17 protein_coding missense_variant MODERATE 377C>T Ala126Val
M0169531 ICFMFLEK_00071 61870 4 Gut 0.17 protein_coding synonymous_variant LOW 369T>G Pro123Pro
M0169532 ICFMFLEK_00071 61873 4 Gut 0.17 protein_coding synonymous_variant LOW 366G>A Gln122Gln
M0169533 ICFMFLEK_00071 61878 4 Gut 0.17 protein_coding missense_variant MODERATE 361C>A Pro121Thr
M0169534 ICFMFLEK_00071 61885 4 Gut 0.17 protein_coding missense_variant MODERATE 354A>G Ile118Met
M0169535 ICFMFLEK_00071 61894 4 Gut 0.17 protein_coding synonymous_variant LOW 345T>C Ser115Ser
M0169536 ICFMFLEK_00071 61898 4 Gut 0.17 protein_coding missense_variant MODERATE 341C>T Ala114Val
M0169537 ICFMFLEK_00073 63034 3 Gut 0.13 protein_coding synonymous_variant LOW 576G>C Gly192Gly
M0169538 ICFMFLEK_00073 63043 3 Gut 0.13 protein_coding synonymous_variant LOW 567T>C Ser189Ser
M0169539 ICFMFLEK_00073 63046 3 Gut 0.13 protein_coding synonymous_variant LOW 564A>G Ala188Ala
M0169540 ICFMFLEK_00073 63464 4 Gut 0.17 protein_coding missense_variant MODERATE 146G>A Arg49Gln
M0169541 ICFMFLEK_00073 63556 4 Gut 0.17 protein_coding missense_variant MODERATE 54G>A Met18Ile
M0169542 ICFMFLEK_00073 63572 3 Gut 0.13 protein_coding missense_variant MODERATE 38C>T Ala13Val
M0169543 ICFMFLEK_00074 63604 3 Gut 0.13 protein_coding missense_variant MODERATE 385T>A Ser129Thr
M0169544 ICFMFLEK_00073 63605 3 Gut 0.13 protein_coding missense_variant MODERATE 5T>C Leu2Pro
M0169545 ICFMFLEK_00074 63610 3 Gut 0.13 protein_coding missense_variant MODERATE 379A>G Asn127Asp
M0169546 ICFMFLEK_00074 63614 3 Gut 0.13 protein_coding synonymous_variant LOW 375C>G Gly125Gly
M0169547 ICFMFLEK_00074 63615 3 Gut 0.13 protein_coding missense_variant MODERATE 374G>A Gly125Asp
M0169548 ICFMFLEK_00074 63616 3 Gut 0.13 protein_coding missense_variant MODERATE 373G>A Gly125Ser
M0169549 ICFMFLEK_00074 63937 5 Gut 0.22 protein_coding missense_variant MODERATE 52G>A Asp18Asn
M0169550 ICFMFLEK_00075 64098 5 Gut 0.22 protein_coding synonymous_variant LOW 159A>T Ser53Ser
M0169551 ICFMFLEK_00076 64264 4 Gut 0.17 protein_coding synonymous_variant LOW 528A>G Gly176Gly
M0169552 ICFMFLEK_00076 64393 4 Gut 0.17 protein_coding synonymous_variant LOW 399T>C Ile133Ile
M0169553 ICFMFLEK_00076 64420 4 Gut 0.17 protein_coding missense_variant MODERATE 372C>G Asp124Glu
M0169554 ICFMFLEK_00076 64435 4 Gut 0.17 protein_coding synonymous_variant LOW 357G>A Leu119Leu
M0169555 ICFMFLEK_00076 64489 4 Gut 0.17 protein_coding synonymous_variant LOW 303C>T Ser101Ser
M0169556 ICFMFLEK_00076 64569 4 Gut 0.17 protein_coding synonymous_variant LOW 223T>C Leu75Leu
M0169557 ICFMFLEK_00076 64573 4 Gut 0.17 protein_coding synonymous_variant LOW 219C>G Val73Val
M0169558 ICFMFLEK_00076 64640 4 Gut 0.17 protein_coding missense_variant MODERATE 152C>A Ala51Glu
M0169559 ICFMFLEK_00076 64642 4 Gut 0.17 protein_coding missense_variant MODERATE 150G>A Met50Ile
M0169560 ICFMFLEK_00076 64643 4 Gut 0.17 protein_coding missense_variant MODERATE 149T>C Met50Thr
M0169561 ICFMFLEK_00076 64645 4 Gut 0.17 protein_coding synonymous_variant LOW 147G>A Arg49Arg
M0169562 ICFMFLEK_00076 64655 4 Gut 0.17 protein_coding missense_variant MODERATE 137T>C Met46Thr
M0169563 ICFMFLEK_00076 64658 4 Gut 0.17 protein_coding missense_variant MODERATE 134A>G Asp45Gly
M0169564 ICFMFLEK_00076 64690 4 Gut 0.17 protein_coding synonymous_variant LOW 102G>C Gly34Gly
M0169565 ICFMFLEK_00076 64711 4 Gut 0.17 protein_coding synonymous_variant LOW 81G>A Glu27Glu
M0169566 ICFMFLEK_00076 64748 4 Gut 0.17 protein_coding missense_variant MODERATE 44T>C Val15Ala
M0169567 ICFMFLEK_00076 64753 4 Gut 0.17 protein_coding missense_variant MODERATE 39A>G Ile13Met
M0169568 ICFMFLEK_00071 65101 4 Gut 0.17 protein_coding upstream_gene_variant MODIFIER -2863C>T None
M0169569 ICFMFLEK_00071 65140 4 Gut 0.17 protein_coding upstream_gene_variant MODIFIER -2902T>C None
M0169570 ICFMFLEK_00071 65178 4 Gut 0.17 protein_coding upstream_gene_variant MODIFIER -2940A>G None
M0169571 ICFMFLEK_00078 65268 4 Gut 0.17 protein_coding synonymous_variant LOW 660C>T Arg220Arg
M0169572 ICFMFLEK_00078 65721 3 Gut 0.13 protein_coding synonymous_variant LOW 207T>C Ala69Ala
M0169573 ICFMFLEK_00078 65736 3 Gut 0.13 protein_coding synonymous_variant LOW 192G>T Arg64Arg
M0169574 ICFMFLEK_00078 65757 3 Gut 0.13 protein_coding synonymous_variant LOW 171G>A Ala57Ala
M0169575 ICFMFLEK_00078 65758 3 Gut 0.13 protein_coding missense_variant MODERATE 170C>T Ala57Val
M0169576 ICFMFLEK_00078 65833 3 Gut 0.13 protein_coding missense_variant MODERATE 95A>C Asn32Thr
M0169577 ICFMFLEK_00078 65871 3 Gut 0.13 protein_coding synonymous_variant LOW 57G>A Gly19Gly
M0169578 ICFMFLEK_00079 65945 3 Gut 0.13 protein_coding missense_variant MODERATE 236A>G Asn79Ser
M0169579 ICFMFLEK_00071 66202 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3964G>T None
M0169580 ICFMFLEK_00080 66942 3 Gut 0.13 protein_coding synonymous_variant LOW 1074T>G Pro358Pro
M0169581 ICFMFLEK_00080 66990 3 Gut 0.13 protein_coding synonymous_variant LOW 1026C>T Val342Val
M0169582 ICFMFLEK_00080 67108 3 Gut 0.13 protein_coding missense_variant MODERATE 908C>A Ala303Glu
M0169583 ICFMFLEK_00080 67245 3 Gut 0.13 protein_coding synonymous_variant LOW 771G>A Thr257Thr
M0169584 ICFMFLEK_00080 67299 3 Gut 0.13 protein_coding synonymous_variant LOW 717A>T Ala239Ala
M0169585 ICFMFLEK_00080 67358 3 Gut 0.13 protein_coding missense_variant MODERATE 658G>A Val220Ile
M0169586 ICFMFLEK_00080 67458 3 Gut 0.13 protein_coding synonymous_variant LOW 558T>A Arg186Arg
M0169587 ICFMFLEK_00080 67512 3 Gut 0.13 protein_coding synonymous_variant LOW 504T>C Ser168Ser
M0169588 ICFMFLEK_00080 67549 3 Gut 0.13 protein_coding missense_variant MODERATE 467G>A Cys156Tyr
M0169589 ICFMFLEK_00080 67683 3 Gut 0.13 protein_coding synonymous_variant LOW 333C>T Ile111Ile
M0169590 ICFMFLEK_00080 67686 3 Gut 0.13 protein_coding synonymous_variant LOW 330T>C Phe110Phe
M0169591 ICFMFLEK_00080 67704 3 Gut 0.13 protein_coding synonymous_variant LOW 312T>G Leu104Leu
M0169592 ICFMFLEK_00080 67731 3 Gut 0.13 protein_coding synonymous_variant LOW 285C>A Ser95Ser
M0169593 ICFMFLEK_00080 67743 3 Gut 0.13 protein_coding synonymous_variant LOW 273C>T Thr91Thr
M0169594 ICFMFLEK_00080 67821 3 Gut 0.13 protein_coding synonymous_variant LOW 195A>T Gly65Gly
M0169595 ICFMFLEK_00016 11550 3 Gut 0.13 protein_coding synonymous_variant LOW 558T>C Ser186Ser
M0169596 ICFMFLEK_00016 11551 3 Gut 0.13 protein_coding missense_variant MODERATE 559G>A Ala187Thr
M0169597 ICFMFLEK_00016 11553 3 Gut 0.13 protein_coding synonymous_variant LOW 561A>T Ala187Ala
M0169598 ICFMFLEK_00016 11560 3 Gut 0.13 protein_coding missense_variant MODERATE 568A>C Ile190Leu
M0169599 ICFMFLEK_00016 11605 3 Gut 0.13 protein_coding missense_variant MODERATE 613C>A Gln205Lys
M0169600 ICFMFLEK_00016 11721 3 Gut 0.13 protein_coding synonymous_variant LOW 729C>T Cys243Cys
M0169601 ICFMFLEK_00016 11746 3 Gut 0.13 protein_coding synonymous_variant LOW 754T>C Leu252Leu
M0169602 ICFMFLEK_00016 11754 3 Gut 0.13 protein_coding synonymous_variant LOW 762T>C Phe254Phe
M0169603 ICFMFLEK_00016 11787 3 Gut 0.13 protein_coding synonymous_variant LOW 795A>G Gly265Gly
M0169604 ICFMFLEK_00016 11829 3 Gut 0.13 protein_coding synonymous_variant LOW 837T>G Pro279Pro
M0169605 ICFMFLEK_00016 11859 3 Gut 0.13 protein_coding synonymous_variant LOW 867T>A Ser289Ser
M0169606 ICFMFLEK_00016 11937 3 Gut 0.13 protein_coding synonymous_variant LOW 945C>T Phe315Phe
M0169607 ICFMFLEK_00016 11999 3 Gut 0.13 protein_coding missense_variant MODERATE 1007C>G Ala336Gly
M0169608 ICFMFLEK_00016 12003 3 Gut 0.13 protein_coding synonymous_variant LOW 1011G>T Ala337Ala
M0169609 ICFMFLEK_00016 12061 3 Gut 0.13 protein_coding synonymous_variant LOW 1069C>T Leu357Leu
M0169610 ICFMFLEK_00016 12099 3 Gut 0.13 protein_coding synonymous_variant LOW 1107C>T Ala369Ala
M0169611 ICFMFLEK_00016 12105 3 Gut 0.13 protein_coding missense_variant MODERATE 1113G>A Met371Ile
M0169612 ICFMFLEK_00016 12120 3 Gut 0.13 protein_coding synonymous_variant LOW 1128T>C Ala376Ala
M0169613 ICFMFLEK_00016 12129 3 Gut 0.13 protein_coding synonymous_variant LOW 1137G>T Pro379Pro
M0169614 ICFMFLEK_00016 12150 3 Gut 0.13 protein_coding synonymous_variant LOW 1158G>A Leu386Leu
M0169615 ICFMFLEK_00016 12221 3 Gut 0.13 protein_coding missense_variant MODERATE 1229G>A Ser410Asn
M0169616 ICFMFLEK_00016 12234 3 Gut 0.13 protein_coding synonymous_variant LOW 1242G>A Arg414Arg
M0169617 ICFMFLEK_00016 12260 3 Gut 0.13 protein_coding missense_variant MODERATE 1268G>A Arg423His
M0169618 ICFMFLEK_00016 12273 3 Gut 0.13 protein_coding synonymous_variant LOW 1281G>A Leu427Leu
M0169619 ICFMFLEK_00011 12325 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4238T>C None
M0169620 ICFMFLEK_00011 12359 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4272C>T None
M0169621 ICFMFLEK_00017 12399 3 Gut 0.13 protein_coding synonymous_variant LOW 18G>A Glu6Glu
M0169622 ICFMFLEK_00017 12404 3 Gut 0.13 protein_coding missense_variant MODERATE 23C>T Thr8Ile
M0169623 ICFMFLEK_00017 12744 3 Gut 0.13 protein_coding missense_variant MODERATE 363G>T Lys121Asn
M0169624 ICFMFLEK_00017 12993 3 Gut 0.13 protein_coding synonymous_variant LOW 612G>A Lys204Lys
M0169625 ICFMFLEK_00018 13221 3 Gut 0.13 protein_coding synonymous_variant LOW 105A>G Arg35Arg
M0169626 ICFMFLEK_00018 13244 3 Gut 0.13 protein_coding missense_variant MODERATE 82G>A Val28Ile
M0169627 ICFMFLEK_00012 13435 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4176A>T None
M0169628 ICFMFLEK_00012 13594 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4335A>G None
M0169629 ICFMFLEK_00012 13641 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4382G>A None
M0169630 ICFMFLEK_00012 13664 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4405A>G None
M0169631 ICFMFLEK_00012 13668 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4409A>G None
M0169632 ICFMFLEK_00012 13675 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4416G>A None
M0169633 ICFMFLEK_00012 13696 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4437C>T None
M0169634 ICFMFLEK_00019 13755 3 Gut 0.13 protein_coding missense_variant MODERATE 41G>A Gly14Glu
M0169635 ICFMFLEK_00019 13792 3 Gut 0.13 protein_coding synonymous_variant LOW 78C>T Val26Val
M0169636 ICFMFLEK_00019 13815 3 Gut 0.13 protein_coding missense_variant MODERATE 101T>C Leu34Pro
M0169637 ICFMFLEK_00019 13827 3 Gut 0.13 protein_coding missense_variant MODERATE 113G>A Arg38Lys
M0169638 ICFMFLEK_00019 13880 3 Gut 0.13 protein_coding missense_variant MODERATE 166A>T Ile56Phe
M0169639 ICFMFLEK_00012 14165 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4906G>C None
M0169640 ICFMFLEK_00014 14651 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4273G>A None
M0169641 ICFMFLEK_00014 14722 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4344A>G None
M0169642 ICFMFLEK_00014 14727 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4349A>G None
M0169643 ICFMFLEK_00014 14729 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4351T>A None
M0169644 ICFMFLEK_00014 14736 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -4358T>C None
M0169645 ICFMFLEK_00021 15255 3 Gut 0.13 protein_coding missense_variant MODERATE 37A>G Ile13Val
M0169646 ICFMFLEK_00021 15277 3 Gut 0.13 protein_coding synonymous_variant LOW 15G>A Thr5Thr
M0169647 ICFMFLEK_00018 15426 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -2101C>T None
M0169648 ICFMFLEK_00018 15521 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -2196T>A None
M0169649 ICFMFLEK_00018 15729 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -2404T>C None
M0169650 ICFMFLEK_00018 15865 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -2540T>C None
M0169651 ICFMFLEK_00022 15946 3 Gut 0.13 protein_coding synonymous_variant LOW 54A>G Glu18Glu
M0169652 ICFMFLEK_00022 15976 3 Gut 0.13 protein_coding synonymous_variant LOW 84A>G Leu28Leu
M0169653 ICFMFLEK_00022 15985 3 Gut 0.13 protein_coding synonymous_variant LOW 93G>A Gln31Gln
M0169654 ICFMFLEK_00022 16436 3 Gut 0.13 protein_coding missense_variant MODERATE 544G>A Glu182Lys
M0169655 ICFMFLEK_00022 16471 3 Gut 0.13 protein_coding synonymous_variant LOW 579T>C Asn193Asn
M0169656 ICFMFLEK_00022 16486 3 Gut 0.13 protein_coding missense_variant MODERATE 594C>A Asp198Glu
M0169657 ICFMFLEK_00022 16733 3 Gut 0.13 protein_coding missense_variant MODERATE 841G>C Glu281Gln
M0169658 ICFMFLEK_00022 16804 3 Gut 0.13 protein_coding synonymous_variant LOW 912A>G Arg304Arg
M0169659 ICFMFLEK_00018 16898 3 Gut 0.13 protein_coding upstream_gene_variant MODIFIER -3573T>C None
M0169660 ICFMFLEK_00023 17150 3 Gut 0.13 protein_coding synonymous_variant LOW 87T>C Val29Val
M0169661 ICFMFLEK_00023 17180 3 Gut 0.13 protein_coding synonymous_variant LOW 117T>C Tyr39Tyr
M0169662 ICFMFLEK_00137 106913 3 Gut 0.13 protein_coding stop_lost&splice_region_variant HIGH 174A>G Ter58Trpext*?






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition
ICFMFLEK_00103 VFG001445 TraJ 99.5 2.3e-115 1 200 0.8772 0.995 Invasion unknown protein experiment
ICFMFLEK_00149 VFG002039 Heat-stable toxin (ST) 97.2 1.4e-34 1 72 1.0 1 Exotoxin heat stable enterotoxin I experiment
ICFMFLEK_00162 VFG034541 EtpA 94.5 0 1 1539 1.0 1 Adherence Two-partner secreted adhesin EtpA experiment
ICFMFLEK_00163 VFG042382 EtpA 99.5 0 1 603 1.0 1 Adherence two-partner secretion transporter EtpB experiment
ICFMFLEK_00178 VFG036068 Heat-labile toxin (LT) 99.2 1.4e-66 1 124 1.0 1 Exotoxin enterotoxin subunit B (from human) experiment
ICFMFLEK_00179 VFG036066 Heat-labile toxin (LT) 99.5 5.3e-130 1 218 1.0 0.845 Exotoxin heat-labile enterotoxin A prepeptide (from human) experiment
ICFMFLEK_00051 VFG042522 Adhesive fimbriae 100 2.7e-215 1 363 1.0 1 Adherence CS19 fimbrial ahesin CsdD prediction
ICFMFLEK_00052 VFG042521 Adhesive fimbriae 100 0 1 872 1.0 1 Adherence CS19 fimbrial usher CsdC prediction
ICFMFLEK_00053 VFG042520 Adhesive fimbriae 100 2.5e-83 1 166 1.0 1 Adherence CS19 fimbrial subunit CsdA prediction
ICFMFLEK_00054 VFG042519 Adhesive fimbriae 100 5.1e-130 1 237 1.0 1 Adherence CS19 fimbrial chaperone CsdB prediction
ICFMFLEK_00103 VFG001445 TraJ 99.5 1.7e-114 1 200 0.8772 0.995 Invasion unknown protein prediction
ICFMFLEK_00149 VFG002039 Heat-stable toxin (ST) 97.2 1e-33 1 72 1.0 1 Exotoxin heat stable enterotoxin I prediction
ICFMFLEK_00162 VFG034541 EtpA 94.5 0 1 1539 1.0 1 Adherence Two-partner secreted adhesin EtpA prediction
ICFMFLEK_00163 VFG042382 EtpA 99.5 0 1 603 1.0 1 Adherence two-partner secretion transporter EtpB prediction
ICFMFLEK_00178 VFG036068 Heat-labile toxin (LT) 99.2 1e-65 1 124 1.0 1 Exotoxin enterotoxin subunit B (from human) prediction
ICFMFLEK_00179 VFG036065 Heat-labile toxin (LT) 100 1.1e-129 1 218 1.0 0.845 Exotoxin heat-labile enterotoxin A prepeptide (from human) prediction
ICFMFLEK_00202 VFG033834 Pic 98.3 0 1 1364 1.0 0.9985 Effector delivery system Pic serine protease precursor, autotransporter prediction







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant
ICFMFLEK_00178 PHI:699 CtxB 79 3e-52 1 124 1.0000 1.0000 primates cholera Cholera toxin (CT) reduced virulence
ICFMFLEK_00179 PHI:698 CtxA 80.7 2.9e-106 1 218 1.0000 0.8450 primates cholera Cholera toxin (CT) reduced virulence






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage
ICFMFLEK_00105 AHG18083.1|GH23 98.1 6.45e-154 1 215 1 1
ICFMFLEK_00161 CBJ04457.1|GT41 98.7 0 1 636 1 0.9984





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
ICFMFLEK_00021 1.E.53.1.10 86 2.2e-14 8 50 0.8600 1.0000 1 Channels/Pores 1.E Holins 1.E.53 The Toxic Hok/Gef Protein (Hok/Gef) Family
ICFMFLEK_00023 3.A.7.10.1 92.1 3.5e-88 1 164 0.9939 1.7083 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
ICFMFLEK_00030 8.B.24.2.1 100 1.8e-68 1 127 1.0000 1.0000 8 Accessory Factors Involved in Transport 8.B Ribosomally synthesized protein/peptide toxins/agonists that target channels and carriers 8.B.24 The Colicin Immunity Protein (ColIP) Functional Family
ICFMFLEK_00160 9.B.127.1.3 95.1 3.1e-89 1 164 1.0000 1.0000 9 Incompletely Characterized Transport Systems 9.B Putative transport proteins 9.B.127 The DUF2919 (PF11143) Family
ICFMFLEK_00163 1.B.20.3.3 99.5 0 1 603 1.0000 1.0000 1 Channels/Pores 1.B β-Barrel Porins 1.B.20 The Two-Partner Secretion (TPS) Family
ICFMFLEK_00179 1.C.72.4.1 99.5 3.1e-129 1 218 1.0000 0.8450 1 Channels/Pores 1.C Pore-Forming Toxins (Proteins and Peptides) 1.C.72 The Pertussis Toxin (PTX) Family