Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C653
  Reference Plasmid   NZ_CP042005.1
  Reference Plasmid Size   16596
  Reference Plasmid GC Content   0.29
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0096330 KPOBHALI_00010 7415 4 Skin 0.44 protein_coding missense_variant MODERATE 418T>G Ser140Ala
M0096331 KPOBHALI_00010 7418 4 Skin 0.44 protein_coding missense_variant MODERATE 421G>A Glu141Lys
M0096332 KPOBHALI_00010 7420 4 Skin 0.44 protein_coding missense_variant MODERATE 423A>C Glu141Asp
M0096333 KPOBHALI_00010 7422 4 Skin 0.44 protein_coding missense_variant MODERATE 425G>C Ser142Thr
M0096334 KPOBHALI_00010 7453 4 Skin 0.44 protein_coding synonymous_variant LOW 456T>A Gly152Gly
M0096335 KPOBHALI_00010 7472 4 Skin 0.44 protein_coding missense_variant MODERATE 475G>A Gly159Arg
M0096336 KPOBHALI_00010 7474 4 Skin 0.44 protein_coding synonymous_variant LOW 477A>G Gly159Gly
M0096337 KPOBHALI_00010 7493 4 Skin 0.44 protein_coding synonymous_variant LOW 496C>T Leu166Leu
M0096338 KPOBHALI_00010 7510 4 Skin 0.44 protein_coding synonymous_variant LOW 513G>A Ala171Ala
M0096339 KPOBHALI_00010 7558 5 Skin 0.56 protein_coding synonymous_variant LOW 561T>C Gly187Gly
M0096340 KPOBHALI_00010 7561 5 Skin 0.56 protein_coding synonymous_variant LOW 564C>A Ala188Ala
M0096341 KPOBHALI_00010 7621 5 Skin 0.56 protein_coding synonymous_variant LOW 624T>C Phe208Phe
M0096342 KPOBHALI_00010 7624 5 Skin 0.56 protein_coding missense_variant MODERATE 627A>G Ile209Met
M0096343 KPOBHALI_00010 7642 5 Skin 0.56 protein_coding synonymous_variant LOW 645A>T Ser215Ser
M0096344 KPOBHALI_00010 7663 5 Skin 0.56 protein_coding synonymous_variant LOW 666C>T Tyr222Tyr
M0096345 KPOBHALI_00010 7666 5 Skin 0.56 protein_coding synonymous_variant LOW 669C>T Ile223Ile
M0096346 KPOBHALI_00010 7672 5 Skin 0.56 protein_coding synonymous_variant LOW 675A>C Pro225Pro
M0096347 KPOBHALI_00010 7720 5 Skin 0.56 protein_coding synonymous_variant LOW 723G>A Ser241Ser
M0096348 KPOBHALI_00010 7721 5 Skin 0.56 protein_coding synonymous_variant LOW 724T>C Leu242Leu
M0096349 KPOBHALI_00010 7768 5 Skin 0.56 protein_coding synonymous_variant LOW 771T>C Ile257Ile
M0096350 KPOBHALI_00010 7814 5 Skin 0.56 protein_coding missense_variant MODERATE 817A>G Ile273Val
M0096351 KPOBHALI_00010 7870 5 Skin 0.56 protein_coding synonymous_variant LOW 873T>C Asn291Asn
M0096352 KPOBHALI_00011 7911 4 Skin 0.44 protein_coding synonymous_variant LOW 15T>C Asp5Asp
M0096353 KPOBHALI_00011 7917 5 Skin 0.56 protein_coding synonymous_variant LOW 21G>A Leu7Leu
M0096354 KPOBHALI_00011 7924 5 Skin 0.56 protein_coding missense_variant MODERATE 28A>T Ile10Leu
M0096355 KPOBHALI_00011 7935 5 Skin 0.56 protein_coding synonymous_variant LOW 39G>A Gln13Gln
M0096356 KPOBHALI_00011 7972 6 Skin 0.67 protein_coding missense_variant MODERATE 76A>C Lys26Gln
M0096357 KPOBHALI_00011 7977 6 Skin 0.67 protein_coding synonymous_variant LOW 81G>A Glu27Glu
M0096358 KPOBHALI_00011 7979 6 Skin 0.67 protein_coding missense_variant MODERATE 83G>A Ser28Asn
M0096359 KPOBHALI_00011 7984 6 Skin 0.67 protein_coding missense_variant MODERATE 88A>G Lys30Glu
M0096360 KPOBHALI_00011 7989 6 Skin 0.67 protein_coding synonymous_variant LOW 93G>A Glu31Glu
M0096361 KPOBHALI_00011 7992 6 Skin 0.67 protein_coding missense_variant MODERATE 96T>G Asn32Lys
M0096362 KPOBHALI_00011 8003 6 Skin 0.67 protein_coding missense_variant MODERATE 107T>A Val36Asp
M0096363 KPOBHALI_00007 8033 6 Skin 0.67 protein_coding upstream_gene_variant MODIFIER -2048C>G None
M0096364 KPOBHALI_00007 8057 6 Skin 0.67 protein_coding upstream_gene_variant MODIFIER -2072C>T None
M0096365 KPOBHALI_00012 8077 6 Skin 0.67 protein_coding missense_variant MODERATE 7C>T Pro3Ser
M0096366 KPOBHALI_00012 8115 8 Skin 0.89 protein_coding synonymous_variant LOW 45G>A Leu15Leu
M0096367 KPOBHALI_00012 8161 7 Skin 0.78 protein_coding missense_variant MODERATE 91T>C Tyr31His
M0096368 KPOBHALI_00012 8167 7 Skin 0.78 protein_coding missense_variant MODERATE 97A>C Ile33Leu
M0096369 KPOBHALI_00012 8263 8 Skin 0.89 protein_coding missense_variant MODERATE 193A>C Lys65Gln
M0096370 KPOBHALI_00012 8309 8 Skin 0.89 protein_coding missense_variant MODERATE 239G>A Arg80Lys
M0096371 KPOBHALI_00012 8333 9 Skin 1.00 protein_coding missense_variant MODERATE 263C>G Ala88Gly
M0096372 KPOBHALI_00012 8343 9 Skin 1.00 protein_coding missense_variant MODERATE 273C>A Asn91Lys
M0096373 KPOBHALI_00012 8427 8 Skin 0.89 protein_coding missense_variant MODERATE 357G>T Lys119Asn
M0096374 KPOBHALI_00012 8428 8 Skin 0.89 protein_coding missense_variant MODERATE 358G>A Ala120Thr
M0096375 KPOBHALI_00012 8430 8 Skin 0.89 protein_coding synonymous_variant LOW 360A>G Ala120Ala
M0096376 KPOBHALI_00012 8466 9 Skin 1.00 protein_coding synonymous_variant LOW 396C>T Ile132Ile
M0096377 KPOBHALI_00012 8473 9 Skin 1.00 protein_coding synonymous_variant LOW 403A>C Arg135Arg
M0096378 KPOBHALI_00012 8520 8 Skin 0.89 protein_coding missense_variant MODERATE 450A>T Lys150Asn
M0096379 KPOBHALI_00012 8544 8 Skin 0.89 protein_coding synonymous_variant LOW 474A>T Ile158Ile
M0096380 KPOBHALI_00012 8586 9 Skin 1.00 protein_coding synonymous_variant LOW 516C>T Ala172Ala
M0096381 KPOBHALI_00012 8643 9 Skin 1.00 protein_coding synonymous_variant LOW 573T>A Pro191Pro
M0096382 KPOBHALI_00012 8647 8 Skin 0.89 protein_coding synonymous_variant LOW 577T>C Leu193Leu
M0096383 KPOBHALI_00012 8742 8 Skin 0.89 protein_coding synonymous_variant LOW 672A>G Arg224Arg
M0096384 KPOBHALI_00012 8787 9 Skin 1.00 protein_coding synonymous_variant LOW 717T>G Gly239Gly
M0096385 KPOBHALI_00012 8859 9 Skin 1.00 protein_coding synonymous_variant LOW 789C>T Asn263Asn
M0096386 KPOBHALI_00012 8892 9 Skin 1.00 protein_coding synonymous_variant LOW 822C>T Gly274Gly
M0096387 KPOBHALI_00012 8973 9 Skin 1.00 protein_coding synonymous_variant LOW 903T>C Thr301Thr
M0096388 KPOBHALI_00012 9019 8 Skin 0.89 protein_coding missense_variant MODERATE 949A>C Asn317His
M0096389 KPOBHALI_00012 9031 9 Skin 1.00 protein_coding missense_variant MODERATE 961A>C Asn321His
M0096390 KPOBHALI_00012 9114 9 Skin 1.00 protein_coding synonymous_variant LOW 1044C>T Phe348Phe
M0096391 KPOBHALI_00012 9135 8 Skin 0.89 protein_coding synonymous_variant LOW 1065T>G Ser355Ser
M0096392 KPOBHALI_00012 9138 9 Skin 1.00 protein_coding synonymous_variant LOW 1068G>A Arg356Arg
M0096393 KPOBHALI_00012 9144 9 Skin 1.00 protein_coding synonymous_variant LOW 1074G>A Leu358Leu
M0096394 KPOBHALI_00012 9213 8 Skin 0.89 protein_coding synonymous_variant LOW 1143A>G Gly381Gly
M0096395 KPOBHALI_00012 9285 9 Skin 1.00 protein_coding synonymous_variant LOW 1215C>T Asp405Asp
M0096396 KPOBHALI_00012 9303 8 Skin 0.89 protein_coding synonymous_variant LOW 1233C>T Val411Val
M0096397 KPOBHALI_00012 9312 8 Skin 0.89 protein_coding synonymous_variant LOW 1242C>T Asn414Asn
M0096398 KPOBHALI_00012 9333 9 Skin 1.00 protein_coding synonymous_variant LOW 1263A>G Ala421Ala
M0096399 KPOBHALI_00012 9378 8 Skin 0.89 protein_coding synonymous_variant LOW 1308A>C Ile436Ile
M0096400 KPOBHALI_00012 9384 8 Skin 0.89 protein_coding synonymous_variant LOW 1314G>A Arg438Arg
M0096401 KPOBHALI_00012 9450 8 Skin 0.89 protein_coding synonymous_variant LOW 1380C>T Asn460Asn
M0096402 KPOBHALI_00012 9466 8 Skin 0.89 protein_coding missense_variant MODERATE 1396C>A Pro466Thr
M0096403 KPOBHALI_00012 9482 8 Skin 0.89 protein_coding missense_variant MODERATE 1412C>T Ser471Leu
M0096404 KPOBHALI_00012 9502 8 Skin 0.89 protein_coding missense_variant MODERATE 1432A>G Ile478Val
M0096405 KPOBHALI_00013 9565 7 Skin 0.78 protein_coding synonymous_variant LOW 33G>A Gln11Gln
M0096406 KPOBHALI_00013 9613 7 Skin 0.78 protein_coding synonymous_variant LOW 81T>C Tyr27Tyr
M0096407 KPOBHALI_00013 9661 7 Skin 0.78 protein_coding synonymous_variant LOW 129G>A Ala43Ala
M0096408 KPOBHALI_00013 9706 6 Skin 0.67 protein_coding synonymous_variant LOW 174G>A Glu58Glu
M0096409 KPOBHALI_00013 9740 6 Skin 0.67 protein_coding missense_variant MODERATE 208G>C Asp70His
M0096410 KPOBHALI_00013 9742 6 Skin 0.67 protein_coding synonymous_variant LOW 210T>C Asp70Asp
M0096411 KPOBHALI_00013 9790 6 Skin 0.67 protein_coding synonymous_variant LOW 258T>A Pro86Pro
M0096412 KPOBHALI_00013 9797 6 Skin 0.67 protein_coding missense_variant MODERATE 265C>T Pro89Ser
M0096413 KPOBHALI_00013 9877 6 Skin 0.67 protein_coding synonymous_variant LOW 345A>G Lys115Lys
M0096414 KPOBHALI_00013 9910 5 Skin 0.56 protein_coding synonymous_variant LOW 378T>A Val126Val
M0096415 KPOBHALI_00013 9923 5 Skin 0.56 protein_coding missense_variant MODERATE 391G>A Gly131Ser
M0096416 KPOBHALI_00013 9925 5 Skin 0.56 protein_coding synonymous_variant LOW 393T>G Gly131Gly
M0096417 KPOBHALI_00013 9949 5 Skin 0.56 protein_coding synonymous_variant LOW 417T>C Ile139Ile
M0096418 KPOBHALI_00013 9967 5 Skin 0.56 protein_coding synonymous_variant LOW 435A>G Arg145Arg
M0096419 KPOBHALI_00013 9992 5 Skin 0.56 protein_coding missense_variant MODERATE 460G>A Val154Ile
M0096420 KPOBHALI_00013 10012 5 Skin 0.56 protein_coding synonymous_variant LOW 480G>A Gln160Gln
M0096421 KPOBHALI_00013 10045 5 Skin 0.56 protein_coding synonymous_variant LOW 513A>G Pro171Pro
M0096422 KPOBHALI_00013 10047 4 Skin 0.44 protein_coding missense_variant MODERATE 515G>T Gly172Val
M0096423 KPOBHALI_00013 10048 5 Skin 0.56 protein_coding synonymous_variant LOW 516T>C Gly172Gly
M0096424 KPOBHALI_00013 10054 5 Skin 0.56 protein_coding synonymous_variant LOW 522A>G Glu174Glu
M0096425 KPOBHALI_00013 10060 5 Skin 0.56 protein_coding synonymous_variant LOW 528G>A Arg176Arg
M0096426 KPOBHALI_00013 10087 5 Skin 0.56 protein_coding synonymous_variant LOW 555C>T Ser185Ser
M0096427 KPOBHALI_00013 10090 5 Skin 0.56 protein_coding synonymous_variant LOW 558T>C Arg186Arg
M0096428 KPOBHALI_00013 10123 5 Skin 0.56 protein_coding synonymous_variant LOW 591C>T Ser197Ser
M0096429 KPOBHALI_00013 10126 5 Skin 0.56 protein_coding synonymous_variant LOW 594T>C Asn198Asn
M0096430 KPOBHALI_00013 10129 5 Skin 0.56 protein_coding synonymous_variant LOW 597C>T Asp199Asp
M0096431 KPOBHALI_00013 10141 5 Skin 0.56 protein_coding synonymous_variant LOW 609T>C His203His
M0096432 KPOBHALI_00013 10160 5 Skin 0.56 protein_coding missense_variant MODERATE 628G>A Asp210Asn
M0096433 KPOBHALI_00013 10165 5 Skin 0.56 protein_coding synonymous_variant LOW 633G>A Glu211Glu
M0096434 KPOBHALI_00013 10171 5 Skin 0.56 protein_coding synonymous_variant LOW 639C>A Ser213Ser
M0096435 KPOBHALI_00013 10183 5 Skin 0.56 protein_coding synonymous_variant LOW 651C>T Ser217Ser
M0096436 KPOBHALI_00013 10210 5 Skin 0.56 protein_coding synonymous_variant LOW 678T>C Ser226Ser
M0096437 KPOBHALI_00013 10234 5 Skin 0.56 protein_coding synonymous_variant LOW 702T>C Thr234Thr
M0096438 KPOBHALI_00013 10261 5 Skin 0.56 protein_coding synonymous_variant LOW 729A>G Arg243Arg
M0096439 KPOBHALI_00013 10262 5 Skin 0.56 protein_coding missense_variant MODERATE 730C>T Leu244Phe
M0096440 KPOBHALI_00013 10264 5 Skin 0.56 protein_coding synonymous_variant LOW 732C>A Leu244Leu
M0096441 KPOBHALI_00013 10276 5 Skin 0.56 protein_coding synonymous_variant LOW 744C>T Ile248Ile
M0096442 KPOBHALI_00013 10291 5 Skin 0.56 protein_coding synonymous_variant LOW 759G>A Glu253Glu
M0096443 KPOBHALI_00013 10303 5 Skin 0.56 protein_coding synonymous_variant LOW 771A>G Leu257Leu
M0096444 KPOBHALI_00013 10336 5 Skin 0.56 protein_coding synonymous_variant LOW 804T>G Ala268Ala
M0096445 KPOBHALI_00013 10345 5 Skin 0.56 protein_coding synonymous_variant LOW 813A>T Gly271Gly
M0096446 KPOBHALI_00013 10349 5 Skin 0.56 protein_coding synonymous_variant LOW 817T>C Leu273Leu
M0096447 KPOBHALI_00013 10363 5 Skin 0.56 protein_coding synonymous_variant LOW 831C>T Asn277Asn
M0096448 KPOBHALI_00007 10380 5 Skin 0.56 protein_coding upstream_gene_variant MODIFIER -4395C>G None
M0096449 KPOBHALI_00007 10386 5 Skin 0.56 protein_coding upstream_gene_variant MODIFIER -4401G>A None
M0096450 KPOBHALI_00014 10500 4 Skin 0.44 protein_coding missense_variant MODERATE 112A>G Ile38Val
M0096451 KPOBHALI_00014 10514 4 Skin 0.44 protein_coding synonymous_variant LOW 126G>A Glu42Glu
M0096452 KPOBHALI_00014 10531 4 Skin 0.44 protein_coding missense_variant MODERATE 143G>A Ser48Asn
M0096453 KPOBHALI_00014 10556 4 Skin 0.44 protein_coding synonymous_variant LOW 168C>T Asn56Asn
M0096454 KPOBHALI_00014 10580 4 Skin 0.44 protein_coding synonymous_variant LOW 192G>A Leu64Leu
M0096455 KPOBHALI_00014 10587 4 Skin 0.44 protein_coding synonymous_variant LOW 199C>T Leu67Leu
M0096456 KPOBHALI_00014 10601 4 Skin 0.44 protein_coding synonymous_variant LOW 213C>T Pro71Pro
M0096457 KPOBHALI_00014 10667 3 Skin 0.33 protein_coding synonymous_variant LOW 279T>C Asn93Asn
M0096458 KPOBHALI_00014 10668 3 Skin 0.33 protein_coding synonymous_variant LOW 280C>T Leu94Leu
M0096459 KPOBHALI_00014 10670 3 Skin 0.33 protein_coding synonymous_variant LOW 282A>G Leu94Leu
M0096460 KPOBHALI_00014 10671 3 Skin 0.33 protein_coding missense_variant MODERATE 283A>G Asn95Asp
M0096461 KPOBHALI_00014 10691 3 Skin 0.33 protein_coding missense_variant MODERATE 303C>A Asp101Glu
M0096462 KPOBHALI_00014 10713 3 Skin 0.33 protein_coding missense_variant MODERATE 325G>A Val109Ile
M0096463 KPOBHALI_00014 10751 3 Skin 0.33 protein_coding synonymous_variant LOW 363G>A Val121Val
M0096464 KPOBHALI_00014 10797 3 Skin 0.33 protein_coding synonymous_variant LOW 409A>C Arg137Arg
M0096465 KPOBHALI_00014 10799 3 Skin 0.33 protein_coding synonymous_variant LOW 411G>A Arg137Arg
M0096466 KPOBHALI_00014 10809 3 Skin 0.33 protein_coding synonymous_variant LOW 421A>C Arg141Arg
M0096467 KPOBHALI_00014 10811 3 Skin 0.33 protein_coding synonymous_variant LOW 423A>G Arg141Arg
M0096468 KPOBHALI_00014 10823 3 Skin 0.33 protein_coding missense_variant MODERATE 435G>T Met145Ile
M0096469 KPOBHALI_00014 10842 3 Skin 0.33 protein_coding missense_variant MODERATE 454T>A Tyr152Asn
M0096470 KPOBHALI_00014 10890 3 Skin 0.33 protein_coding missense_variant MODERATE 502T>G Ser168Ala
M0096471 KPOBHALI_00014 10942 3 Skin 0.33 protein_coding missense_variant MODERATE 554T>C Met185Thr
M0096472 KPOBHALI_00007 10951 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -4966C>T None
M0096473 KPOBHALI_00007 10971 3 Skin 0.33 protein_coding upstream_gene_variant MODIFIER -4986T>G None
M0096474 KPOBHALI_00012 8922 7 Skin 0.78 protein_coding synonymous_variant LOW 852C>T Arg284Arg






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term