Annotation Categories of the Plasmid Cluster







Summary of the plasmid cluster

Basic Information about the Plasmid Cluster

  Cluster Information   Plasmid Cluster ID   C741
  Reference Plasmid   NZ_CP054005.1
  Reference Plasmid Size   25845
  Reference Plasmid GC Content   0.31
  Reference Plasmid Mobility Type   mobilizable





Mutation sites in the plasmid cluster


The table lists mutations identified in the plasmid cluster.
Note: Mutations identified in this plasmid cluster are listed below. Click on a mutation ID to view full details..

mutid gname pos count tissue frequnt biotype consequence impact nucchange aachange
M0100975 OMEBPAMO_00013 14950 5 Skin 0.09 protein_coding upstream_gene_variant MODIFIER -4956A>C None
M0100976 OMEBPAMO_00019 15037 7 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -81G>A None
M0100977 OMEBPAMO_00019 15059 5 Skin 0.09 protein_coding upstream_gene_variant MODIFIER -59T>A None
M0100978 OMEBPAMO_00019 15065 5 Skin 0.09 protein_coding upstream_gene_variant MODIFIER -53A>G None
M0100979 OMEBPAMO_00019 15068 7 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -50T>C None
M0100980 OMEBPAMO_00019 15204 5 Skin 0.09 protein_coding synonymous_variant LOW 87C>T Val29Val
M0100981 OMEBPAMO_00019 15294 5 Skin 0.09 protein_coding synonymous_variant LOW 177T>C Ile59Ile
M0100982 OMEBPAMO_00019 15477 8 Skin 0.14 protein_coding synonymous_variant LOW 360C>T Asn120Asn
M0100983 OMEBPAMO_00019 15492 8 Skin 0.14 protein_coding synonymous_variant LOW 375C>T Thr125Thr
M0100984 OMEBPAMO_00019 15591 6 Skin 0.10 protein_coding synonymous_variant LOW 474C>T His158His
M0100985 OMEBPAMO_00019 15610 11 Skin 0.19 protein_coding missense_variant MODERATE 493G>A Ala165Thr
M0100986 OMEBPAMO_00019 15619 8 Skin 0.14 protein_coding missense_variant MODERATE 502A>G Ser168Gly
M0100987 OMEBPAMO_00019 15622 8 Skin 0.14 protein_coding missense_variant MODERATE 505T>G Ser169Ala
M0100988 OMEBPAMO_00019 15631 6 Skin 0.10 protein_coding missense_variant MODERATE 514G>T Ala172Ser
M0100989 OMEBPAMO_00019 15633 6 Skin 0.10 protein_coding synonymous_variant LOW 516T>C Ala172Ala
M0100990 OMEBPAMO_00019 15637 8 Skin 0.14 protein_coding missense_variant MODERATE 520A>C Ile174Leu
M0100991 OMEBPAMO_00019 15638 8 Skin 0.14 protein_coding missense_variant MODERATE 521T>C Ile174Thr
M0100992 OMEBPAMO_00019 15667 6 Skin 0.10 protein_coding missense_variant MODERATE 550G>A Val184Ile
M0100993 OMEBPAMO_00019 15810 8 Skin 0.14 protein_coding synonymous_variant LOW 693G>T Thr231Thr
M0100994 OMEBPAMO_00019 15921 7 Skin 0.12 protein_coding synonymous_variant LOW 804C>T Ile268Ile
M0100995 OMEBPAMO_00019 15945 6 Skin 0.10 protein_coding synonymous_variant LOW 828T>C Gly276Gly
M0100996 OMEBPAMO_00019 16021 8 Skin 0.14 protein_coding missense_variant MODERATE 904T>G Ser302Ala
M0100997 OMEBPAMO_00019 16035 8 Skin 0.14 protein_coding synonymous_variant LOW 918T>C Phe306Phe
M0100998 OMEBPAMO_00019 16138 7 Skin 0.12 protein_coding missense_variant MODERATE 1021T>A Ser341Thr
M0100999 OMEBPAMO_00019 16165 8 Skin 0.14 protein_coding missense_variant MODERATE 1048C>T Pro350Ser
M0101000 OMEBPAMO_00019 16314 12 Skin 0.21 protein_coding synonymous_variant LOW 1197T>C Ala399Ala
M0101001 OMEBPAMO_00019 16323 12 Skin 0.21 protein_coding synonymous_variant LOW 1206G>A Leu402Leu
M0101002 OMEBPAMO_00019 16416 7 Skin 0.12 protein_coding synonymous_variant LOW 1299C>T Asp433Asp
M0101003 OMEBPAMO_00019 16438 9 Skin 0.16 protein_coding missense_variant MODERATE 1321G>T Val441Leu
M0101004 OMEBPAMO_00019 16610 9 Skin 0.16 protein_coding missense_variant MODERATE 1493A>G Asp498Gly
M0101005 OMEBPAMO_00019 16869 9 Skin 0.16 protein_coding synonymous_variant LOW 1752C>T Leu584Leu
M0101006 OMEBPAMO_00019 16885 9 Skin 0.16 protein_coding missense_variant MODERATE 1768G>A Val590Ile
M0101007 OMEBPAMO_00019 16974 8 Skin 0.14 protein_coding synonymous_variant LOW 1857C>T Asp619Asp
M0101008 OMEBPAMO_00019 17230 8 Skin 0.14 protein_coding missense_variant MODERATE 2113A>G Ile705Val
M0101009 OMEBPAMO_00019 17312 6 Skin 0.10 protein_coding missense_variant MODERATE 2195A>G Asn732Ser
M0101010 OMEBPAMO_00019 17320 6 Skin 0.10 protein_coding missense_variant MODERATE 2203G>T Ala735Ser
M0101011 OMEBPAMO_00019 17368 5 Skin 0.09 protein_coding missense_variant MODERATE 2251C>T His751Tyr
M0101012 OMEBPAMO_00019 17416 5 Skin 0.09 protein_coding missense_variant MODERATE 2299G>A Asp767Asn
M0101013 OMEBPAMO_00019 17451 5 Skin 0.09 protein_coding missense_variant MODERATE 2334T>A His778Gln
M0101014 OMEBPAMO_00019 17526 7 Skin 0.12 protein_coding synonymous_variant LOW 2409G>A Glu803Glu
M0101015 OMEBPAMO_00019 17572 6 Skin 0.10 protein_coding missense_variant MODERATE 2455G>C Asp819His
M0101016 OMEBPAMO_00019 17595 6 Skin 0.10 protein_coding synonymous_variant LOW 2478C>T Phe826Phe
M0101017 OMEBPAMO_00020 17769 6 Skin 0.10 protein_coding upstream_gene_variant MODIFIER -12A>G None
M0101018 OMEBPAMO_00020 17837 8 Skin 0.14 protein_coding synonymous_variant LOW 57T>C Ala19Ala
M0101019 OMEBPAMO_00020 17869 6 Skin 0.10 protein_coding missense_variant MODERATE 89G>A Ser30Asn
M0101020 OMEBPAMO_00020 17928 6 Skin 0.10 protein_coding missense_variant MODERATE 148C>T Pro50Ser
M0101021 OMEBPAMO_00020 18045 16 Skin 0.28 protein_coding missense_variant MODERATE 265A>G Thr89Ala
M0101022 OMEBPAMO_00020 18086 9 Skin 0.16 protein_coding synonymous_variant LOW 306C>A Ile102Ile
M0101023 OMEBPAMO_00020 18261 8 Skin 0.14 protein_coding missense_variant MODERATE 481A>G Thr161Ala
M0101024 OMEBPAMO_00020 18423 10 Skin 0.17 protein_coding missense_variant MODERATE 643T>G Ser215Ala
M0101025 OMEBPAMO_00020 18437 10 Skin 0.17 protein_coding synonymous_variant LOW 657T>C Ser219Ser
M0101026 OMEBPAMO_00020 18479 10 Skin 0.17 protein_coding synonymous_variant LOW 699T>A Pro233Pro
M0101027 OMEBPAMO_00020 18531 10 Skin 0.17 protein_coding missense_variant MODERATE 751A>G Asn251Asp
M0101028 OMEBPAMO_00020 18542 10 Skin 0.17 protein_coding synonymous_variant LOW 762G>A Glu254Glu
M0101029 OMEBPAMO_00020 18564 8 Skin 0.14 protein_coding missense_variant MODERATE 784A>G Ile262Val
M0101030 OMEBPAMO_00020 18668 18 Skin 0.31 protein_coding synonymous_variant LOW 888C>T Tyr296Tyr
M0101031 OMEBPAMO_00020 18721 7 Skin 0.12 protein_coding missense_variant MODERATE 941A>T Asn314Ile
M0101032 OMEBPAMO_00021 18735 7 Skin 0.12 protein_coding upstream_gene_variant MODIFIER -339T>A None
M0101033 OMEBPAMO_00021 18740 10 Skin 0.17 protein_coding upstream_gene_variant MODIFIER -334T>A None
M0101034 OMEBPAMO_00021 18803 17 Skin 0.29 protein_coding upstream_gene_variant MODIFIER -271A>G None
M0101035 OMEBPAMO_00021 19041 17 Skin 0.29 protein_coding upstream_gene_variant MODIFIER -33T>C None
M0101036 OMEBPAMO_00021 19263 10 Skin 0.17 protein_coding missense_variant MODERATE 190G>A Ala64Thr
M0101037 OMEBPAMO_00021 19284 9 Skin 0.16 protein_coding missense_variant MODERATE 211G>A Gly71Ser
M0101038 OMEBPAMO_00021 19311 10 Skin 0.17 protein_coding missense_variant MODERATE 238T>C Ser80Pro
M0101039 OMEBPAMO_00020 18042 5 Skin 0.09 protein_coding missense_variant MODERATE 262G>A Ala88Thr
M0101040 OMEBPAMO_00020 18059 5 Skin 0.09 protein_coding synonymous_variant LOW 279C>T Asn93Asn
M0101041 OMEBPAMO_00020 18709 7 Skin 0.12 protein_coding missense_variant MODERATE 929G>A Gly310Asp
M0101042 OMEBPAMO_00019 16695 6 Skin 0.10 protein_coding synonymous_variant LOW 1578C>T Ile526Ile
M0101043 OMEBPAMO_00019 16711 8 Skin 0.14 protein_coding missense_variant MODERATE 1594G>T Val532Phe
M0101044 OMEBPAMO_00019 16737 5 Skin 0.09 protein_coding synonymous_variant LOW 1620A>G Ser540Ser
M0101045 OMEBPAMO_00021 18813 9 Skin 0.16 protein_coding upstream_gene_variant MODIFIER -261A>G None
M0101046 OMEBPAMO_00021 19334 9 Skin 0.16 protein_coding synonymous_variant LOW 261T>C Ile87Ile
M0101047 OMEBPAMO_00021 19344 9 Skin 0.16 protein_coding missense_variant MODERATE 271T>G Cys91Gly
M0101048 OMEBPAMO_00021 19422 11 Skin 0.19 protein_coding missense_variant MODERATE 349G>A Gly117Ser
M0101049 OMEBPAMO_00021 19445 11 Skin 0.19 protein_coding synonymous_variant LOW 372T>C Asn124Asn
M0101050 OMEBPAMO_00021 19446 10 Skin 0.17 protein_coding missense_variant MODERATE 373T>C Ser125Pro
M0101051 OMEBPAMO_00021 19462 12 Skin 0.21 protein_coding missense_variant MODERATE 389G>C Gly130Ala
M0101052 OMEBPAMO_00021 19630 8 Skin 0.14 protein_coding missense_variant MODERATE 557A>G Tyr186Cys
M0101053 OMEBPAMO_00021 19545 8 Skin 0.14 protein_coding synonymous_variant LOW 472C>A Arg158Arg
M0101054 OMEBPAMO_00020 18671 3 Skin 0.05 protein_coding synonymous_variant LOW 891G>A Val297Val
M0101055 OMEBPAMO_00002 2331 4 Skin 0.07 protein_coding synonymous_variant LOW 972A>T Val324Val
M0101056 OMEBPAMO_00020 17822 3 Skin 0.05 protein_coding synonymous_variant LOW 42C>T Ala14Ala
M0101057 OMEBPAMO_00021 18868 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -206A>G None
M0101058 OMEBPAMO_00021 18894 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -180T>C None
M0101059 OMEBPAMO_00021 18912 3 Skin 0.05 protein_coding upstream_gene_variant MODIFIER -162T>C None
M0101060 OMEBPAMO_00003 3580 3 Skin 0.05 protein_coding synonymous_variant LOW 78C>T Val26Val
M0101061 OMEBPAMO_00003 3589 3 Skin 0.05 protein_coding synonymous_variant LOW 87T>A Val29Val






Analysis of virulence factors contributing to bacterial pathogenicity


This table presents virulence factors identified within the plasmid cluster.
      Note: Virulence factor analysis was performed using VFDB. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known virulence factors are listed.

Gene Name vf_gene_id vf_name identity evalue qstart qend query_coverage subject_coverage vf_category gene_description condition







        Analysis of biocide and heavy metal resistance genes to assess antimicrobial risk and environmental impact


This table presents biocides and heavy metals resistance genes identified within the plasmid cluster.
      Note: Analyzing biocide and heavy metal resistance genes based on BacMet to evaluate bacterial resistance risk and the potential impact of environmental heavy metal contamination. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, E-value < 1e-5) to known biocide and heavy metal resistance genes are listed.

Gene Name compound identity evalue qstart qend query_coverage subject_coverage group
OMEBPAMO_00024 Cadmium (Cd), Zinc (Zn) 88.3 2.2e-96 1 205 1.0000 1.0000 experiment
AKELKGGF_00024 Cadmium (Cd), Zinc (Zn) 88.3 2.2e-96 1 205 1.0000 1.0000 experiment
OMEBPAMO_00015 Copper (Cu), Silver (Ag) 75.6 0 1 795 1.0000 1.0013 prediction
OMEBPAMO_00016 Copper (Cu) 100 1.6e-33 1 69 1.0000 1.0000 prediction
OMEBPAMO_00024 Cadmium (Cd), Zinc (Zn) 97.1 1.6e-100 1 205 1.0000 1.0000 prediction
AKELKGGF_00015 Copper (Cu), Silver (Ag) 75.6 0 1 795 1.0000 1.0013 prediction
AKELKGGF_00016 Copper (Cu) 100 1.6e-33 1 69 1.0000 1.0000 prediction
AKELKGGF_00024 Cadmium (Cd), Zinc (Zn) 97.1 1.6e-100 1 205 1.0000 1.0000 prediction






        Analyzing antimicrobial resistance genes to assess bacterial resistance to antibiotics and other antimicrobial agents


This table presents antimicrobial resistance genes identified within the plasmid cluster.
      Note: Antimicrobial resistance was performed using CARD. Genes in plasmid clusters showing strong homology (identity > 70%, coverage > 70%, E-value < 1e-5) to known antimicrobial resistance genes are listed.

Gene Name aro_accession identity evalue qstart qend query_coverage subject_coverage drug_class amr_gene_family resistance_mechanism






Analysis of pathogenicity genes to explore pathogen-host interactions


This table presents host pathogen-host interactions within the plasmid cluster.
      Note: Analyzing pathogenicity-related genes using PHI-base to understand pathogen virulence mechanisms and their impact on host interactions. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e-5) to known pathogenicity-related genes are listed.

Gene Name phi_molconn_id host gene_name identity evalue qstart qend query_coverage subject_coverage host_descripton disease_name function phenotype_of_mutant






        Analyzing carbohydrate-active enzyme genes to uncover mechanisms of nutrient degradation


This table presents carbohydrate-active enzyme genes identified within the plasmid cluster.
      Note: Annotation of carbohydrate-active enzyme genes was performed using CAZy to explore mechanisms of nutrient breakdown and utilization. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known CAZyme genes are listed.

Gene Name cazy_id identity evalue qstart qend query_coverage subject_coverage





        Analyzing transport proteins to understand bacterial strategies for substrate uptake and detoxification


This table presents transport proteins within the plasmid cluster.
      Note: Investigation of transport proteins based on TCDB to uncover bacterial mechanisms of substrate transport and environmental detoxification. Genes in plasmid clusters showing strong homology (identity > 70%, subject coverage > 70%, and E-value < 1e−5) to known transport protein entries are listed.

Gene Name tcid identity evalue qstart qend query_coverage subject_coverage class_field class_term subclass subclass_term family family_term
OMEBPAMO_00015 3.A.3.5.19 73.6 0 4 795 0.9962 0.9888 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.3 The P-type ATPase (P-ATPase) Superfamily
OMEBPAMO_00020 3.A.1.12.16 98.1 7.4e-172 1 314 1.0000 1.0000 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
OMEBPAMO_00024 2.A.77.1.1 87.8 1.8e-94 1 205 1.0000 0.9809 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.77 The Cadmium Resistance (CadD) Family
AKELKGGF_00015 3.A.3.5.19 73.6 0 4 795 0.9962 0.9888 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.3 The P-type ATPase (P-ATPase) Superfamily
AKELKGGF_00020 3.A.1.12.16 98.1 7.4e-172 1 314 1.0000 1.0000 3 Primary Active Transporters 3.A P-P-bond-hydrolysis-driven transporters 3.A.1 The ATP-binding Cassette (ABC) Superfamily
AKELKGGF_00024 2.A.77.1.1 87.8 1.8e-94 1 205 1.0000 0.9809 2 Electrochemical Potential-driven Transporters 2.A Porters (uniporters, symporters, antiporters) 2.A.77 The Cadmium Resistance (CadD) Family