Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C695
  Reference Plasmid   NZ_CP048434.1
  Reference Plasmid Size   23044
  Reference Plasmid GC Content   0.57
  Reference Plasmid Mobility Type   non-mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0172734 CFHLOIIF_00003 1982 4 Gut 0.29 protein_coding synonymous_variant LOW 534G>A Gly178Gly
M0172735 CFHLOIIF_00004 3087 4 Gut 0.29 protein_coding synonymous_variant LOW 733C>T Leu245Leu
M0172736 CFHLOIIF_00004 3481 3 Gut 0.21 protein_coding synonymous_variant LOW 339T>C Tyr113Tyr
M0172737 CFHLOIIF_00004 3496 4 Gut 0.29 protein_coding synonymous_variant LOW 324C>A Thr108Thr
M0172738 CFHLOIIF_00004 3503 6 Gut 0.43 protein_coding missense_variant MODERATE 317A>G Asp106Gly
M0172739 CFHLOIIF_00004 3661 4 Gut 0.29 protein_coding synonymous_variant LOW 159A>C Ala53Ala
M0172740 CFHLOIIF_00004 3715 4 Gut 0.29 protein_coding synonymous_variant LOW 105G>T Ala35Ala
M0172741 CFHLOIIF_00004 2572 3 Gut 0.21 protein_coding synonymous_variant LOW 1248A>G Gln416Gln
M0172742 CFHLOIIF_00004 2667 3 Gut 0.21 protein_coding missense_variant MODERATE 1153A>G Thr385Ala
M0172743 CFHLOIIF_00004 2738 3 Gut 0.21 protein_coding missense_variant MODERATE 1082A>G Asn361Ser
M0172744 CFHLOIIF_00004 3291 3 Gut 0.21 protein_coding missense_variant MODERATE 529G>A Gly177Ser
M0172745 CFHLOIIF_00004 3618 3 Gut 0.21 protein_coding missense_variant MODERATE 202G>A Ala68Thr
M0172746 CFHLOIIF_00004 3790 3 Gut 0.21 protein_coding synonymous_variant LOW 30G>A Glu10Glu
M0172747 CFHLOIIF_00005 1684 3 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -2328A>T None
M0172748 CFHLOIIF_00005 1686 3 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -2326T>C None
M0172749 CFHLOIIF_00003 2315 3 Gut 0.21 protein_coding synonymous_variant LOW 201G>A Arg67Arg
M0172750 CFHLOIIF_00003 4345 3 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -1830C>T None
M0172751 CFHLOIIF_00003 4379 3 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -1864C>T None
M0172752 CFHLOIIF_00006 4494 3 Gut 0.21 protein_coding synonymous_variant LOW 111G>A Thr37Thr
M0172753 CFHLOIIF_00006 4602 3 Gut 0.21 protein_coding synonymous_variant LOW 219A>G Val73Val
M0172754 CFHLOIIF_00014 11919 3 Gut 0.21 protein_coding missense_variant MODERATE 679A>G Thr227Ala
M0172755 CFHLOIIF_00014 11929 3 Gut 0.21 protein_coding missense_variant MODERATE 689T>A Val230Glu
M0172756 CFHLOIIF_00015 12043 3 Gut 0.21 protein_coding synonymous_variant LOW 108C>T Asn36Asn
M0172757 CFHLOIIF_00015 12098 3 Gut 0.21 protein_coding missense_variant MODERATE 163A>G Thr55Ala
M0172758 CFHLOIIF_00015 12100 3 Gut 0.21 protein_coding synonymous_variant LOW 165G>A Thr55Thr
M0172759 CFHLOIIF_00008 12176 3 Gut 0.21 protein_coding upstream_gene_variant MODIFIER -4197T>C None
M0172760 CFHLOIIF_00016 12185 3 Gut 0.21 protein_coding synonymous_variant LOW 6G>A Glu2Glu
M0172761 CFHLOIIF_00016 12288 3 Gut 0.21 protein_coding missense_variant MODERATE 109A>G Asn37Asp
M0172762 CFHLOIIF_00016 12292 3 Gut 0.21 protein_coding missense_variant MODERATE 113A>G His38Arg
M0172763 CFHLOIIF_00016 12308 3 Gut 0.21 protein_coding missense_variant MODERATE 129T>G His43Gln
M0172764 CFHLOIIF_00016 12357 3 Gut 0.21 protein_coding missense_variant MODERATE 178A>G Lys60Glu
M0172765 CFHLOIIF_00016 12396 3 Gut 0.21 protein_coding missense_variant MODERATE 217A>G Thr73Ala
M0172766 CFHLOIIF_00016 12542 3 Gut 0.21 protein_coding synonymous_variant LOW 363T>C Asp121Asp
M0172767 CFHLOIIF_00016 12559 3 Gut 0.21 protein_coding missense_variant MODERATE 380A>G Glu127Gly
M0172768 CFHLOIIF_00016 12574 3 Gut 0.21 protein_coding missense_variant MODERATE 395A>G Asp132Gly






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term